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Anzahl der Publikationen: 31
Zeitschriftenartikel
Zibold, Julia; Lessard, Lola E. R.; Picard, Flavien; da Silva, Lara Gruijs; Zadorozhna, Yelyzaveta; Streichenberger, Nathalie; Belotti, Edwige; Osseni, Alexis; Emerit, Andrea; Errazuriz-Cerda, Elisabeth; Michel-Calemard, Laurence; Menassa, Rita; Coudert, Laurent; Wiessner, Manuela; Stucka, Rolf; Klopstock, Thomas; Simonetti, Francesca; Hutten, Saskia; Nonaka, Takashi; Hasegawa, Masato; Strom, Tim M.; Bernard, Emilien; Ollagnon, Elisabeth; Urtizberea, Andoni; Dormann, Dorothee; Petiot, Philippe; Schaeffer, Laurent; Senderek, Jan und Leblanc, Pascal
(2023):
The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis.
In: Brain
[PDF, 1MB]
Riemenschneider, Henrick; Simonetti, Francesca; Sheth, Udit; Katona, Eszter; Roth, Stefan; Hutten, Saskia; Farny, Daniel; Michaelsen, Meike; Nuscher, Brigitte; Schmidt, Michael K.; Flatley, Andrew; Schepers, Aloys; da Silva, Lara Gruijs A.; Zhou, Qihui; Klopstock, Thomas; Liesz, Arthur; Arzberger, Thomas; Herms, Jochen; Feederle, Regina; Gendron, Tania F.; Dormann, Dorothee und Edbauer, Dieter
(2023):
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo.
In: Acta Neuropathologica Communications, Bd. 11, Nr. 1, 112
[PDF, 6MB]
Strohm, Laura; Hu, Zehan; Suk, Yongwon; Rühmkorf, Alina; Sternburg, Erin; Gattringer, Vanessa; Riemenschneider, Henrick; Berutti, Riccardo; Graf, Elisabeth; Weishaupt, Jochen H. 
ORCID: https://orcid.org/0000-0002-3399-9784; Brill, Monika S.; Harbauer, Angelika B.; Dormann, Dorothee; Dengjel, Jörn; Edbauer, Dieter und Behrends, Christian
(1. Juli 2022):
Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutants.
In: Life Science Alliance, Bd. 5, Nr. 11
[PDF, 6MB]
ORCID: https://orcid.org/0000-0002-3399-9784; Brill, Monika S.; Harbauer, Angelika B.; Dormann, Dorothee; Dengjel, Jörn; Edbauer, Dieter und Behrends, Christian
(1. Juli 2022):
Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutants.
In: Life Science Alliance, Bd. 5, Nr. 11
[PDF, 6MB]
Dormann, Dorothee und Behrends, Christian
(2022):
Only solid waste, please!
In: Molecular Cell, Bd. 82, Nr. 8: S. 1408-1410
[PDF, 479kB]
da Silva, Lara A. Gruijs; Simonetti, Francesca; Hutten, Saskia; Riemenschneider, Henrick; Sternburg, Erin L.; Pietrek, Lisa M.; Gebel, Jakob; Doetsch, Volker; Edbauer, Dieter; Hummer, Gerhard; Stelzl, Lukas S. und Dormann, Dorothee
(2022):
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
In: EMBO Journal, Bd. 41, Nr. 8, e108443
[PDF, 6MB]
Zambusi, Alessandro; Novoselc, Klara Tereza; Hutten, Saskia; Kalpazidou, Sofia; Koupourtidou, Christina; Schieweck, Rico; Aschenbroich, Sven; Silva, Lara; Yazgili, Ayse Seda; Bebber, Frauke van; Schmid, Bettina; Moeller, Gabriel; Tritscher, Clara; Stigloher, Christian; Delbridge, Claire; Sirko, Swetlana; Gunes, Zeynep Irem; Liebscher, Sabine; Schlegel, Jürgen; Aliee, Hananeh; Theis, Fabian; Meiners, Silke; Kiebler, Michael; Dormann, Dorothee und Ninkovic, Jovica
(2022):
TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury.
In: Nature Neuroscience, Bd. 25, Nr. 12: S. 1608-1625
Lenard, Aneta J.; Hutten, Saskia; Zhou, Qishun; Usluer, Sinem; Zhang, Fangrong; Bourgeois, Benjamin M. R.; Dormann, Dorothee und Madl, Tobias
(19. Oktober 2021):
Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation.
In: Frontiers in Molecular Biosciences, Bd. 8, 689687
[EPUB, 1MB]
Reber, Stefan; Jutzi, Daniel; Lindsay, Helen; Devoy, Anny; Mechtersheimer, Jonas; Levone, Brunno Rocha; Domanski, Michal; Bentmann, Eva; Dormann, Dorothee; Muehlemann, Oliver; Barabino, Silvia M. L. und Ruepp, Marc-David
(2021):
The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.
In: Nucleic Acids Research, Bd. 49, Nr. 13: S. 7713-7731
[PDF, 11MB]
Baade, Imke; Hutten, Saskia; Sternburg, Erin L.; Poerschke, Marius; Hofweber, Mario; Dormann, Dorothee und Kehlenbach, Ralph H.
(2021):
The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors.
In: Journal of Biological Chemistry, Bd. 296, 100659
[PDF, 4MB]
Hutten, Saskia; Usluer, Sinem; Bourgeois, Benjamin; Simonetti, Francesca; Odeh, Hana M.; Fare, Charlotte M.; Czuppa, Mareike; Hruska-Plochan, Marian; Hofweber, Mario; Polymenidou, Magdalini; Shorter, James; Edbauer, Dieter; Madl, Tobias und Dormann, Dorothee
(2020):
Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions.
In: Cell Reports, Bd. 33, Nr. 12, 108538
[PDF, 3MB]
Dormann, Dorothee
(2020):
Molecular mechanisms of neurodegeneration.
In: Seminars in Cell & Developmental Biology, Bd. 99: S. 131-132
Dormann, Dorothee
(2020):
FG-nucleoporins caught in the act of liquid-liquid phase separation.
In: Journal of Cell Biology, Bd. 219, Nr. 1, e201910211
[PDF, 781kB]
Hutten, Saskia und Dormann, Dorothee
(2020):
Nucleocytoplasmic transport defects in neurodegeneration - Cause or consequence?
In: Seminars in Cell & Developmental Biology, Bd. 99: S. 151-162
Hutten, Saskia und Dormann, Dorothee
(2020):
A Quantitative Assay to Measure Stress Granule Association of Proteins and Peptides in Semi-permeabilized Human Cells.
In: Bio-Protocol, Bd. 10, Nr. 24, e3846
[PDF, 4MB]
Bourgeois, Benjamin; Hutten, Saskia; Gottschalk, Benjamin; Hofweber, Mario; Richter, Gesa; Sternat, Julia; Abou-Ajram, Claudia; Goebl, Christoph; Leitinger, Gerd; Graier, Wolfgang F.; Dormann, Dorothee und Madl, Tobias
(2020):
Nonclassical nuclear localization signals mediate nuclear import of CIRBP.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 117, Nr. 15: S. 8503-8514
[PDF, 3MB]
Alberti, Simon und Dormann, Dorothee
(2019):
Liquid-Liquid Phase Separation in Disease.
In: Annual Review of Genetics, Vol 53, Bd. 53: S. 171-194
Ukmar-Godec, Tina; Hutten, Saskia; Grieshop, Matthew P.; Rezaei-Ghaleh, Nasrollah; Cima-Omori, Maria-Sol; Biernat, Jacek; Mandelkow, Eckhard; Söding, Johannes; Dormann, Dorothee und Zweckstetter, Markus
(2019):
Lysine/RNA-interactions drive and regulate biomolecular condensation.
In: Nature Communications, Bd. 10, 2909
[PDF, 4MB]
Hofweber, Mario und Dormann, Dorothee
(2019):
Friend or foePost-translational modifications as regulators of phase separation and RNP granule dynamics.
In: Journal of Biological Chemistry, Bd. 294, Nr. 18: S. 7137-7150
Hutten, Saskia und Dormann, Dorothee
(2019):
RAN translation down.
In: Nature Neuroscience, Bd. 22, Nr. 9: S. 1379-1380
Hofweber, Mario; Hutten, Saskia; Bourgeois, Benjamin; Spreitzer, Emil; Niedner-Boblenz, Annika; Schifferer, Martina; Ruepp, Marc-David; Simons, Mikael; Niessing, Dierk; Madl, Tobias und Dormann, Dorothee
(2018):
Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.
In: Cell, Bd. 173, Nr. 3: S. 706-719
Hock, Eva-Maria; Maniecka, Zuzanna; Hruska-Plochan, Marian; Reber, Stefan; Laferriere, Florent; Sahadevan, Sonu M. K.; Ederle, Helena; Gittings, Lauren; Pelkmans, Lucas; Dupuis, Luc; Lashley, Tammaryn; Ruepp, Marc-David; Dormann, Dorothee und Polymenidou, Magdalini
(2018):
Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function.
In: Cell Reports, Bd. 24, Nr. 4: S. 987-1000
[PDF, 5MB]
Woodsmith, Jonathan; Casado-Medrano, Victoria; Benlasfer, Nouhad; Eccles, Rebecca L.; Hutten, Saskia; Heine, Christian L.; Thormann, Verena; Abou-Ajram, Claudia; Rocks, Oliver; Dormann, Dorothee und Stelzl, Ulrich
(2018):
Interaction modulation through arrays of clustered methyl-arginine protein modifications.
In: Life Science Alliance, Bd. 1, Nr. 5, e201800178
[PDF, 2MB]
Simandi, Zoltan; Pajer, Krisztian; Karolyi, Katalin; Sieler, Tatiana; Jiang, Lu-Lin; Kolostyak, Zsuzsanna; Sari, Zsanett; Fekecs, Zoltan; Pap, Attila; Patsalos, Andreas; Contreras, Gerardo Alvarado; Reho, Balint; Papp, Zoltan; Guo, Xiufang; Horvath, Attila; Kiss, Greta; Keresztessy, Zsolt; Vamosi, Gyorgy; Hickman, James; Xu, Huaxi; Dormann, Dorothee; Hortobagyi, Tibor; Antal, Miklos; Nogradi, Antal und Nagy, Laszlo
(2018):
Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons.
In: Journal of Neuroscience, Bd. 38, Nr. 35: S. 7683-7700
Ederle, Helena; Funk, Christina; Abou-Ajram, Claudia; Hutten, Saskia; Funk, Eva B. E.; Kehlenbach, Ralph H.; Bailer, Susanne M. und Dormann, Dorothee
(2018):
Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1.
In: Scientific Reports, Bd. 8, 7084
[PDF, 5MB]
Khosravi, Bahram; Hartmann, Hannelore; May, Stephanie; Möhl, Christoph; Ederle, Helena; Michaelsen, Meike; Schludi, Martin H.; Dormann, Dorothee und Edbauer, Dieter
(2017):
Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD.
In: Human Molecular Genetics, Bd. 26, Nr. 4: S. 790-800
[PDF, 1MB]
Scekic-Zahirovic, Jelena; El Oussini, Hajer; Mersmann, Sina; Drenner, Kevin; Wagner, Marina; Sun, Ying; Allmeroth, Kira; Dieterle, Stephane; Sinniger, Jerome; Dirrig-Grosch, Sylvie; Rene, Frederique; Dormann, Dorothee; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Ludolph, Albert C.; Lagier-Tourenne, Clotilde; Storkebaum, Erik und Dupuis, Luc
(2017):
Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.
In: Acta Neuropathologica, Bd. 133, Nr. 6: S. 887-906
ORCID: https://orcid.org/0000-0002-4869-1627; Ludolph, Albert C.; Lagier-Tourenne, Clotilde; Storkebaum, Erik und Dupuis, Luc
(2017):
Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.
In: Acta Neuropathologica, Bd. 133, Nr. 6: S. 887-906
Ederle, Helena und Dormann, Dorothee
(2017):
TDP-43 and FUS en route from the nucleus to the cytoplasm.
In: Febs Letters, Bd. 591, Nr. 11: S. 1489-1507
Dormann, Dorothee
(2016):
FUScinating insights into motor neuron degeneration.
In: Embo Journal, Bd. 35, Nr. 10: S. 1015-1017
Suárez-Calvet, Marc; Neumann, Manuela; Arzberger, Thomas; Abou-Ajram, Claudia; Funk, Eva; Hartmann, Hannelore; Edbauer, Dieter; Kremmer, Elisabeth; Göbl, Christoph; Resch, Moritz; Bourgeois, Benjamin; Madl, Tobias; Reber, Stefan; Jutzi, Daniel; Ruepp, Marc-David; Mackenzie, Ian R. A.; Ansorge, Olaf; Dormann, Dorothee und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2016):
Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.
In: Acta Neuropathologica, Bd. 131, Nr. 4: S. 587-604
ORCID: https://orcid.org/0000-0002-4869-1627
(2016):
Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.
In: Acta Neuropathologica, Bd. 131, Nr. 4: S. 587-604
Bowden, Hilary A. und Dormann, Dorothee
(2016):
Altered mRNP granule dynamics in FTLD pathogenesis.
In: Journal of Neurochemistry, Bd. 138: S. 112-133
Hutten, Saskia und Dormann, Dorothee
(2016):
hnRNPA2/B1 Function in Neurodegeneration: It's a Gain, Not a Loss.
In: Neuron, Bd. 92, Nr. 4: S. 672-674