DPP9 restrains NLRP1 activation

Bauernfried, Stefan und Hornung, Veit (2021): DPP9 restrains NLRP1 activation. In: Nature Structural & Molecular Biology, Vol. 28, No. 4: pp. 333-336

Abstract

NLRP1 was the first inflammasome-forming sensor to be identified, but only recently has its mode of action been in the spotlight. Two groups now report cryo-EM structures demonstrating how NLRP1 is kept in check by the dipeptidyl peptidase DPP9, and they illuminate how DPP9 inhibition leads to NLRP1 inflammasome activation.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Biochemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1545-9993
• Language: English