Anzahl der Publikationen: 54
Zeitschriftenartikel
Scotto Rosato, Anna; Krogsaeter, Einar K; Jaślan, Dawid; Abrahamian, Carla; Montefusco, Sandro; Soldati, Chiara; Spix, Barbara; Pizzo, Maria Teresa; Grieco, Giuseppina; Böck, Julia; Wyatt, Amanda; Wünkhaus, Daniela; Passon, Marcel; Stieglitz, Marc; Keller, Marco; Hermey, Guido; Markmann, Sandra; Gruber‐Schoffnegger, Doris; Cotman, Susan; Johannes, Ludger; Crusius, Dennis; Boehm, Ulrich; Wahl-Schott, Christian; Biel, Martin; Bracher, Franz; De Leonibus, Elvira; Polishchuk, Elena; Medina, Diego L; Paquet, Dominik und Grimm, Christian
(5. August 2022):
TPC2 rescues lysosomal storage in mucolipidosis type IV , Niemann–Pick type C1, and Batten disease.
In: EMBO Molecular Medicine, Bd. 14, Nr. 9
[PDF, 27MB]
Spix, Barbara; Butz, Elisabeth S.; Chen, Cheng-Chang; Rosato, Anna Scotto; Tang, Rachel; Jeridi, Aicha; Kudrina, Veronika; Plesch, Eva; Wartenberg, Philipp; Arlt, Elisabeth; Briukhovetska, Daria; Ansari, Meshal; Günsel, Gizem Günes; Conlon, Thomas M.; Wyatt, Amanda; Wetzel, Sandra; Teupser, Daniel; Holdt, Lesca M.; Ectors, Fabien; Boekhoff, Ingrid; Boehm, Ulrich; García-Añoveros, Jaime; Saftig, Paul; Giera, Martin; Kobold, Sebastian; Schiller, Herbert B.; Zierler, Susanna; Gudermann, Thomas; Wahl-Schott, Christian; Bracher, Franz; Yildirim, Ali Önder; Biel, Martin und Grimm, Christian
(2022):
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
In: Nature Communications, Bd. 13, 318
[PDF, 3MB]
Fernandez, Belen; Olmedo, Pablo; Gil, Fernando; Fdez, Elena; Naaldijk, Yahaira; Rivero-Rios, Pilar; Bracher, Franz; Grimm, Christian; Churchill, Grant C. und Hilfiker, Sabine
(2022):
Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB.
In: Cell Death & Disease, Bd. 13, Nr. 12, 1047
Siow, Wei Xiong; Kabiri, Yaschar; Tang, Rachel; Chao, Yu-Kai; Plesch, Eva; Eberhagen, Carola; Flenkenthaler, Florian; Froehlich, Thomas; Bracher, Franz; Grimm, Christian; Biel, Martin; Zischka, Hans; Vollmar, Angelika M. und Bartel, Karin
(2022):
Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells.
In: Journal of Cell Science, Bd. 135, Nr. 6, jcs259455
Yuan, Yu; Jaslan, Dawid; Rahman, Taufiq; Bolsover, Stephen R.; Arige, Vikas; Wagner, Larry E.; Abrahamian, Carla; Tang, Rachel; Keller, Marco; Hartmann, Jonas; Rosato, Anna S.; Weiden, Eva-Maria; Bracher, Franz; Yule, David I.; Grimm, Christian und Patel, Sandip
(2022):
Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes.
In: Nature Communications, Bd. 13, Nr. 1, 4481
Patel, Sandip; Yuan, Yu; Chen, Cheng-Chang; Jaslan, Dawid; Gunaratne, Gihan; Grimm, Christian; Rahman, Taufiq und Marchant, Jonathan S.
(2022):
Electrophysiology of Endolysosomal Two-Pore Channels: A Current Account.
In: Cells, Bd. 11, Nr. 15, 2368
Spix, Barbara; Castiglioni, Andrew J.; Remis, Natalie N.; Flores, Emma N.; Wartenberg, Philipp; Wyatt, Amanda; Boehm, Ulrich; Gudermann, Thomas; Biel, Martin; Garcia-Anoveros, Jaime und Grimm, Christian
(2022):
Whole-body analysis of TRPML3 (MCOLN3) expression using a GFP-reporter mouse model reveals widespread expression in secretory cells and endocrine glands.
In: PLOS One
17(12), e0278848
Yuan, Yu; Kilpatrick, Bethan S.; Gerndt, Susanne; Bracher, Franz; Grimm, Christian; Schapira, Anthony H. und Patel, Sandip
(2021):
The lysosomotrope GPN mobilises Ca2+ from acidic organelles.
In: Journal of Cell Science, Bd. 134, Nr. 6, jcs256578
Netcharoensirisuk, Ponsawan; Abrahamian, Carla; Tang, Rachel; Chen, Cheng-Chang; Rosato, Anna Scotto; Beyers, Wyatt; Chao, Yu-Kai; Filippini, Antonio; Di Pietro, Santiago; Bartel, Karin; Biel, Martin; Vollmar, Angelika M.; Umehara, Kaoru; De-Eknamkul, Wanchai und Grimm, Christian
(2021):
Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2.
In: Scientific reports, Bd. 11, Nr. 1, 8515
[PDF, 4MB]
Rühl, Philipp; Rosato, Anna Scotto; Urban, Nicole; Gerndt, Susanne; Tang, Rachel; Abrahamian, Carla; Leser, Charlotte; Sheng, Jiansong; Jha, Archana; Vollmer, Günter; Schaefer, Michael; Bracher, Franz ORCID: https://orcid.org/0000-0003-0009-8629 und Grimm, Christian
(2021):
Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
In: Scientific reports, Bd. 11, Nr. 1, 8313
[PDF, 7MB]
Leser, Charlotte; Keller, Marco; Gerndt, Susanne; Urban, Nicole; Chen, Cheng-Chang; Schaefer, Michael; Grimm, Christian und Bracher, Franz
(2021):
Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3.
In: European Journal of Medicinal Chemistry, Bd. 210, 112966
Li, Yanfen; Schoen, Christian; Chen, Cheng-Chang; Yang, Zhuo; Liegl, Raffael; Murenu, Elisa; Schworm, Benedikt; Klugbauer, Norbert; Grimm, Christian; Wahl-Schott, Christian; Michalakis, Stylianos und Biel, Martin
(2021):
TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration.
In: Life Science Alliance, Bd. 4, Nr. 8, e202101047
Müller, Martin; Gerndt, Susanne; Chao, Yu-Kai; Zisis, Themistoklis; Ong, Nam Phuong Nguyen; Gerwien, Aaron; Urban, Nicole; Müller, Christoph; Gegenfurtner, Florian A.; Geisslinger, Franz; Ortler, Carina; Chen, Cheng-Chang; Zahler, Stefan; Biel, Martin; Schäfer, Michael; Grimm, Christian; Bracher, Franz; Vollmar, Angelika M. und Bartel, Karin
(2021):
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth.
In: Cell Chemical Biology, Bd. 28, Nr. 8:
1119-
Ruehl, Philipp; Rosato, Anna Scotto; Urban, Nicole; Gerndt, Susanne; Tang, Rachel; Abrahamian, Carla; Leser, Charlotte; Sheng, Jiansong; Jha, Archana; Vollmer, Guenter; Schaefer, Michael; Bracher, Franz und Grimm, Christian
(2021):
Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
In: Scientific Reports, Bd. 11, Nr. 1, 8313
Gerndt, Susanne; Chen, Cheng-Chang; Chao, Yu-Kai; Yuan, Yu; Burgstaller, Sandra; Rosato, Anna Scotto; Krogsaeter, Einar; Urban, Nicole; Jacob, Katharina; Ong, Nam Phuong Nguyen; Miller, Meghan T.; Keller, Marco; Vollmar, Angelika M.; Gudermann, Thomas; Zierler, Susanna; Schredelseker, Johann; Schaefer, Michael; Biel, Martin; Malli, Roland; Wahl-Schott, Christian; Bracher, Franz; Patel, Sandip und Grimm, Christian
(2020):
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
In: eLife, Bd. 9, e54712
[PDF, 4MB]
Weber, Jonas; Rajan, Suhasini; Schremmer, Christian; Chao, Yu-Kai; Krasteva-Christ, Gabriela; Kannler, Martina; Yildirim, Ali Onder; Brosien, Monika; Schredelseker, Johann; Weissmann, Norbert; Grimm, Christian; Gudermann, Thomas und Dietrich, Alexander
(2020):
TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema.
In: Jci Insight, Bd. 5, Nr. 20, e134464
Chen, Cheng-Chang; Krogsaeter, Einar; Butz, Elisabeth S.; Li, Yanfen; Puertollano, Rosa; Wahl-Schott, Christian; Biel, Martin und Grimm, Christian
(2020):
TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles.
In: Science Advances, Bd. 6, Nr. 46, eabb5064
Arlt, Elisabeth; Fraticelli, Marco; Tsvilovskyy, Volodymyr; Nadolni, Wiebke; Breit, Andreas; O'Neill, Thomas J.; Resenberger, Stefanie; Wennemuth, Gunther; Wahl-Schott, Christian; Biel, Martin; Grimm, Christian; Freichel, Marc; Gudermann, Thomas; Klugbauer, Norbert; Boekhoff, Ingrid und Zierler, Susanna
(2020):
TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 117, Nr. 30: S. 18068-18078
Villella, Valeria R.; Venerando, Andrea; Cozza, Giorgio; Esposito, Speranza; Ferrari, Eleonora; Monzani, Romina; Spinella, Mara C.; Oikonomou, Vasilis; Renga, Giorgia; Tosco, Antonella; Rossin, Federica; Guido, Stefano; Silano, Marco; Garaci, Enrico; Chao, Yu-Kai; Grimm, Christian; Luciani, Alessandro; Romani, Luigina; Piacentini, Mauro; Raia, Valeria; Kroemer, Guido und Maiuri, Luigi
(2019):
A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.
In: EMBO Journal, Bd. 38, Nr. 2, e100101
Goodridge, Jodie P.; Jacobs, Benedikt; Saetersmoen, Michelle L.; Clement, Dennis; Hammer, Quirin; Clancy, Trevor; Skarpen, Ellen; Brech, Andreas; Landskron, Johannes; Grimm, Christian; Pfefferle, Aline; Meza-Zepeda, Leonardo; Lorenz, Susanne; Wiiger, Merete Thune; Louch, William E.; Ask, Eivind Heggernes; Liu, Lisa L.; Oei, Vincent Yi Sheng; Kjallquist, Una; Linnarsson, Sten; Patel, Sandip; Tasken, Kjetil; Stenmark, Harald und Malmberg, Karl-Johan
(2019):
Remodeling of secretory lysosomes during education tunes functional potential in NK cells.
In: Nature Communications, Bd. 10, 514
[PDF, 3MB]
Barben, Maya; Ail, Divya; Storti, Federica; Klee, Katrin; Schori, Christian; Samardzija, Marijana; Michalakis, Stylianos; Biel, Martin; Meneau, Isabelle; Blaser, Frank; Barthelmes, Daniel und Grimm, Christian
(2018):
Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress.
In: Cell Death and Differentiation, Bd. 25, Nr. 12: S. 2071-2085
[PDF, 6MB]
Plesch, Eva; Chen, Cheng-Chang; Butz, Elisabeth; Rosato, Anna Scotto; Krogsaeter, Einar K.; Yinan, Hua; Bartel, Karin; Keller, Marco; Robaa, Dina; Teupser, Daniel; Holdt, Lesca M.; Vollmar, Angelika M.; Sippl, Wolfgang; Puertollano, Rosa; Medina, Diego; Biel, Martin; Wahl-Schott, Christian; Bracher, Franz und Grimm, Christian
(2018):
Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells.
In: eLife, Bd. 7, e39720
[PDF, 4MB]
Nguyen, Ong Nam Phuong; Grimm, Christian; Schneider, Lina S.; Chao, Yu-Kai; Atzberger, Carina; Bartel, Karin; Watermann, Anna; Ulrich, Melanie; Mayr, Doris; Wahl-Schott, Christian; Biel, Martin und Vollmar, Angelika M.
(2017):
Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.
In: Cancer Research, Bd. 77, Nr. 6: S. 1427-1438
Chao, Yu-Kai; Schludi, Verena; Chen, Cheng-Chang; Butz, Elisabeth; Nguyen, O. N. Phuong; Müller, Martin; Krüger, Jens; Kammerbauer, Claudia; Ben-Johny, Manu; Vollmar, Angelika M.; Berking, Carola; Biel, Martin; Wahl-Schott, Christian A. und Grimm, Christian
(2017):
TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 114, Nr. 41, E8595-E8602
Castonguay, Jan; Orth, Joachim H. C.; Müller, Thomas; Sleman, Faten; Grimm, Christian; Wahl-Schott, Christian; Biel, Martin; Mallmann, Robert Theodor; Bildl, Wolfgang; Schulte, Uwe und Klugbauer, Norbert
(2017):
The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.
In: Scientific Reports, Bd. 7, 10038
[PDF, 4MB]
Chen, Cheng-Chang; Cang, Chunlei; Fenske, Stefanie; Butz, Elisabeth; Chao, Yu-Kai; Biel, Martin; Ren, Dejian; Wahl-Schott, Christian und Grimm, Christian
(2017):
Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.
In: Nature Protocols, Bd. 12, Nr. 8: S. 1639-1658
Chen, Cheng-Chang; Butz, Elisabeth S.; Chao, Yu-Kai; Grishchuk, Yulia; Becker, Lars; Heller, Stefan; Slaugenhaupt, Susan A.; Biel, Martin; Wahl-Schott, Christian und Grimm, Christian
(2017):
Small Molecules for Early Endosome-Specific Patch Clamping.
In: Cell Chemical Biology, Bd. 24, Nr. 7: S. 907-916
Bobak, Nicole; Feliciangeli, Sylvain; Chen, Cheng-Chang; Ben Soussia, Ismail; Bittner, Stefan; Pagnotta, Sophie; Ruck, Tobias; Biel, Martin; Wahl-Schott, Christian; Grimm, Christian; Meuth, Sven G. und Lesage, Florian
(2017):
Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels.
In: Scientific Reports, Bd. 7, 649
[PDF, 11MB]
Grimm, Christian; Barben, Maya; Ail, Divya; Kast, Brigitt; Schori, Christian; Giger-Lange, Christina; Michalakis, Stylianos und Samardzija, Marijana
(2016):
Inactivation of Hif1a rescues rods and cones from degeneration induced by a chronic hypoxia-like response: HIF1A as therapeutic target in AMD?
In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12
Beck, Simon; Henß, Lisa; Weidner, Tatjana; Herrmann, Jennifer; Müller, Rolf; Chao, Yu-Kai; Grimm, Christian; Weber, Christopher; Sliva, Katja und Schnierle, Barbara S.
(2016):
Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library.
In: Antiviral Research, Bd. 132: S. 85-91
Grimm, Christian; Holdt, Lesca M.; Chen, Cheng-Chang; Hassan, Sami; Müller, Christoph; Jörs, Simone; Cuny, Hartmut; Kissing, Sandra; Schröder, Bernd; Butz, Elisabeth; Northoff, Bernd; Castonguay, Jan; Luber, Christian A.; Moser, Markus; Spahn, Saskia; Luellmann-Rauch, Renate; Fendel, Christina; Klugbauer, Norbert; Griesbeck, Oliver; Haas, Albert; Mann, Matthias; Bracher, Franz; Teupser, Daniel; Saftig, Paul; Biel, Martin und Wahl-Schott, Christian
(2014):
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.
In: Nature Communications, Bd. 5, 4699
[PDF, 3MB]
Chen, Cheng-Chang; Keller, Marco; Hess, Martin; Schiffmann, Raphael; Urban, Nicole; Wolfgardt, Annette; Schaefer, Michael; Bracher, Franz; Biel, Martin; Wahl-Schott, Christian und Grimm, Christian
(2014):
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.
In: Nature Communications, Bd. 5, 4681
[PDF, 1MB]
Fischer, M. Dominik; Huber, Gesine; Beck, Susanne C.; Tanimoto, Naoyuki; Muehlfriedel, Regine; Fahl, Edda; Grimm, Christian; Wenzel, Andreas; Remé, Charlotte E.; van de Pavert, Serge A.; Wijnholds, Jan; Pacal, Marek; Bremner, Rod und Seeliger, Mathias W.
(2009):
Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography.
In: PLOS ONE
4(10), e7507
[PDF, 1MB]
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