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Publications by Klymiuk, Nikolai

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Number of items: 42.

Journal article

Laengin, Matthias; Mayr, Tanja; Reichart, Bruno; Michel, Sebastian; Buchholz, Stefan; Guethoff, Sonja; Dashkevich, Alexey; Bähr, Andrea; Egerer, Stefanie; Bauer, Andreas; Mihalj, Maks; Panelli, Alessandro; Issl, Lara; Ying, Jiawei; Fresch, Ann Kathrin; Buttgereit, Ines; Mokelke, Maren; Radan, Julia; Werner, Fabian; Lutzmann, Isabelle; Steen, Stig; Sjoberg, Trygve; Paskevicius, Audrius; Qiuming, Liao; Sfriso, Riccardo; Rieben, Robert; Dahlhoff, Maik; Kessler, Barbara; Kemter, Elisabeth; Klett, Katharina; Hinkel, Rabea; Kupatt, Christian; Falkenau, Almuth; Reu, Simone; Ellgass, Reinhard; Herzog, Rudolf; Binder, Uli; Wich, Guenter; Skerra, Arne; Ayares, David; Kind, Alexander; Schönmann, Uwe; Kaup, Franz-Josef; Hagl, Christian; Wolf, Eckhard; Klymiuk, Nikolai; Brenner, Paolo; Abicht, Jan-Michael (2018): Consistent success in life-supporting porcine cardiac xenotransplantation. In: Nature, Vol. 564, No. 7736: pp. 430-433

Abicht, Jan-Michael; Sfriso, Riccardo; Reichart, Bruno; Laengin, Matthias; Gahle, Katja; Yung, Gisella L. Puga; Seebach, Jörg D.; Rieben, Robert; Ayares, David; Wolf, Eckhard; Klymiuk, Nikolai; Bähr, Andrea; Kind, Alexander; Mayr, Tanja; Bauer, Andreas (2018): Multiple genetically modified GTKO/hCD46/HLA‐E/hβ2−mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood. In: Xenotransplantation, Vol. 25, No. 5, e12390

Egerer, Stefanie; Fiebig, Uwe; Kessler, Barbara; Zakhartchenko, Valeri; Kurome, Mayuko; Reichart, Bruno; Kupatt, Christian; Klymiuk, Nikolai; Wolf, Eckhard; Denner, Joachim; Bähr, Andrea (2018): Early weaning completely eliminates porcine cytomegalovirus from a newly established pig donor facility for xenotransplantation. In: Xenotransplantation, Vol. 25, No. 4, e12449

Rothammer, Sophie; Kunz, Elisabeth; Krebs, Stefan; Bitzer, Fanny; Hauser, Andreas; Zinovieva, Natalia; Klymiuk, Nikolai; Medugorac, Ivica (2018): Remapping of the belted phenotype in cattle on BTA3 identifies a multiplication event as the candidate causal mutation. In: Genetics Selection Evolution 50:36 [PDF, 2MB]

Yung, Gisella Puga; Bongoni, Anjan K.; Pradier, Amandine; Madelon, Natacha; Papaserafeim, Maria; Sfriso, Riccardo; Ayares, David L.; Wolf, Eckhard; Klymiuk, Nikolai; Bähr, Andrea; Constantinescu, Mihai A.; Vögelin, Esther; Kiermeir, David; Jenni, Hansjorg; Rieben, Robert; Seebach, Jörg D. (2018): Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood. In: Xenotransplantation, Vol. 25, No. 1, e12357

Trillo-Muyo, Sergio; Nilsson, Harriet E.; Recktenwald, Christian V.; Ermund, Anna; Ridley, Caroline; Meiss, Lauren N.; Bähr, Andrea; Klymiuk, Nikolai; Wine, Jeffrey J.; Koeck, Philip J. B.; Thornton, David J.; Hebert, Hans; Hansson, Gunnar C. (2018): Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers. In: Journal of Biological Chemistry, Vol. 293, No. 15: pp. 5746-5754

Mundhenk, Lars; Erickson, Nancy A.; Klymiuk, Nikolai; Gruber, Achim D. (2018): Interspecies diversity of chloride channel regulators, calcium-activated 3 genes.
In: PLOS One 13(1), e0191512 [PDF, 24MB]

Ermund, Anna; Meiss, Lauren N.; Dolan, Brendan; Bähr, Andrea; Klymiuk, Nikolai; Hansson, Gunnar C. (2018): The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation. In: European Respiratory Journal, Vol. 52, No. 2, 1800457

Matsunari, Hitomi; Watanabe, Masahito; Nakano, Kazuaki; Enosawa, Shin; Umeyama, Kazuhiro; Uchikura, Ayuko; Yashima, Sayaka; Fukuda, Toru; Klymiuk, Nikolai; Kurome, Mayuko; Kessler, Barbara; Wünschd, Annegret; Zakhartchenko, Valeri; Wolf, Eckhard; Hanazono, Yutaka; Nagaya, Masaki; Umezawa, Akihiro; Nakauchi, Hiromitsu; Nagashima, Hiroshi (2018): Modeling lethal X-linked genetic disorders in pigs with ensured fertility. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 4: pp. 708-713

Simmet, Kilian; Zakhartchenko, Valeri; Philippou-Massier, Julia; Blum, Helmut; Klymiuk, Nikolai; Wolf, Eckhard (2018): OCT4/POU5F1 is required for NANOG expression in bovine blastocysts. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 11: pp. 2770-2775

Denner, Joachim; Morozov, Vladimir A.; Reichart, Bruno; Plotzki, Elena; Fiebig, Uwe; Heinrichs, Gerd; Wolf-van Buerck, Lelia; Abicht, Jan-Michael; Petersen, Björn; Mayr, Tanja; Knauf, Yvonne; Becker, Tamara; Fischer, Konrad; Mätz-Rensing, Kerstin; Schuster, Marion; Bähr, Andrea; Klymiuk, Nikolai; Wynyard, Shaun; Matsumoto, Shinichi; Abalovich, Adrian; Elliott, Robert; Seissler, Jochen; Rotem, Avi; Barkai, Uriel; Ludwig, Barbara; Bornstein, Stefan; Schnieke, Angelika; Niemann, Heiner; Wolf, Eckhard (2017): New detection methods for porcine viruses: screening of donor pigs and human and non-human primate xenotransplant recipients. In: Xenotransplantation, Vol. 24, No. 5

Brenner, Paolo; Mayr, Tanja; Güthoff, Sonja; Buchholz, Stefan; Dashkevich, Alexander; Michel, Sebastian; Lutzmann, Isabelle; Werner, Fabian; Bauer, Andreas; Klymiuk, Nikolai; Wolf, Eckhard; Reimann, Keith; Mohiuddin, Muhammad; Hermanns, Walter; Ayares, David; McGregor, Christopher; Hagl, Christian; Steen, Stig; Reichart, Bruno; Abicht, Jan-Michael (2017): Orthotopic cardiac xenotransplantation of GalKO/hCD46/hTM-transgenic pig hearts into baboons (40 days survival) using a CD40mAb or CD40L-Ab costimulation blockade. In: Xenotransplantation, Vol. 24, No. 5

Byrne, Guerard; McGregor, Christopher G. A.; Reichart, Bruno; Brenner, Paolo; Mayr, Tanja; Klymiuk, Nikolai; Wolf, Eckhard; Skerra, Arne; Binder, Uli; Abicht, Jan-Michael (2017): Analysis of non-gal antibody responses after orthotopic pig to baboon cardiac xenotransplantation. In: Xenotransplantation, Vol. 24, No. 5

Hinrichs, Arne; Klymiuk, Nikolai; Reichart, Bruno; Kessler, Barbara; Kurome, Mayuko; Bähr, Andrea; Dahlhoff, Maik; Wolf, Eckhard (2017): Inactivation of the GHR gene - a strategy to overcome excess growth of orthotopic pig-to-baboon cardiac xenografts? In: Xenotransplantation, Vol. 24, No. 5

Kola, Ingrid; Reichart, Bruno; Wolf, Eckhard; Klymiuk, Nikolai (2017): Deleting PERV-C proviruses from the genome of multiple modified donor pigs. In: Xenotransplantation, Vol. 24, No. 5

Längin, Matthias; Mayr, Tanja A.; Reichart, Bruno; Mingquian, Li; Pohla, Heike; Buchholz, Stefan; Werner, Fabian; Bauer, Andreas; Ayares, David; Wolf, Eckhard; Klymiuk, Nikolai; Bähr, Andrea; Kessler, Barbara; Kind, Alex; Güthoff, Sonja; Brenner, Paolo; Abicht, Jan-Michael (2017): Immunologic effects of myeloablative pre-treatment and total lymphoid irradiation in heterotopic intrathoracic pig-to-baboon cardiac xenotransplantation. In: Xenotransplantation, Vol. 24, No. 5

Wünsch, Annegret; Kameritsch, Petra; Sfriso, Riccardo; Bähr, Andrea; Kemter, Elisabeth; Kurome, Mayuko; Kessler, Barbara; Rieben, Robert; Wolf, Eckhard; Klymiuk, Nikolai (2017): Monitoring the activation status of endothelial cells by a genetically encoded calcium-sensor. In: Xenotransplantation, Vol. 24, No. 5

Rieben, Robert; Sfriso, Riccardo; Abicht, Jan-Michael; Mayr, Tanja; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard; Reichart, Bruno (2017): Assessment of complement and NK cell activation in Ga1TKO/hCD46/HIA-E porcine hearts ex vivo xenoperfused with human blood. In: Molecular Immunology, Vol. 89: p. 207

Sfriso, Riccardo; Abicht, Jan; Mayr, Tanja; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard; Reichart, Bruno; Rieben, Robert (2017): Evaluation of innate immune activation after ex vivo xenoperfusion of GTKO/Hcd46/HLA-E transgenic pig hearts with human blood. In: Xenotransplantation, Vol. 24, No. 5

Beshr, Ghamdan; Sikandar, Asfandyar; Jemiller, Eva-Maria; Klymiuk, Nikolai; Hauck, Dirk; Wagner, Stefanie; Wolf, Eckhard; Koehnke, Jesko; Titz, Alexander (2017): Photorhabdus luminescens lectin A (PllA): A new probe for detecting -galactoside-terminating glycoconjugates. In: Journal of Biological Chemistry, Vol. 292, No. 48: pp. 19935-19951

Kurome, Mayuko; Leuchs, Simon; Kessler, Barbara; Kemter, Elisabeth; Jemiller, Eva-Maria; Foerster, Beatrix; Klymiuk, Nikolai; Zakhartchenko, Valeri; Wolf, Eckhard (2017): Direct introduction of gene constructs into the pronucleus-like structure of cloned embryos: a new strategy for the generation of genetically modified pigs. In: Transgenic Research, Vol. 26, No. 2: pp. 309-318

Ermund, Anna; Meiss, Lauren N.; Rodriguez-Pineiro, Ana M.; Bähr, Andrea; Nilsson, Harriet E.; Trillo-Muyo, Sergio; Ridley, Caroline; Thornton, David J.; Wine, Jeffrey J.; Hebert, Hans; Klymiuk, Nikolai; Hansson, Gunnar C. (2017): The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin. In: Biochemical and Biophysical Research Communications, Vol. 492, No. 3: pp. 331-337

Sfriso, Riccardo; Bongoni, Anjan; Banz, Yara; Klymiuk, Nikolai; Wolf, Eckhard; Rieben, Robert (2017): Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood. In: Jove-Journal of Visualized Experiments, No. 127, e56227

Abdelhafez, Mai; Shaw, Jane; Banz, Yara; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard; Rieben, Robert (2017): Reduced susceptibility of pig hearts overexpressing human membrane cofactor protein to ischemia/reperfusion injury. In: Xenotransplantation, Vol. 24, No. 5

Klymiuk, Nikolai (2017): Clarifying the integration sites of transgenes in xenotransplantation-relevant breeding animals. In: Xenotransplantation, Vol. 24, No. 5

Abdelhafez, Mai; Shaw, Jane; Banz, Yara; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard; Rieben, Robert (2017): Reduction of myocardial ischemia reperfusion injury in pigs by (over) expression of human membrane co-factor protein. In: Molecular Immunology, Vol. 89: p. 129

Sfriso, Riccardo; Steck, Oliver; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard; Rieben, Robert (2017): In vitro assessment of xenogeneic complement and endothelial cell activation using a microvascular flow model. In: Molecular Immunology, Vol. 89: p. 209

Bongoni, Anjan K.; Salvaris, Evelyn; Nordling, Sofia; Klymiuk, Nikolai; Wolf, Eckhard; Ayares, David L.; Rieben, Robert; Magnusson, Peetra U.; Cowan, Peter J. (2017): Surface modification of pig endothelial cells with a branched heparin conjugate improves their compatibility with human blood. In: Scientific Reports, Vol. 7, 4450 [PDF, 2MB]

Cohrs, Christian M.; Chen, Chunguang; Jahn, Stephan R.; Stertmann, Julia; Chmelova, Helena; Weitz, Jürgen; Bähr, Andrea; Klymiuk, Nikolai; Steffen, Anja; Ludwig, Barbara; Kamvissi, Virginia; Wolf, Eckhard; Bornstein, Stefan R.; Solimena, Michele; Speier, Stephan (2017): Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation. In: Endocrinology, Vol. 158, No. 5: pp. 1373-1385

Laird, Christopher T.; Burdorf, Lars; French, Beth M.; Kubicki, Natalia; Cheng, Xiangfei; Braileanu, Gheorghe; Sun, Wenji; O'Neill, Natalie A.; Cimeno, Arielle; Parsell, Dawn; So, Edward; Bähr, Andrea; Klymiuk, Nikolai; Phelps, Carol J.; Ayares, David; Azimzadeh, Agnes M.; Pierson, Richard N. (2017): Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury. In: Xenotransplantation, Vol. 24, No. 2, e12294

Fröhlich, Thomas; Kemter, Elisabeth; Flenkenthaler, Florian; Klymiuk, Nikolai; Otte, Kathrin A.; Blutke, Andreas; Krause, Sabine; Walter, Maggie C.; Wanke, Rüdiger; Wolf, Eckhard; Arnold, Georg J. (2016): Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy. In: Scientific Reports, Vol. 6, 33362 [PDF, 2MB]

Bähr, Andrea; Käser, Tobias; Kemter, Elisabeth; Gerner, Wilhelm; Kurome, Mayuko; Baars, Wiebke; Herbach, Nadja; Witter, Kirsti; Wünsch, Annegret; Talker, Stephanie C.; Kessler, Barbara; Nagashima, Hiroshi; Saalmüller, Armin; Schwinzer, Reinhard; Wolf, Eckhard; Klymiuk, Nikolai (2016): Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs.
In: PLOS ONE 11(5), e0155676 [PDF, 18MB]

Mohiuddin, Muhammad M.; Singh, Avneesh K.; Corcoran, Philip C.; Thomas, Marvin L.; Clark, Tannia; Lewis, Billeta G.; Hoyt, Robert F.; Eckhaus, Michael; Pierson, Richard N.; Belli, Aaron J.; Wolf, Eckhard; Klymiuk, Nikolai; Phelps, Carol; Reimann, Keith A.; Ayares, David; Horvath, Keith A. (2016): Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft. In: Nature Communications, Vol. 7, 11138 [PDF, 1MB]

Rataj, Dennis; Werwitzke, Sonja; Haarmeijer, Birgitt; Winkler, Michael; Ramackers, Wolf; Petersen, Björn; Niemann, Heiner; Wünsch, Annegret; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard; Abicht, Jan-Michael; Ayares, David; Tiede, Andreas (2016): Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation. In: Xenotransplantation, Vol. 23, No. 2: pp. 117-127

Sfriso, Riccardo; Klymiuk, Nikolai; Wuensch, Annegret; Seebach, Joerg D.; Wolf, Eckhard; Rieben, Robert (2016): Activation of complement and coagulation in xenotransplantation: Effect of growth hormone receptor knockout on porcine aortic endothelial cells. In: Immunobiology, Vol. 221, No. 10: pp. 1174-1175

Bongoni, Anjan K.; Klymiuk, Nikolai; Wolf, Eckhard; Ayares, David; Rieben, Robert; Cowan, Peter J. (2016): Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation. In: Transplantation, Vol. 100, No. 9: pp. 1871-1879

Klymiuk, Nikolai; Seeliger, Frank; Bohlooly-Y, Mohammad; Blutke, Andreas; Rudmann, Daniel G.; Wolf, Eckhard (2016): Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies. In: Toxicologic Pathology, Vol. 44, No. 3: pp. 346-357 [PDF, 559kB]

Guillon, Antoine; Chevaleyre, Claire; Barc, Celine; Berri, Mustapha; Adriaensen, Hans; Lecompte, Francois; Villemagne, Thierry; Pezant, Jeremy; Delaunay, Remi; Moenne-Loccoz, Joseph; Berthon, Patricia; Baehr, Andrea; Wolf, Eckhard; Klymiuk, Nikolai; Attucci, Sylvie; Ramphal, Reuben; Sarradin, Pierre; Buzoni-Gatel, Dominique; Si-Tahar, Mustapha; Caballero, Ignacio (2015): Computed Tomography (CT) Scanning Facilitates Early Identification of Neonatal Cystic Fibrosis Piglets.
In: PLOS ONE 10(11), e0143459 [PDF, 2MB]

Plog, Stephanie; Klymiuk, Nikolai; Binder, Stefanie; Hook, Matthew J. van; Thoreson, Wallace B.; Gruber, Achim D.; Mundhenk, Lars (2015): Naturally Occurring Deletion Mutants of the Pig-Specific, Intestinal Crypt Epithelial Cell Protein CLCA4b without Apparent Phenotype.
In: PLOS ONE 10(10), e0140050 [PDF, 2MB]

Bongoni, Anjan K.; Kiermeir, David; Jenni, Hansjoerg; Wünsch, Annegret; Bähr, Andrea; Ayares, David; Seebach, Joerg D.; Wolf, Eckhard; Klymiuk, Nikolai; Constantinescu, Mihai A.; Voegelin, Esther; Rieben, Robert (November 2013): Activation of the Lectin Pathway of Complement in Pig-to-Human Xenotransplantation Models. In: Transplantation, Vol. 96, No. 9: pp. 791-799 [PDF, 17MB]

Kurome, Mayuko; Geistlinger, Ludwig; Kessler, Barbara; Zakhartchenko, Valeri; Klymiuk, Nikolai; Wuensch, Annegret; Richter, Anne; Baehr, Andrea; Kraehe, Katrin; Burkhardt, Katinka; Flisikowski, Krzysztof; Flisikowska, Tatiana; Merkl, Claudia; Landmann, Martina; Durkovic, Marina; Tschukes, Alexander; Kraner, Simone; Schindelhauer, Dirk; Petri, Tobias; Kind, Alexander; Nagashima, Hiroshi; Schnieke, Angelika; Zimmer, Ralf; Wolf, Eckhard (2013): Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set. In: BMC Biotechnology 13:43 [PDF, 617kB]

Richter, Anne; Kurome, Mayuko; Kessler, Barbara; Zakhartchenko, Valeri; Klymiuk, Nikolai; Nagashima, Hiroshi; Wolf, Eckhard; Wuensch, Annegret (2012): Potential of primary kidney cells for somatic cell nuclear transfer mediated transgenesis in pig. In: BMC Biotechnology 12:84 [PDF, 1MB]

This list was generated on Sat Aug 8 02:16:04 2020 CEST.