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Eine Ebene höherGruppiert nach: Dokumententyp |
Veröffentlichungsdatum
Anzahl der Publikationen: 102
2024
Assfalg, Marlene; Guener, Goekhan; Mueller, Stephan A.; Breimann, Stephan; Langosch, Dieter; Muhle-Goll, Claudia; Frishman, Dmitrij; Steiner, Harald und Lichtenthaler, Stefan F.
(2024):
Cleavage efficiency of the intramembrane protease γ-secretase is reduced by the palmitoylation of a substrate's transmembrane domain.
In: Faseb Journal, Bd. 38, Nr. 2, e23442
[PDF, 12MB]
Todorov-Voelgyi, Katalin; Gonzalez-Gallego, Judit; Mueller, Stephan A.; Beaufort, Nathalie; Malik, Rainer; Schifferer, Martina; Todorov, Mihail Ivilinov; Crusius, Dennis; Robinson, Sophie; Schmidt, Andree; Koerbelin, Jakob; Bareyre, Florence; Ertuerk, Ali; Haass, Christian; Simons, Mikael; Paquet, Dominik; Lichtenthaler, Stefan F. und Dichgans, Martin 
ORCID: https://orcid.org/0000-0002-0654-387X
(2024):
Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging.
In: Nature Aging, Bd. 4, Nr. 4
[PDF, 170MB]
ORCID: https://orcid.org/0000-0002-0654-387X
(2024):
Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging.
In: Nature Aging, Bd. 4, Nr. 4
[PDF, 170MB]
Calligaris, Matteo; Spano, Donatella P.; Bonelli, Simone; Mueller, Stephan A.; Carcione, Claudia; D'apolito, Danilo; Amico, Giandomenico; Miele, Monica; Di Bella, Mariangela; Zito, Giovanni; Nuti, Elisa; Rossello, Armando; Blobel, Carl P.; Lichtenthaler, Stefan F. und Scilabra, Simone D.
(2024):
iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I.
In: Cellular and Molecular Life Sciences, Bd. 81, Nr. 1, 163
[PDF, 5MB]
Schmidt, Andree; Hrupka, Brian; Bebber, Frauke van; Sunil Kumar, Sanjay; Feng, Xiaoqi; Tschirner, Sarah K.; Aßfalg, Marlene; Müller, Stephan A.; Hilger, Laura Sophie; Hofmann, Laura I.; Pigoni, Martina; Jocher, Georg ORCID: https://orcid.org/0000-0002-7089-3487; Voytyuk, Iryna ORCID: https://orcid.org/0000-0003-3484-3658; Self, Emily L.; Ito, Mana; Hyakkoku, Kana; Yoshimura, Akimasa; Horiguchi, Naotaka; Feederle, Regina; Strooper, Bart De; Schulte-Merker, Stefan; Lammert, Eckhard; Moechars, Dieder; Schmid, Bettina und Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575
(2024):
The Alzheimer’s disease–linked protease BACE2 cleaves VEGFR3 and modulates its signaling.
In: Journal of Clinical Investigation, Bd. 134, Nr. 16, e170550
[PDF, 8MB]
ORCID: https://orcid.org/0000-0002-7089-3487; Voytyuk, Iryna ORCID: https://orcid.org/0000-0003-3484-3658; Self, Emily L.; Ito, Mana; Hyakkoku, Kana; Yoshimura, Akimasa; Horiguchi, Naotaka; Feederle, Regina; Strooper, Bart De; Schulte-Merker, Stefan; Lammert, Eckhard; Moechars, Dieder; Schmid, Bettina und Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575
(2024):
The Alzheimer’s disease–linked protease BACE2 cleaves VEGFR3 and modulates its signaling.
In: Journal of Clinical Investigation, Bd. 134, Nr. 16, e170550
[PDF, 8MB]
Song, Feizhi; Kovac, Valerija; Mohammadi, Behnam; Littau, Jessica L.; Scharfenberg, Franka; Matamoros Angles, Andreu; Vanni, Ilaria; Shafiq, Mohsin; Orge, Leonor; Galliciotti, Giovanna; Djakkani, Salma; Linsenmeier, Luise; Černilec, Maja; Hartman, Katrina; Jung, Sebastian; Tatzelt, Jörg; Neumann, Julia E.; Damme, Markus; Tschirner, Sarah K.; Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575; Ricklefs, Franz L.; Sauvigny, Thomas; Schmitz, Matthias; Zerr, Inga; Puig, Berta; Tolosa, Eva; Ferrer, Isidro; Magnus, Tim; Rupnik, Marjan S.; Sepulveda-Falla, Diego; Matschke, Jakob; Šmid, Lojze M.; Bresjanac, Mara; Andreoletti, Olivier; Krasemann, Susanne; Foliaki, Simote T.; Nonno, Romolo; Becker-Pauly, Christoph; Monzo, Cecile; Crozet, Carole; Haigh, Cathryn L.; Glatzel, Markus; Curin Serbec, Vladka und Altmeppen, Hermann C. ORCID: https://orcid.org/0000-0001-9439-6533
(2024):
Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.
In: Acta Neuropathologica, Bd. 148, Nr. 1, 2
[PDF, 5MB]
ORCID: https://orcid.org/0000-0003-2211-2575; Ricklefs, Franz L.; Sauvigny, Thomas; Schmitz, Matthias; Zerr, Inga; Puig, Berta; Tolosa, Eva; Ferrer, Isidro; Magnus, Tim; Rupnik, Marjan S.; Sepulveda-Falla, Diego; Matschke, Jakob; Šmid, Lojze M.; Bresjanac, Mara; Andreoletti, Olivier; Krasemann, Susanne; Foliaki, Simote T.; Nonno, Romolo; Becker-Pauly, Christoph; Monzo, Cecile; Crozet, Carole; Haigh, Cathryn L.; Glatzel, Markus; Curin Serbec, Vladka und Altmeppen, Hermann C. ORCID: https://orcid.org/0000-0001-9439-6533
(2024):
Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.
In: Acta Neuropathologica, Bd. 148, Nr. 1, 2
[PDF, 5MB]
Beaufort, Nathalie ORCID: https://orcid.org/0000-0002-7088-4206; Ingendahl, Linda; Merdanovic, Melisa; Schmidt, Andree ORCID: https://orcid.org/0000-0002-8254-0777; Podlesainski, David ORCID: https://orcid.org/0000-0002-1111-8042; Richter, Tim ORCID: https://orcid.org/0009-0003-8310-6803; Neumann, Thorben; Kuszner, Michael; Vetter, Ingrid R.; Stege, Patricia; Burston, Steven G. ORCID: https://orcid.org/0000-0003-1848-1853; Filipovic, Anto; Ruiz-Blanco, Yasser B.; Bravo-Rodriguez, Kenny; Mieres-Perez, Joel ORCID: https://orcid.org/0000-0002-7875-0886; Beuck, Christine ORCID: https://orcid.org/0000-0001-7513-7384; Uebel, Stephan ORCID: https://orcid.org/0000-0002-3726-3942; Zobawa, Monika; Schillinger, Jasmin; Malik, Rainer ORCID: https://orcid.org/0000-0001-9212-2520; Todorov-Völgyi, Katalin ORCID: https://orcid.org/0009-0007-8073-9524; Rey, Juliana; Roberti, Annabell; Hagemeier, Birte; Wefers, Benedikt ORCID: https://orcid.org/0000-0002-2492-9389; Müller, Stephan A. ORCID: https://orcid.org/0000-0003-3414-307X; Wurst, Wolfgang ORCID: https://orcid.org/0000-0003-4422-7410; Sanchez-Garcia, Elsa; Zimmermann, Alexander; Hu, Xiao-Yu ORCID: https://orcid.org/0000-0002-9634-315X; Clausen, Tim ORCID: https://orcid.org/0000-0003-1582-6924; Huber, Robert; Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575; Schmuck, Carsten ORCID: https://orcid.org/0000-0001-6062-0357; Giese, Michael; Kaiser, Markus ORCID: https://orcid.org/0000-0002-6540-8520; Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X und Dichgans, Martin ORCID: https://orcid.org/0000-0002-0654-387X
(2024):
Rational correction of pathogenic conformational defects in HTRA1.
In: Nature Communications, Bd. 15, 5944
[PDF, 3MB]
ORCID: https://orcid.org/0000-0002-7088-4206; Ingendahl, Linda; Merdanovic, Melisa; Schmidt, Andree ORCID: https://orcid.org/0000-0002-8254-0777; Podlesainski, David ORCID: https://orcid.org/0000-0002-1111-8042; Richter, Tim ORCID: https://orcid.org/0009-0003-8310-6803; Neumann, Thorben; Kuszner, Michael; Vetter, Ingrid R.; Stege, Patricia; Burston, Steven G. ORCID: https://orcid.org/0000-0003-1848-1853; Filipovic, Anto; Ruiz-Blanco, Yasser B.; Bravo-Rodriguez, Kenny; Mieres-Perez, Joel ORCID: https://orcid.org/0000-0002-7875-0886; Beuck, Christine ORCID: https://orcid.org/0000-0001-7513-7384; Uebel, Stephan ORCID: https://orcid.org/0000-0002-3726-3942; Zobawa, Monika; Schillinger, Jasmin; Malik, Rainer ORCID: https://orcid.org/0000-0001-9212-2520; Todorov-Völgyi, Katalin ORCID: https://orcid.org/0009-0007-8073-9524; Rey, Juliana; Roberti, Annabell; Hagemeier, Birte; Wefers, Benedikt ORCID: https://orcid.org/0000-0002-2492-9389; Müller, Stephan A. ORCID: https://orcid.org/0000-0003-3414-307X; Wurst, Wolfgang ORCID: https://orcid.org/0000-0003-4422-7410; Sanchez-Garcia, Elsa; Zimmermann, Alexander; Hu, Xiao-Yu ORCID: https://orcid.org/0000-0002-9634-315X; Clausen, Tim ORCID: https://orcid.org/0000-0003-1582-6924; Huber, Robert; Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575; Schmuck, Carsten ORCID: https://orcid.org/0000-0001-6062-0357; Giese, Michael; Kaiser, Markus ORCID: https://orcid.org/0000-0002-6540-8520; Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X und Dichgans, Martin ORCID: https://orcid.org/0000-0002-0654-387X
(2024):
Rational correction of pathogenic conformational defects in HTRA1.
In: Nature Communications, Bd. 15, 5944
[PDF, 3MB]
Calligaris, Matteo; Spanò, Donatella Pia; Puccio, Maria Chiara; Müller, Stephan A. ORCID: https://orcid.org/0000-0003-3414-307X; Bonelli, Simone; Pinto, Margot Lo; Zito, Giovanni; Blobel, Carl P.; Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575; Troeberg, Linda und Scilabra, Simone Dario ORCID: https://orcid.org/0000-0001-7300-6153
(2024):
Development of a Proteomic Workflow for the Identification of Heparan Sulphate Proteoglycan‐Binding Substrates of ADAM17.
In: Proteomics, Bd. 24, Nr. 23-24, e202400076
[PDF, 7MB]
ORCID: https://orcid.org/0000-0003-3414-307X; Bonelli, Simone; Pinto, Margot Lo; Zito, Giovanni; Blobel, Carl P.; Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575; Troeberg, Linda und Scilabra, Simone Dario ORCID: https://orcid.org/0000-0001-7300-6153
(2024):
Development of a Proteomic Workflow for the Identification of Heparan Sulphate Proteoglycan‐Binding Substrates of ADAM17.
In: Proteomics, Bd. 24, Nr. 23-24, e202400076
[PDF, 7MB]
Bonelli, Simone ORCID: https://orcid.org/0009-0003-7789-2502; Pinto, Margot Lo ORCID: https://orcid.org/0009-0003-0394-9414; Ye, Yihong; Müller, Stephan A. ORCID: https://orcid.org/0000-0003-3414-307X; Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575 und Scilabra, Simone Dario ORCID: https://orcid.org/0000-0001-7300-6153
(2024):
Proteomic Characterization of Ubiquitin Carboxyl-Terminal Hydrolase 19 Deficient Cells Reveals a Role for USP19 in the Secretion of Lysosomal Proteins.
In: Molecular & Cellular Proteomics, Bd. 23, Nr. 11, 100854
[PDF, 3MB]
ORCID: https://orcid.org/0009-0003-7789-2502; Pinto, Margot Lo ORCID: https://orcid.org/0009-0003-0394-9414; Ye, Yihong; Müller, Stephan A. ORCID: https://orcid.org/0000-0003-3414-307X; Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575 und Scilabra, Simone Dario ORCID: https://orcid.org/0000-0001-7300-6153
(2024):
Proteomic Characterization of Ubiquitin Carboxyl-Terminal Hydrolase 19 Deficient Cells Reveals a Role for USP19 in the Secretion of Lysosomal Proteins.
In: Molecular & Cellular Proteomics, Bd. 23, Nr. 11, 100854
[PDF, 3MB]
2023
Bernhardt, Alexander M. ORCID: https://orcid.org/0000-0002-2572-5062; Tiedt, Steffen; Teupser, Daniel; Dichgans, Martin ORCID: https://orcid.org/0000-0002-0654-387X; Meyer, Bernhard; Gempt, Jens; Kuhn, Peer-Hendrik; Simons, Mikael; Palleis, Carla; Weidinger, Endy; Nübling, Georg; Holdt, Lesca; Hönikl, Lisa; Gasperi, Christiane; Giesbertz, Pieter; Müller, Stephan A.; Breimann, Stephan; Lichtenthaler, Stefan F.; Kuster, Bernhard; Mann, Matthias; Imhof, Axel; Barth, Teresa; Hauck, Stefanie M.; Zetterberg, Henrik; Otto, Markus; Weichert, Wilko; Hemmer, Bernhard ORCID: https://orcid.org/0000-0001-5985-6784 und Levin, Johannes
(2023):
A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases.
In: eBioMedicine, Bd. 89, 104456
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-2572-5062; Tiedt, Steffen; Teupser, Daniel; Dichgans, Martin ORCID: https://orcid.org/0000-0002-0654-387X; Meyer, Bernhard; Gempt, Jens; Kuhn, Peer-Hendrik; Simons, Mikael; Palleis, Carla; Weidinger, Endy; Nübling, Georg; Holdt, Lesca; Hönikl, Lisa; Gasperi, Christiane; Giesbertz, Pieter; Müller, Stephan A.; Breimann, Stephan; Lichtenthaler, Stefan F.; Kuster, Bernhard; Mann, Matthias; Imhof, Axel; Barth, Teresa; Hauck, Stefanie M.; Zetterberg, Henrik; Otto, Markus; Weichert, Wilko; Hemmer, Bernhard ORCID: https://orcid.org/0000-0001-5985-6784 und Levin, Johannes
(2023):
A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases.
In: eBioMedicine, Bd. 89, 104456
[PDF, 1MB]
Pratsch, Katrin; Unemura, Chie; Ito, Mana; Lichtenthaler, Stefan F.; Horiguchi, Naotaka und Herms, Jochen
(2023):
New Highly Selective BACE1 Inhibitors and Their Effects on Dendritic Spine Density In Vivo.
In: International Journal of Molecular Sciences, Bd. 24, Nr. 15, 12283
[PDF, 993kB]
Njavro, Jasenka Rudan; Vukicevic, Marija; Fiorini, Emma; Dinkel, Lina; Mueller, Stephan A.; Berghofer, Anna; Bordier, Chiara; Kozlov, Stanislav; Halle, Annett; Buschmann, Katrin; Capell, Anja; Giudici, Camilla; Willem, Michael; Feederle, Regina; Lichtenthaler, Stefan F.; Babolin, Chiara; Montanari, Paolo; Pfeifer, Andrea; Kosco-Vilbois, Marie und Tahirovic, Sabina
(2023):
Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model.
In: Cells, Bd. 12, Nr. 1, 79
[PDF, 17MB]
Calligaris, Matteo; Yang, Chun Y.; Bonelli, Simone; Spano, Donatella Pia; Mueller, Stephan A.; Lichtenthaler, Stefan F.; Troeberg, Linda und Scilabra, Simone D.
(2023):
Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics.
In: Frontiers in Molecular Biosciences, Bd. 10, 1162504
[PDF, 1MB]
Rabinowitsch, Ariana I.; Maretzky, Thorsten; Weskamp, Gisela; Haxaire, Coline; Tueshaus, Johanna; Lichtenthaler, Stefan F.; Monette, Sebastien und Blobei, Carl P.
(2023):
Analysis of the function of ADAM17 in iRhom2 curlyoare and tylosis with esophageal cancer mutant mice.
In: Journal of Cell Science, Bd. 136, Nr. 13, jcs260910
Pesaemaa, Ida; Mueller, Stephan A.; Robinson, Sophie; Darcher, Alana; Paquet, Dominik; Zetterberg, Henrik; Lichtenthaler, Stefan F. und Haass, Christian
(2023):
A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer's disease patients from controls.
In: Molecular Neurodegeneration, Bd. 18, Nr. 1, 70
[PDF, 5MB]
Muller, Stephan A.; Shmueli, Merav D.; Feng, Xiao; Tushaus, Johanna; Schumacher, Neele; Clark, Ryan; Smith, Brad E.; Chi, An; Rose-John, Stefan; Kennedy, Matthew E. und Lichtenthaler, Stefan F.
(2023):
The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130.
In: Molecular Neurodegeneration, Bd. 18, Nr. 1, 13
[PDF, 2MB]
Bartos, Laura M.; Kirchleitner, Sabrina V.; Kolabas, Zeynep Ilgin; Quach, Stefanie; Beck, Alexander; Lorenz, Julia; Blobner, Jens; Mueller, Stephan A.; Ulukaya, Selin; Hoeher, Luciano; Horvath, Izabela; Wind-Mark, Karin; Holzgreve, Adrien; Ruf, Viktoria C.; Gold, Lukas; Kunze, Lea H.; Kunte, Sebastian T.; Beumers, Philipp; Park, Ha Eun; Antons, Melissa; Zatcepin, Artem; Briel, Nils; Hoermann, Leonie; Schaefer, Rebecca; Messerer, Denise; Bartenstein, Peter; Riemenschneider, Markus J.; Lindner, Simon; Ziegler, Sibylle; Herms, Jochen; Lichtenthaler, Stefan F.; Ertuerk, Ali; Tonn, Joerg C.; von Baumgarten, Louisa; Albert, Nathalie L. und Brendel, Matthias
(2023):
Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution.
In: Science Advances, Bd. 9, Nr. 43, eadi8986
[PDF, 3MB]
Tran, Mai Ly; Tueshaus, Johanna; Kim, Yeongho; Ramazanov, Bulat R.; Devireddy, Swathi; Lichtenthaler, Stefan F.; Ferguson, Shawn M. und von Blume, Julia
(2023):
Cab45 deficiency leads to the mistargeting of progranulin and prosaposin and aberrant lysosomal positioning.
In: Traffic, Bd. 24, Nr. 1: S. 4-19
Tai, Yi-Heng; Engels, Daniel; Locatelli, Giuseppe; Emmanouilidis, Ioanna; Fecher, Caroline; Theodorou, Delphine; Mueller, Stephan A.; Licht-Mayer, Simon; Kreutzfeldt, Mario; Wagner, Ingrid; de Mello, Natalia Prudente; Gkotzamani, Sofia-Natsouko; Trovo, Laura; Kendirli, Arek; Aljovic, Almir; Breckwoldt, Michael O.; Naumann, Ronald; Bareyre, Florence M.; Perocchi, Fabiana; Mahad, Don; Merkler, Doron; Lichtenthaler, Stefan F.; Kerschensteiner, Martin und Misgeld, Thomas
(2023):
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions.
In: Nature Metabolism, Bd. 5, Nr. 8:
1364-+
[PDF, 26MB]
Werner, Nadine T. T.; Hoegel, Philipp; Guener, Gokhan; Stelzer, Walter; Wozny, Manfred; Assfalg, Marlene; Lichtenthaler, Stefan F.; Steiner, Harald und Langosch, Dieter
(2023):
Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase.
In: Communications Biology, Bd. 6, Nr. 1, 177
[PDF, 3MB]
Liu, Shu; Heumueller, Stefanie-Elisabeth; Hossinger, Andre; Mueller, Stephan A.; Buravlova, Oleksandra; Lichtenthaler, Stefan F.; Denner, Philip und Vorberg, Ina M.
(2023):
Reactivated endogenous retroviruses promote protein aggregate spreading.
In: Nature Communications, Bd. 14, Nr. 1, 5034
[PDF, 2MB]
Nalbach, Karsten; Schifferer, Martina; Bhattacharya, Debjani; Ho-Xuan, Hung; Tseng, Wei; Williams, Luis A.; Stolz, Alexandra; Lichtenthaler, Stefan F.; Elazar, Zvulun und Behrends, Christian
(2023):
Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2.
In: Nature Communications, Bd. 14, Nr. 1, 870
[PDF, 7MB]
Kardell, Oliver; von Toerne, Christine; Merl-Pham, Juliane; Koenig, Ann-Christine; Blindert, Marcel; Barth, Teresa K.; Mergner, Julia; Ludwig, Christina; Tueshaus, Johanna; Eckert, Stephan; Mu''ller, Stephan A.; Breimann, Stephan; Giesbertz, Pieter; Bernhardt, Alexander M.; Schweizer, Lisa; Albrecht, Vincent; Teupser, Daniel; Imhof, Axel; Kuster, Bernhard; Lichtenthaler, Stefan F.; Mann, Matthias; Cox, Jurgen und Hauck, Stefanie M.
(2023):
Multicenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens.
In: Journal of Proteome Research, Bd. 23, Nr. 1: S. 117-129
[PDF, 5MB]
Amin, Abdulbasit; Badenes, Marina; Tueshaus, Johanna; de Carvalho, Erika; Burbridge, Emma; Faisca, Pedro; Travnickova, Kveta; Barros, Andre; Carobbio, Stefania; Domingos, Pedro M.; Vidal-Puig, Antonio; Moita, Luis F.; Maguire, Sarah; Strisovsky, Kvido; Ortega, Francisco J.; Fernandez-Real, Jose Manuel; Lichtenthaler, Stefan F. und Adrain, Colin
(2023):
Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis.
In: Molecular Metabolism, Bd. 73, 101731
[PDF, 4MB]
Overby, Malene; Serrano-Rodriguez, Antonio; Dadras, Somayeh; Christiansen, Ann Kathrine; Ozcelik, Goezde; Lichtenthaler, Stefan F.; Weick, Jason Porter und Mueller, Heidi Kaastrup
(2023):
Neuron-specific gene NSG1 binds to and positively regulates sortilin ectodomain shedding via a metalloproteinasedependent mechanism.
In: Journal of Biological Chemistry, Bd. 299, Nr. 12, 105446
[PDF, 2MB]
2022
Zellner, Andreas; Müller, Stephan A.; Lindner, Barbara; Beaufort, Nathalie; Rozemuller, Annemieke J. M.; Arzberger, Thomas; Gassen, Nils C.; Lichtenthaler, Stefan F.; Kuster, Bernhard; Haffner, Christof und Dichgans, Martin ORCID: https://orcid.org/0000-0002-0654-387X
(2022):
Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates.
In: Acta neuropathologica communications, Bd. 10, 6
[PDF, 37MB]
ORCID: https://orcid.org/0000-0002-0654-387X
(2022):
Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates.
In: Acta neuropathologica communications, Bd. 10, 6
[PDF, 37MB]
Schneider, Marius F.; Müller, Veronika; Müller, Stephan A.; Lichtenthaler, Stefan F.; Becker, Peter B. und Scheuermann, Johanna C.
(2022):
LncRNA RUS shapes the gene expression program towards neurogenesis.
In: Life Science Alliance, Bd. 5, Nr. 10
[PDF, 3MB]
Martin-de-Saavedra, M. Dolores; Dos Santos, Marc; Culotta, Lorenza; Varea, Olga; Spielman, Benjamin P.; Parnell, Euan; Forrest, Marc P.; Gao, Ruoqi; Yoon, Sehyoun; McCoig, Emmarose; Jalloul, Hiba A.; Myczek, Kristoffer; Khalatyan, Natalia; Hall, Elizabeth A.; Turk, Liam S.; Sanz-Clemente, Antonio; Comoletti, Davide; Lichtenthaler, Stefan F.; Burgdorf, Jeffrey S.; Barbolina, Maria V.; Savas, Jeffrey N. und Penzes, Peter
(2022):
Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2.
In: Neuron, Bd. 110, Nr. 4, E9: S. 627-643
[PDF, 3MB]
Eninger, Timo; Mueller, Stephan A.; Bacioglu, Mehtap; Schweighauser, Manuel; Lambert, Marius; Maia, Luis F.; Neher, Jonas J.; Hornfeck, Sarah M.; Obermueller, Ulrike; Kleinberger, Gernot; Haass, Christian; Kahle, Philipp J.; Staufenbiel, Matthias; Ping, Lingyan; Duong, Duc M.; Levey, Allan I.; Seyfried, Nicholas T.; Lichtenthaler, Stefan F.; Jucker, Mathias und Kaeser, Stephan A.
(2022):
Signatures of glial activity can be detected in the CSF proteome.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 119, Nr. 24, e2119804119
[PDF, 2MB]
Papadopoulou, Alkmini A.; Stelzer, Walter; Silber, Mara; Schlosser, Christine; Spitz, Charlotte; Haug-Kröper, Martina; Straub, Tobias; Mueller, Stephan A.; Lichtenthaler, Stefan F.; Muhle-Goll, Claudia; Langosch, Dieter und Fluhrer, Regina
(2022):
Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage.
In: Scientific Reports, Bd. 12, Nr. 1, 20987
[PDF, 2MB]
Lichtenthaler, Stefan F.; Tschirner, Sarah K. und Steiner, Harald
(2022):
Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2.
In: Current Opinion in Neurobiology, Bd. 72: S. 101-110
[PDF, 7MB]
Jocher, Georg; Grass, Vincent; Tschirner, Sarah K.; Riepler, Lydia; Breimann, Stephan; Kaya, Tugberk; Oelsner, Madlen; Hamad, M. Sabri; Hofmann, Laura I.; Blobel, Carl P.; Schmidt-Weber, Carsten B.; Gökce, Özgün; Jakwerth, Constanze A.; Trimpert, Jakob; Kimpel, Janine; Pichlmair, Andreas und Lichtenthaler, Stefan F.
(2022):
ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion.
In: EMBO Reports, Bd. 23, Nr. 6, e54305
[PDF, 2MB]
Guener, Goekhan; Assfalg, Marlene; Zhao, Kai; Dreyer, Tobias; Lahiri, Shibojyoti; Lo, Yun; Slivinschi, Bianca Ionela; Imhof, Axel; Jocher, Georg; Strohm, Laura; Behrends, Christian; Langosch, Dieter; Bronger, Holger; Nimsky, Christopher; Bartsch, Joerg W.; Riddell, Stanley R.; Steiner, Harald und Lichtenthaler, Stefan F.
(2022):
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for gamma-secretase activity.
In: EMBO Molecular Medicine, Bd. 14, Nr. 10, e16084
[PDF, 1MB]
Biechele, Gloria; Monasor, Laura Sebastian; Wind, Karin; Blume, Tanja; Parhizkar, Samira; Arzberger, Thomas; Sacher, Christian; Beyer, Leonie; Eckenweber, Florian; Gildehaus, Franz-Josef; Ungern-Sternberg, Barbara von; Willem, Michael; Bartenstein, Peter; Cumming, Paul; Rominger, Axel; Herms, Jochen; Lichtenthaler, Stefan F.; Haass, Christian; Tahirovic, Sabina und Brendel, Matthias ORCID: https://orcid.org/0000-0002-9247-2843
(2022):
Glitter in the Darkness? Nonfibrillar beta-Amyloid Plaque Components Significantly Impact the beta-Amyloid PET Signal in Mouse Models of Alzheimer Disease.
In: Journal of Nuclear Medicine, Bd. 63, Nr. 1: S. 117-124
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-9247-2843
(2022):
Glitter in the Darkness? Nonfibrillar beta-Amyloid Plaque Components Significantly Impact the beta-Amyloid PET Signal in Mouse Models of Alzheimer Disease.
In: Journal of Nuclear Medicine, Bd. 63, Nr. 1: S. 117-124
[PDF, 1MB]
Yang, Chun-Yao; Bonelli, Simone; Calligaris, Matteo; Carreca, Anna Paola; Mueller, Stephan A.; Lichtenthaler, Stefan F.; Troeberg, Linda und Scilabra, Simone D.
(2022):
Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State.
In: Membranes, Bd. 12, Nr. 6, 578
[PDF, 2MB]
Rother, Christine; Uhlmann, Ruth E.; Mueller, Stephan A.; Schelle, Juliane; Skodras, Angelos; Obermuller, Ulrike; Hasler, Lisa M.; Lambert, Marius; Baumann, Frank; Xu, Ying; Bergmann, Carina; Salvadori, Giulia; Loos, Maarten; Brzak, Irena; Shimshek, Derya; Neumann, Ulf; Walker, Lary C.; Schultz, Stephanie A.; Chhatwal, Jasmeer P.; Kaeser, Stephan A.; Lichtenthaler, Stefan F.; Staufenbiel, Matthias und Jucker, Mathias
(2022):
Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae.
In: Nature Communications, Bd. 13, Nr. 1, 7333
[PDF, 1MB]
2021
Boehmer, Daniel F. R.; Formisano, Simone; Mann, Carina C. de Oliveira; Mueller, Stephan A.; Kluge, Michael; Metzger, Philipp; Rohlfs, Meino; Hoerth, Christine; Kocheise, Lorenz; Lichtenthaler, Stefan F.; Hopfner, Karl-Peter; Endres, Stefan; Rothenfusser, Simon; Friedel, Caroline C.; Duewell, Peter; Schnurr, Max und Koenig, Lars M.
(2021):
OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis.
In: Science Immunology, Bd. 6, Nr. 61, eabe2550
Colombo, Alessio; Dinkel, Lina; Mueller, Stephan A.; Monasor, Laura Sebastian; Schifferer, Martina; Cantuti-Castelvetri, Ludovico; Koenig, Jasmin; Vidatic, Lea; Bremova-Ertl, Tatiana; Lieberman, Andrew P.; Hecimovic, Silva; Simons, Mikael; Lichtenthaler, Stefan F.; Strupp, Michael; Schneider, Susanne A. und Tahirovic, Sabina
(2021):
Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia.
In: Nature Communications, Bd. 12, Nr. 1, 1158
[PDF, 7MB]
Macrini, Caterina; Gerhards, Ramona; Winklmeier, Stephan; Bergmann, Lena; Mader, Simone; Spadaro, Melania; Vural, Atay; Smolle, Michaela; Hohlfeld, Reinhard; Kuempfel, Tania; Lichtenthaler, Stefan F.; Franquelim, Henri G.; Jenne, Dieter und Meinl, Edgar
(2021):
Features of MOG required for recognition by patients with MOG antibody-associated disorders.
In: Brain, Bd. 144: S. 2375-2389
[PDF, 1MB]
Ong-Palsson, Emma; Njavro, Jasenka Rudan; Wilson, Yvette; Pigoni, Martina; Schmidt, Andree; Mueller, Stephan A.; Meyer, Michael; Hartmann, Jana; Busche, Marc Aurel; Gunnersen, Jenny M.; Munro, Kathryn M. und Lichtenthaler, Stefan F.
(2021):
The beta-Secretase Substrate Seizure 6-Like Protein (SEZ6L) Controls Motor Functions in Mice.
In: Molecular Neurobiology, Bd. 59, Nr. 2: S. 1183-1198
[PDF, 1MB]
Tueshaus, Johanna; Mueller, Stephan A.; Shrouder, Joshua; Arends, Martina; Simons, Mikael; Plesnila, Nikolaus; Blobel, Carl P. und Lichtenthaler, Stefan F.
(2021):
The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.
In: FASEB Journal, Bd. 35, Nr. 11, e21962
[PDF, 934kB]
Dominko, Kristina; Rastija, Ana; Sobocanec, Sandra; Vidatic, Lea; Meglaj, Sarah; Lovincic Babic, Andrea; Hutter-Paier, Birgit; Colombo, Alessio-Vittorio; Lichtenthaler, Stefan F.; Tahirovic, Sabina und Hecimovic, Silva
(2021):
Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation.
In: International Journal of Molecular Sciences, Bd. 22, Nr. 24, 13256
[PDF, 7MB]
Carreca, Anna Paola; Pravata, Veronica Maria; D'Apolito, Danilo; Bonelli, Simone; Calligaris, Matteo; Monaca, Elisa; Mueller, Stephan A.; Lichtenthaler, Stefan F. und Scilabra, Simone Dario
(2021):
Quantitative Proteomics Reveals Changes Induced by TIMP-3 on Cell Membrane Composition and Novel Metalloprotease Substrates.
In: International Journal of Molecular Sciences, Bd. 22, Nr. 5, 2392
[PDF, 2MB]
Brouwers, Bas; Coppola, Ilaria; Vints, Katlijn; Dislich, Bastian; Jouvet, Nathalie; Van Lommel, Leentje; Segers, Charlotte; Gounko, Natalia V.; Thorrez, Lieven; Schuit, Frans; Lichtenthaler, Stefan F.; Estall, Jennifer L.; Declercq, Jeroen; Ramos-Molina, Bruno und Creemers, John W. M.
(2021):
Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction.
In: Diabetes, Bd. 70, Nr. 2: S. 492-503
Sachs, Marlies; Wetzel, Sebastian; Reichelt, Julia; Sachs, Wiebke; Schebsdat, Lisa; Zielinski, Stephanie; Seipold, Lisa; Heintz, Lukas; Muller, Stephan A.; Kretz, Oliver; Lindenmeyer, Maja; Wiech, Thorsten; Huber, Tobias B.; Lullmann-Rauch, Renate; Lichtenthaler, Stefan F.; Saftig, Paul und Meyer-Schwesinger, Catherine
(2021):
ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage.
In: Journal of the American Society of Nephrology, Bd. 32, Nr. 6: S. 1389-1408
[PDF, 72MB]
Galanis, Christos; Fellenz, Meike; Becker, Denise; Bold, Charlotte; Lichtenthaler, Stefan F.; Mueller, Ulrike C.; Deller, Thomas und Vlachos, Andreas
(2021):
Amyloid-Beta Mediates Homeostatic Synaptic Plasticity.
In: Journal of Neuroscience, Bd. 41, Nr. 24: S. 5157-5172
[PDF, 4MB]
de la Vega, Maria Pagnon; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena; Guener, Goekhan; Zielinski, Mara; Lowenmark, Malin; Brundin, RoseMarie; Danfors, Torsten; Soderberg, Linda; Alafuzoff, Irina; Nilsson, Lars N. G.; Erlandsson, Anna; Willbold, Dieter; Mueller, Stephan A.; Schroeder, Gunnar F.; Hanrieder, Jorg; Lichtenthaler, Stefan F.; Lannfelt, Lars; Sehlin, Dag und Ingelsson, Martin
(2021):
The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation.
In: Science Translational Medicine, Bd. 13, Nr. 606, eabc6184
[PDF, 5MB]
Hsia, Hung-En; Tueshaus, Johanna; Feng, Xiao; Hofmann, Laura; Wefers, Benedikt; Marciano, Denise K.; Wurst, Wolfgang und Lichtenthaler, Stefan F.
(2021):
Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons.
In: Faseb Journal, Bd. 35, Nr. 9, e21813
[PDF, 1MB]
Liu, Shu; Hossinger, Andre; Heumuller, Stefanie-Elisabeth; Hornberger, Annika; Buravlova, Oleksandra; Konstantoulea, Katerina; Muller, Stephan A.; Paulsen, Lydia; Rousseau, Frederic; Schymkowitz, Joost; Lichtenthaler, Stefan F.; Neumann, Manuela; Denner, Philip und Vorberg, Ina M.
(2021):
Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions.
In: Nature Communications, Bd. 12, Nr. 1, 5739
[PDF, 6MB]
Lora, Jose; Weskamp, Gisela; Li, Thomas M.; Maretzky, Thorsten; Shola, Dorjee T. N.; Monette, Sebastien; Lichtenthaler, Stefan F.; Lu, Theresa T.; Yang, Chingwen und Blobel, Carl P.
(2021):
Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype.
In: Journal of Biological Chemistry, Bd. 296, 100733
[PDF, 5MB]
Penkert, Horst; Bertrand, Alix; Tiwari, Vini; Breimann, Stephan; Mueller, Stephan A.; Jordan, Paul M.; Gerl, Mathias J.; Klose, Christian; Cantuti-Castelvetri, Ludovico; Bosch-Queralt, Mar; Levental, Ilya; Lichtenthaler, Stefan F.; Werz, Oliver und Simons, Mikael
(2021):
Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery.
In: Cell Reports, Bd. 37, Nr. 4, 109898
[PDF, 5MB]
Tueshaus, Johanna; Kataka, Evans Sioma; Zaucha, Jan; Frishman, Dmitrij; Mueller, Stephan A. und Lichtenthaler, Stefan F.
(2021):
Neuronal Differentiation of LUHMES Cells Induces Substantial Changes of the Proteome.
In: Proteomics, Bd. 21, Nr. 1, 2000174
[PDF, 1MB]
2020
Kumar, Rohit; Donakonda, Sainitin; Müller, Stephan A.; Lichtenthaler, Stefan F.; Bötzel, Kai; Höglinger, Günter U. und Köglsperger, Thomas
(2020):
Basic Fibroblast Growth Factor 2-Induced Proteome Changes Endorse Lewy Body Pathology in Hippocampal Neurons.
In: Iscience, Bd. 23, Nr. 8, 101349
[PDF, 7MB]
Cunha, Maria Ines; Su, Minhui; Cantuti-Castelvetri, Ludovico; Müller, Stephan A.; Schifferer, Martina; Djannatian, Minou; Alexopoulos, Ioannis; Meer, Franziska van der; Winkler, Anne; Ham, Tjakko J. van; Schmid, Bettina; Lichtenthaler, Stefan F.; Stadelmann, Christine und Simons, Mikael
(2020):
Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis.
In: Journal of Experimental Medicine, Bd. 217, Nr. 5, e20191390
[PDF, 8MB]
Gerhards, Ramona; Pfeffer, Lena Kristina; Lorenz, Jessica; Starost, Laura; Nowack, Luise; Thaler, Franziska S.; Schlueter, Miriam; Ruebsamen, Heike; Macrini, Caterina; Winklmeier, Stephan; Mader, Simone; Bronge, Mattias; Groenlund, Hans; Feederle, Regina; Hsia, Hung-En; Lichtenthaler, Stefan F.; Merl-Pham, Juliane; Hauck, Stefanie M.; Kuhlmann, Tanja; Bauer, Isabel J.; Beltran, Eduardo; Gerdes, Lisa Ann; Mezydlo, Aleksandra; Bar-Or, Amit; Banwell, Brenda; Khademi, Mohsen; Olsson, Tomas; Hohlfeld, Reinhard; Lassmann, Hans; Kuempfel, Tania; Kawakami, Naoto und Meinl, Edgar
(2020):
Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS.
In: Acta Neuropathologica Communications, Bd. 8, Nr. 1, 207
[PDF, 7MB]
Pigoni, Martina; Hsia, Hung-En; Hartmann, Jana; Rudan Njavro, Jasenka; Shmueli, Merav D.; Müller, Stephan A.; Guener, Goekhan; Tueshaus, Johanna; Kuhn, Peer-Hendrik; Kumar, Rohit; Gao, Pan; Tran, Mai Ly; Ramazanov, Bulat; Blank, Birgit; Hipgrave Ederveen, Agnes L.; Blume, Julia von; Mulle, Christophe; Gunnersen, Jenny M.; Wuhrer, Manfred; Rammes, Gerhard; Busche, Marc Aurel; Köglsperger, Thomas und Lichtenthaler, Stefan F.
(2020):
Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
In: EMBO Journal, Bd. 39, Nr. 15, e103457
[PDF, 2MB]
Monasor, Laura Sebastian; Müller, Stephan A.; Colombo, Alessio Vittorio; Tanrioever, Gaye; König, Jasmin; Roth, Stefan; Liesz, Arthur; Berghofer, Anna; Piechotta, Anke; Prestel, Matthias; Saito, Takashi; Saido, Takaomi C.; Herms, Jochen; Willem, Michael; Haass, Christian; Lichtenthaler, Stefan F. und Tahirovic, Sabina
(2020):
Fibrillar Aβ (beta) triggers microglial proteome alterations and dysfunction in Alzheimer mouse models.
In: eLife, Bd. 9, e54083
[PDF, 14MB]
Kumar, Rohit; Tang, Qilin; Müller, Stephan A.; Gao, Pan; Mahlstedt, Diana; Zampagni, Sofia; Tan, Yi; Klingl, Andreas; Bötzel, Kai; Lichtenthaler, Stefan F.; Höglinger, Günter U. und Köglsperger, Thomas
(2020):
Fibroblast Growth Factor 2-Mediated Regulation of Neuronal Exosome Release Depends on VAMP3/Cellubrevin in Hippocampal Neurons.
In: Advanced Science, Bd. 7, Nr. 6, 1902372
[PDF, 6MB]
Tueshaus, Johanna; Mueller, Stephan A.; Kataka, Evans Sioma; Zaucha, Jan; Sebastian Monasor, Laura; Su, Minhui; Guener, Goekhan; Jocher, Georg; Tahirovic, Sabina; Frishman, Dmitrij; Simons, Mikael und Lichtenthaler, Stefan F.
(2020):
An optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome.
In: EMBO Journal, Bd. 39, Nr. 20, e105693
[PDF, 6MB]
Nash, Amelia; Aumann, Timothy D.; Pigoni, Martina; Lichtenthaler, Stefan F.; Takeshima, Hiroshi; Munro, Kathryn M. und Gunnersen, Jenny M.
(2020):
Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties.
In: Cerebral Cortex, Bd. 30, Nr. 4: S. 2167-2184
[PDF, 1MB]
Koo, Chek Ziu; Harrison, Neale; Noy, Peter J.; Szyroka, Justyna; Matthews, Alexandra L.; Hsia, Hung-En; Mueller, Stephan A.; Tueshaus, Johanna; Goulding, Joelle; Willis, Katie; Apicella, Clara; Cragoe, Bethany; Davis, Edward; Keles, Murat; Malinova, Antonia; McFarlane, Thomas A.; Morrison, Philip R.; Nguyen, Hanh T. H.; Sykes, Michael C.; Ahmed, Haroon; Di Maio, Alessandro; Seipold, Lisa; Saftig, Paul; Cull, Eleanor; Pliotas, Christos; Rubinstein, Eric; Poulter, Natalie S.; Briddon, Stephen J.; Holliday, Nicholas D.; Lichtenthaler, Stefan F. und Tomlinson, Michael G.
(2020):
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
In: Journal of Biological Chemistry, Bd. 295, Nr. 36: S. 12822-12839
[PDF, 2MB]
Weskamp, Gisela; Tueshaus, Johanna; Li, Daniel; Feederle, Regina; Maretzky, Thorsten; Swendemann, Steven; Falck-Pedersen, Erik; McIlwain, David R.; Mak, Tak W.; Salmon, Jane E.; Lichtenthaler, Stefan F. und Blobel, Carl P.
(2020):
ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).
In: Journal of Biological Chemistry, Bd. 295, Nr. 13: S. 4350-4358
[PDF, 617kB]
Scharfenberg, Franka; Helbig, Andreas; Sammel, Martin; Benzel, Julia; Schlomann, Uwe; Peters, Florian; Wichert, Rielana; Bettendorff, Maximilian; Schmidt-Arras, Dirk; Rose-John, Stefan; Moali, Catherine; Lichtenthaler, Stefan F.; Pietrzik, Claus U.; Bartsch, Joerg W.; Tholey, Andreas und Becker-Pauly, Christoph
(2020):
Degradome of soluble ADAM10 and ADAM17 metalloproteases.
In: Cellular and Molecular Life Sciences, Bd. 77, Nr. 2: S. 331-350
Güner, Gökhan und Lichtenthaler, Stefan F.
(2020):
The substrate repertoire of γ-secretase/presenilin.
In: Seminars in Cell & Developmental Biology, Bd. 105: S. 27-42
[PDF, 1MB]
Lichtenthaler, Stefan F. und Meinl, Edgar
(2020):
To cut or not to cut: New rules for proteolytic shedding of membrane proteins.
In: Journal of Biological Chemistry, Bd. 295, Nr. 35: S. 12353-12355
[PDF, 402kB]
2019
Montagna, Elena; Crux, Sophie; Luckner, Manja; Herber, Julia; Colonnbo, Alessio; Marinkovic, Petar; Tahirovic, Sabina; Lichtenthaler, Stefan F.; Wanner, Gerhard; Müller, Ulrike C.; Sgobio, Carmelo und Herms, Jochen
(2019):
In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria.
In: Glia, Bd. 67, Nr. 5: S. 985-998
[PDF, 1MB]
Rudan Njavro, Jasenka; Klotz, Jakob; Dislich, Bastian; Wanngren, Johanna; Shmueli, Merav D.; Herber, Julia; Kuhn, Peer-Hendrik; Kumar, Rohit; Koeglsperger, Thomas; Conrad, Marcus; Wurst, Wolfgang; Feederle, Regina; Vlachos, Andreas; Michalakis, Stylianos; Jedlicka, Peter; Müller, Stephan A. und Lichtenthaler, Stefan F.
(2019):
Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.
In: FASEB Journal, Bd. 34, Nr. 2: S. 2465-2482
[PDF, 708kB]
Peters, Finn; Salihoglu, Hazal; Pratsch, Katrin; Herzog, Etienne; Pigoni, Martina; Sgobio, Carmelo; Lichtenthaler, Stefan F.; Neumann, Ulf und Herms, Jochen
(2019):
Tau deletion reduces plaque-associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease.
In: EMBO Journal, Bd. 38, Nr. 23, e102345
[PDF, 4MB]
Bartels, Martin; Weckbecker, Daniel; Kuhn, Peer-Hendrik; Ryazanov, Sergey; Leonov, Andrei; Griesinger, Christian; Lichtenthaler, Stefan F.; Boetzel, Kai und Giese, Armin
(2019):
Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression.
In: Scientific Reports, Bd. 9, 9100
[PDF, 7MB]
Brummer, Tobias; Müller, Stephan A.; Pan-Montojo, Francisco; Yoshida, Fumiaki; Fellgiebel, Andreas; Tomita, Taisuke; Endres, Kristina und Lichtenthaler, Stefan F.
(2019):
NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease.
In: EMBO Molecular Medicine, Bd. 11, Nr. 4, e9695
[PDF, 3MB]
Niemeyer, Johannes; Mentrup, Torben; Heidasch, Ronny; Müller, Stephan A.; Biswas, Uddipta; Meyer, Rieke; Papadopoulou, Alkmini A.; Dederer, Verena; Haug-Kroeper, Martina; Adamski, Vivian; Luellmann-Rauch, Renate; Bergmann, Martin; Mayerhofer, Artur; Saftig, Paul; Wennemuth, Gunther; Jessberger, Rolf; Fluhrer, Regina; Lichtenthaler, Stefan F.; Lemberg, Marius K. und Schröder, Bernd
(2019):
The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.
In: EMBO Reports, Bd. 20, Nr. 3, e46449
[PDF, 2MB]
Papadopoulou, Alkmini A.; Müller, Stephan A.; Mentrup, Torben; Shmueli, Merav D.; Niemeyer, Johannes; Haug-Kroeper, Martina; Blume, Julia von; Mayerhofer, Artur; Feederle, Regina; Schröder, Bernd; Lichtenthaler, Stefan F. und Fluhrer, Regina
(2019):
Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins.
In: EMBO Reports, Bd. 20, Nr. 3, e46451
[PDF, 8MB]
Parhizkar, Samira; Arzberger, Thomas; Brendel, Matthias; Kleinberger, Gernot; Deussing, Maximilian; Focke, Carola; Nuscher, Brigitte; Xiong, Monica; Ghasemigharagoz, Alireza; Katzmarski, Natalie; Krasemann, Susanne; Lichtenthaler, Stefan F.; Müller, Stephan A.; Colombo, Alessio; Monasor, Laura Sebastian; Tahirovic, Sabina; Herms, Jochen; Willem, Michael; Pettkus, Nadine; Butovsky, Oleg; Bartenstein, Peter; Edbauer, Dieter; Rominger, Axel; Ertuerk, Ali; Grathwohl, Stefan A.; Neher, Jonas J.; Holtzman, David M.; Meyer-Luehmann, Melanie und Haass, Christian
(2019):
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
In: Nature Neuroscience, Bd. 22, Nr. 2
[PDF, 6MB]
Fecher, Caroline; Trovo, Laura; Müller, Stephan A.; Snaidero, Nicolas; Wettmarshausen, Jennifer; Heink, Sylvia; Ortiz, Oskar; Wagner, Ingrid; Kühn, Ralf; Hartmann, Jana; Karl, Rosa Maria; Konnerth, Arthur; Korn, Thomas; Wurst, Wolfgang; Merkler, Doron; Lichtenthaler, Stefan F.; Perocchi, Fabiana und Misgeld, Thomas
(2019):
Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.
In: Nature Neuroscience, Bd. 22, Nr. 10
Hoefling, Corinna; Shehabi, Emira; Kuhn, Peer-Hendrik; Lichtenthaler, Stefan F.; Hartlage-Ruebsamen, Maike und Rossner, Steffen
(2019):
Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer's Disease.
In: Frontiers in Neuroscience, Bd. 13, 137
[PDF, 3MB]
Yates, Sharon C.; Groeneboom, Nicolaas E.; Coello, Christopher; Lichtenthaler, Stefan F.; Kuhn, Peer-Hendrik; Demuth, Hans-Ulrich; Hartlage-Ruebsamen, Maike; Rossner, Steffen; Leergaard, Trygve; Kreshuk, Anna; Puchades, Maja A. und Bjaalie, Jan G.
(2019):
QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain.
In: Frontiers in Neuroinformatics, Bd. 13, 75
[PDF, 6MB]
Riemschoss, Katrin; Arndt, Verena; Bolognesi, Benedetta; Von Eisenhart-Rothe, Philipp; Liu, Shu; Buravlova, Oleksandra; Duernberger, Yvonne; Paulsen, Lydia; Hornberger, Annika; Hossinger, Andre; Lorenzo-Gotor, Nieves; Hogl, Sebastian; Muller, Stephan A.; Tartaglia, Gian; Lichtenthaler, Stefan F. und Vorberg, Ina M.
(2019):
Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells.
In: Life Science Alliance, Bd. 2, Nr. 4, e201800280
[PDF, 2MB]
Lichtenthaler, Stefan F. und Guener, Goekhan
(2019):
Pathology-linked protease caught in action.
In: Science, Bd. 363, Nr. 6428: S. 690-691
Fang, Wei-Shuo; Sun, De-yang; Yang, Shuang; Cheng, Chen; Moschke, Katrin; Li, Tianqi; Sun, Shanshan; Lichtenthaler, Stefan F.; Huang, Jian und Wang, Yinghong
(2019):
Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR.
In: Bioorganic Chemistry, Bd. 92, 103253
Hsia, Hung-En; Tueshaus, Johanna; Brummer, Tobias; Zheng, Yuanpeng; Scilabra, Simone D. und Lichtenthaler, Stefan F.
(2019):
Functions of A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system.
In: Cellular and Molecular Life Sciences, Bd. 76, Nr. 16: S. 3055-3081
2018
Zhu, Kaichuan; Xiang, Xianyuan; Filser, Severin; Marinkovic, Petar; Dorostkar, Mario M.; Crux, Sophie; Neumann, Ulf; Shimshek, Derya R.; Rammes, Gerhard; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Lichtenthaler, Stefan F.; Gunnersen, Jenny M. und Herms, Jochen
(2018):
Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.
In: Biological Psychiatry, Bd. 83, Nr. 5: S. 428-437
ORCID: https://orcid.org/0000-0002-4869-1627; Lichtenthaler, Stefan F.; Gunnersen, Jenny M. und Herms, Jochen
(2018):
Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.
In: Biological Psychiatry, Bd. 83, Nr. 5: S. 428-437
Blume, Tanja; Filser, Severin; Jaworska, Anna; Blain, Jean-Francois; König, Gerhard; Moschke, Katrin; Lichtenthaler, Stefan F. und Herms, Jochen
(2018):
BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines.
In: Frontiers in Aging Neuroscience, Bd. 10, 229
[PDF, 1MB]
Zellner, Andreas; Scharrer, Eva; Arzberger, Thomas; Oka, Chio; Domenga-Denier, Valerie; Joutel, Anne; Lichtenthaler, Stefan F.; Müller, Stephan A.; Dichgans, Martin ORCID: https://orcid.org/0000-0002-0654-387X und Haffner, Christof
(2018):
CADASIL brain vessels show a HTRA1 loss-of-function profile.
In: Acta Neuropathologica, Bd. 136, Nr. 1: S. 111-125
ORCID: https://orcid.org/0000-0002-0654-387X und Haffner, Christof
(2018):
CADASIL brain vessels show a HTRA1 loss-of-function profile.
In: Acta Neuropathologica, Bd. 136, Nr. 1: S. 111-125
Abdullahi, Sarah; Jaekel, Melanie; Behrend, Sabine J.; Steiger, Katja; Topping, Geoffrey; Krabbe, Teresa; Colombo, Alessio; Sandig, Volker; Schiergens, Tobias S.; Thasler, Wolfgang E.; Werner, Jens; Lichtenthaler, Stefan F.; Schmid, Roland M.; Ebert, Oliver und Altomonte, Jennifer
(2018):
A Novel Chimeric Oncolytic Virus Vector for Improved Safety and Efficacy as a Platform for the Treatment of Hepatocellular Carcinoma.
In: Journal of Virology, Bd. 92, Nr. 23, e01386-18
Scilabra, Simone D.; Pigoni, Martina; Pravata, Veronica; Schätzl, Tobias; Müller, Stephan A.; Troeberg, Linda und Lichtenthaler, Stefan F.
(2018):
Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor.
In: Scientific Reports, Bd. 8, 14697
[PDF, 3MB]
Herber, Julia; Njavro, Jasenka; Feederle, Regina; Schepers, Ute; Müller, Ulrike C.; Braese, Stefan; Müller, Stephan A. und Lichtenthaler, Stefan F.
(2018):
Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome.
In: Molecular & Cellular Proteomics, Bd. 17, Nr. 8: S. 1487-1501
Duernberger, Yvonne; Liu, Shu; Riemschoss, Katrin; Paulsen, Lydia; Bester, Romina; Kuhn, Peer-Hendrik; Schölling, Manuel; Lichtenthaler, Stefan F. und Vorberg, Ina
(2018):
Prion Replication in the Mammalian Cytosol: Functional Regions within a Prion Domain Driving Induction, Propagation, and Inheritance.
In: Molecular and Cellular Biology, Bd. 38, Nr. 15
[PDF, 8MB]
Causevic, Mirsada; Dominko, Kristina; Malnar, Martina; Vidatic, Lea; Cermak, Stjepko; Pigoni, Martina; Kuhn, Peer-Hendrik; Colombo, Alessio; Havas, Daniel; Flunkert, Stefanie; McDonald, Jessica; Gunnersen, Jenny M.; Hutter-Paier, Birgit; Tahirovic, Sabina; Windisch, Manfred; Krainc, Dimitri; Lichtenthaler, Stefan F. und Hecimovic, Silva
(2018):
BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.
In: PLOS One 13(7), e0200344 [PDF, 74MB]
In: PLOS One 13(7), e0200344 [PDF, 74MB]
Hartlage-Ruebsamen, Maike; Bluhm, Alexandra; Piechotta, Anke; Linnert, Miriam; Rahfeld, Jens-Ulrich; Demuth, Hans-Ulrich; Lues, Inge; Kuhn, Peer-Hendrik; Lichtenthaler, Stefan F.; Rossner, Steffen und Hoefling, Corinna
(2018):
Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation.
In: Molecules, Bd. 23, Nr. 4, 924
[PDF, 48MB]
Lichtenthaler, Stefan F.; Lemberg, Marius K. und Fluhrer, Regina
(2018):
Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments.
In: EMBO Journal, Bd. 37, Nr. 15, e99456
Colombo, Alessio; Hsia, Hung-En; Wang, Mengzhe; Kuhn, Peer-Hendrik; Brill, Monika S.; Canevazzi, Paolo; Feederle, Regina; Taveggia, Carla; Misgeld, Thomas und Lichtenthaler, Stefan F.
(2018):
Non-cell-autonomous function of DR6 in Schwann cell proliferation.
In: EMBO Journal, Bd. 37, Nr. 7, e97390
2017
Schlepckow, Kai; Kleinberger, Gernot; Fukumori, Akio; Feederle, Regina; Lichtenthaler, Stefan F.; Steiner, Harald und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2017):
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
In: Embo Molecular Medicine, Bd. 9, Nr. 10: S. 1356-1365
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-4869-1627
(2017):
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
In: Embo Molecular Medicine, Bd. 9, Nr. 10: S. 1356-1365
[PDF, 1MB]
Scilabra, Simone D.; Yamamoto, Kazuhiro; Pigoni, Martina; Sakamoto, Kazuma; Müller, Stephan A.; Papadopoulou, Alkmini; Lichtenthaler, Stefan F.; Tröberg, Linda; Nagase, Hideaki und Kadomatsu, Kenji
(2017):
Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.
In: Matrix Biology, Bd. 59: S. 69-79
Bruch, Julius; Xu, Hong; Rösler, Thomas W.; Andrade, Anderson de; Kuhn, Peer-Hendrik; Lichtenthaler, Stefan F.; Arzberger, Thomas; Winklhofer, Konstanze F.; Müller, Ulrich und Höglinger, Günter U.
(2017):
PERK activation mitigates tau pathology in vitro and in vivo.
In: Embo Molecular Medicine, Bd. 9, Nr. 3: S. 371-384
2016
Höfling, Corinna; Morawski, Markus; Zeitschel, Ulrike; Zanier, Elisa R.; Moschke, Katrin; Serdaroglu, Alperen; Canneva, Fabio; Hörsten, Stephan von; De Simoni, Maria-Grazia; Forloni, Gianluigi; Jäger, Carsten; Kremmer, Elisabeth; Rossner, Steffen; Lichtenthaler, Stefan F. und Kuhn, Peer-Hendrik
(2016):
Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies.
In: Aging Cell, Bd. 15, Nr. 5: S. 953-963
[PDF, 1MB]
Kretner, Benedikt; Trambauer, Johannes; Fukumori, Akio; Mielke, Janina; Kuhn, Peer-Hendrik; Kremmer, Elisabeth; Giese, Armin; Lichtenthaler, Stefan F.; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas und Steiner, Harald
(2016):
Generation and deposition of A43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
In: Embo Molecular Medicine, Bd. 8, Nr. 5: S. 458-465
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas und Steiner, Harald
(2016):
Generation and deposition of A43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
In: Embo Molecular Medicine, Bd. 8, Nr. 5: S. 458-465
[PDF, 1MB]
Kuhn, Peer-Hendrik; Colombo, Alessio Vittorio; Schusser, Benjamin; Dreymueller, Daniela; Wetzel, Sebastian; Schepers, Ute; Herber, Julia; Ludwig, Andreas; Kremmer, Elisabeth; Montag, Dirk; Müller, Ulrike; Schweizer, Michaels; Saftig, Paul; Bräse, Stefan und Lichtenthaler, Stefan F.
(2016):
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function.
In: eLife, Bd. 5, e12748
[PDF, 6MB]
Kretner, Benedikt; Trambauer, Johannes; Fukumori, Akio; Mielke, Janina; Kuhn, Peer-Hendrik; Kremmer, Elisabeth; Giese, Armin; Lichtenthaler, Stefan F.; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas und Steiner, Harald
(2016):
Generation and deposition of A43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
In: Embo Molecular Medicine, Bd. 8, Nr. 5: S. 458-465
ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas und Steiner, Harald
(2016):
Generation and deposition of A43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
In: Embo Molecular Medicine, Bd. 8, Nr. 5: S. 458-465
2015
Laurent, Sarah A.; Hoffmann, Franziska S.; Kuhn, Peer-Hendrik; Cheng, Qingyu; Chu, Yuanyuan; Schmidt-Supprian, Marc; Hauck, Stefanie M.; Schuh, Elisabeth; Krumbholz, Markus; Ruebsamen, Heike; Wanngren, Johanna; Khademi, Mohsen; Olsson, Tomas; Alexander, Tobias; Hiepe, Falk; Pfister, Hans-Walter; Weber, Frank; Jenne, Dieter; Wekerle, Hartmut; Hohlfeld, Reinhard; Lichtenthaler, Stefan F. und Meinl, Edgar
(2015):
gamma-secretase directly sheds the survival receptor BCMA from plasma cells.
In: Nature Communications, Bd. 6, 7333
[PDF, 1MB]
2011
Hogl, Sebastian; Kuhn, Peer-Hendrik; Colombo, Alessio und Lichtenthaler, Stefan F.
(2011):
Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.
In: PLOS ONE 6(6), e21337 [PDF, 2MB]
In: PLOS ONE 6(6), e21337 [PDF, 2MB]
2009
Leuchtenberger, Stefanie; Maler, Juan; Czirr, Eva; Ness, Julia; Lichtenthaler, Stefan F.; Esselmann, Hermann; Pietrzik, Claus U.; Wiltfang, Jens und Weggen, Sascha
(2009):
Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein.
In: Neurodegenerative Diseases, Nr. 1-2: S. 1-8
[PDF, 377kB]
2006
Lichtenthaler, Stefan F.
(2006):
Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers.
In: Neurodegenerative Diseases, Nr. 4-5: S. 262-269
[PDF, 163kB]
Naus, Silvia; Reipschläger, Simone; Wildeboer, Dirk; Lichtenthaler, Stefan F.; Mitterreiter, Stefan; Guan, Ziqiang; Moss, Marcia L. und Bartsch, Jörg W.
(2006):
Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8.
In: Biological Chemistry, Bd. 387, Nr. 3: S. 337-346
[PDF, 272kB]