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Eine Ebene höherGruppiert nach: Dokumententyp |
Veröffentlichungsdatum
Anzahl der Publikationen: 43
2024
Jürgens, David Christian; Müller, Joschka T.; Nguyen, An Ny und Merkel, Olivia M. 
ORCID: https://orcid.org/0000-0002-4151-3916
(2024):
Tailoring lipid nanoparticles for T-cell targeting in allergic asthma: Insights into efficacy and specificity.
In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 198, 114242
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-4151-3916
(2024):
Tailoring lipid nanoparticles for T-cell targeting in allergic asthma: Insights into efficacy and specificity.
In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 198, 114242
[PDF, 2MB]
Hartl, Natascha; Gabold, Bettina; Uhl, Philipp; Kromer, Adrian; Xiao, Ximian; Fricker, Gert; Mier, Walter; Liu, Runhui und Merkel, Olivia M. ORCID: https://orcid.org/0000-0002-4151-3916
(2024):
ApoE—functionalization of nanoparticles for targeted brain delivery—a feasible method for polyplexes?
In: Drug Delivery and Translational Research, Bd. 14, Nr. 6: S. 1660-1677
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-4151-3916
(2024):
ApoE—functionalization of nanoparticles for targeted brain delivery—a feasible method for polyplexes?
In: Drug Delivery and Translational Research, Bd. 14, Nr. 6: S. 1660-1677
[PDF, 1MB]
2023
Adams, Friederike ORCID: https://orcid.org/0000-0002-4362-0387; Zimmermann, Christoph M.; Baldassi, Domizia; Pehl, Thomas M. ORCID: https://orcid.org/0000-0001-5930-8091; Weingarten, Philipp; Kachel, Iris; Kränzlein, Moritz ORCID: https://orcid.org/0000-0001-9851-0735; Jürgens, David C.; Braubach, Peter ORCID: https://orcid.org/0000-0003-3673-7779; Alexopoulos, Ioannis ORCID: https://orcid.org/0000-0002-5601-2831; Wygrecka, Malgorzata ORCID: https://orcid.org/0000-0002-3656-2932 und Merkel, Olivia M. ORCID: https://orcid.org/0000-0002-4151-3916
(2023):
Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis.
In: Small
[PDF, 3MB]
ORCID: https://orcid.org/0000-0002-4362-0387; Zimmermann, Christoph M.; Baldassi, Domizia; Pehl, Thomas M. ORCID: https://orcid.org/0000-0001-5930-8091; Weingarten, Philipp; Kachel, Iris; Kränzlein, Moritz ORCID: https://orcid.org/0000-0001-9851-0735; Jürgens, David C.; Braubach, Peter ORCID: https://orcid.org/0000-0003-3673-7779; Alexopoulos, Ioannis ORCID: https://orcid.org/0000-0002-5601-2831; Wygrecka, Malgorzata ORCID: https://orcid.org/0000-0002-3656-2932 und Merkel, Olivia M. ORCID: https://orcid.org/0000-0002-4151-3916
(2023):
Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis.
In: Small
[PDF, 3MB]
2022
Oliveira-Filho, Edmar R.; de Macedo, Matheus A.; Lemos, Aline C. C.; Adams, Friederike; Merkel, Olivia M.; Taciro, Marilda K.; Gomez, Jose Gregorio C. und Silva, Luiziana F.
(2022):
Engineering Burkholderia sacchari to enhance poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] production from xylose and hexanoate.
In: International Journal of Biological Macromolecules, Bd. 213: S. 902-914
Baldassi, Domizia; Ngo, Thi My Hanh und Merkel, Olivia M.
(2022):
Optimization of Lung Surfactant Coating of siRNA Polyplexes for Pulmonary Delivery.
In: Pharmaceutical Research
[PDF, 6MB]
Gabold, Bettina; Adams, Friederike; Brameyer, Sophie; Jung, Kirsten; Ried, Christian L.; Merdan, Thomas und Merkel, Olivia M.
(2022):
Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins.
In: Drug Delivery and Translational Research, Bd. 13, Nr. 3: S. 822-838
[PDF, 2MB]
Labouta, Hagar I.; Langer, Robert; Cullis, Pieter R.; Merkel, Olivia M.; Prausnitz, Mark R.; Gomaa, Yasmine; Nogueira, Sara S. und Kumeria, Tushar
(2022):
Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective.
In: Drug Delivery and Translational Research, Bd. 12, Nr. 11: S. 2581-2588
Keil, Tobias W. M.; Deiringer, Natalie; Friess, Wolfgang und Merkel, Olivia M.
(2022):
Evaluation of adsorption of DNA/PEI polyplexes to tubing materials.
In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 179: S. 58-64
Merkel, Olivia M.
(2022):
Can pulmonary RNA delivery improve our pandemic preparedness?
In: Journal of Controlled Release, Bd. 345: S. 549-556
Baldassi, Domizia; Ambike, Shubhankar; Feuerherd, Martin; Cheng, Cho-Chin; Peeler, David J.; Feldmann, Daniel P.; Porras-Gonzalez, Diana Leidy; Wei, Xin; Keller, Lea-Adriana; Kneidinger, Nikolaus; Stoleriu, Mircea Gabriel; Popp, Andreas; Burgstaller, Gerald; Pun, Suzie H.; Michler, Thomas und Merkel, Olivia M.
(2022):
Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes.
In: Journal of Controlled Release, Bd. 345: S. 661-674
Zimmermann, Christoph M.; Baldassi, Domizia; Chan, Karen; Adams, Nathan B. P.; Neumann, Alina; Porras-Gonzalez, Diana Leidy; Wei, Xin; Kneidinger, Nikolaus; Stoleriu, Mircea Gabriel; Burgstaller, Gerald; Witzigmann, Dominik; Luciani, Paola und Merkel, Olivia M.
(2022):
Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery.
In: Journal of Controlled Release, Bd. 351: S. 137-150
Winkeljann, Benjamin; Keul, David C. und Merkel, Olivia M.
(2022):
Engineering poly- and micelleplexes for nucleic acid delivery-A reflection on their endosomal escape.
In: Journal of Controlled Release, Bd. 353: S. 518-534
Conte, Gemma; Costabile, Gabriella; Baldassi, Domizia; Rondelli, Valeria; Bassi, Rosaria; Colombo, Diego; Linardos, Giulia; Fiscarelli, Ersilia V.; Sorrentino, Raffaella; Miro, Agnese; Quaglia, Fabiana; Brocca, Paola; D'Angelo, Ivana; Merkel, Olivia M. und Ungaro, Francesca
(2022):
Hybrid Lipid/Polymer Nanoparticles to Tackle the Cystic Fibrosis Mucus Barrier in siRNA Delivery to the Lungs: Does PEGylation Make the Difference?
In: ACS Applied Materials & Interfaces, Bd. 14, Nr. 6: S. 7565-7578
Ambike, Shubhankar; Cheng, Cho-Chin; Feuerherd, Martin; Velkov, Stoyan; Baldassi, Domizia; Afridi, Suliman Qadir; Porras-Gonzalez, Diana; Wei, Xin; Hagen, Philipp; Kneidinger, Nikolaus; Stoleriu, Mircea Gabriel; Grass, Vincent; Burgstaller, Gerald; Pichlmair, Andreas; Merkel, Olivia M.; Ko, Chunkyu und Michler, Thomas
(2022):
Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread.
In: Nucleic Acids Research, Bd. 50, Nr. 1: S. 333-349
2021
Petrini, Matteo; Lokerse, Wouter J. M.; Mach, Agnieszka; Hossann, Martin; Merkel, Olivia M. und Lindner, Lars H.
(2021):
Effects of Surface Charge, PEGylation and Functionalization with Dipalmitoylphosphatidyldiglycerol on Liposome- Cell Interactions and Local Drug Delivery to Solid Tumors via Thermosensitive Liposomes.
In: International Journal of Nanomedicine, Bd. 16: S. 4045-4061
Mehta, Aditi; Michler, Thomas und Merkel, Olivia M.
(2021):
siRNA Therapeutics against Respiratory Viral Infections-What Have We Learned for Potential COVID-19 Therapies?
In: Advanced Healthcare Materials, Bd. 10, Nr. 7, 2001650
Keil, Tobias W. M.; Zimmermann, Christoph; Baldassi, Domizia; Adams, Friederike; Frieß, Wolfgang; Mehta, Aditi und Merkel, Olivia M.
(2021):
Impact of Crystalline and Amorphous Matrices on Successful Spray Drying of siRNA Polyplexes for Inhalation of Nano-in-Microparticles.
In: Advanced Therapeutics, Bd. 4, Nr. 6, 2100073
Keil, Tobias W. M. und Merkel, Olivia M.
(2021):
Characterization of positively charged polyplexes by tunable resistive pulse sensing.
In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 158: S. 359-364
Baldassi, Domizia; Gabold, Bettina und Merkel, Olivia M.
(2021):
Air-Liquid Interface Cultures of the Healthy and Diseased Human Respiratory Tract: Promises, Challenges, and Future Directions.
In: Advanced Nanobiomed Research, Bd. 1, Nr. 6, 2000111
2020
Merkel, Olivia M. ORCID: https://orcid.org/0000-0002-4151-3916 und Mehta, Aditi
(20. Oktober 2020):
Characterization techniques for studying the properties of nanocarriers for systemic delivery.
In:
Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications, Bd. 13. Cham: Springer. S. 57-86
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-4151-3916 und Mehta, Aditi
(20. Oktober 2020):
Characterization techniques for studying the properties of nanocarriers for systemic delivery.
In:
Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications, Bd. 13. Cham: Springer. S. 57-86
[PDF, 1MB]
Feldmann, Daniel P.; Heyza, Joshua; Zimmermann, Christoph M.; Patrick, Steve M. und Merkel, Olivia M.
(2020):
Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy.
In: Molecules, Bd. 25, Nr. 8, 1994
Mehta, Aditi und Merkel, Olivia M.
(2020):
Immunogenicity of Cas9 Protein.
In: Journal of Pharmaceutical Sciences, Bd. 109, Nr. 1: S. 62-67
Strack, Patrick; Kuelzer, Raimund; Sommer, Florian; Bretschneider, Tom; Merkel, Olivia M. und Grube, Achim
(2020):
A smart approach to enable preclinical studies in pharmaceutical industry: PLGA-based extended release formulation platform for subcutaneous applications.
In: Drug Development and Industrial Pharmacy, Bd. 46, Nr. 4: S. 635-645
Hartl, Natascha; Adams, Friederike und Merkel, Olivia M.
(2020):
From Adsorption to Covalent Bonding: Apolipoprotein E Functionalization of Polymeric Nanoparticles for Drug Delivery Across the Blood-Brain Barrier.
In: Advanced Therapeutics, Bd. 4, Nr. 1, 2000092
[PDF, 2MB]
Keil, Tobias W. M.; Baldassi, Domizia und Merkel, Olivia M.
(2020):
T‐cell targeted pulmonary siRNA delivery for the treatment of asthma.
In: WIREs Nanomedicine and Nanobiotechnology, Bd. 12, Nr. 5, e1634
[PDF, 5MB]
2019
Kandil, Rima und Merkel, Olivia M.
(2019):
Recent progress of polymeric nanogels for gene delivery.
In: Current Opinion in Colloid & Interface Science, Bd. 39: S. 11-23
Siepmann, Jürgen; Faham, Amina; Clas, Sophie-Dorothee; Boyd, Ben J.; Jannin, Vincent; Bernkop-Schnuerch, Andreas; Zhao, Hang; Lecommandoux, Sebastien; Evans, James C.; Allen, Christine; Merkel, Olivia M.; Costabile, Gabriella; Alexander, Morgan R.; Wildman, Ricky D.; Roberts, Clive J. und Leroux, Jean-Christophe
(2019):
Lipids and polymers in pharmaceutical technology: Lifelong companions.
In: International Journal of Pharmaceutics, Bd. 558: S. 128-142
Mehta, Aditi; Vedove, Elena Dalle; Isert, Lorenz und Merkel, Olivia M.
(2019):
Targeting KRAS Mutant Lung Cancer Cells with siRNA-Loaded Bovine Serum Albumin Nanoparticles.
In: Pharmaceutical Research, Bd. 36, Nr. 9, UNSP 133
Keil, Tobias W. M.; Feldmann, Daniel P.; Costabile, Gabriella; Zhong, Qian; da Rocha, Sandro und Merkel, Olivia M.
(2019):
Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles.
In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 143: S. 61-69
Hartl, Natascha; Adams, Friederike; Costabile, Gabriella; Isert, Lorenz; Doeblinger, Markus; Xiao, Ximian; Liu, Runhui und Merkel, Olivia M.
(2019):
The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells.
In: Nanomaterials, Bd. 9, Nr. 7, 986
2018
Vedove, Elena Dalle; Costabile, Gabriella und Merkel, Olivia M.
(2018):
Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy.
In: Advanced Healthcare Materials, Bd. 7, Nr. 14, 1701398
Gemechu, Jickssa M.; Sharma, Akhil; Yu, Dongyue; Xie, Yuran; Merkel, Olivia M. und Moszczynska, Anna
(2018):
Characterization of Dopaminergic System in the Striatum of Young Adult Park2(-/-) Knockout Rats.
In: Scientific Reports, Bd. 8, 1517
[PDF, 2MB]
Andima, Moses; Costabile, Gabriella; Isert, Lorenz; Ndakala, Albert J.; Derese, Solomon und Merkel, Olivia M.
(2018):
Evaluation of beta-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity.
In: Pharmaceutics, Bd. 10, Nr. 4, 232
[PDF, 3MB]
Jones, Steven K.; Douglas, Kirk; Shields, Anthony F. und Merkel, Olivia M.
(2018):
Correlating quantitative tumor accumulation and gene knockdown using SPECT/CT and bioluminescence imaging within an orthotopic ovarian cancer model.
In: Biomaterials, Bd. 178: S. 183-192
Feldmann, Daniel P.; Cheng, Yilong; Kandil, Rima; Xie, Yuran; Mohammadi, Mariam; Harz, Hartmann; Sharma, Akhil; Peeler, David J.; Moszczynska, Anna; Leonhardt, Heinrich; Pun, Suzie H. und Merkel, Olivia M.
(2018):
In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells.
In: Journal of Controlled Release, Bd. 276: S. 50-58
Costabile, Gabriella; Gasteyer, Kathrin I.; Nadithe, Venkatereddy; Denburgh, Katherine van; Lin, Qian; Sharma, Shiv; Reineke, Joshua J.; Firestine, Steven M. und Merkel, Olivia M.
(2018):
Physicochemical and In Vitro Evaluation of Drug Delivery of an Antibacterial Synthetic Benzophenone in Biodegradable PLGA Nanoparticles.
In: Aaps Pharmscitech, Bd. 19, Nr. 8: S. 3561-3570
2017
Feldmann, Daniel P.; Xie, Yuran; Jones, Steven K.; Yu, Dongyue; Moszczynska, Anna und Merkel, Olivia M.
(2017):
The impact of microfluidic mixing of triblock micelleplexes on in vitro/in vivo gene silencing and intracellular trafficking.
In: Nanotechnology, Bd. 28, Nr. 22, 224001
Jones, Steven K.; Sarkar, Anwesha; Feldmann, Daniel P.; Hoffmann, Peter und Merkel, Olivia M.
(2017):
Revisiting the value of competition assays in folate receptor-mediated drug delivery.
In: Biomaterials, Bd. 138: S. 35-45
2016
Xie, Yuran; Killinger, Bryan; Moszczynska, Anna und Merkel, Olivia M.
(2016):
Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine.
In: Molecules, Bd. 21, Nr. 10, 1334
[PDF, 2MB]
Xie, Yuran; Kim, Na Hyung; Nadithe, Venkatareddy; Schalk, Dana; Thakur, Archana; Kılıç, Ayşe; Lum, Lawrence G.; Bassett, David J. P. und Merkel, Olivia M.
(2016):
Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma.
In: Journal of Controlled Release, Bd. 229: S. 120-129
Mohammadi, Mariam; Li, Ying; Abebe, Daniel G.; Xie, Yuran; Kandil, Rima; Kraus, Teresa; Gomez-Lopez, Nardhy; Fujiwara, Tomoko und Merkel, Olivia M.
(2016):
Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages.
In: Journal of Controlled Release, Bd. 244: S. 269-279
Zhong, Qian; Merkel, Olivia M.; Reineke, Joshua J. und Rocha, Sandro R. P. da
(2016):
Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution.
In: Molecular Pharmaceutics, Bd. 13, Nr. 6: S. 1866-1878
Movassaghian, Sara; Xie, Yuran; Hildebrandt, Claudia; Rosati, Rayna; Li, Ying; Kim, Na Hyung; Conti, Denise S.; Rocha, Sandro R. P. da; Yang, Zeng-Quan und Merkel, Olivia M.
(2016):
Post-Transcriptional Regulation of the GASC1 Oncogene with Active Tumor-Targeted siRNA-Nanoparticles.
In: Molecular Pharmaceutics, Bd. 13, Nr. 8: S. 2605-2621