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Anzahl der Publikationen: 22
Zeitschriftenartikel
Titus, Katelyn R.; Simandi, Zoltan; Chandrashekar, Harshini; Paquet, Dominik 
ORCID: https://orcid.org/0000-0003-2065-1639 und Phillips-Cremins, Jennifer E.
(2024):
Cell-type-specific loops linked to RNA polymerase II elongation in human neural differentiation.
In: Cell Genomics, Bd. 4, Nr. 8, 100606
[PDF, 9MB]
ORCID: https://orcid.org/0000-0003-2065-1639 und Phillips-Cremins, Jennifer E.
(2024):
Cell-type-specific loops linked to RNA polymerase II elongation in human neural differentiation.
In: Cell Genomics, Bd. 4, Nr. 8, 100606
[PDF, 9MB]
Carraro, Caterina; Montgomery, Jessica V.; Klimmt, Julien ORCID: https://orcid.org/0000-0003-0781-6400; Paquet, Dominik ORCID: https://orcid.org/0000-0003-2065-1639; Schultze, Joachim L. und Beyer, Marc D.
(2024):
Tackling neurodegeneration in vitro with omics: a path towards new targets and drugs.
In: Frontiers in Molecular Neuroscience, Bd. 17, 1414886
[PDF, 1MB]
ORCID: https://orcid.org/0000-0003-0781-6400; Paquet, Dominik ORCID: https://orcid.org/0000-0003-2065-1639; Schultze, Joachim L. und Beyer, Marc D.
(2024):
Tackling neurodegeneration in vitro with omics: a path towards new targets and drugs.
In: Frontiers in Molecular Neuroscience, Bd. 17, 1414886
[PDF, 1MB]
Reich, Marvin ORCID: https://orcid.org/0000-0002-4567-0994; Simon, Matthew J. ORCID: https://orcid.org/0000-0002-0065-6486; Polke, Beate; Paris, Iñaki ORCID: https://orcid.org/0000-0002-3887-0277; Werner, Georg ORCID: https://orcid.org/0000-0001-5328-3049; Schrader, Christian; Spieth, Lena; Davis, Sonnet S. ORCID: https://orcid.org/0000-0001-7189-1427; Robinson, Sophie ORCID: https://orcid.org/0000-0003-1261-1370; de Melo, Gabrielly Lunkes ORCID: https://orcid.org/0009-0002-1342-3080; Schlaphoff, Lennart ORCID: https://orcid.org/0000-0001-8043-4025; Buschmann, Katrin; Berghoff, Stefan ORCID: https://orcid.org/0000-0002-3794-7295; Logan, Todd ORCID: https://orcid.org/0000-0003-2081-782X; Nuscher, Brigitte ORCID: https://orcid.org/0009-0000-4661-0742; de Weerd, Lis ORCID: https://orcid.org/0000-0002-3641-1851; Edbauer, Dieter ORCID: https://orcid.org/0000-0002-7186-4653; Simons, Mikael ORCID: https://orcid.org/0000-0001-5329-192X; Suh, Jung H. ORCID: https://orcid.org/0000-0001-8119-326X; Sandmann, Thomas ORCID: https://orcid.org/0000-0002-6601-8890; Kariolis, Mihalis S. ORCID: https://orcid.org/0000-0003-2067-4013; DeVos, Sarah L. ORCID: https://orcid.org/0000-0003-0921-1763; Lewcock, Joseph W. ORCID: https://orcid.org/0000-0003-3012-7881; Paquet, Dominik ORCID: https://orcid.org/0000-0003-2065-1639; Capell, Anja ORCID: https://orcid.org/0000-0003-3118-911X; Di Paolo, Gilbert ORCID: https://orcid.org/0000-0003-1032-1265 und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2024):
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
In: Science Translational Medicine, Bd. 16, Nr. 750
ORCID: https://orcid.org/0000-0002-4567-0994; Simon, Matthew J. ORCID: https://orcid.org/0000-0002-0065-6486; Polke, Beate; Paris, Iñaki ORCID: https://orcid.org/0000-0002-3887-0277; Werner, Georg ORCID: https://orcid.org/0000-0001-5328-3049; Schrader, Christian; Spieth, Lena; Davis, Sonnet S. ORCID: https://orcid.org/0000-0001-7189-1427; Robinson, Sophie ORCID: https://orcid.org/0000-0003-1261-1370; de Melo, Gabrielly Lunkes ORCID: https://orcid.org/0009-0002-1342-3080; Schlaphoff, Lennart ORCID: https://orcid.org/0000-0001-8043-4025; Buschmann, Katrin; Berghoff, Stefan ORCID: https://orcid.org/0000-0002-3794-7295; Logan, Todd ORCID: https://orcid.org/0000-0003-2081-782X; Nuscher, Brigitte ORCID: https://orcid.org/0009-0000-4661-0742; de Weerd, Lis ORCID: https://orcid.org/0000-0002-3641-1851; Edbauer, Dieter ORCID: https://orcid.org/0000-0002-7186-4653; Simons, Mikael ORCID: https://orcid.org/0000-0001-5329-192X; Suh, Jung H. ORCID: https://orcid.org/0000-0001-8119-326X; Sandmann, Thomas ORCID: https://orcid.org/0000-0002-6601-8890; Kariolis, Mihalis S. ORCID: https://orcid.org/0000-0003-2067-4013; DeVos, Sarah L. ORCID: https://orcid.org/0000-0003-0921-1763; Lewcock, Joseph W. ORCID: https://orcid.org/0000-0003-3012-7881; Paquet, Dominik ORCID: https://orcid.org/0000-0003-2065-1639; Capell, Anja ORCID: https://orcid.org/0000-0003-3118-911X; Di Paolo, Gilbert ORCID: https://orcid.org/0000-0003-1032-1265 und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2024):
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
In: Science Translational Medicine, Bd. 16, Nr. 750
Todorov-Voelgyi, Katalin; Gonzalez-Gallego, Judit; Mueller, Stephan A.; Beaufort, Nathalie; Malik, Rainer; Schifferer, Martina; Todorov, Mihail Ivilinov; Crusius, Dennis; Robinson, Sophie; Schmidt, Andree; Koerbelin, Jakob; Bareyre, Florence; Ertuerk, Ali; Haass, Christian; Simons, Mikael; Paquet, Dominik; Lichtenthaler, Stefan F. und Dichgans, Martin ORCID: https://orcid.org/0000-0002-0654-387X
(2024):
Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging.
In: Nature Aging, Bd. 4, Nr. 4
[PDF, 170MB]
ORCID: https://orcid.org/0000-0002-0654-387X
(2024):
Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging.
In: Nature Aging, Bd. 4, Nr. 4
[PDF, 170MB]
Dawkins, Edgar; Derks, Rico J. E.; Schifferer, Martina; Trambauer, Johannes; Winkler, Edith; Simons, Mikael; Paquet, Dominik; Giera, Martin; Kamp, Frits und Steiner, Harald
(2023):
Membrane lipid remodeling modulates γ-secretase processivity.
In: Journal of Biological Chemistry, Bd. 299, Nr. 4, 103027
[PDF, 2MB]
Dannert, Angelika; Klimmt, Julien; Goncalves, Carolina Cardoso; Crusius, Dennis und Paquet, Dominik
(2023):
Reproducible and scalable differentiation of highly pure cortical neurons from human induced pluripotent stem cells.
In: Star Protocols, Bd. 4, Nr. 2, 102266
[PDF, 8MB]
Gottschlich, Adrian; Thomas, Moritz; Gruenmeier, Ruth; Lesch, Stefanie; Rohrbacher, Lisa; Igl, Veronika; Briukhovetska, Daria; Benmebarek, Mohamed-Reda; Vick, Binje; Dede, Sertac; Mueller, Katharina; Xu, Tao; Dhoqina, Dario; Maerkl, Florian; Robinson, Sophie; Sendelhofert, Andrea; Schulz, Heiko; Umut, Oeykue; Kavaka, Vladyslav; Tsiverioti, Christina Angeliki; Carlini, Emanuele; Nandi, Sayantan; Strzalkowski, Thaddaeus; Lorenzini, Theo; Stock, Sophia; Mueller, Philipp Jie; Doerr, Janina; Seifert, Matthias; Cadilha, Bruno L.; Brabenec, Ruben; Roeder, Natalie; Rataj, Felicitas; Nueesch, Manuel; Modemann, Franziska; Wellbrock, Jasmin; Fiedler, Walter; Kellner, Christian; Beltran, Eduardo; Herold, Tobias; Paquet, Dominik; Jeremias, Irmela; von Baumgarten, Louisa; Endres, Stefan; Subklewe, Marion; Marr, Carsten und Kobold, Sebastian
(2023):
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia.
In: Nature Biotechnology, Bd. 41, Nr. 11:
1618-+
[PDF, 7MB]
Dichgans, Martin ORCID: https://orcid.org/0000-0002-0654-387X; Faraci, Frank M.; Betsholtz, Christer; Hillman, Elizabeth; Joutel, Anne; Nelson, Mark und Paquet, Dominik
(2023):
Brain endothelium: a nexus for cerebral small vessel disease.
In: European Heart Journal, Bd. 44, Nr. 40: S. 4211-4213
[PDF, 672kB]
ORCID: https://orcid.org/0000-0002-0654-387X; Faraci, Frank M.; Betsholtz, Christer; Hillman, Elizabeth; Joutel, Anne; Nelson, Mark und Paquet, Dominik
(2023):
Brain endothelium: a nexus for cerebral small vessel disease.
In: European Heart Journal, Bd. 44, Nr. 40: S. 4211-4213
[PDF, 672kB]
Pesaemaa, Ida; Mueller, Stephan A.; Robinson, Sophie; Darcher, Alana; Paquet, Dominik; Zetterberg, Henrik; Lichtenthaler, Stefan F. und Haass, Christian
(2023):
A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer's disease patients from controls.
In: Molecular Neurodegeneration, Bd. 18, Nr. 1, 70
[PDF, 5MB]
Scotto Rosato, Anna; Krogsaeter, Einar K; Jaślan, Dawid; Abrahamian, Carla; Montefusco, Sandro; Soldati, Chiara; Spix, Barbara; Pizzo, Maria Teresa; Grieco, Giuseppina; Böck, Julia; Wyatt, Amanda; Wünkhaus, Daniela; Passon, Marcel; Stieglitz, Marc; Keller, Marco; Hermey, Guido; Markmann, Sandra; Gruber‐Schoffnegger, Doris; Cotman, Susan; Johannes, Ludger; Crusius, Dennis; Boehm, Ulrich; Wahl-Schott, Christian; Biel, Martin; Bracher, Franz; De Leonibus, Elvira; Polishchuk, Elena; Medina, Diego L; Paquet, Dominik und Grimm, Christian
(5. August 2022):
TPC2 rescues lysosomal storage in mucolipidosis type IV , Niemann–Pick type C1, and Batten disease.
In: EMBO Molecular Medicine, Bd. 14, Nr. 9
[PDF, 27MB]
Pantazis, Caroline B.; Yang, Andrian; Lara, Erika; McDonough, Justin A.; Blauwendraat, Cornelis; Peng, Lirong; Oguro, Hideyuki; Kanaujiya, Jitendra; Zou, Jizhong; Sebesta, David; Pratt, Gretchen; Cross, Erin; Blockwick, Jeffrey; Buxton, Philip; Kinner-Bibeau, Lauren; Medura, Constance; Tompkins, Christopher; Hughes, Stephen; Santiana, Marianita; Faghri, Faraz; Nalls, Mike A.; Vitale, Daniel; Ballard, Shannon; Qi, Yue A.; Ramos, Daniel M.; Anderson, Kailyn M.; Stadler, Julia; Narayan, Priyanka; Papademetriou, Jason; Reilly, Luke; Nelson, Matthew P.; Aggarwal, Sanya; Rosen, Leah U.; Kirwan, Peter; Pisupati, Venkat; Coon, Steven L.; Scholz, Sonja W.; Priebe, Theresa; Ottl, Miriam; Dong, Jian; Meijer, Marieke; Janssen, Lara J. M.; Lourenco, Vanessa S.; Kant, Rik van der; Crusius, Dennis; Paquet, Dominik; Raulin, Ana-Caroline; Bu, Guojun; Held, Aaron; Wainger, Brian J.; Gabriele, Rebecca M. C.; Casey, Jackie M.; Wray, Selina; Abu-Bonsrah, Dad; Parish, Clare L.; Beccari, Melinda S.; Cleveland, Don W.; Li, Emmy; Rose, Indigo V. L.; Kampmann, Martin; Aristoy, Carles Calatayud; Verstreken, Patrik; Heinrich, Laurin; Chen, Max Y.; Schule, Birgitt; Dou, Dan; Holzbaur, Erika L. F.; Zanellati, Maria Clara; Basundra, Richa; Deshmukh, Mohanish; Cohen, Sarah; Khanna, Richa; Raman, Malavika; Nevin, Zachary S.; Matia, Madeline; Lent, Jonas; Timmerman, Vincent; Conklin, Bruce R.; Chase, Katherine Johnson; Zhang, Ke; Funes, Salome; Bosco, Daryl A.; Erlebach, Lena; Welzer, Marc; Kronenberg-Versteeg, Deborah; Lyu, Guochang; Arenas, Ernest; Coccia, Elena; Sarrafha, Lily; Ahfeldt, Tim; Marioni, John C. van; Skarnes, William C.; Cookson, Mark R.; Ward, Michael E. und Merkle, Florian T.
(2022):
A reference human induced pluripotent stem cell line for collaborative studies.
In: Cell Stem Cell, Bd. 29, Nr. 12, E22: S. 1685-1702
[PDF, 5MB]
Reifschneider, Anika; Robinson, Sophie; Lengerich, Bettina van; Gnörich, Johannes; Logan, Todd; Heindl, Steffanie; Vogt, Miriam A.; Weidinger, Endy; Riedl, Lina; Wind, Karin; Zatcepin, Artem; Pesaemaa, Ida; Haberl, Sophie; Nuscher, Brigitte; Kleinberger, Gernot; Klimmt, Julien; Götzl, Julia K.; Liesz, Arthur; Bürger, Katharina; Brendel, Matthias; Levin, Johannes; Diehl-Schmid, Janine; Suh, Jung; Di Paolo, Gilbert; Lewcock, Joseph W.; Monroe, Kathryn M.; Paquet, Dominik; Capell, Anja und Haass, Christian
(2022):
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.
In: EMBO Journal, Bd. 41, Nr. 4, e109108
[PDF, 3MB]
Weisheit, Isabel; Kroeger, Joseph A.; Malik, Rainer; Wefers, Benedikt; Lichtner, Peter; Wurst, Wolfgang; Dichgans, Martin ORCID: https://orcid.org/0000-0002-0654-387X und Paquet, Dominik
(2021):
Simple and reliable detection of CRISPR-induced on-target effects by qgPCR and SNP genotyping.
In: Nature Protocols, Bd. 16, Nr. 3: S. 1714-1739
ORCID: https://orcid.org/0000-0002-0654-387X und Paquet, Dominik
(2021):
Simple and reliable detection of CRISPR-induced on-target effects by qgPCR and SNP genotyping.
In: Nature Protocols, Bd. 16, Nr. 3: S. 1714-1739
Soldati, Chiara; Lopez-Fabuel, Irene; Wanderlingh, Luca G.; Garcia-Macia, Marina; Monfregola, Jlenia; Esposito, Alessandra; Napolitano, Gennaro; Guevara-Ferrer, Marta; Scotto Rosato, Anna; Krogsaeter, Einar K.; Paquet, Dominik; Grimm, Christian M.; Montefusco, Sandro; Braulke, Thomas; Storch, Stephan; Mole, Sara E.; De Matteis, Maria A.; Ballabio, Andrea; Sampaio, Julio L.; McKay, Tristan; Johannes, Ludger; Bolanos, Juan P. und Medina, Diego L.
(2021):
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype.
In: EMBO Molecular Medicine, Bd. 13, Nr. 10, e202013742
[PDF, 5MB]
Klimmt, Julien; Dannert, Angelika und Paquet, Dominik
(2020):
Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer's disease.
In: Current Opinion in Neurobiology, Bd. 61: S. 96-104
[PDF, 1MB]
Weisheit, Isabel; Kroeger, Joseph A.; Malik, Rainer; Klimmt, Julien; Crusius, Dennis; Dannert, Angelika; Dichgans, Martin und Paquet, Dominik
(2020):
Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing.
In: Cell Reports, Bd. 31, Nr. 8, 107689
[PDF, 16MB]
Kwart, Dylan; Gregg, Andrew; Scheckel, Claudia; Murphy, Elisabeth; Paquet, Dominik; Duffield, Michael; Fak, John; Olsen, Olav; Darnell, Robert und Tessier-Lavigne, Marc
(2019):
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP beta-CTFs, Not A beta.
In: Neuron, Bd. 104, Nr. 2
Lafaille, Fabien G.; Harschnitz, Oliver; Lee, Yoon Seung; Zhang, Peng; Hasek, Mary L.; Kerner, Gaspard; Itan, Yuval; Ewaleifoh, Osefame; Rapaport, Franck; Carlile, Thomas M.; Carter-Timofte, Madalina E.; Paquet, Dominik; Dobbs, Kerry; Zimmer, Bastian; Gao, Daxing; Rojas-Duran, Maria F.; Kwart, Dylan; Rattina, Vimel; Ciancanelli, Michael J.; McAlpine, Jessica L.; Lorenzo, Lazaro; Boucherit, Soraya; Rozenberg, Flore; Halwani, Rabih; Henry, Benoit; Amenzoui, Naima; Alsum, Zobaida; Marques, Laura; Church, Joseph A.; Al-Muhsen, Saleh; Tardieu, Marc; Bousfiha, Ahmed Aziz; Paludan, Soren R.; Mogensen, Trine Hyrup; Quintana-Murci, Lluis; Tessier-Lavigne, Marc; Smith, Gregory A.; Notarangelo, Luigi D.; Studer, Lorenz; Gilbert, Wendy; Abel, Laurent; Casanova, Jean-Laurent und Zhang, Shen-Ying
(2019):
Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis.
In: Nature Medicine, Bd. 25, Nr. 12
[PDF, 4MB]
Martin-Maestro, Patricia; Sproul, Andrew; Martinez, Hector; Paquet, Dominik; Gerges, Meri; Noggle, Scott und Starkov, Anatoly A.
(2019):
Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells.
In: Molecular Neurobiology, Bd. 56, Nr. 12: S. 8220-8236
Engerer, Peter; Plucinska, Gabriela; Thong, Rachel; Trovò, Laura; Paquet, Dominik und Godinho, Leanne
(2016):
Imaging Subcellular Structures in the Living Zebrafish Embryo.
In: Jove-Journal of Visualized Experiments, Nr. 110, e53456
Fett, Mareike E.; Pilsl, Anna; Paquet, Dominik; Bebber, Frauke van; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Tatzelt, Jörg; Schmid, Bettina und Winklhofer, Konstanze F.
(30. Juli 2010):
Parkin is protective against proteotoxic stress in a transgenic zebrafish model.
In: PLOS ONE 5(7), e11783 [PDF, 3MB]
ORCID: https://orcid.org/0000-0002-4869-1627; Tatzelt, Jörg; Schmid, Bettina und Winklhofer, Konstanze F.
(30. Juli 2010):
Parkin is protective against proteotoxic stress in a transgenic zebrafish model.
In: PLOS ONE 5(7), e11783 [PDF, 3MB]
Paquet, Dominik; Schmid, Bettina und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2010):
Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo.
In: Neurodegenerative Diseases, Nr. 1-3, S: S. 99-102
[PDF, 100kB]
ORCID: https://orcid.org/0000-0002-4869-1627
(2010):
Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo.
In: Neurodegenerative Diseases, Nr. 1-3, S: S. 99-102
[PDF, 100kB]