Microglia contribute to the propagation of A beta into unaffected brain tissue

d'Errico, Paolo; Ziegler-Waldkirch, Stephanie; Aires, Vanessa; Hoffmann, Philippe; Mezoe, Charlotte; Erny, Daniel; Monasor, Laura Sebastian; Liebscher, Sabine; Ravi, Vidhya M.; Joseph, Kevin; Schnell, Oliver; Kierdorf, Katrin; Staszewski, Ori; Tahirovic, Sabina; Prinz, Marco und Meyer-Luehmann, Melanie (2021): Microglia contribute to the propagation of A beta into unaffected brain tissue. In: Nature Neuroscience, Bd. 25, Nr. 1: S. 20-25

Abstract

Microglia appear activated in the vicinity of amyloid beta (A beta) plaques, but whether microglia contribute to A beta propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that A beta enters WT grafts, and that this is accompanied by microglia infiltration. Manipulation of microglia function reduced A beta deposition within grafts. Furthermore, in vivo imaging identified microglia as carriers of A beta pathology in previously unaffected tissue. Our data thus argue for a hitherto unexplored mechanism of A beta propagation. This study shows that A beta from transgenic host tissue is able to enter and deposit within wild-type grafts via microglia, thus identifying microglia as carriers of A beta deposition into previously unaffected brain tissue.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin ; Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1097-6256
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198