![[höher]](/style/images/multi_up.png)
Eine Ebene höherGruppiert nach: Dokumententyp |
Veröffentlichungsdatum
Anzahl der Publikationen: 68
2024
Bérouti, Marleen; Lammens, Katja; Heiss, Matthias; Hansbauer, Larissa; Bauernfried, Stefan; Stöckl, Jan; Pinci, Francesca; Piseddu, Ignazio; Greulich, Wilhelm; Wang, Meiyue; Jung, Christophe; Fröhlich, Thomas; Carell, Thomas 
ORCID: https://orcid.org/0000-0001-7898-2831; Hopfner, Karl-Peter ORCID: https://orcid.org/0000-0002-4528-8357 und Hornung, Veit ORCID: https://orcid.org/0000-0002-4150-194X
(2024):
Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation.
In: Immunity, Bd. 57, Nr. 7: S. 1482-1496
[PDF, 5MB]
ORCID: https://orcid.org/0000-0001-7898-2831; Hopfner, Karl-Peter ORCID: https://orcid.org/0000-0002-4528-8357 und Hornung, Veit ORCID: https://orcid.org/0000-0002-4150-194X
(2024):
Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation.
In: Immunity, Bd. 57, Nr. 7: S. 1482-1496
[PDF, 5MB]
2022
Khatamzas, Elham; Antwerpen, Markus H.; Rehn, Alexandra; Graf, Alexander; Hellmuth, Johannes Christian; Hollaus, Alexandra; Mohr, Anne-Wiebe; Gaitzsch, Erik; Weiglein, Tobias; Georgi, Enrico; Scherer, Clemens; Stecher, Stephanie-Susanne; Gruetzner, Stefanie; Blum, Helmut; Krebs, Stefan; Reischer, Anna; Leutbecher, Alexandra; Subklewe, Marion; Dick, Andrea; Zange, Sabine; Girl, Philipp; Müller, Katharina; Weigert, Oliver; Hopfner, Karl-Peter; Stemmler, Hans-Joachim; Bergwelt-Baildon, Michael von; Keppler, Oliver T.; Wölfel, Roman; Muenchhoff, Maximilian und Moosmann, Andreas
(23. September 2022):
Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection.
In: Nature Communications, Bd. 13
[PDF, 3MB]
Hohle, Markus Matthias; Lammens, Katja; Gut, Fabian; Wang, Bingzhi; Kahler, Sophia; Kugler, Kathrin; Till, Michael; Beckmann, Roland; Hopfner, Karl-Peter und Jung, Christophe
(12. September 2022):
Ice thickness monitoring for cryo-EM grids by interferometry imaging.
In: Scientific Reports, Bd. 12
[PDF, 2MB]
Gut, Fabian; Kaeshammer, Lisa; Lammens, Katja; Bartho, Joseph D.; Boggusch, Anna-Maria; Logt, Erik van de; Kessler, Brigitte und Hopfner, Karl-Peter
(2022):
Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
In: Molecular Cell, Bd. 82, Nr. 18: S. 3513-3522
Kessler, Nina; Viehmann, Susanne F.; Krollmann, Calvin; Mai, Karola; Kirschner, Katharina M.; Luksch, Hella; Kotagiri, Prasanti; Böhner, Alexander M. C.; Huugen, Dennis; Mann, Carina C. de Oliveira; Otten, Simon; Weiss, Stefanie A. I.; Zillinger, Thomas; Dobrikova, Kristiyana; Jenne, Dieter E.; Behrendt, Rayk; Ablasser, Andrea; Bartok, Eva; Hartmann, Gunther; Hopfner, Karl-Peter; Lyons, Paul A.; Boor, Peter; Rösen-Wolff, Angela; Teichmann, Lino L.; Heeringa, Peter; Kurts, Christian und Garbi, Natalio
(2022):
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.
In: Journal of Experimental Medicine, Bd. 219, Nr. 10, e20220759
Metzner, Felix J.; Wenzl, Simon J.; Kugler, Michael; Krebs, Stefan; Hopfner, Karl-Peter und Lammens, Katja
(2022):
Mechanistic understanding of human SLFN11.
In: Nature Communications, Bd. 13, Nr. 1, 5464
Veth, Simon; Fuchs, Adrian; Özdemir, Dilara; Dialer, Clemens; Drexler, David Jan; Knechtel, Fabian; Witte, Gregor; Hopfner, Karl-Peter; Carell, Thomas und Ploetz, Evelyn
(2022):
Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides c(th)GAMP.
In: Chembiochem, Bd. 23, Nr. 8
[PDF, 3MB]
Kunert, Franziska; Metzner, Felix J.; Jung, James; Höpfler, Markus; Woike, Stephan; Schall, Kevin; Kostrewa, Dirk; Moldt, Manuela; Chen, Jia-Xuan; Bantele, Susanne; Pfander, Boris; Eustermann, Sebastian und Hopfner, Karl-Peter
(2022):
Structural mechanism of extranucleosomal DNA readout by the INO80 complex.
In: Science Advances, Bd. 8, Nr. 49
[PDF, 3MB]
Metzner, Felix J.; Huber, Elisabeth; Hopfner, Karl-Peter und Lammens, Katja
(2022):
Structural and biochemical characterization of human Schlafen 5.
In: Nucleic Acids Research, Bd. 50, Nr. 2: S. 1147-1161
[PDF, 4MB]
Stazzoni, Samuele; Böhmer, Daniel F. R.; Hernichel, Fabian; Özdemir, Dilara; Pappa, Aikaterini; Drexler, David; Bauernfried, Stefan; Witte, Gregor; Wagner, Mirko; Veth, Simon; Hopfner, Karl-Peter; Hornung, Veit; König, Lars M. und Carell, Thomas
(2022):
Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists.
In: Angewandte Chemie International Edition, Bd. 61, Nr. 40
[PDF, 2MB]
2021
Benmebarek, Mohamed-Reda; Cadilha, Bruno L.; Herrmann, Monika; Lesch, Stefanie; Schmitt, Saskia; Stoiber, Stefan; Darwich, Abbass; Augsberger, Christian; Brauchle, Bettina; Rohrbacher, Lisa; Oner, Arman; Seifert, Matthias; Schwerdtfeger, Melanie; Gottschlich, Adrian; Rataj, Felicitas; Fenn, Nadja C.; Klein, Christian; Subklewe, Marion; Endres, Stefan; Hopfner, Karl-Peter und Kobold, Sebastian
(2021):
A modular and controllable T cell therapy platform for acute myeloid leukemia.
In: Leukemia, Bd. 35, Nr. 8: S. 2243-2257
Benmebarek, Mohamed-Reda; Cadilha, Bruno L.; Herrmann, Monika; Lesch, Stefanie; Schmitt, Saskia; Stoiber, Stefan; Darwich, Abbass; Augsberger, Christian; Brauchle, Bettina; Rohrbacher, Lisa; Oner, Arman; Seifert, Matthias; Schwerdtfeger, Melanie; Gottschlich, Adrian; Rataj, Felicitas; Fenn, Nadja C.; Klein, Christian ORCID: https://orcid.org/0000-0001-7594-7280; Subklewe, Marion; Endres, Stefan; Hopfner, Karl-Peter ORCID: https://orcid.org/0000-0002-4528-8357 und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2021):
A modular and controllable T cell therapy platform for acute myeloid leukemia.
In: Leukemia, Bd. 35: S. 2243-2257
[PDF, 5MB]
ORCID: https://orcid.org/0000-0001-7594-7280; Subklewe, Marion; Endres, Stefan; Hopfner, Karl-Peter ORCID: https://orcid.org/0000-0002-4528-8357 und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2021):
A modular and controllable T cell therapy platform for acute myeloid leukemia.
In: Leukemia, Bd. 35: S. 2243-2257
[PDF, 5MB]
Tahk, Siret; Vick, Binje; Hiller, Björn; Schmitt, Saskia; Marcinek, Anetta; Perini, Enrico D.; Leutbecher, Alexandra; Augsberger, Christian; Reischer, Anna; Tast, Benjamin; Humpe, Andreas; Jeremias, Irmela; Subklewe, Marion; Fenn, Nadja C. und Hopfner, Karl-Peter ORCID: https://orcid.org/0000-0002-4528-8357
(2021):
SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells.
In: Journal of hematology & oncology, Bd. 14, 155
[PDF, 3MB]
ORCID: https://orcid.org/0000-0002-4528-8357
(2021):
SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells.
In: Journal of hematology & oncology, Bd. 14, 155
[PDF, 3MB]
Apel, Falko; Andreeva, Liudmila; Knackstedt, Lorenz Sebastian; Streeck, Robert; Frese, Christian Karl; Goosmann, Christian; Hopfner, Karl-Peter und Zychlinsky, Arturo
(2021):
The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps.
In: Science Signaling, Bd. 14, Nr. 673, eaax7942
Bandera, Adrian M.; Bartho, Joseph; Lammens, Katja; Drexler, David Jan; Kleinschwaerzer, Jasmin; Hopfner, Karl-Peter und Witte, Gregor
(2021):
BusR senses bipartite DNA binding motifs by a unique molecular ruler architecture.
In: Nucleic Acids Research, Bd. 49, Nr. 17: S. 10166-10177
Boehmer, Daniel F. R.; Formisano, Simone; Mann, Carina C. de Oliveira; Mueller, Stephan A.; Kluge, Michael; Metzger, Philipp; Rohlfs, Meino; Hoerth, Christine; Kocheise, Lorenz; Lichtenthaler, Stefan F.; Hopfner, Karl-Peter; Endres, Stefan; Rothenfusser, Simon; Friedel, Caroline C.; Duewell, Peter; Schnurr, Max und Koenig, Lars M.
(2021):
OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis.
In: Science Immunology, Bd. 6, Nr. 61, eabe2550
Jansma, Marijke und Hopfner, Karl-Peter
(2021):
Structural basis of the (in)activity of the apical DNA damage response kinases ATM, ATR and DNA-PKcs.
In: Progress in Biophysics & Molecular Biology, Bd. 163: S. 120-129
Oberbeckmann, Elisa; Krietenstein, Nils; Niebauer, Vanessa; Wang, Yingfei; Schall, Kevin; Moldt, Manuela; Straub, Tobias; Rohs, Remo; Hopfner, Karl-Peter; Korber, Philipp und Eustermann, Sebastian
(2021):
Genome information processing by the INO80 chromatin remodeler positions nucleosomes.
In: Nature Communications, Bd. 12, Nr. 1, 3231
Oberbeckmann, Elisa; Niebauer, Vanessa; Watanabe, Shinya; Farnung, Lucas; Moldt, Manuela; Schmid, Andrea; Cramer, Patrick; Peterson, Craig L.; Eustermann, Sebastian; Hopfner, Karl-Peter und Korber, Philipp
(2021):
Ruler elements in chromatin remodelers set nucleosome array spacing and phasing.
In: Nature Communications, Bd. 12, Nr. 1, 3232
Oliveira Mann, Carina C. de und Hopfner, Karl-Peter
(2021):
Nuclear cGAS: guard or prisoner?
In: EMBO Journal, Bd. 40, Nr. 16, e108293
Tahk, Siret; Vick, Binje; Hiller, Björn; Schmitt, Saskia; Marcinek, Anetta; Perini, Enrico D.; Leutbecher, Alexandra; Augsberger, Christian; Reischer, Anna; Tast, Benjamin; Humpe, Andreas; Jeremias, Irmela; Subklewe, Marion; Fenn, Nadja C. und Hopfner, Karl-Peter
(2021):
SIRP alpha-alpha CD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells.
In: Journal of Hematology & Oncology, Bd. 14, Nr. 1, 155
2020
Schmitt, Saskia; Tahk, Siret; Lohner, Alina; Haenel, Gerulf; Maiser, Andreas; Hauke, Martina; Patel, Lubna; Rothe, Maurine; Josenhans, Christine; Leonhardt, Heinrich; Griffioen, Marieke; Deiser, Katrin; Fenn, Nadja C.; Hopfner, Karl-Peter und Subklewe, Marion
(12. November 2020):
Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells.
In: Frontiers in Immunology, Bd. 11, 602802: S. 1-16
[PDF, 3MB]
Jungblut, Anna; Hopfner, Karl-Peter ORCID: https://orcid.org/0000-0002-4528-8357 und Eustermann, Sebastian
(6. August 2020):
Megadalton chromatin remodelers: Common principles for versatile functions.
In: Current Opinion in Structural Biology, Bd. 64, 32771531: S. 134-144
[PDF, 3MB]
ORCID: https://orcid.org/0000-0002-4528-8357 und Eustermann, Sebastian
(6. August 2020):
Megadalton chromatin remodelers: Common principles for versatile functions.
In: Current Opinion in Structural Biology, Bd. 64, 32771531: S. 134-144
[PDF, 3MB]
Hopfner, Karl-Peter ORCID: https://orcid.org/0000-0002-4528-8357 und Hornung, Veit ORCID: https://orcid.org/0000-0002-4150-194X
(18. Mai 2020):
Molecular mechanisms and cellular functions of cGAS-STING signalling.
In: Nature Reviews Molecular Cell Biology, Bd. 21: S. 501-521
[PDF, 13MB]
ORCID: https://orcid.org/0000-0002-4528-8357 und Hornung, Veit ORCID: https://orcid.org/0000-0002-4150-194X
(18. Mai 2020):
Molecular mechanisms and cellular functions of cGAS-STING signalling.
In: Nature Reviews Molecular Cell Biology, Bd. 21: S. 501-521
[PDF, 13MB]
Michalski, Sebastian; de Oliveira Mann, Carina C.; Stafford, Che A.; Witte, Gregor; Bartho, Joseph; Lammens, Katja; Hornung, Veit und Hopfner, Karl-Peter
(2020):
Structural basis for sequestration and autoinhibition of cGAS by chromatin.
In: Nature, Bd. 587, Nr. 7835: S. 678-682
Basu, Aakash; Bobrovnikov, Dmitriy G.; Qureshi, Zan; Kayikcioglu, Tunc; Ngo, Thuy T. M.; Ranjan, Anand; Eustermann, Sebastian; Cieza, Basilio; Morgan, Michael T.; Hejna, Miroslav; Rube, H. Tomas; Hopfner, Karl-Peter; Wolberger, Cynthia; Song, Jun S. und Ha, Taekjip
(2020):
Measuring DNA mechanics on the genome scale.
In: Nature, Bd. 589, Nr. 7842: S. 462-467
Jansma, Marijke; Linke-Winnebeck, Christian; Eustermann, Sebastian; Lammens, Katja; Kostrewa, Dirk; Stakyte, Kristina; Litz, Claudia; Kessler, Brigitte und Hopfner, Karl-Peter
(2020):
Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
In: Structure, Bd. 28, Nr. 1: S. 83-95
Bararia, Deepak; Hildebrand, Johannes A.; Stolz, Sebastian; Haebe, Sarah; Alig, Stefan; Trevisani, Christopher P.; Osorio-Barrios, Francisco; Bartoschek, Michael D.; Mentz, Michael; Pastore, Alessandro; Gaitzsch, Erik; Heide, Michael; Jurinovic, Vindi; Rautter, Katharina; Gunawardana, Jay; Sabdia, Muhammed B.; Szczepanowski, Monika; Richter, Julia; Klapper, Wolfram; Louissaint, Abner; Ludwig, Christina; Bultmann, Sebastian; Leonhardt, Heinrich; Eustermann, Sebastian; Hopfner, Karl-Peter; Hiddemann, Wolfgang; Bergwelt-Baildon, Michael von; Steidl, Christian; Kridel, Robert; Tobin, Joshua W. D.; Gandhi, Maher K.; Weinstock, David M.; Schmidt-Supprian, Marc; Sarosi, Menyhart B.; Rudelius, Martina; Passerini, Verena; Mautner, Josef und Weigert, Oliver
(2020):
Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma.
In: Cell Reports, Bd. 31, Nr. 5, 107522
2019
Sustmann, Claudio; Dickopf, Steffen; Regula, Jörg T.; Kettenberger, Hubert; Molhoj, Michael; Gassner, Christian; Weininger, Diana; Fenn, Sebastian; Manigold, Tobias; Kling, Lothar; Kuenkele, Klaus-Peter; Schwaiger, Manfred; Bossenmaier, Birgit; Griese, Julia J.; Hopfner, Karl-Peter; Graff-Meyer, Alexandra; Stahlberg, Henning; Ringler, Philippe; Lauer, Matthias E.; Brinkmann, Ulrich; Schäfer, Wolfgang und Klein, Christian
(2019):
DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity.
In: Mabs, Bd. 11, Nr. 8: S. 1402-1414
Kaeshammer, Lisa; Saathoff, Jan-Hinnerk; Lammens, Katja; Gut, Fabian; Bartho, Joseph; Alt, Aaron; Kessler, Brigitte und Hopfner, Karl-Peter
(2019):
Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.
In: Molecular Cell, Bd. 76, Nr. 3
Dialer, Clemens Reto; Stazzoni, Samuele; Drexler, David Jan; Müller, Felix Moritz; Veth, Simon; Pichler, Alexander; Okamura, Hidenori; Witte, Gregor; Hopfner, Karl-Peter und Carell, Thomas
(2019):
A Click-Chemistry Linked 23-cGAMP Analogue.
In: Chemistry-A European Journal, Bd. 25, Nr. 8: S. 2089-2095
2018
Dialer, Clemens Reto ORCID: https://orcid.org/0000-0002-5659-2776; Stazzoni, Samuele; Drexler, David Jan; Müller, Felix Moritz; Veth, Simon; Pichler, Alexander; Okamura, Hidenori ORCID: https://orcid.org/0000-0002-2792-9595; Witte, Gregor ORCID: https://orcid.org/0000-0003-0313-0962; Hopfner, Karl-Peter ORCID: https://orcid.org/0000-0002-4528-8357 und Carell, Thomas ORCID: https://orcid.org/0000-0001-7898-2831
(10. Dezember 2018):
A Click-Chemistry Linked 2’3’-cGAMP Analog.
In: Chemistry-A European Journal, Bd. 25: S. 2089-2095
[PDF, 8MB]
ORCID: https://orcid.org/0000-0002-5659-2776; Stazzoni, Samuele; Drexler, David Jan; Müller, Felix Moritz; Veth, Simon; Pichler, Alexander; Okamura, Hidenori ORCID: https://orcid.org/0000-0002-2792-9595; Witte, Gregor ORCID: https://orcid.org/0000-0003-0313-0962; Hopfner, Karl-Peter ORCID: https://orcid.org/0000-0002-4528-8357 und Carell, Thomas ORCID: https://orcid.org/0000-0001-7898-2831
(10. Dezember 2018):
A Click-Chemistry Linked 2’3’-cGAMP Analog.
In: Chemistry-A European Journal, Bd. 25: S. 2089-2095
[PDF, 8MB]
Chiang, Jessica J.; Sparrer, Konstantin M. J.; Gent, Michiel van; Laessig, Charlotte; Huang, Teng; Osterrieder, Nikolaus; Hopfner, Karl-Peter und Gack, Michaela U.
(2018):
Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.
In: Nature Immunology, Bd. 19, Nr. 1: S. 53-62
Laessig, Charlotte; Lammens, Katja; Lopez, Jacob Lucian Gorenflos; Michalski, Sebastian; Fettscher, Olga und Hopfner, Karl-Peter
(2018):
Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants.
In: eLife, Bd. 7, e38958
[PDF, 1MB]
Saathoff, Jan-Hinnerk; Käshammer, Lisa; Lammens, Katja; Byrne, Robert Thomas und Hopfner, Karl-Peter
(2018):
The bacterial Mre11-Rad50 homolog SbcCD cleaves opposing strands of DNA by two chemically distinct nuclease reactions.
In: Nucleic Acids Research, Bd. 46, Nr. 21: S. 11303-11314
[PDF, 3MB]
Eustermann, Sebastian; Schall, Kevin; Kostrewa, Dirk; Lakomek, Kristina; Strauss, Mike; Moldt, Manuela und Hopfner, Karl-Peter
(2018):
Structural basis for ATP-dependent chromatin remodelling by the INO80 complex.
In: Nature, Bd. 556, Nr. 7701: S. 386-390
Schwarz, Marianne; Schall, Kevin; Kallis, Eleni; Eustermann, Sebastian; Guariento, Mara; Moldt, Manuela; Hopfner, Karl-Peter und Michaelis, Jens
(2018):
Single-molecule nucleosome remodeling by INO80 and effects of histone tails.
In: Febs Letters, Bd. 592, Nr. 3: S. 318-331
Schlauderer, Florian; Seeholzer, Thomas; Desfosses, Ambroise; Gehring, Torben; Strauss, Mike; Hopfner, Karl-Peter; Gutsche, Irina; Krappmann, Daniel und Lammens, Katja
(2018):
Molecular architecture and regulation of BCL10-MALT1 filaments.
In: Nature Communications, Bd. 9, 4041
[PDF, 3MB]
Knoll, Kilian R.; Eustermann, Sebastian; Niebauer, Vanessa; Oberbeckmann, Elisa; Stoehr, Gabriele; Schall, Kevin; Tosi, Alessandro; Schwarz, Marianne; Buchfellner, Andrea; Korber, Philipp und Hopfner, Karl-Peter
(2018):
The nuclear actin-containing Arp8 module is a linker DNA sensor driving IN080 chromatin remodeling.
In: Nature Structural & Molecular Biology, Bd. 25, Nr. 9: S. 823-832
Braciak, Todd A.; Roskopf, Claudia C.; Wildenhain, Sarah; Fenn, Nadja C.; Schiller, Christian B.; Schubert, Ingo A.; Jacob, Uwe; Honegger, Annemarie; Krupka, Christina; Subklewe, Marion; Spiekermann, Karsten; Hopfner, Karl-Peter; Fey, Georg H.; Aigner, Michael; Krause, Stefan; Mackensen, Andreas und Oduncu, Fuat S.
(2018):
Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells.
In: Oncoimmunology, Bd. 7, Nr. 9, e1472195
Kotlarz, Daniel; Marquardt, Benjamin; Baroy, Tuva; Lee, Way S.; Konnikova, Liza; Hollizeck, Sebastian; Magg, Thomas; Lehle, Anna S.; Walz, Christoph; Borggraefe, Ingo; Hauck, Fabian; Bufler, Philip; Conca, Raffaele; Wall, Sarah M.; Schumacher, Eva M.; Misceo, Doriana; Frengen, Eirik; Bentsen, Beint S.; Uhlig, Holm H.; Hopfner, Karl-Peter; Muise, Aleixo M.; Snapper, Scott B.; Stromme, Petter und Klein, Christoph
(2018):
Human TGF-beta 1 deficiency causes severe inflammatory bowel disease and encephalopathy.
In: Nature Genetics, Bd. 50, Nr. 3: S. 344-348
Herrmann, Monika; Krupka, Christina; Deiser, Katrin; Brauchle, Bettina; Marcinek, Anetta; Wagner, Ana Ogrinc; Rataj, Felicitas; Mocikat, Ralph; Metzeler, Klaus H.; Spiekermann, Karsten; Kobold, Sebastian; Fenn, Nadja C.; Hopfner, Karl-Peter und Subklewe, Marion
(2018):
Bifunctional PD-1 x alpha CD3 x alpha CD33 fusion protein reverses adaptive immune escape in acute myeloid leukemia.
In: Blood, Bd. 132, Nr. 23: S. 2484-2494
Butryn, Agata; Woike, Stephan; Shetty, Savera J.; Auble, David T. und Hopfner, Karl-Peter
(2018):
Crystal structure of the full Swi2/Snf2 remodeler Mot1 in the resting state.
In: eLife, 7:e37774: S. 1-12
[PDF, 1MB]
2017
Ahdash, Zainab; Byrne, Robert; Hopfner, Karl-Peter und Politis, Argyris
(2017):
Dissecting the Mechanism of the HerA NurA DNA Break Resection Complex using Native Mass Spectrometry.
In: Biophysical Journal, Bd. 112, Nr. 3:
515A-515A
Ponce, Laia Pascual; Fenn, Nadja C.; Moritz, Nadine; Krupka, Christina; Kozik, Jan-Hendrik; Lauber, Kirsten; Subklewe, Marion und Hopfner, Karl-Peter
(2017):
SIRP alpha-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells.
In: Oncotarget, Bd. 8, Nr. 7: S. 11284-11301
[PDF, 6MB]
Andreeva, Liudmila; Hiller, Björn; Kostrewa, Dirk; Lässig, Charlotte; Oliveira Mann, Carina C. de; Drexler, David Jan; Maiser, Andreas; Gaidt, Moritz; Leonhardt, Heinrich; Hornung, Veit und Hopfner, Karl-Peter
(2017):
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
In: Nature, Bd. 549, Nr. 7672: S. 394-398
Lässig, Charlotte und Hopfner, Karl-Peter
(2017):
Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors.
In: Journal of Biological Chemistry, Bd. 292, Nr. 22: S. 9000-9009
2016
Hopfner, Karl-Peter
(20. Mai 2016):
Architectures and mechanisms of ATP binding cassette proteins.
In: Biopolymers, Bd. 105, Nr. 8: S. 492-504
[PDF, 1MB]
Seifert, Florian Ulrich; Lammens, Katja; Stoehr, Gabriele; Kessler, Brigitte und Hopfner, Karl-Peter
(2016):
Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50.
In: Embo Journal, Bd. 35, Nr. 7: S. 759-772
Mann, Carina C. de Oliveira; Kiefersauer, Reiner; Witte, Gregor und Hopfner, Karl-Peter
(2016):
Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1.
In: Scientific Reports, Bd. 6, 27498
[PDF, 3MB]
Hartmann, Luise; Dutta, Sayantanee; Opatz, Sabrina; Vosberg, Sebastian; Reiter, Katrin; Leubolt, Georg; Metzeler, Klaus H.; Herold, Tobias; Bamopoulos, Stefanos A.; Bräundl, Kathrin; Zellmeier, Evelyn; Ksienzyk, Bianka; Konstandin, Nikola P.; Schneider, Stephanie; Hopfner, Karl-Peter; Graf, Alexander; Krebs, Stefan; Blum, Helmut; Middeke, Jan Moritz; Stölzel, Friedrich; Thiede, Christian; Wolf, Stephan; Bohlander, Stefan K.; Preiss, Caroline; Chen-Wichmann, Linping; Wichmann, Christian; Sauerland, Maria Cristina; Büchner, Thomas; Berdel, Wolfgang E.; Wörmann, Bernhard J.; Braess, Jan; Hiddemann, Wolfgang; Spiekermann, Karsten und Greif, Philipp A.
(2016):
ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.
In: Nature Communications, Bd. 7, 11733
[PDF, 1MB]
Roskopf, Claudia C.; Braciak, Todd A.; Fenn, Nadja C.; Kobold, Sebastian; Fey, Georg H.; Hopfner, Karl-Peter und Oduncu, Fuat S.
(2016):
Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19(+) CD33(+) leukemia cells.
In: Oncotarget, Bd. 7, Nr. 16: S. 22579-22589
Stahl, Evi; Praetorius, Florian; Mann, Carina C. de Oliveira; Hopfner, Karl-Peter und Dietz, Hendrik
(2016):
Impact of Heterogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth.
In: Acs Nano, Bd. 10, Nr. 10: S. 9156-9164
Barford, David und Hopfner, Karl-Peter
(2016):
Editorial overview: Macromolecular machines and assemblies.
In: Current Opinion in Structural Biology, Bd. 37:
VI-VIII
Schwarz, Marianne; Michaelis, Jens und Hopfner, Karl-Peter
(2016):
Catalytic Mechanism of the INO80 Chromatin Remodeler Acting on the Nucleosome.
In: Biophysical Journal, Bd. 110, Nr. 3:
236A-236A
Chatzopoulou, Elisavet I.; Roskopf, Claudia C.; Sekhavati, Farzad; Braciak, Todd A.; Fenn, Nadja C.; Hopfner, Karl-Peter; Oduncu, Fuat S.; Fey, Georg H. und Rädler, Joachim O.
(2016):
Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody.
In: Analyst, Bd. 141, Nr. 7: S. 2284-2295
Poli, Jérôme; Gerhold, Christian-Benedikt; Tosi, Alessandro; Hustedt, Nicole; Seeber, Andrew; Sack, Ragna; Herzog, Franz; Pasero, Philippe; Shimada, Kenji; Hopfner, Karl-Peter und Gasser, Susan M.
(2016):
Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.
In: Genes & Development, Bd. 30, Nr. 3: S. 337-354
Schiller, Christian B.; Braciak, Todd A.; Fenn, Nadja C.; Seidel, Ursula J. E.; Roskopf, Claudia C.; Wildenhain, Sarah; Honegger, Annemarie; Schubert, Ingo A.; Schele, Alexandra; Lämmermann, Kerstin; Fey, Georg H.; Jacob, Uwe; Lang, Peter; Hopfner, Karl-Peter und Oduncu, Fuat S.
(2016):
CD19-specific triplebody SPM-1 engages NK and gd T cells for rapid and efficient lysis of malignant B-lymphoid cells.
In: Oncotarget, Bd. 7, Nr. 50: S. 83392-83408
2015
Seifert, Florian; Lammens, Katja und Hopfner, Karl-Peter
(22. Mai 2015):
Structure of the catalytic domain of Mre11 from Chaetomium thermophilum.
In: Acta Crystallographica Section F : Structural Biology Communications, Bd. 71, Nr. 6: S. 752-757
[PDF, 1MB]
Butryn, Agata; Schuller, Jan M.; Stoehr, Gabriele; Runge-Wollmann, Petra; Förster, Friedrich; Auble, David T. und Hopfner, Karl-Peter
(2015):
Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1.
In: eLife, Bd. 4, e07432
[PDF, 3MB]
Laessig, Charlotte; Matheisl, Sarah; Sparrer, Konstantin M. J.; Mann, Carina C. de Oliveira; Moldt, Manuela; Patel, Jenish R.; Goldeck, Marion; Hartmann, Gunther; Garcia-Sastre, Adolfo; Hornung, Veit; Conzelmann, Karl-Klaus; Beckmann, Roland und Hopfner, Karl-Peter
(2015):
ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
In: eLife, Bd. 4, e10859
[PDF, 2MB]
2014
Hopfner, Karl-Peter
(11. September 2014):
ATP puts the brake on DNA double-strand break repair. A new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.
In: BioEssays, Bd. 36, Nr. 12: S. 1170-1178
[PDF, 837kB]
Janke, Hanna; Pastore, Friederike; Schumacher, Daniela; Herold, Tobias; Hopfner, Karl-Peter; Schneider, Stephanie; Berdel, Wolfgang E.; Büchner, Thomas; Woermann, Bernhard J.; Subklewe, Marion; Bohlander, Stefan K.; Hiddemann, Wolfgang; Spiekermann, Karsten und Polzer, Harald
(2014):
Activating FLT3 Mutants Show Distinct Gain-of-Function Phenotypes In Vitro and a Characteristic Signaling Pathway Profile Associated with Prognosis in Acute Myeloid Leukemia.
In: PLOS ONE 9(3), e89560 [PDF, 2MB]
In: PLOS ONE 9(3), e89560 [PDF, 2MB]
Runge, Simon; Sparrer, Konstantin M. J.; Lässig, Charlotte; Hembach, Katharina; Baum, Alina; Garcia-Sastre, Adolfo; Söding, Johannes; Conzelmann, Karl-Klaus und Hopfner, Karl-Peter
(2014):
In Vivo Ligands of MDA5 and RIG-I in Measles Virus-Infected Cells.
In: PLOS Pathogens 10(4), e1004081 [PDF, 1MB]
In: PLOS Pathogens 10(4), e1004081 [PDF, 1MB]
2013
Lammens, Alfred; Baehner, Monika; Kohnert, Ulrich; Niewoehner, Jens; Proff, Leopold von; Schraeml, Michael; Lammens, Katja und Hopfner, Karl-Peter
(2013):
Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding.
In: PLOS ONE 8(5), e62697 [PDF, 1MB]
In: PLOS ONE 8(5), e62697 [PDF, 1MB]
Braciak, Todd A.; Wildenhain, Sarah; Roskopf, Claudia C.; Schubert, Ingo A.; Fey, Georg H.; Jacob, Uwe; Hopfner, Karl-Peter und Oduncu, Fuat S.
(2013):
NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2.
In: Journal of Translational Medicine
11:289
[PDF, 3MB]
Fenn, Sebastian; Schiller, Christian B.; Griese, Julia J.; Duerr, Harald; Imhof-Jung, Sabine; Gassner, Christian; Moelleken, Joerg; Regula, Joerg Thomas; Schaefer, Wolfgang; Thomas, Markus; Klein, Christian; Hopfner, Karl-Peter und Kettenberger, Hubert
(2013):
Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain.
In: PLOS ONE 8(4), e61953 [PDF, 2MB]
In: PLOS ONE 8(4), e61953 [PDF, 2MB]
2012
Hopfner, Karl-Peter
(2012):
Rustless translation.
In: Biological Chemistry, Bd. 393, Nr. 10: S. 1079-1088
[PDF, 847kB]