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Anzahl der Publikationen: 35
Zeitschriftenartikel
Stallhofer, Johannes; Veith, Lisa; Diegelmann, Julia; Probst, Philipp; Brand, Stephan; Schnitzler, Fabian; Olszak, Torsten; Toeroek, Helga; Mayerle, Julia; Stallmach, Andreas und Beigel, Florian
(2022):
Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression.
In: Clinical and Translational Gastroenterology, Bd. 13, Nr. 1, e00450
Schardey, Josefine; Zehl, Sophie; Kappenberger, Alina S.; Zimmermann, Petra; Beigel, Florian; Schiergens, Tobias S.; Kasparek, Michael S.; Kühn, Florian; Werner, Jens und Wirth, Ulrich
(2022):
It is not NOD2-genetic and clinical risk factors for postoperative complications following ileocolic resection in Crohn's disease.
In: International Journal of Colorectal Disease, Bd. 37, Nr. 8: S. 1901-1908
[PDF, 675kB]
Winkelmann, Paula; Unterweger, Anna-Lena; Khullar, Diya; Beigel, Florian; Koletzko, Leandra; Siebeck, Matthias und Gropp, Roswitha
(2021):
The PI3K pathway as a therapeutic intervention point in inflammatory bowel disease.
In: Immunity Inflammation and Disease, Bd. 9, Nr. 3: S. 804-818
Unterweger, Anna-Lena; Rüscher, Alena; Seuß, Marietta; Winkelmann, Paula; Beigel, Florian; Koletzko, Leandra; Breiteneicher, Simone; Siebeck, Matthias; Gropp, Roswitha und Aszodi, Attila
(2021):
NOD/scid IL-2R gamma(null) mice reconstituted with peripheral blood mononuclear cells from patients with Crohn's disease reflect the human pathological phenotype.
In: Immunity Inflammation and Disease, Bd. 9, Nr. 4: S. 1631-1647
Unterweger, Anna-Lena; Jensen, Morten O.; Giordanetto, Fabrizio; Jogini, Vishwanath; Rueschher, Alena; Seuss, Marietta; Winkelmann, Paula; Koletzko, Leandra; Shaw, David E.; Siebeck, Matthias; Gropp, Roswitha; Beigel, Florian und Aszodi, Attila
(2021):
Suppressing Kv1.3 Ion Channel Activity with a Novel Small Molecule Inhibitor Ameliorates Inflammation in a Humanised Mouse Model of Ulcerative Colitis.
In: Journal of Crohns & Colitis, Bd. 15, Nr. 11: S. 1943-1958
Jodeleit, Henrika; Winkelmann, Paula; Caesar, Janina; Sterz, Sebastian; Holdt, Lesca M.; Beigel, Florian; Stallhofer, Johannes; Breiteneicher, Simone; Bartnik, Eckart; Leeuw, Thomas; Siebeck, Matthias und Gropp, Roswitha
(2021):
Head-to-head study of oxelumab and adalimumab in a mouse reconstituted with human peripheral blood mononuclear cells.
In: Disease Models & Mechanisms, Bd. 14, Nr. 1
Jodeleit, Henrika; Winkelmann, Paula; Caesar, Janina; Sterz, Sebastian; Holdt, Lesca M.; Beigel, Florian; Stallhofer, Johannes; Breiteneicher, Simone; Bartnik, Eckart; Leeuw, Thomas; Siebeck, Matthias 
ORCID: https://orcid.org/0000-0001-5290-5344 und Gropp, Roswitha ORCID: https://orcid.org/0000-0003-4756-261X
(2021):
Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγnull mice reconstituted with human peripheral blood mononuclear cells.
In: Disease Models & Mechanisms, Bd. 14, Nr. 1, dmm046995
[PDF, 3MB]
ORCID: https://orcid.org/0000-0001-5290-5344 und Gropp, Roswitha ORCID: https://orcid.org/0000-0003-4756-261X
(2021):
Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγnull mice reconstituted with human peripheral blood mononuclear cells.
In: Disease Models & Mechanisms, Bd. 14, Nr. 1, dmm046995
[PDF, 3MB]
Schnitzler, Fabian; Friedrich, Matthias; Angelberger, Marianne; Diegelmann, Julia; Stallhofer, Johannes; Wolf, Christiane; Dütschler, Joel; Truniger, Samuel; Olszak, Torsten; Beigel, Florian; Tillack, Cornelia; Lohse, Peter und Brand, Stephan
(2020):
Development of a uniform, very aggressive disease phenotype in all homozygous carriers of the NOD2 mutation p.Leu1007fsX1008 with Crohn's disease and active smoking status resulting in ileal stenosis requiring surgery.
In: PLOS One 15(7), e0236421 [PDF, 881kB]
In: PLOS One 15(7), e0236421 [PDF, 881kB]
Jodeleit, Henrika; Caesar, Janina; Aguilera, Christina Villarroel; Sterz, Sebastian; Holdt, Lesca; Beigel, Florian; Stallhofer, Johannes; Breiteneicher, Simone; Bartnik, Eckart; Siebeck, Matthias und Gropp, Roswitha
(2020):
The Combination of Patient Profiling and Preclinical Studies in a Mouse Model Based on NOD/Scid IL2R gamma(null) Mice Reconstituted With Peripheral Blood Mononuclear Cells From Patients With Ulcerative Colitis May Lead to Stratification of Patients for Treatment With Adalimumab.
In: Inflammatory Bowel Diseases, Bd. 26, Nr. 4: S. 557-569
Jodeleit, Henrika; Milchram, Lisa; Soldo, Regina; Beikircher, Gabriel; Schoenthaler, Silvia; Al-amodi, Omar; Wolf, Eckhard; Beigel, Florian; Weinhaeusel, Andreas; Siebeck, Matthias und Gropp, Roswitha
(2020):
Autoantibodies as diagnostic markers and potential drivers of inflammation in ulcerative colitis.
In: PLOS One 15(2), e0228615 [PDF, 2MB]
In: PLOS One 15(2), e0228615 [PDF, 2MB]
Pinter, Andreas; Beigel, Florian; Koerber, Andreas; Homey, Bernhard; Beissert, Stefan; Gerdes, Sascha; Staubach-Renz, Petra; Radtke, Marc-Alexander und Moessner, Rotraut
(2019):
Gastrointestinale Beschwerden unter Apremilast. Charakterisierung und Management.
In: Hautarzt, Bd. 70, Nr. 5: S. 354-361
Jodeleit, Henrika; Al-Amodi, Omar; Caesar, Janina; Aguilera, Christina Villarroel; Holdt, Lesca; Gropp, Roswitha; Beigel, Florian und Siebeck, Matthias
(2018):
Targeting ulcerative colitis by suppressing glucose uptake with ritonavir.
In: Disease Models & Mechanisms, Bd. 11, Nr. 11
[PDF, 3MB]
Al-amodi, Omar; Jodeleit, Henrika; Beigel, Florian; Wolf, Eckhard; Siebeck, Matthias und Gropp, Roswitha
(2018):
CD1a-Expressing Monocytes as Mediators of Inflammation in Ulcerative Colitis.
In: Inflammatory Bowel Diseases, Bd. 24, Nr. 6: S. 1225-1236
Jodeleit, Henrika; Palamides, Pia; Beigel, Florian; Müller, Thomas; Wolf, Eckhard; Siebeck, Matthias und Gropp, Roswitha
(2017):
Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model.
In: Journal of Translational Medicine
15:265
[PDF, 15MB]
Palamides, Pia; Jodeleit, Henrika; Föhlinger, Michael; Beigel, Florian; Herbach, Nadja; Müller, Thomas; Wolf, Eckhard; Siebeck, Matthias und Gropp, Roswitha
(2016):
A mouse model for ulcerative colitis based on NOD-scid IL2R gamma(null) mice reconstituted with peripheral blood mononuclear cells from affected individuals.
In: Disease Models & Mechanisms, Bd. 9, Nr. 9: S. 985-997
[PDF, 2MB]
Schnitzler, Fabian; Friedrich, Matthias; Stallhofer, Johannes; Schoenermarck, Ulf; Fischereder, Michael; Habicht, Antje; Karbalai, Nazanin; Wolf, Christiane; Angelberger, Marianne; Olszak, Torsten; Beigel, Florian; Tillack, Cornelia; Goeke, Burkhard; Zachoval, Reinhart; Denk, Gerald; Guba, Markus; Rust, Christian; Gruener, Norbert und Brand, Stephan
(2015):
Solid Organ Transplantation in Patients with Inflammatory Bowel Diseases (IBD): Analysis of Transplantation Outcome and IBD Activity in a Large Single Center Cohort.
In: PLOS ONE 10(8), e0135807 [PDF, 545kB]
In: PLOS ONE 10(8), e0135807 [PDF, 545kB]
Schnitzler, Fabian; Friedrich, Matthias; Wolf, Christiane; Stallhofer, Johannes; Angelberger, Marianne; Diegelmann, Julia; Olszak, Torsten; Tillack, Cornelia; Beigel, Florian; Goeke, Burkhard; Glas, Jürgen; Lohse, Peter und Brand, Stephan
(2015):
The NOD2 Single Nucleotide Polymorphism rs72796353 (IVS4+10 A > C) Is a Predictor for Perianal Fistulas in Patients with Crohn's Disease in the Absence of Other NOD2 Mutations.
In: PLOS ONE 10(7), e0116044 [PDF, 233kB]
In: PLOS ONE 10(7), e0116044 [PDF, 233kB]
Beigel, Florian; Friedrich, Matthias; Probst, Corina; Sotlar, Karl; Göke, Burkhard; Diegelmann, Julia und Brand, Stephan
(2014):
Oncostatin M Mediates STAT3-Dependent Intestinal Epithelial Restitution via Increased Cell Proliferation, Decreased Apoptosis and Upregulation of SERPIN Family Members.
In: PLOS ONE 9(4), e93498 [PDF, 3MB]
In: PLOS ONE 9(4), e93498 [PDF, 3MB]
Tillack, Cornelia; Ehmann, Laura Maximiliane; Friedrich, Matthias; Laubender, Ruediger P.; Papay, Pavol; Vogelsang, Harald; Stallhofer, Johannes; Beigel, Florian; Bedynek, Andrea; Wetzke, Martin; Maier, Harald; Koburger, Maria; Wagner, Johanna; Glas, Jürgen; Diegelmann, Julia; Koglin, Sarah; Dombrowski, Yvonne; Schauber, Jürgen; Wollenberg, Andreas und Brand, Stephan
(2014):
Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-gamma-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment.
In: Gut, Bd. 63, Nr. 4: S. 567-577
[PDF, 1MB]
Beigel, Florian; Deml, Matthias; Schnitzler, Fabian; Breiteneicher, Simone; Göke, Burkhard; Ochsenkühn, Thomas und Brand, Stephan
(2014):
Rate and Predictors of Mucosal Healing in Patients with Inflammatory Bowel Disease Treated with Anti-TNF-Alpha Antibodies.
In: PLOS ONE 9(6), e99293 [PDF, 509kB]
In: PLOS ONE 9(6), e99293 [PDF, 509kB]
Schnitzler, Fabian; Friedrich, Matthias; Wolf, Christiane; Angelberger, Marianne; Diegelmann, Julia; Olszak, Torsten; Beigel, Florian; Tillack, Cornelia; Stallhofer, Johannes; Göke, Burkhard; Glas, Jürgen; Lohse, Peter und Brand, Stephan
(2014):
The NOD2 p.Leu1007fsX1008 Mutation (rs2066847) Is a Stronger Predictor of the Clinical Course of Crohn's Disease than the FOXO3A Intron Variant rs12212067.
In: PLOS ONE 9(11), e108503 [PDF, 220kB]
In: PLOS ONE 9(11), e108503 [PDF, 220kB]
Tillack, Cornelia; Ehmann, Laura Maximiliane; Friedrich, Matthias; Laubender, Rüdiger P.; Papay, Pavol; Vogelsang, Harald; Stallhofer, Johannes; Beigel, Florian; Bedynek, Andrea; Wetzke, Martin; Maier, Harald; Koburger, Maria; Wagner, Johanna; Glas, Jürgen; Diegelmann, Julia; Koglin, Sarah; Dombrowski, Yvonne; Schauber, Jürgen; Wollenberg, Andreas und Brand, Stephan
(2014):
Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-gamma-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment.
In: Gut, Bd. 63, Nr. 4: S. 567-577
Glas, Jürgen; Seiderer, Julia; Bues, Stephanie; Stallhofer, Johannes; Fries, Christoph; Olszak, Torsten; Tsekeri, Eleni; Wetzke, Martin; Beigel, Florian; Steib, Christian; Friedrich, Matthias; Göke, Burkhard; Diegelmann, Julia; Czamara, Darina und Brand, Stephan
(2013):
IRGM variants and susceptibility to inflammatory bowel disease in the German population.
In: PLOS ONE 8(1), e54338 [PDF, 214kB]
In: PLOS ONE 8(1), e54338 [PDF, 214kB]
Glas, Jürgen; Seiderer, Julia; Wagner, Johanna; Olszak, Torsten; Fries, Christoph; Tillack, Cornelia; Friedrich, Matthias; Beigel, Florian; Stallhofer, Johannes; Steib, Christian; Wetzke, Martin; Göke, Burkhard; Ochsenkühn, Thomas; Diegelmann, Julia; Czamara, Darina und Brand, Stephan
(2012):
Analysis of IL12B gene variants in inflammatory bowel disease.
In: PLOS ONE 7(3), e34349 [PDF, 136kB]
In: PLOS ONE 7(3), e34349 [PDF, 136kB]
Beigel, Florian; Löhr, Beate; Laubender, Rüdiger P.; Tillack, Cornelia; Schnitzler, Fabian; Breiteneicher, Simone; Weidinger, Maria; Göke, Burkhard; Seiderer, Julia; Ochsenkühn, Thomas und Brand, Stephan
(2012):
Iron Status and Analysis of Efficacy and Safety of Ferric Carboxymaltose Treatment in Patients with Inflammatory Bowel Disease.
In: Digestion, Nr. 1: S. 47-54
[PDF, 464kB]
Glas, Jürgen; Wagner, Johanna; Seiderer, Julia; Olszak, Torsten; Wetzke, Martin; Beigel, Florian; Tillack, Cornelia; Stallhofer, Johannes; Friedrich, Matthias; Steib, Christian; Göke, Burkhard; Ochsenkühn, Thomas; Karbalai, Nazanin; Diegelmann, Julia; Czamara, Darina und Brand, Stephan
(2012):
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.
In: PLOS ONE 7(3), e33682 [PDF, 145kB]
In: PLOS ONE 7(3), e33682 [PDF, 145kB]
Glas, Jürgen; Seiderer, Julia; Fries, Christoph; Tillack, Cornelia; Pfennig, Simone; Weidinger, Maria; Beigel, Florian; Olszak, Torsten; Lass, Ulrich; Göke, Burkhard; Ochsenkühn, Thomas; Wolf, Christiane; Lohse, Peter; Müller-Myhsok, Bertram; Diegelmann, Julia; Czamara, Darina und Brand, Stephan
(2011):
CEACAM6 gene variants in inflammatory bowel disease.
In: PLOS ONE 6(4), e19319 [PDF, 214kB]
In: PLOS ONE 6(4), e19319 [PDF, 214kB]
Glas, Jürgen; Seiderer, Julia; Bayrle, Corinna; Wetzke, Martin; Fries, Christoph; Tillack, Cornelia; Olszak, Torsten; Beigel, Florian; Steib, Christian; Friedrich, Matthias; Diegelmann, Julia; Czamara, Darina und Brand, Stephan
(2011):
The role of osteopontin (OPN/SPP1) haplotypes in the susceptibility to Crohn's disease.
In: PLOS ONE 6(12), e29309 [PDF, 129kB]
In: PLOS ONE 6(12), e29309 [PDF, 129kB]
Glas, Jürgen; Seiderer, Julia; Nagy, Melinda; Fries, Christoph; Beigel, Florian; Weidinger, Maria; Pfennig, Simone; Klein, Wolfram; Epplen, Jörg T.; Lohse, Peter; Folwaczny, Matthias; Göke, Burkhard; Ochsenkühn, Thomas; Diegelmann, Julia; Müller-Myhsok, Bertram; Roeske, Darina und Brand, Stephan
(2010):
Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
In: PLOS ONE 5(4), e10373 [PDF, 128kB]
In: PLOS ONE 5(4), e10373 [PDF, 128kB]
Glas, Jürgen; Seiderer, Julia; Tillack, Cornelia; Pfennig, Simone; Beigel, Florian; Jürgens, Matthias; Olszak, Torsten; Laubender, Rüdiger P.; Weidinger, Maria; Müller-Myhsok, Bertram; Göke, Burkhard; Ochsenkühn, Thomas; Lohse, Peter; Diegelmann, Julia; Czamara, Darina und Brand, Stephan
(2010):
The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants.
In: PLOS ONE 5(12), e14466 [PDF, 125kB]
In: PLOS ONE 5(12), e14466 [PDF, 125kB]
Diegelmann, Julia; Beigel, Florian; Zitzmann, Kathrin; Kaul, Artur; Göke, Burkhard; Auernhammer, Christoph J.; Bartenschlager, Ralf; Diepolder, Helmut M. und Brand, Stephan
(2010):
Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus.
In: PLOS ONE 5(12), e15200 [PDF, 572kB]
In: PLOS ONE 5(12), e15200 [PDF, 572kB]
Jürgens, Matthias; Brand, S.; Laubender, Rüdiger P.; Seiderer, Julia; Glas, Jürgen; Wetzke, M.; Wagner, J.; Pfennig, S.; Tillack, C.; Beigel, Florian; Weidinger, M.; Schnitzler, Fabian; Kreis, M. E.; Göke, Burkhard; Lohse, P.; Herrmann, K. und Ochsenkühn, Thomas
(2010):
The presence of fistulas and NOD2 homozygosity strongly predict intestinal stenosis in Crohn’s disease independent of the IL23R genotype.
In: Journal of Gastroenterology, Bd. 45, Nr. 7: S. 721-731
Jürgens, Matthias; Laubender, Rüdiger P.; Hartl, F.; Weidinger, M.; Seiderer, Julia; Wagner, J.; Wetzke, M.; Beigel, Florian; Pfennig, S.; Stallhofer, J.; Schnitzler, Fabian; Tillack, Cornelia; Lohse, Peter; Göke, Burkhard; Glas, Jürgen; Ochsenkühn, Thomas und Brand, Stephan
(2010):
Disease Activity, ANCA, and IL23R Genotype Status Determine Early Response to Infliximab in Patients With Ulcerative Colitis.
In: American Journal of Gastroenterology, Bd. 105, Nr. 8: S. 1811-1819
Dambacher, J.; Beigel, Florian; Zitzmann, K.; Toni, Enrico N. de; Göke, Burkhard; Diepolder, Helmut M.; Auernhammer, Christoph J. und Brand, Stephan
(2009):
The role of the novel Th17 cytokine IL-26 in intestinal inflammation.
In: Gut, Bd. 58, Nr. 9: S. 1207-1217
[PDF, 4MB]
Dambacher, Julia; Beigel, Florian; Seiderer, Julia; Haller, Dirk; Göke, Burkhard; Auernhammer, Christoph J. und Brand, Stephan
(2007):
Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease.
In: Gut, Bd. 56, Nr. 9: S. 1257-1265
[PDF, 559kB]