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Veröffentlichungsdatum
Anzahl der Publikationen: 54
2022
Li, Sihan; Ikeuchi, Ken; Kato, Misaki; Buschauer, Robert; Sugiyama, Takato; Adachi, Shungo; Kusano, Hideo; Natsume, Tohru; Berninghausen, Otto; Matsuo, Yoshitaka; Becker, Thomas; Beckmann, Roland und Inada, Toshifumi
(2022):
Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover.
In: Molecular Cell, Bd. 82, Nr. 18, E8: S. 3424-3437
Cheng, Jingdong; La Venuta, Giuseppe; Lau, Benjamin; Berninghausen, Otto; Beckmann, Roland und Hurt, Ed
(2022):
In vitro structural maturation of an early stage pre-40S particle coupled with U3 snoRNA release and central pseudoknot formation.
In: Nucleic Acids Research, Bd. 50, Nr. 20: S. 11916-11923
Czech, Laura; Mais, Christopher-Nils; Kratzat, Hanna; Sarmah, Pinku; Giammarinaro, Pietro; Freibert, Sven-Andreas; Esser, Hanna Folke; Musial, Joanna; Berninghausen, Otto; Steinchen, Wieland; Beckmann, Roland; Koch, Hans-Georg und Bange, Gert
(2022):
Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp.
In: Nature Communications, Bd. 13, Nr. 1, 1069
Cheng, Jingdong; Lau, Benjamin; Thoms, Matthias; Ameismeier, Michael; Berninghausen, Otto; Hurt, Ed und Beckmann, Roland
(2022):
The nucleoplasmic phase of pre-40S formation prior to nuclear export.
In: Nucleic Acids Research, Bd. 50, Nr. 20: S. 11924-11937
Saito, Kazuki; Kratzat, Hanna; Campbell, Annabelle; Buschauer, Robert; Burroughs, A. Maxwell; Berninghausen, Otto; Aravind, L.; Green, Rachel; Beckmann, Roland und Buskirk, Allen R.
(2022):
Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria.
In: Nature, Bd. 603, Nr. 7901: S. 503-508
2021
Kratzat, Hanna; Mackens‐Kiani, Timur; Ameismeier, Michael; Potocnjak, Mia; Cheng, Jingdong; Dacheux, Estelle; Namane, Abdelkader; Berninghausen, Otto; Herzog, Franz 
ORCID: https://orcid.org/0000-0001-8270-1449; Fromont‐Racine, Micheline; Becker, Thomas und Beckmann, Roland
(2021):
A structural inventory of native ribosomal ABCE1‐43S pre‐initiation complexes.
In: EMBO, Bd. 40, Nr. 1
[PDF, 12MB]
ORCID: https://orcid.org/0000-0001-8270-1449; Fromont‐Racine, Micheline; Becker, Thomas und Beckmann, Roland
(2021):
A structural inventory of native ribosomal ABCE1‐43S pre‐initiation complexes.
In: EMBO, Bd. 40, Nr. 1
[PDF, 12MB]
Su, Ting; Kudva, Renuka; Becker, Thomas; Buschauer, Robert; Komar, Tobias; Berninghausen, Otto; Heijne, Gunnar von; Cheng, Jingdong und Beckmann, Roland
(2021):
Structural basis of L-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide.
In: Nucleic Acids Research, Bd. 49, Nr. 16: S. 9539-9547
Pochopien, Agnieszka A.; Beckert, Bertrand; Kasvandik, Sergo; Berninghausen, Otto; Beckmann, Roland; Tenson, Tanel und Wilson, Daniel N.
(2021):
Structure of Gcn1 bound to stalled and colliding 80S ribosomes.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 118, Nr. 14, e2022756118
Lau, Benjamin; Cheng, Jingdong; Flemming, Dirk; La Venuta, Giuseppe; Berninghausen, Otto; Beckmann, Roland und Hurt, Ed
(2021):
Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.
In: Molecular Cell, Bd. 81, Nr. 2:
293-
Cheng, Jingdong; Berninghausen, Otto und Beckmann, Roland
(2021):
A distinct assembly pathway of the human 39S late pre-mitoribosome.
In: Nature Communications, Bd. 12, Nr. 1, 4544
[PDF, 3MB]
Cheng, Jingdong; Berninghausen, Otto und Beckmann, Roland
(2021):
A distinct assembly pathway of the human 39S late pre-mitoribosome.
In: Nature Communications, Bd. 12, 4544
[PDF, 3MB]
2020
Kater, Lukas; Wagener, Nikola; Berninghausen, Otto; Becker, Thomas; Neupert, Walter und Beckmann, Roland
(2020):
Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins.
In: Nature Structural & Molecular Biology, Bd. 27, Nr. 2: S. 142-149
Thoms, Matthias; Buschauer, Robert; Ameismeier, Michael; Koepke, Lennart; Denk, Timo; Hirschenberger, Maximilian; Kratzat, Hanna; Hayn, Manuel; Mackens-Kiani, Timur; Cheng, Jingdong; Straub, Jan H.; Stürzel, Christina M.; Fröhlich, Thomas; Berninghausen, Otto; Becker, Thomas; Kirchhoff, Frank; Sparrer, Konstantin M. J. und Beckmann, Roland
(2020):
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
In: Science, Bd. 369, Nr. 6508: S. 1249-1255
Kratzat, Hanna; Mackens-Kiani, Timur; Ameismeier, Michael; Potocnjak, Mia; Cheng, Jingdong; Dacheux, Estelle; Namane, Abdelkader; Berninghausen, Otto; Herzog, Franz; Fromont-Racine, Micheline; Becker, Thomas und Beckmann, Roland
(2020):
A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes.
In: EMBO Journal, Bd. 40, Nr. 1, e105179
Kater, Lukas; Mitterer, Valentin; Thoms, Matthias; Cheng, Jingdong; Berninghausen, Otto; Beckmann, Roland und Hurt, Ed
(2020):
Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis.
In: Molecular Cell, Bd. 79, Nr. 4: S. 615-628
Ameismeier, Michael; Zemp, Ivo; Heuvel, Jasmin van den; Thoms, Matthias; Berninghausen, Otto; Kutay, Ulrike und Beckmann, Roland
(2020):
Structural basis for the final steps of human 40S ribosome maturation.
In: Nature, Bd. 587, Nr. 7835: S. 683-687
Buschauer, Robert; Matsuo, Yoshitaka; Sugiyama, Takato; Chen, Ying-Hsin; Alhusaini, Najwa; Sweet, Thomas; Ikeuchi, Ken; Cheng, Jingdong; Matsuki, Yasuko; Nobuta, Risa; Gilmozzi, Andrea; Berninghausen, Otto; Tesina, Petr; Becker, Thomas; Coller, Jeff; Inada, Toshifumi und Beckmann, Roland
(2020):
The Ccr4-Not complex monitors the translating ribosome for codon optimality.
In: Science, Bd. 368, Nr. 6488, eaay6912
Nuerenberg-Goloub, Elina; Kratzat, Hanna; Heinemann, Holger; Heuer, Andre; Koetter, Peter; Berninghausen, Otto; Becker, Thomas; Tampe, Robert und Beckmann, Roland
(2020):
Molecular analysis of the ribosome recycling factor ABCE1 bound to the 30S post-splitting complex.
In: EMBO Journal, Bd. 39, Nr. 9, e103788
Weng, Tsai-Hsuan; Steinchen, Wieland; Beatrix, Birgitta; Berninghausen, Otto; Becker, Thomas; Bange, Gert; Cheng, Jingdong und Beckmann, Roland
(2020):
Architecture of the active post-translational Sec translocon.
In: EMBO Journal, Bd. 40, Nr. 3, e105643
Cheng, Jingdong; Lau, Benjamin; La Venuta, Giuseppe; Ameismeier, Michael; Berninghausen, Otto; Hurt, Ed und Beckmann, Roland
(2020):
90S pre-ribosome transformation into the primordial 40S subunit.
In: Science, Bd. 369, Nr. 6510: S. 1470-1476
2019
Tesina, Petr; Heckel, Elisabeth; Cheng, Jingdong; Fromont-Racine, Micheline; Buschauer, Robert; Kater, Lukas; Beatrix, Birgitta; Berninghausen, Otto; Jacquier, Alain; Becker, Thomas und Beckmann, Roland
(2019):
Structure of the 80S ribosome-Xrn1 nuclease complex.
In: Nature Structural & Molecular Biology, Bd. 26, Nr. 4
Shanmuganathan, Vivekanandan; Schiller, Nina; Magoulopoulou, Anastasia; Cheng, Jingdong; Braunger, Katharina; Cymer, Florian; Berninghausen, Otto; Beatrix, Birgitta; Kohno, Kenji; Heijne, Gunnar von und Beckmann, Roland
(2019):
Structural and mutational analysis of the ribosome-arresting human XBP1u.
In: eLife, Bd. 8, e46267
[PDF, 4MB]
Kater, Lukas; Frieg, Benedikt; Berninghausen, Otto; Gohlke, Holger; Beckmann, Roland und Kedrov, Alexej
(2019):
Partially inserted nascent chain unzips the lateral gate of the Sec translocon.
In: EMBO Reports, Bd. 20, Nr. 10, e48191
Knorr, Alexandra G.; Schmidt, Christian; Tesina, Petr; Berninghausen, Otto; Becker, Thomas; Beatrix, Birgitta und Beckmann, Roland
(2019):
Ribosome-NatA architecture reveals that rRNA expansion segments coordinate N-terminal acetylation.
In: Nature Structural & Molecular Biology, Bd. 26, Nr. 1
Cheng, Jingdong; Bassler, Jochen; Fischer, Paulina; Lau, Benjamin; Kellner, Nikola; Kunze, Ruth; Griesel, Sabine; Kallas, Martina; Berninghausen, Otto; Strauss, Daniela; Beckmann, Roland und Hurt, Ed
(2019):
Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
In: Molecular Cell, Bd. 75, Nr. 6
Tesina, Petr; Lessen, Laura N.; Buschauer, Robert; Cheng, Jingdong; Wu, Colin Chih-Chien; Berninghausen, Otto; Buskirk, Allen R.; Becker, Thomas; Beckmann, Roland und Green, Rachel
(2019):
Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.
In: EMBO Journal, Bd. 39, Nr. 3, e103365
Su, Ting; Izawa, Toshiaki; Thoms, Matthias; Yamashita, Yui; Cheng, Jingdong; Berninghausen, Otto; Hartl, F. Ulrich; Inada, Toshifumi; Neupert, Walter und Beckmann, Roland
(2019):
Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.
In: Nature, Bd. 570, Nr. 7762
2018
Beckert, Bertrand; Turk, Martin; Czech, Andreas; Berninghausen, Otto; Beckmann, Roland; Ignatova, Zoya; Plitzko, Jürgen M. und Wilson, Daniel N.
(2018):
Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1.
In: Nature Microbiology, Bd. 3, Nr. 10: S. 1115-1121
Ameismeier, Michael; Cheng, Jingdong; Berninghausen, Otto und Beckmann, Roland
(2018):
Visualizing late states of human 40S ribosomal subunit maturation.
In: Nature, Bd. 558, Nr. 7709: S. 249-253
Braunger, Katharina; Pfeffer, Stefan; Shrimal, Shiteshu; Gilmore, Reid; Berninghausen, Otto; Mandon, Elisabet C.; Becker, Thomas; Förster, Friedrich und Beckmann, Roland
(2018):
Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.
In: Science, Bd. 360, Nr. 6385: S. 215-218
2017
Heuer, Andre; Gerovac, Milan; Schmidt, Christian; Trowitzsch, Simon; Preis, Anne; Kötter, Peter; Berninghausen, Otto; Becker, Thomas; Beckmann, Roland und Tampe, Robert
(2017):
Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation.
In: Nature Structural & Molecular Biology, Bd. 24, Nr. 5: S. 453-460
Su, Ting; Cheng, Jingdong; Sohmen, Daniel; Hedman, Rickard; Berninghausen, Otto; Heijne, Gunnar von; Wilson, Daniel N. und Beckmann, Roland
(2017):
The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling.
In: Elife, Bd. 6, e25642
[PDF, 7MB]
Cheng, Jingdong; Kellner, Nikola; Berninghausen, Otto; Hurt, Ed und Beckmann, Roland
(2017):
3.2-angstrom-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.
In: Nature Structural & Molecular Biology, Bd. 24, Nr. 11: S. 954-964
Heuer, Andre; Thomson, Emma; Schmidt, Christian; Berninghausen, Otto; Becker, Thomas; Hurt, Ed und Beckmann, Roland
(2017):
Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae.
In: Elife, Bd. 6, e30189
[PDF, 7MB]
Kater, Lukas; Thoms, Matthias; Barrio-Garcia, Clara; Cheng, Jingdong; Ismail, Sherif; Ahmed, Yasar Luqman; Bange, Gert; Kressler, Dieter; Berninghausen, Otto; Sinning, Irmgard; Hurt, Ed und Beckmann, Roland
(2017):
Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
In: Cell, Bd. 171, Nr. 7: S. 1599-1610
Huter, Paul; Müller, Claudia; Beckert, Bertrand; Arenz, Stefan; Berninghausen, Otto; Beckmann, Roland und Wilson, Daniel N.
(2017):
Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons.
In: Nature, Bd. 541, Nr. 7638
Beckert, Bertrand; Abdelshahid, Maha; Schäfer, Heinrich; Steinchen, Wieland; Arenz, Stefan; Berninghausen, Otto; Beckmann, Roland; Bange, Gert; Turgay, Kürsad und Wilson, Daniel N.
(2017):
Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.
In: Embo Journal, Bd. 36, Nr. 14: S. 2061-2072
Florin, Tanja; Maracci, Cristina; Graf, Michael; Karki, Prajwal; Klepacki, Dorota; Berninghausen, Otto; Beckmann, Roland; Vazquez-Laslop, Nora; Wilson, Daniel N.; Rodnina, Marina V. und Mankin, Alexander S.
(2017):
An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.
In: Nature Structural & Molecular Biology, Bd. 24, Nr. 9: S. 752-757
Huter, Paul; Arenz, Stefan; Bock, Lars V.; Graf, Michael; Frister, Jan Ole; Heuer, Andre; Peil, Lauri; Starosta, Agata L.; Wohlgemuth, Ingo; Peske, Frank; Novacek, Jiri; Berninghausen, Otto; GrubMüller, Helmut; Tenson, Tanel; Beckmann, Roland; Rodnina, Marina V.; Vaiana, Andrea C. und Wilson, Daniel N.
(2017):
Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P.
In: Molecular Cell, Bd. 68, Nr. 3: S. 515-527
2016
Schmidt, Christian; Becker, Thomas; Heuer, Andre; Braunger, Katharina; Shanmuganathan, Vivekanandan; Pech, Markus; Berninghausen, Otto; Wilson, Daniel N. und Beckmann, Roland
(2016):
Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome.
In: Nucleic Acids Research, Bd. 44, Nr. 4: S. 1944-1951
[PDF, 3MB]
Kedrov, Alexej; Wickles, Stephan; Crevenna, Alvaro H.; Sluis, Eli O. van der; Buschauer, Robert; Berninghausen, Otto; Lamb, Don C. und Beckmann, Roland
(2016):
Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis.
In: Cell Reports, Bd. 17, Nr. 11: S. 2943-2954
[PDF, 5MB]
Kornprobst, Markus; Turk, Martin; Kellner, Nikola; Cheng, Jingdong; Flemming, Dirk; Kos-Braun, Isabelle; Kos, Martin; Thoms, Matthias; Berninghausen, Otto; Beckmann, Roland und Hurt, Ed
(2016):
Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome.
In: Cell, Bd. 166, Nr. 2: S. 380-393
Schmidt, Christian; Kowalinski, Eva; Shanmuganathan, Vivekanandan; Defenouillere, Quentin; Braunger, Katharina; Heuer, Andre; Pech, Markus; Namane, Abdelkader; Berninghausen, Otto; Fromont-Racine, Micheline; Jacquier, Alain; Conti, Elena; Becker, Thomas und Beckmann, Roland
(2016):
The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
In: Science, Bd. 354, Nr. 6318: S. 1431-1433
Arenz, Stefan; Abdelshahid, Maha; Sohmen, Daniel; Payoe, Roshani; Starosta, Agata L.; Berninghausen, Otto; Hauryliuk, Vasili; Beckmann, Roland und Wilson, Daniel N.
(2016):
The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.
In: Nucleic Acids Research, Bd. 44, Nr. 13: S. 6471-6481
[PDF, 3MB]
2015
Sohmen, Daniel; Chiba, Shinobu; Shimokawa-Chiba, Naomi; Innis, C. Axel; Berninghausen, Otto; Beckmann, Roland; Ito, Koreaki und Wilson, Daniel N.
(2015):
Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling.
In: Nature Communications, Bd. 6, 6941
[PDF, 2MB]
Sluis, Eli O. van der; Bauerschmitt, Heike; Becker, Thomas; Mielke, Thorsten; Frauenfeld, Jens; Berninghausen, Otto; Neupert, Walter; Herrmann, Johannes M. und Beckmann, Roland
(2015):
Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes.
In: Genome Biology and Evolution, Bd. 7, Nr. 5: S. 1235-1251
[PDF, 1MB]
Matheisl, Sarah; Berninghausen, Otto; Becker, Thomas und Beckmann, Roland
(2015):
Structure of a human translation termination complex.
In: Nucleic Acids Research, Bd. 43, Nr. 18: S. 8615-8626
[PDF, 6MB]
2014
Leidig, Christoph; Thoms, Matthias; Holdermann, Iris; Bradatsch, Bettina; Berninghausen, Otto; Bange, Gert; Sinning, Irmgard; Hurt, Ed und Beckmann, Roland
(2014):
60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.
In: Nature Communications, Bd. 5, 3491
[PDF, 1MB]
Arenz, Stefan; Ramu, Haripriya; Gupta, Pulkit; Berninghausen, Otto; Beckmann, Roland; Vazquez-Laslop, Nora; Mankin, Alexander S. und Wilson, Daniel N.
(2014):
Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide.
In: Nature Communications, Bd. 5, 3501
[PDF, 3MB]
Bischoff, Lukas; Wickles, Stephan; Berninghausen, Otto; Sluis, Eli O. van der und Beckmann, Roland
(2014):
Visualization of a polytopic membrane protein during SecY-mediated membrane insertion.
In: Nature Communications, Bd. 5, 4103
[PDF, 2MB]
Wickles, Stephan; Singharoy, Abhishek; Andreani, Jessica; Seemayer, Stefan; Bischoff, Lukas; Berninghausen, Otto; Soeding, Johannes; Schulten, Klaus; Sluis, Eli O. van der und Beckmann, Roland
(2014):
A structural model of the active ribosome-bound membrane protein insertase YidC.
In: eLife, Bd. 3, e03035
[PDF, 3MB]
Preis, Anne; Heuer, Andre; Barrio-Garcia, Clara; Hauser, Andreas ORCID: https://orcid.org/0000-0002-3997-7252; Eyler, Daniel E.; Berninghausen, Otto; Green, Rachel; Becker, Thomas und Beckmann, Roland
(2014):
Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing eRF1-eRF3 or eRF1-ABCE1.
In: Cell Reports, Bd. 8, Nr. 1: S. 59-65
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-3997-7252; Eyler, Daniel E.; Berninghausen, Otto; Green, Rachel; Becker, Thomas und Beckmann, Roland
(2014):
Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing eRF1-eRF3 or eRF1-ABCE1.
In: Cell Reports, Bd. 8, Nr. 1: S. 59-65
[PDF, 2MB]
Bischoff, Lukas; Berninghausen, Otto und Beckmann, Roland
(2014):
Molecular Basis for the Ribosome Functioning as an L-Tryptophan Sensor.
In: Cell Reports, Bd. 9, Nr. 2: S. 469-475
[PDF, 3MB]
2011
Bhushan, Shashi; Hoffmann, Thomas; Seidelt, Birgit; Frauenfeld, Jens; Mielke, Thorsten; Berninghausen, Otto; Wilson, Daniel N und Beckmann, Roland
(2011):
SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center.
In: PLOS Biology 9(1), e1000581 [PDF, 4MB]
In: PLOS Biology 9(1), e1000581 [PDF, 4MB]