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Veröffentlichungsdatum
Anzahl der Publikationen: 71
2024
Bender, Martin 
ORCID: https://orcid.org/0000-0002-9590-4728; Panelli, Alessandro; Reichart, Bruno ORCID: https://orcid.org/0000-0003-2859-3664; Radan, Julia; Mokelke, Maren; Neumann, Elisabeth; Buttgereit, Ines; Michel, Sebastian; Bauer, Andreas; Fresch, Ann Kathrin; Mayr, Tanja; Werner, Fabian; Egerer, Stefanie; Bähr, Andrea ORCID: https://orcid.org/0000-0001-8075-8222; Kessler, Barbara; Klymiuk, Nikolai; Ayares, David; Wolf, Eckhard ORCID: https://orcid.org/0000-0002-0430-9510; Hagl, Christian; Brenner, Paolo; Längin, Matthias ORCID: https://orcid.org/0000-0003-0996-4941 und Abicht, Jan‐Michael ORCID: https://orcid.org/0000-0001-7361-1249
(2024):
Hemodynamics in pig‐to‐baboon heterotopic thoracic cardiac xenotransplantation: Recovery from perioperative cardiac xenograft dysfunction and impairment by cardiac overgrowth.
In: Xenotransplantation, Bd. 31, Nr. 1
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-9590-4728; Panelli, Alessandro; Reichart, Bruno ORCID: https://orcid.org/0000-0003-2859-3664; Radan, Julia; Mokelke, Maren; Neumann, Elisabeth; Buttgereit, Ines; Michel, Sebastian; Bauer, Andreas; Fresch, Ann Kathrin; Mayr, Tanja; Werner, Fabian; Egerer, Stefanie; Bähr, Andrea ORCID: https://orcid.org/0000-0001-8075-8222; Kessler, Barbara; Klymiuk, Nikolai; Ayares, David; Wolf, Eckhard ORCID: https://orcid.org/0000-0002-0430-9510; Hagl, Christian; Brenner, Paolo; Längin, Matthias ORCID: https://orcid.org/0000-0003-0996-4941 und Abicht, Jan‐Michael ORCID: https://orcid.org/0000-0001-7361-1249
(2024):
Hemodynamics in pig‐to‐baboon heterotopic thoracic cardiac xenotransplantation: Recovery from perioperative cardiac xenograft dysfunction and impairment by cardiac overgrowth.
In: Xenotransplantation, Bd. 31, Nr. 1
[PDF, 2MB]
2022
Grotz, Sophia; Schaefer, Jessica; Wunderlich, Kirsten A.; Ellederova, Zdenka; Auch, Hannah; Baehr, Andrea; Runa-Vochozkova, Petra; Fadl, Janet; Arnold, Vanessa; Ardan, Taras; Veith, Miroslav; Santamaria, Gianluca; Dhom, Georg; Hitzl, Wolfgang; Kessler, Barbara; Eckardt, Christian; Klein, Joshua; Brymova, Anna; Linnert, Joshua; Kurome, Mayuko; Zakharchenko, Valeri; Fischer, Andrea; Blutke, Andreas; Doering, Anna; Suchankova, Stepanka; Popelar, Jiri; Rodriguez-Bocanegra, Eduardo; Dlugaiczyk, Julia; Straka, Hans; May-Simera, Helen; Wang, Weiwei; Laugwitz, Karl-Ludwig; Vandenberghe, Luk H.; Wolf, Eckhard; Nagel-Wolfrum, Kerstin; Peters, Tobias; Motlik, Jan; Fischer, M. Dominik; Wolfrum, Uwe und Klymiuk, Nikolai
(2022):
Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes.
In: EMBO Molecular Medicine, Bd. 14, Nr. 4, e14817
Poch, Christine M.; Foo, Kylie S.; De Angelis, Maria Teresa; Jennbacken, Karin; Santamaria, Gianluca; Baehr, Andrea; Wang, Qing-Dong; Reiter, Franziska; Hornaschewitz, Nadja; Zawada, Dorota; Bozoglu, Tarik; My, Ilaria; Meier, Anna; Dorn, Tatjana; Hege, Simon; Lehtinen, Miia L.; Tsoi, Yat Long; Hovdal, Daniel; Hyllner, Johan; Schwarz, Sascha; Sudhop, Stefanie; Jurisch, Victoria; Sini, Marcella; Fellows, Mick D.; Cummings, Matthew; Clarke, Jonathan; Baptista, Ricardo; Eroglu, Elif; Wolf, Eckhard; Klymiuk, Nikolai; Lu, Kun; Tomasi, Roland; Dendorfer, Andreas; Gaspari, Marco; Parrotta, Elvira; Cuda, Giovanni; Krane, Markus; Sinnecker, Daniel; Hoppmann, Petra; Kupatt, Christian; Fritsche-Danielson, Regina; Moretti, Alessandra; Chien, Kenneth R. und Laugwitz, Karl-Ludwig
(2022):
Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors.
In: Nature Cell Biology, Bd. 24, Nr. 5: S. 659-671
Bartenschlager, Florian; Klymiuk, Nikolai; Gruber, Achim D. und Mundhenk, Lars
(2022):
Genomic, biochemical and expressional properties reveal strong conservation of the CLCA2 gene in birds and mammals.
In: PeerJ, Bd. 10, e14202
Bartenschlager, Florian; Klymiuk, Nikolai; Weise, Christoph; Kuropka, Benno; Gruber, Achim D. und Mundhenk, Lars
(2022):
Evolutionarily conserved properties of CLCA proteins 1, 3 and 4, as revealed by phylogenetic and biochemical studies in avian homologues.
In: PLOS One 17(4), e0266937
In: PLOS One 17(4), e0266937
Fleurot, Isabelle; Lopez-Galvez, Raquel; Barbry, Pascal; Guillon, Antoine; Si-Tahar, Mustapha; Bahr, Andrea; Klymiuk, Nikolai; Sirard, Jean-Claude und Caballero, Ignacio
(2022):
TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium.
In: Journal of Cystic Fibrosis, Bd. 21, Nr. 2, E117-E121
Stirm, Michael; Fonteyne, Lina Marie; Shashikadze, Bachuki; Stoeckl, Jan B.; Kurome, Mayuko; Kessler, Barbara; Zakhartchenko, Valeri; Kemter, Elisabeth; Blum, Helmut; Arnold, Georg J.; Matiasek, Kaspar; Wanke, Ruediger; Wurst, Wolfgang; Nagashima, Hiroshi; Knieling, Ferdinand; Walter, Maggie C.; Kupatt, Christian; Froehlich, Thomas; Klymiuk, Nikolai; Blutke, Andreas und Wolf, Eckhard
(2022):
Pig models for Duchenne muscular dystrophy-from disease mechanisms to validation of new diagnostic and therapeutic concepts.
In: Neuromuscular Disorders, Bd. 32, Nr. 7: S. 543-556
2021
Stirm, Michael; Fonteyne, Lina Marie; Shashikadze, Bachuki; Lindner, Magdalena; Chirivi, Maila; Lange, Andreas; Kaufhold, Clara; Mayer, Christian; Medugorac, Ivica; Kessler, Barbara; Kurome, Mayuko; Zakhartchenko, Valeri; Hinrichs, Arne; Kemter, Elisabeth; Krause, Sabine; Wanke, Rüdiger; Arnold, Georg J.; Wess, Gerhard; Nagashima, Hiroshi; de Angelis, Marin Hrabe; Flenkenthaler, Florian; Kobelke, Levin Arne; Bearzi, Claudia; Rizzi, Roberto; Bähr, Andreas; Reese, Sven ORCID: https://orcid.org/0000-0002-4605-9791; Matiasek, Kaspar; Walter, Maggie C.; Kupatt, Christian; Ziegler, Sibylle; Bartenstein, Peter; Fröhlich, Thomas; Klymiuk, Nikolai; Blutke, Andreas und Wolf, Eckhard
(19. November 2021):
A scalable, clinically severe pig model for Duchenne muscular dystrophy.
In: Disease Models & Mechanisms, Bd. 14, Nr. 12
[PDF, 3MB]
ORCID: https://orcid.org/0000-0002-4605-9791; Matiasek, Kaspar; Walter, Maggie C.; Kupatt, Christian; Ziegler, Sibylle; Bartenstein, Peter; Fröhlich, Thomas; Klymiuk, Nikolai; Blutke, Andreas und Wolf, Eckhard
(19. November 2021):
A scalable, clinically severe pig model for Duchenne muscular dystrophy.
In: Disease Models & Mechanisms, Bd. 14, Nr. 12
[PDF, 3MB]
Veltman, Mieke; De Sanctis, Juan B.; Stolarczyk, Marta; Klymiuk, Nikolai; Baehr, Andrea; Brouwer, Rutger W.; Oole, Edwin; Shah, Juhi; Ozdian, Tomas; Liao, Jie; Martini, Carolina; Radzioch, Danuta; Hanrahan, John W. und Scholte, Bob J.
(4. Februar 2021):
CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells.
In: Frontiers in Physiology, Bd. 12, 619442
[PDF, 1MB]
Querdel, Eva; Reinsch, Marina; Castro, Liesa; Kose, Deniz; Bahr, Andrea; Reich, Svenja; Geertz, Birgit; Ulmer, Barbel; Schulze, Mirja; Lemoine, Marc D.; Krause, Tobias; Lemme, Marta; Sani, Jascha; Shibamiya, Aya; Stuedemann, Tim; Koehne, Maria; Bibra, Constantin von; Hornaschewitz, Nadja; Pecha, Simon; Nejahsie, Yusuf; Mannhardt, Ingra; Christ, Torsten; Reichenspurner, Hermann; Hansen, Arne; Klymiuk, Nikolai; Krane, M.; Kupatt, C.; Eschenhagen, Thomas und Weinberger, Florian
(2021):
Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner.
In: Circulation, Bd. 143, Nr. 20: S. 1991-2006
Caballero, Ignacio; Ringot-Destrez, Belinda; Si-Tahar, Mustapha; Barbry, Pascal; Guillon, Antoine; Lantier, Isabelle; Berri, Mustapha; Chevaleyre, Claire; Fleurot, Isabelle; Barc, Celine; Ramphal, Reuben; Pons, Nicolas; Paquet, Agnes; Lebrigand, Kevin; Baron, Carole; Baehr, Andrea; Klymiuk, Nikolai; Leonard, Renaud und Robbe-Masselot, Catherine
(2021):
Evidence of early increased sialylation of airway mucins and defective mucociliary clearance in CFTR-deficient piglets.
In: Journal of Cystic Fibrosis, Bd. 20, Nr. 1: S. 173-182
Ermund, Anna; Meiss, Lauren N.; Dolan, Brendan; Jaudas, Florian; Ewaldsson, Lars; Bahr, Andrea; Klymiuk, Nikolai und Hansson, Gunnar C.
(2021):
Mucus threads from surface goblet cells clear particles from the airways.
In: Respiratory Research, Bd. 22, Nr. 1, 303
Giorgetti, Melania; Klymiuk, Nikolai; Baehr, Andrea; Hemmerling, Martin; Jinton, Lisa; Tarran, Robert; Malmgren, Anna; Astrand, Annika; Hansson, Gunnar C. und Ermund, Anna
(2021):
New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger inhibition.
In: European Journal of Pharmacology, Bd. 904, 174123
Lopez-Galvez, Raquel; Fleurot, Isabelle; Chamero, Pablo; Trapp, Sascha; Olivier, Michel; Chevaleyre, Claire; Barc, Celine; Riou, Mickael; Rossignol, Christelle; Guillon, Antoine; Si-Tahar, Mustapha; May, Tobias; Barbry, Pascal; Bahr, Andrea; Klymiuk, Nikolai; Sirard, Jean-Claude und Caballero, Ignacio
(2021):
Airway Administration of Flagellin Regulates the Inflammatory Response to Pseudomonas aeruginosa.
In: American Journal of Respiratory Cell and Molecular Biology, Bd. 65, Nr. 4: S. 378-389
Stirm, Michael; Fonteyne, Lina Marie; Shashikadze, Bachuki; Lindner, Magdalena; Chirivi, Maila; Lange, Andreas; Kaufhold, Clara; Mayer, Christian; Medugorac, Ivica; Kessler, Barbara; Kurome, Mayuko; Zakhartchenko, Valeri; Hinrichs, Arne; Kemter, Elisabeth; Krause, Sabine; Wanke, Rudiger; Arnold, Georg J.; Wess, Gerhard; Nagashima, Hiroshi; de Angelis, Martin Hrabe; Flenkenthaler, Florian; Kobelke, Levin Arne; Bearzi, Claudia; Rizzi, Roberto; Baehr, Andrea; Reese, Sven; Matiasek, Kaspar; Walter, Maggie C.; Kupatt, Christian; Ziegler, Sibylle; Bartenstein, Peter; Froehlich, Thomas; Klymiuk, Nikolai; Blutke, Andreas und Wolf, Eckhard
(2021):
A scalable, clinically severe pig model for Duchenne muscular dystrophy.
In: Disease Models & Mechanisms, Bd. 14, Nr. 12, dmm049285
2020
Wuensch, Annegret; Kameritsch, Petra; Sfriso, Riccardo; Jemiller, Eva-Maria; Baehr, Andrea; Kurome, Mayuko; Kessler, Barbara; Kemter, Elisabeth; Kupatt, Christian; Reichart, Bruno; Rieben, Robert; Wolf, Eckhard und Klymiuk, Nikolai
(2020):
Genetically encoded Ca2+-sensor reveals details of porcine endothelial cell activation upon contact with human serum.
In: Xenotransplantation, Bd. 27, Nr. 5, e12585
[PDF, 1MB]
Reichart, Bruno; Langin, Matthias; Radan, Julia; Mokelke, Maren; Buttgereit, Ines; Ying, Jiawei; Fresch, Ann Kathrin; Mayr, Tanja; Issl, Lara; Buchholz, Stefan; Michel, Sebastian; Ellgass, Reinhard; Mihalj, Maks; Egerer, Stefanie; Baehr, Andrea; Kessler, Barbara; Kemter, Elisabeth; Kurome, Mayuko; Zakhartchenko, Valeri; Steen, Stig; Sjoberg, Trygve; Paskevicius, Audrius; Kruger, Luise; Fiebig, Uwe; Denner, Joachim; Godehardt, Antonia W.; Tonjes, Ralf R.; Milusev, Anastasia; Rieben, Robert; Sfriso, Riccardo; Walz, Christoph; Kirchner, Thomas; Ayares, David; Lampe, Karen; Schonmann, Uwe; Hagl, Christian; Wolf, Eckhard; Klymiuk, Nikolai; Abicht, Jan-Michael und Brenner, Paolo
(2020):
Pig-to-non-human primate heart transplantation: The final step toward clinical xenotransplantation?
In: Journal of Heart and Lung Transplantation, Bd. 39, Nr. 8: S. 751-757
Laengin, Matthias; Reichart, Bruno; Steen, Stig; Sjoberg, Trygve; Paskevicius, Audrius; Liao, Qiuming; Qin, Guangqi; Mokelke, Maren; Mayr, Tanja; Radan, Julia; Issl, Lara; Buttgereit, Ines; Ying, Jiawei; Fresch, Ann Kathrin; Panelli, Alessandro; Egerer, Stefanie; Baehr, Andrea; Kessler, Barbara; Milusev, Anastasia; Sfriso, Riccardo; Rieben, Robert; Ayares, David; Murray, Peter J.; Ellgass, Reinhard; Walz, Christoph; Klymiuk, Nikolai; Wolf, Eckhard; Abicht, Jan-Michael und Brenner, Paolo
(2020):
Cold non-ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig-to-baboon xenotransplantation.
In: Xenotransplantation, Bd. 28, Nr. 1, e12636
[PDF, 1MB]
Tamiyakul, Hathaichanok; Kemter, Elisabeth; Kösters, Miwako; Ebner, Stefanie; Blutke, Andreas; Klymiuk, Nikolai; Flenkenthaler, Florian; Wolf, Eckhard; Arnold, Georg J. und Fröhlich, Thomas
(2020):
Progressive Proteome Changes in the Myocardium of a Pig Model for Duchenne Muscular Dystrophy.
In: Iscience, Bd. 23, Nr. 9, 101516
Braux, Julien; Jourdain, Marie-Laure; Guillaume, Christine; Untereiner, Valerie; Piot, Olivier; Baehr, Andrea; Klymiuk, Nikolai; Winter, Nathalie; Berri, Mustapha; Buzoni-Gatel, Dominique; Caballero, Ignaccio; Guillon, Antoine; Si-Tahar, Mustapha; Jacquot, Jacky und Velard, Frederic
(2020):
CFTR-deficient pigs display alterations of bone microarchitecture and composition.
In: Journal of Cystic Fibrosis, Bd. 19, Nr. 3: S. 466-475
Ramackers, Wolf; Rataj, Dennis; Werwitzke, Sonja; Bergmann, Sabine; Winkler, Michael; Wuensch, Annegret; Baehr, Andrea; Wolf, Eckard; Klymiuk, Nikolai; Ayares, David und Tiede, Andreas
(2020):
Expression of human thrombomodulin on porcine endothelial cells can reduce platelet aggregation but did not reduce activation of complement or endothelium - an experimental study.
In: Transplant International, Bd. 33, Nr. 4: S. 437-449
Brea, Deborah; Soler, Laura; Fleurot, Isabelle; Melo, Sandrine; Chevaleyre, Claire; Berri, Mustapha; Labas, Valerie; Teixeira-Gomes, Ana-Paula; Pujo, Julien; Cenac, Nicolas; Baehr, Andrea; Klymiuk, Nikolai; Guillon, Antoine; Si-Tahar, Mustapha und Caballero, Ignacio
(2020):
Intrinsic alterations in peripheral neutrophils from cystic fibrosis newborn piglets.
In: Journal of Cystic Fibrosis, Bd. 19, Nr. 5: S. 830-836
Hinrichs, Arne; Riedel, Evamaria O.; Klymiuk, Nikolai; Blutke, Andreas; Kemter, Elisabeth; Laengin, Matthias; Dahlhoff, Maik; Kessler, Barbara; Kurome, Mayuko; Zakhartchenko, Valeri; Jemiller, Eva-Maria; Ayares, David; Bidlingmaier, Martin; Flenkenthaler, Florian; Hrabe de Angelis, Martin; Arnold, Georg J.; Reichart, Bruno; Fröhlich, Thomas und Wolf, Eckhard
(2020):
Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies.
In: Xenotransplantation, Bd. 28, Nr. 2, e12664
Zettler, Silja; Renner, Simone; Kemter, Elisabeth; Hinrichs, Arne; Klymiuk, Nikolai; Backman, Mattias; Riedel, Evamaria Olga; Müller, Christiane; Streckel, Elisabeth; Braun-Reichhart, Christina; Martins, Ana Sofia; Kurome, Mayuko; Kessler, Barbara; Zakhartchenko, Valeri; Flenkenthaler, Florian; Arnold, Georg Josef; Fröhlich, Thomas; Blum, Helmut; Blutke, Andreas; Wanke, Rüdiger und Wolf, Eckhard
(2020):
A decade of experience with genetically tailored pig models for diabetes and metabolic research.
In: Animal Reproduction, Bd. 17, Nr. 3, e20200064
2019
Wolf, Eckhard; Kemter, Elisabeth; Klymiuk, Nikolai und Reichart, Bruno
(Juli 2019):
Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantation.
In: Animal Frontiers, Bd. 9, Nr. 3: S. 13-20
[PDF, 13MB]
Clauss, Sebastian; Bleyer, Christina; Schuettler, Dominik; Tomsits, Philipp; Renner, Simone; Klymiuk, Nikolai; Wakili, Reza; Massberg, Steffen; Wolf, Eckhard und Kaab, Stefan
(2019):
Animal models of arrhythmia: classic electrophysiology to genetically modified large animals.
In: Nature Reviews Cardiology, Bd. 16, Nr. 8: S. 457-475
Regensburger, Adrian P.; Fonteyne, Lina M.; Juengert, Jörg; Wagner, Alexandra L.; Gerhalter, Teresa; Nagel, Armin M.; Heiss, Rafael; Flenkenthaler, Florian; Qurashi, Matthias; Neurath, Markus F.; Klymiuk, Nikolai; Kemter, Elisabeth; Fröhlich, Thomas; Uder, Michael; Woelfle, Joachim; Rascher, Wolfgang; Trollmann, Regina; Wolf, Eckhard; Waldner, Maximilian J. und Knieling, Ferdinand
(2019):
Detection of collagens by multispectral optoacoustic tomography as an imaging biomarker for Duchenne muscular dystrophy.
In: Nature Medicine, Bd. 25, Nr. 12
Kurome, Mayuko; Baehr, Andrea; Simmet, Kilian; Jemiller, Eva-Maria; Egerer, Stefanie; Dahlhoff, Maik; Zakhartchenko, Valeri; Nagashima, Hiroshi; Klymiuk, Nikolai; Kessler, Barbara und Wolf, Eckhard
(2019):
Targeting Gal epitopes for multi-species embryo immunosurgery.
In: Reproduction Fertility and Development, Bd. 31, Nr. 4: S. 820-826
Renner, Simone; Martins, Ana Sofia; Streckel, Elisabeth; Braun-Reichhart, Christina; Backman, Mattias; Prehn, Cornelia; Klymiuk, Nikolai; Bahr, Andrea; Blutke, Andreas; Landbrecht-Schessl, Christina; Wuensch, Annegret; Kessler, Barbara; Kurome, Mayuko; Hinrichs, Arne; Koopmans, Sietse-Jan; Krebs, Stefan; Kemter, Elisabeth; Rathkolb, Birgit; Nagashima, Hiroshi; Blum, Helmut; Ritzmann, Mathias; Wanke, Rüdiger; Aigner, Bernhard; Adamski, Jerzy; de Angelis, Martin Hrabe und Wolf, Eckhard
(2019):
Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring.
In: Disease Models & Mechanisms, Bd. 12, Nr. 8, UNSP dmm039156
[PDF, 2MB]
2018
Rothammer, Sophie; Kunz, Elisabeth; Krebs, Stefan; Bitzer, Fanny; Hauser, Andreas; Zinovieva, Natalia; Klymiuk, Nikolai und Medugorac, Ivica
(2018):
Remapping of the belted phenotype in cattle on BTA3 identifies a multiplication event as the candidate causal mutation.
In: Genetics Selection Evolution
50:36
[PDF, 2MB]
Simmet, Kilian; Zakhartchenko, Valeri; Philippou-Massier, Julia; Blum, Helmut; Klymiuk, Nikolai und Wolf, Eckhard
(2018):
OCT4/POU5F1 is required for NANOG expression in bovine blastocysts.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 115, Nr. 11: S. 2770-2775
Matsunari, Hitomi; Watanabe, Masahito; Nakano, Kazuaki; Enosawa, Shin; Umeyama, Kazuhiro; Uchikura, Ayuko; Yashima, Sayaka; Fukuda, Toru; Klymiuk, Nikolai; Kurome, Mayuko; Kessler, Barbara; Wünschd, Annegret; Zakhartchenko, Valeri; Wolf, Eckhard; Hanazono, Yutaka; Nagaya, Masaki; Umezawa, Akihiro; Nakauchi, Hiromitsu und Nagashima, Hiroshi
(2018):
Modeling lethal X-linked genetic disorders in pigs with ensured fertility.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 115, Nr. 4: S. 708-713
Ermund, Anna; Meiss, Lauren N.; Dolan, Brendan; Bähr, Andrea; Klymiuk, Nikolai und Hansson, Gunnar C.
(2018):
The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation.
In: European Respiratory Journal, Bd. 52, Nr. 2, 1800457
Mundhenk, Lars; Erickson, Nancy A.; Klymiuk, Nikolai und Gruber, Achim D.
(2018):
Interspecies diversity of chloride channel regulators, calcium-activated 3 genes.
In: PLOS One 13(1), e0191512 [PDF, 24MB]
In: PLOS One 13(1), e0191512 [PDF, 24MB]
Trillo-Muyo, Sergio; Nilsson, Harriet E.; Recktenwald, Christian V.; Ermund, Anna; Ridley, Caroline; Meiss, Lauren N.; Bähr, Andrea; Klymiuk, Nikolai; Wine, Jeffrey J.; Koeck, Philip J. B.; Thornton, David J.; Hebert, Hans und Hansson, Gunnar C.
(2018):
Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers.
In: Journal of Biological Chemistry, Bd. 293, Nr. 15: S. 5746-5754
Yung, Gisella Puga; Bongoni, Anjan K.; Pradier, Amandine; Madelon, Natacha; Papaserafeim, Maria; Sfriso, Riccardo; Ayares, David L.; Wolf, Eckhard; Klymiuk, Nikolai; Bähr, Andrea; Constantinescu, Mihai A.; Vögelin, Esther; Kiermeir, David; Jenni, Hansjorg; Rieben, Robert und Seebach, Jörg D.
(2018):
Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood.
In: Xenotransplantation, Bd. 25, Nr. 1, e12357
Egerer, Stefanie; Fiebig, Uwe; Kessler, Barbara; Zakhartchenko, Valeri; Kurome, Mayuko; Reichart, Bruno; Kupatt, Christian; Klymiuk, Nikolai; Wolf, Eckhard; Denner, Joachim und Bähr, Andrea
(2018):
Early weaning completely eliminates porcine cytomegalovirus from a newly established pig donor facility for xenotransplantation.
In: Xenotransplantation, Bd. 25, Nr. 4, e12449
Abicht, Jan-Michael; Sfriso, Riccardo; Reichart, Bruno; Laengin, Matthias; Gahle, Katja; Yung, Gisella L. Puga; Seebach, Jörg D.; Rieben, Robert; Ayares, David; Wolf, Eckhard; Klymiuk, Nikolai; Bähr, Andrea; Kind, Alexander; Mayr, Tanja und Bauer, Andreas
(2018):
Multiple genetically modified GTKO/hCD46/HLA‐E/hβ2−mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood.
In: Xenotransplantation, Bd. 25, Nr. 5, e12390
Laengin, Matthias; Mayr, Tanja; Reichart, Bruno; Michel, Sebastian; Buchholz, Stefan; Guethoff, Sonja; Dashkevich, Alexey; Bähr, Andrea; Egerer, Stefanie; Bauer, Andreas; Mihalj, Maks; Panelli, Alessandro; Issl, Lara; Ying, Jiawei; Fresch, Ann Kathrin; Buttgereit, Ines; Mokelke, Maren; Radan, Julia; Werner, Fabian; Lutzmann, Isabelle; Steen, Stig; Sjoberg, Trygve; Paskevicius, Audrius; Qiuming, Liao; Sfriso, Riccardo; Rieben, Robert; Dahlhoff, Maik; Kessler, Barbara; Kemter, Elisabeth; Klett, Katharina; Hinkel, Rabea; Kupatt, Christian; Falkenau, Almuth; Reu, Simone; Ellgass, Reinhard; Herzog, Rudolf; Binder, Uli; Wich, Guenter; Skerra, Arne; Ayares, David; Kind, Alexander; Schönmann, Uwe; Kaup, Franz-Josef; Hagl, Christian; Wolf, Eckhard; Klymiuk, Nikolai; Brenner, Paolo und Abicht, Jan-Michael
(2018):
Consistent success in life-supporting porcine cardiac xenotransplantation.
In: Nature, Bd. 564, Nr. 7736: S. 430-433
2017
Wünsch, Annegret; Kameritsch, Petra; Sfriso, Riccardo; Bähr, Andrea; Kemter, Elisabeth; Kurome, Mayuko; Kessler, Barbara; Rieben, Robert; Wolf, Eckhard und Klymiuk, Nikolai
(2017):
Monitoring the activation status of endothelial cells by a genetically encoded calcium-sensor.
In: Xenotransplantation, Bd. 24, Nr. 5
Denner, Joachim; Morozov, Vladimir A.; Reichart, Bruno; Plotzki, Elena; Fiebig, Uwe; Heinrichs, Gerd; Wolf-van Buerck, Lelia; Abicht, Jan-Michael; Petersen, Björn; Mayr, Tanja; Knauf, Yvonne; Becker, Tamara; Fischer, Konrad; Mätz-Rensing, Kerstin; Schuster, Marion; Bähr, Andrea; Klymiuk, Nikolai; Wynyard, Shaun; Matsumoto, Shinichi; Abalovich, Adrian; Elliott, Robert; Seissler, Jochen; Rotem, Avi; Barkai, Uriel; Ludwig, Barbara; Bornstein, Stefan; Schnieke, Angelika; Niemann, Heiner und Wolf, Eckhard
(2017):
New detection methods for porcine viruses: screening of donor pigs and human and non-human primate xenotransplant recipients.
In: Xenotransplantation, Bd. 24, Nr. 5
Brenner, Paolo; Mayr, Tanja; Güthoff, Sonja; Buchholz, Stefan; Dashkevich, Alexander; Michel, Sebastian; Lutzmann, Isabelle; Werner, Fabian; Bauer, Andreas; Klymiuk, Nikolai; Wolf, Eckhard; Reimann, Keith; Mohiuddin, Muhammad; Hermanns, Walter; Ayares, David; McGregor, Christopher; Hagl, Christian; Steen, Stig; Reichart, Bruno und Abicht, Jan-Michael
(2017):
Orthotopic cardiac xenotransplantation of GalKO/hCD46/hTM-transgenic pig hearts into baboons (40 days survival) using a CD40mAb or CD40L-Ab costimulation blockade.
In: Xenotransplantation, Bd. 24, Nr. 5
Byrne, Guerard; McGregor, Christopher G. A.; Reichart, Bruno; Brenner, Paolo; Mayr, Tanja; Klymiuk, Nikolai; Wolf, Eckhard; Skerra, Arne; Binder, Uli und Abicht, Jan-Michael
(2017):
Analysis of non-gal antibody responses after orthotopic pig to baboon cardiac xenotransplantation.
In: Xenotransplantation, Bd. 24, Nr. 5
Hinrichs, Arne; Klymiuk, Nikolai; Reichart, Bruno; Kessler, Barbara; Kurome, Mayuko; Bähr, Andrea; Dahlhoff, Maik und Wolf, Eckhard
(2017):
Inactivation of the GHR gene - a strategy to overcome excess growth of orthotopic pig-to-baboon cardiac xenografts?
In: Xenotransplantation, Bd. 24, Nr. 5
Kola, Ingrid; Reichart, Bruno; Wolf, Eckhard und Klymiuk, Nikolai
(2017):
Deleting PERV-C proviruses from the genome of multiple modified donor pigs.
In: Xenotransplantation, Bd. 24, Nr. 5
Längin, Matthias; Mayr, Tanja A.; Reichart, Bruno; Mingquian, Li; Pohla, Heike; Buchholz, Stefan; Werner, Fabian; Bauer, Andreas; Ayares, David; Wolf, Eckhard; Klymiuk, Nikolai; Bähr, Andrea; Kessler, Barbara; Kind, Alex; Güthoff, Sonja; Brenner, Paolo und Abicht, Jan-Michael
(2017):
Immunologic effects of myeloablative pre-treatment and total lymphoid irradiation in heterotopic intrathoracic pig-to-baboon cardiac xenotransplantation.
In: Xenotransplantation, Bd. 24, Nr. 5
Rieben, Robert; Sfriso, Riccardo; Abicht, Jan-Michael; Mayr, Tanja; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard und Reichart, Bruno
(2017):
Assessment of complement and NK cell activation in Ga1TKO/hCD46/HIA-E porcine hearts ex vivo xenoperfused with human blood.
In: Molecular Immunology, Bd. 89: S. 207
Sfriso, Riccardo; Abicht, Jan; Mayr, Tanja; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard; Reichart, Bruno und Rieben, Robert
(2017):
Evaluation of innate immune activation after ex vivo xenoperfusion of GTKO/Hcd46/HLA-E transgenic pig hearts with human blood.
In: Xenotransplantation, Bd. 24, Nr. 5
Beshr, Ghamdan; Sikandar, Asfandyar; Jemiller, Eva-Maria; Klymiuk, Nikolai; Hauck, Dirk; Wagner, Stefanie; Wolf, Eckhard; Koehnke, Jesko und Titz, Alexander
(2017):
Photorhabdus luminescens lectin A (PllA): A new probe for detecting -galactoside-terminating glycoconjugates.
In: Journal of Biological Chemistry, Bd. 292, Nr. 48: S. 19935-19951
Ermund, Anna; Meiss, Lauren N.; Rodriguez-Pineiro, Ana M.; Bähr, Andrea; Nilsson, Harriet E.; Trillo-Muyo, Sergio; Ridley, Caroline; Thornton, David J.; Wine, Jeffrey J.; Hebert, Hans; Klymiuk, Nikolai und Hansson, Gunnar C.
(2017):
The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin.
In: Biochemical and Biophysical Research Communications, Bd. 492, Nr. 3: S. 331-337
Sfriso, Riccardo; Bongoni, Anjan; Banz, Yara; Klymiuk, Nikolai; Wolf, Eckhard und Rieben, Robert
(2017):
Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood.
In: Jove-Journal of Visualized Experiments, Nr. 127, e56227
Abdelhafez, Mai; Shaw, Jane; Banz, Yara; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard und Rieben, Robert
(2017):
Reduced susceptibility of pig hearts overexpressing human membrane cofactor protein to ischemia/reperfusion injury.
In: Xenotransplantation, Bd. 24, Nr. 5
Klymiuk, Nikolai
(2017):
Clarifying the integration sites of transgenes in xenotransplantation-relevant breeding animals.
In: Xenotransplantation, Bd. 24, Nr. 5
Abdelhafez, Mai; Shaw, Jane; Banz, Yara; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard und Rieben, Robert
(2017):
Reduction of myocardial ischemia reperfusion injury in pigs by (over) expression of human membrane co-factor protein.
In: Molecular Immunology, Bd. 89: S. 129
Sfriso, Riccardo; Steck, Oliver; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard und Rieben, Robert
(2017):
In vitro assessment of xenogeneic complement and endothelial cell activation using a microvascular flow model.
In: Molecular Immunology, Bd. 89: S. 209
Bongoni, Anjan K.; Salvaris, Evelyn; Nordling, Sofia; Klymiuk, Nikolai; Wolf, Eckhard; Ayares, David L.; Rieben, Robert; Magnusson, Peetra U. und Cowan, Peter J.
(2017):
Surface modification of pig endothelial cells with a branched heparin conjugate improves their compatibility with human blood.
In: Scientific Reports, Bd. 7, 4450
[PDF, 2MB]
Cohrs, Christian M.; Chen, Chunguang; Jahn, Stephan R.; Stertmann, Julia; Chmelova, Helena; Weitz, Jürgen; Bähr, Andrea; Klymiuk, Nikolai; Steffen, Anja; Ludwig, Barbara; Kamvissi, Virginia; Wolf, Eckhard; Bornstein, Stefan R.; Solimena, Michele und Speier, Stephan
(2017):
Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation.
In: Endocrinology, Bd. 158, Nr. 5: S. 1373-1385
Laird, Christopher T.; Burdorf, Lars; French, Beth M.; Kubicki, Natalia; Cheng, Xiangfei; Braileanu, Gheorghe; Sun, Wenji; O'Neill, Natalie A.; Cimeno, Arielle; Parsell, Dawn; So, Edward; Bähr, Andrea; Klymiuk, Nikolai; Phelps, Carol J.; Ayares, David; Azimzadeh, Agnes M. und Pierson, Richard N.
(2017):
Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury.
In: Xenotransplantation, Bd. 24, Nr. 2, e12294
Kurome, Mayuko; Leuchs, Simon; Kessler, Barbara; Kemter, Elisabeth; Jemiller, Eva-Maria; Foerster, Beatrix; Klymiuk, Nikolai; Zakhartchenko, Valeri und Wolf, Eckhard
(2017):
Direct introduction of gene constructs into the pronucleus-like structure of cloned embryos: a new strategy for the generation of genetically modified pigs.
In: Transgenic Research, Bd. 26, Nr. 2: S. 309-318
2016
Klymiuk, Nikolai; Seeliger, Frank; Bohlooly-Y, Mohammad; Blutke, Andreas; Rudmann, Daniel G. und Wolf, Eckhard
(2016):
Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies.
In: Toxicologic Pathology, Bd. 44, Nr. 3: S. 346-357
[PDF, 559kB]
Fröhlich, Thomas; Kemter, Elisabeth; Flenkenthaler, Florian; Klymiuk, Nikolai; Otte, Kathrin A.; Blutke, Andreas; Krause, Sabine; Walter, Maggie C.; Wanke, Rüdiger; Wolf, Eckhard und Arnold, Georg J.
(2016):
Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy.
In: Scientific Reports, Bd. 6, 33362
[PDF, 2MB]
Bähr, Andrea; Käser, Tobias; Kemter, Elisabeth; Gerner, Wilhelm; Kurome, Mayuko; Baars, Wiebke; Herbach, Nadja; Witter, Kirsti; Wünsch, Annegret; Talker, Stephanie C.; Kessler, Barbara; Nagashima, Hiroshi; Saalmüller, Armin; Schwinzer, Reinhard; Wolf, Eckhard und Klymiuk, Nikolai
(2016):
Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs.
In: PLOS ONE 11(5), e0155676 [PDF, 18MB]
In: PLOS ONE 11(5), e0155676 [PDF, 18MB]
Mohiuddin, Muhammad M.; Singh, Avneesh K.; Corcoran, Philip C.; Thomas, Marvin L.; Clark, Tannia; Lewis, Billeta G.; Hoyt, Robert F.; Eckhaus, Michael; Pierson, Richard N.; Belli, Aaron J.; Wolf, Eckhard; Klymiuk, Nikolai; Phelps, Carol; Reimann, Keith A.; Ayares, David und Horvath, Keith A.
(2016):
Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft.
In: Nature Communications, Bd. 7, 11138
[PDF, 1MB]
Rataj, Dennis; Werwitzke, Sonja; Haarmeijer, Birgitt; Winkler, Michael; Ramackers, Wolf; Petersen, Björn; Niemann, Heiner; Wünsch, Annegret; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard; Abicht, Jan-Michael; Ayares, David und Tiede, Andreas
(2016):
Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation.
In: Xenotransplantation, Bd. 23, Nr. 2: S. 117-127
Sfriso, Riccardo; Klymiuk, Nikolai; Wuensch, Annegret; Seebach, Joerg D.; Wolf, Eckhard und Rieben, Robert
(2016):
Activation of complement and coagulation in xenotransplantation: Effect of growth hormone receptor knockout on porcine aortic endothelial cells.
In: Immunobiology, Bd. 221, Nr. 10: S. 1174-1175
Bongoni, Anjan K.; Klymiuk, Nikolai; Wolf, Eckhard; Ayares, David; Rieben, Robert und Cowan, Peter J.
(2016):
Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation.
In: Transplantation, Bd. 100, Nr. 9: S. 1871-1879
2015
Plog, Stephanie; Klymiuk, Nikolai; Binder, Stefanie; Hook, Matthew J. van; Thoreson, Wallace B.; Gruber, Achim D. und Mundhenk, Lars
(2015):
Naturally Occurring Deletion Mutants of the Pig-Specific, Intestinal Crypt Epithelial Cell Protein CLCA4b without Apparent Phenotype.
In: PLOS ONE 10(10), e0140050 [PDF, 2MB]
In: PLOS ONE 10(10), e0140050 [PDF, 2MB]
Guillon, Antoine; Chevaleyre, Claire; Barc, Celine; Berri, Mustapha; Adriaensen, Hans; Lecompte, Francois; Villemagne, Thierry; Pezant, Jeremy; Delaunay, Remi; Moenne-Loccoz, Joseph; Berthon, Patricia; Baehr, Andrea; Wolf, Eckhard; Klymiuk, Nikolai; Attucci, Sylvie; Ramphal, Reuben; Sarradin, Pierre; Buzoni-Gatel, Dominique; Si-Tahar, Mustapha und Caballero, Ignacio
(2015):
Computed Tomography (CT) Scanning Facilitates Early Identification of Neonatal Cystic Fibrosis Piglets.
In: PLOS ONE 10(11), e0143459 [PDF, 2MB]
In: PLOS ONE 10(11), e0143459 [PDF, 2MB]
2013
Bongoni, Anjan K.; Kiermeir, David; Jenni, Hansjoerg; Wünsch, Annegret; Bähr, Andrea; Ayares, David; Seebach, Joerg D.; Wolf, Eckhard; Klymiuk, Nikolai; Constantinescu, Mihai A.; Voegelin, Esther und Rieben, Robert
(November 2013):
Activation of the Lectin Pathway of Complement in Pig-to-Human Xenotransplantation Models.
In: Transplantation, Bd. 96, Nr. 9: S. 791-799
[PDF, 17MB]
Kurome, Mayuko; Geistlinger, Ludwig; Kessler, Barbara; Zakhartchenko, Valeri; Klymiuk, Nikolai; Wuensch, Annegret; Richter, Anne; Baehr, Andrea; Kraehe, Katrin; Burkhardt, Katinka; Flisikowski, Krzysztof; Flisikowska, Tatiana; Merkl, Claudia; Landmann, Martina; Durkovic, Marina; Tschukes, Alexander; Kraner, Simone; Schindelhauer, Dirk; Petri, Tobias; Kind, Alexander; Nagashima, Hiroshi; Schnieke, Angelika; Zimmer, Ralf und Wolf, Eckhard
(2013):
Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set.
In: BMC Biotechnology
13:43
[PDF, 617kB]
2012
Richter, Anne; Kurome, Mayuko; Kessler, Barbara; Zakhartchenko, Valeri; Klymiuk, Nikolai; Nagashima, Hiroshi; Wolf, Eckhard und Wuensch, Annegret
(2012):
Potential of primary kidney cells for somatic cell nuclear transfer mediated transgenesis in pig.
In: BMC Biotechnology
12:84
[PDF, 1MB]