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Anzahl der Publikationen: 43

Zeitschriftenartikel

Jürgens, David Christian; Müller, Joschka T.; Nguyen, An Ny und Merkel, Olivia M. ORCID logoORCID: https://orcid.org/0000-0002-4151-3916 (2024): Tailoring lipid nanoparticles for T-cell targeting in allergic asthma: Insights into efficacy and specificity. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 198, 114242 [PDF, 2MB]

Hartl, Natascha; Gabold, Bettina; Uhl, Philipp; Kromer, Adrian; Xiao, Ximian; Fricker, Gert; Mier, Walter; Liu, Runhui und Merkel, Olivia M. ORCID logoORCID: https://orcid.org/0000-0002-4151-3916 (2024): ApoE—functionalization of nanoparticles for targeted brain delivery—a feasible method for polyplexes? In: Drug Delivery and Translational Research, Bd. 14, Nr. 6: S. 1660-1677 [PDF, 1MB]

Adams, Friederike ORCID logoORCID: https://orcid.org/0000-0002-4362-0387; Zimmermann, Christoph M.; Baldassi, Domizia; Pehl, Thomas M. ORCID logoORCID: https://orcid.org/0000-0001-5930-8091; Weingarten, Philipp; Kachel, Iris; Kränzlein, Moritz ORCID logoORCID: https://orcid.org/0000-0001-9851-0735; Jürgens, David C.; Braubach, Peter ORCID logoORCID: https://orcid.org/0000-0003-3673-7779; Alexopoulos, Ioannis ORCID logoORCID: https://orcid.org/0000-0002-5601-2831; Wygrecka, Malgorzata ORCID logoORCID: https://orcid.org/0000-0002-3656-2932 und Merkel, Olivia M. ORCID logoORCID: https://orcid.org/0000-0002-4151-3916 (2023): Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis. In: Small [PDF, 3MB]

Oliveira-Filho, Edmar R.; de Macedo, Matheus A.; Lemos, Aline C. C.; Adams, Friederike; Merkel, Olivia M.; Taciro, Marilda K.; Gomez, Jose Gregorio C. und Silva, Luiziana F. (2022): Engineering Burkholderia sacchari to enhance poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] production from xylose and hexanoate. In: International Journal of Biological Macromolecules, Bd. 213: S. 902-914

Baldassi, Domizia; Ngo, Thi My Hanh und Merkel, Olivia M. (2022): Optimization of Lung Surfactant Coating of siRNA Polyplexes for Pulmonary Delivery. In: Pharmaceutical Research [PDF, 6MB]

Gabold, Bettina; Adams, Friederike; Brameyer, Sophie; Jung, Kirsten; Ried, Christian L.; Merdan, Thomas und Merkel, Olivia M. (2022): Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins. In: Drug Delivery and Translational Research, Bd. 13, Nr. 3: S. 822-838 [PDF, 2MB]

Labouta, Hagar I.; Langer, Robert; Cullis, Pieter R.; Merkel, Olivia M.; Prausnitz, Mark R.; Gomaa, Yasmine; Nogueira, Sara S. und Kumeria, Tushar (2022): Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective. In: Drug Delivery and Translational Research, Bd. 12, Nr. 11: S. 2581-2588

Keil, Tobias W. M.; Deiringer, Natalie; Friess, Wolfgang und Merkel, Olivia M. (2022): Evaluation of adsorption of DNA/PEI polyplexes to tubing materials. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 179: S. 58-64

Merkel, Olivia M. (2022): Can pulmonary RNA delivery improve our pandemic preparedness? In: Journal of Controlled Release, Bd. 345: S. 549-556

Baldassi, Domizia; Ambike, Shubhankar; Feuerherd, Martin; Cheng, Cho-Chin; Peeler, David J.; Feldmann, Daniel P.; Porras-Gonzalez, Diana Leidy; Wei, Xin; Keller, Lea-Adriana; Kneidinger, Nikolaus; Stoleriu, Mircea Gabriel; Popp, Andreas; Burgstaller, Gerald; Pun, Suzie H.; Michler, Thomas und Merkel, Olivia M. (2022): Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes. In: Journal of Controlled Release, Bd. 345: S. 661-674

Zimmermann, Christoph M.; Baldassi, Domizia; Chan, Karen; Adams, Nathan B. P.; Neumann, Alina; Porras-Gonzalez, Diana Leidy; Wei, Xin; Kneidinger, Nikolaus; Stoleriu, Mircea Gabriel; Burgstaller, Gerald; Witzigmann, Dominik; Luciani, Paola und Merkel, Olivia M. (2022): Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery. In: Journal of Controlled Release, Bd. 351: S. 137-150

Winkeljann, Benjamin; Keul, David C. und Merkel, Olivia M. (2022): Engineering poly- and micelleplexes for nucleic acid delivery-A reflection on their endosomal escape. In: Journal of Controlled Release, Bd. 353: S. 518-534

Conte, Gemma; Costabile, Gabriella; Baldassi, Domizia; Rondelli, Valeria; Bassi, Rosaria; Colombo, Diego; Linardos, Giulia; Fiscarelli, Ersilia V.; Sorrentino, Raffaella; Miro, Agnese; Quaglia, Fabiana; Brocca, Paola; D'Angelo, Ivana; Merkel, Olivia M. und Ungaro, Francesca (2022): Hybrid Lipid/Polymer Nanoparticles to Tackle the Cystic Fibrosis Mucus Barrier in siRNA Delivery to the Lungs: Does PEGylation Make the Difference? In: ACS Applied Materials & Interfaces, Bd. 14, Nr. 6: S. 7565-7578

Ambike, Shubhankar; Cheng, Cho-Chin; Feuerherd, Martin; Velkov, Stoyan; Baldassi, Domizia; Afridi, Suliman Qadir; Porras-Gonzalez, Diana; Wei, Xin; Hagen, Philipp; Kneidinger, Nikolaus; Stoleriu, Mircea Gabriel; Grass, Vincent; Burgstaller, Gerald; Pichlmair, Andreas; Merkel, Olivia M.; Ko, Chunkyu und Michler, Thomas (2022): Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread. In: Nucleic Acids Research, Bd. 50, Nr. 1: S. 333-349

Petrini, Matteo; Lokerse, Wouter J. M.; Mach, Agnieszka; Hossann, Martin; Merkel, Olivia M. und Lindner, Lars H. (2021): Effects of Surface Charge, PEGylation and Functionalization with Dipalmitoylphosphatidyldiglycerol on Liposome- Cell Interactions and Local Drug Delivery to Solid Tumors via Thermosensitive Liposomes. In: International Journal of Nanomedicine, Bd. 16: S. 4045-4061

Mehta, Aditi; Michler, Thomas und Merkel, Olivia M. (2021): siRNA Therapeutics against Respiratory Viral Infections-What Have We Learned for Potential COVID-19 Therapies? In: Advanced Healthcare Materials, Bd. 10, Nr. 7, 2001650

Keil, Tobias W. M.; Zimmermann, Christoph; Baldassi, Domizia; Adams, Friederike; Frieß, Wolfgang; Mehta, Aditi und Merkel, Olivia M. (2021): Impact of Crystalline and Amorphous Matrices on Successful Spray Drying of siRNA Polyplexes for Inhalation of Nano-in-Microparticles. In: Advanced Therapeutics, Bd. 4, Nr. 6, 2100073

Keil, Tobias W. M. und Merkel, Olivia M. (2021): Characterization of positively charged polyplexes by tunable resistive pulse sensing. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 158: S. 359-364

Baldassi, Domizia; Gabold, Bettina und Merkel, Olivia M. (2021): Air-Liquid Interface Cultures of the Healthy and Diseased Human Respiratory Tract: Promises, Challenges, and Future Directions. In: Advanced Nanobiomed Research, Bd. 1, Nr. 6, 2000111

Feldmann, Daniel P.; Heyza, Joshua; Zimmermann, Christoph M.; Patrick, Steve M. und Merkel, Olivia M. (2020): Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy. In: Molecules, Bd. 25, Nr. 8, 1994

Mehta, Aditi und Merkel, Olivia M. (2020): Immunogenicity of Cas9 Protein. In: Journal of Pharmaceutical Sciences, Bd. 109, Nr. 1: S. 62-67

Strack, Patrick; Kuelzer, Raimund; Sommer, Florian; Bretschneider, Tom; Merkel, Olivia M. und Grube, Achim (2020): A smart approach to enable preclinical studies in pharmaceutical industry: PLGA-based extended release formulation platform for subcutaneous applications. In: Drug Development and Industrial Pharmacy, Bd. 46, Nr. 4: S. 635-645

Hartl, Natascha; Adams, Friederike und Merkel, Olivia M. (2020): From Adsorption to Covalent Bonding: Apolipoprotein E Functionalization of Polymeric Nanoparticles for Drug Delivery Across the Blood-Brain Barrier. In: Advanced Therapeutics, Bd. 4, Nr. 1, 2000092 [PDF, 2MB]

Keil, Tobias W. M.; Baldassi, Domizia und Merkel, Olivia M. (2020): T‐cell targeted pulmonary siRNA delivery for the treatment of asthma. In: WIREs Nanomedicine and Nanobiotechnology, Bd. 12, Nr. 5, e1634 [PDF, 5MB]

Kandil, Rima und Merkel, Olivia M. (2019): Recent progress of polymeric nanogels for gene delivery. In: Current Opinion in Colloid & Interface Science, Bd. 39: S. 11-23

Siepmann, Jürgen; Faham, Amina; Clas, Sophie-Dorothee; Boyd, Ben J.; Jannin, Vincent; Bernkop-Schnuerch, Andreas; Zhao, Hang; Lecommandoux, Sebastien; Evans, James C.; Allen, Christine; Merkel, Olivia M.; Costabile, Gabriella; Alexander, Morgan R.; Wildman, Ricky D.; Roberts, Clive J. und Leroux, Jean-Christophe (2019): Lipids and polymers in pharmaceutical technology: Lifelong companions. In: International Journal of Pharmaceutics, Bd. 558: S. 128-142

Mehta, Aditi; Vedove, Elena Dalle; Isert, Lorenz und Merkel, Olivia M. (2019): Targeting KRAS Mutant Lung Cancer Cells with siRNA-Loaded Bovine Serum Albumin Nanoparticles. In: Pharmaceutical Research, Bd. 36, Nr. 9, UNSP 133

Keil, Tobias W. M.; Feldmann, Daniel P.; Costabile, Gabriella; Zhong, Qian; da Rocha, Sandro und Merkel, Olivia M. (2019): Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 143: S. 61-69

Hartl, Natascha; Adams, Friederike; Costabile, Gabriella; Isert, Lorenz; Doeblinger, Markus; Xiao, Ximian; Liu, Runhui und Merkel, Olivia M. (2019): The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells. In: Nanomaterials, Bd. 9, Nr. 7, 986

Vedove, Elena Dalle; Costabile, Gabriella und Merkel, Olivia M. (2018): Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy. In: Advanced Healthcare Materials, Bd. 7, Nr. 14, 1701398

Gemechu, Jickssa M.; Sharma, Akhil; Yu, Dongyue; Xie, Yuran; Merkel, Olivia M. und Moszczynska, Anna (2018): Characterization of Dopaminergic System in the Striatum of Young Adult Park2(-/-) Knockout Rats. In: Scientific Reports, Bd. 8, 1517 [PDF, 2MB]

Andima, Moses; Costabile, Gabriella; Isert, Lorenz; Ndakala, Albert J.; Derese, Solomon und Merkel, Olivia M. (2018): Evaluation of beta-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity. In: Pharmaceutics, Bd. 10, Nr. 4, 232 [PDF, 3MB]

Jones, Steven K.; Douglas, Kirk; Shields, Anthony F. und Merkel, Olivia M. (2018): Correlating quantitative tumor accumulation and gene knockdown using SPECT/CT and bioluminescence imaging within an orthotopic ovarian cancer model. In: Biomaterials, Bd. 178: S. 183-192

Feldmann, Daniel P.; Cheng, Yilong; Kandil, Rima; Xie, Yuran; Mohammadi, Mariam; Harz, Hartmann; Sharma, Akhil; Peeler, David J.; Moszczynska, Anna; Leonhardt, Heinrich; Pun, Suzie H. und Merkel, Olivia M. (2018): In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells. In: Journal of Controlled Release, Bd. 276: S. 50-58

Costabile, Gabriella; Gasteyer, Kathrin I.; Nadithe, Venkatereddy; Denburgh, Katherine van; Lin, Qian; Sharma, Shiv; Reineke, Joshua J.; Firestine, Steven M. und Merkel, Olivia M. (2018): Physicochemical and In Vitro Evaluation of Drug Delivery of an Antibacterial Synthetic Benzophenone in Biodegradable PLGA Nanoparticles. In: Aaps Pharmscitech, Bd. 19, Nr. 8: S. 3561-3570

Feldmann, Daniel P.; Xie, Yuran; Jones, Steven K.; Yu, Dongyue; Moszczynska, Anna und Merkel, Olivia M. (2017): The impact of microfluidic mixing of triblock micelleplexes on in vitro/in vivo gene silencing and intracellular trafficking. In: Nanotechnology, Bd. 28, Nr. 22, 224001

Jones, Steven K.; Sarkar, Anwesha; Feldmann, Daniel P.; Hoffmann, Peter und Merkel, Olivia M. (2017): Revisiting the value of competition assays in folate receptor-mediated drug delivery. In: Biomaterials, Bd. 138: S. 35-45

Xie, Yuran; Killinger, Bryan; Moszczynska, Anna und Merkel, Olivia M. (2016): Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine. In: Molecules, Bd. 21, Nr. 10, 1334 [PDF, 2MB]

Xie, Yuran; Kim, Na Hyung; Nadithe, Venkatareddy; Schalk, Dana; Thakur, Archana; Kılıç, Ayşe; Lum, Lawrence G.; Bassett, David J. P. und Merkel, Olivia M. (2016): Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma. In: Journal of Controlled Release, Bd. 229: S. 120-129

Mohammadi, Mariam; Li, Ying; Abebe, Daniel G.; Xie, Yuran; Kandil, Rima; Kraus, Teresa; Gomez-Lopez, Nardhy; Fujiwara, Tomoko und Merkel, Olivia M. (2016): Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages. In: Journal of Controlled Release, Bd. 244: S. 269-279

Zhong, Qian; Merkel, Olivia M.; Reineke, Joshua J. und Rocha, Sandro R. P. da (2016): Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution. In: Molecular Pharmaceutics, Bd. 13, Nr. 6: S. 1866-1878

Movassaghian, Sara; Xie, Yuran; Hildebrandt, Claudia; Rosati, Rayna; Li, Ying; Kim, Na Hyung; Conti, Denise S.; Rocha, Sandro R. P. da; Yang, Zeng-Quan und Merkel, Olivia M. (2016): Post-Transcriptional Regulation of the GASC1 Oncogene with Active Tumor-Targeted siRNA-Nanoparticles. In: Molecular Pharmaceutics, Bd. 13, Nr. 8: S. 2605-2621

Buchbeitrag

Merkel, Olivia M. ORCID logoORCID: https://orcid.org/0000-0002-4151-3916 und Mehta, Aditi (20. Oktober 2020): Characterization techniques for studying the properties of nanocarriers for systemic delivery. In: Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications, Bd. 13. Cham: Springer. S. 57-86 [PDF, 1MB]

Diese Liste wurde am Sat Dec 21 23:16:58 2024 CET erstellt.

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