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Veröffentlichungsdatum
Anzahl der Publikationen: 57
2024
Bernauer, Tamara; Nitsche, Valentin; Kaiser, Jesko; Gertzen, Christoph G.W.; Höfner, Georg 
ORCID: https://orcid.org/0000-0002-7957-4503; Niessen, Karin V.; Seeger, Thomas; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425 und Paintner, Franz F.
(2024):
Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents.
In: Toxicology Letters, Bd. 397: S. 151-162
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-7957-4503; Niessen, Karin V.; Seeger, Thomas; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425 und Paintner, Franz F.
(2024):
Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents.
In: Toxicology Letters, Bd. 397: S. 151-162
[PDF, 2MB]
Nitsche, Valentin; Höfner, Georg; Kaiser, Jesko; Gertzen, Christoph G.W.; Seeger, Thomas; Niessen, Karin V.; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Paintner, Franz F. und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 392: S. 94-106
[PDF, 4MB]
ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 392: S. 94-106
[PDF, 4MB]
2022
Müller-Dott, Katharina; Thiermann, Horst; John, Harald und Steinritz, Dirk
(2022):
Isolation of human TRPA1 channel from transfected HEK293 cells and identification of alkylation sites after sulfur mustard exposure.
In: Archives of Toxicology, Bd. 97, Nr. 2: S. 429-439
Schremmer, Christian; Steinritz, Dirk; Gudermann, Thomas; Beech, David J. und Dietrich, Alexander
(2022):
An ex vivo perfused ventilated murine lung model suggests lack of acute pulmonary toxicity of the potential novel anticancer agent (−)‑englerin A.
In: Archives of Toxicology, Bd. 96, Nr. 4: S. 1055-1063
[PDF, 1MB]
2021
Steinritz, Dirk; Luling, Robin; Siegert, Markus; Mueckter, Harald; Popp, Tanja; Reinemer, Peter; Gudermann, Thomas; Thiermann, Horst und John, Harald
(2021):
Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro.
In: Archives of Toxicology, Bd. 95, Nr. 10: S. 3253-3261
Steinritz, Dirk; Lueling, Robin; Siegert, Markus; Herbert, Julia; Mueckter, Harald; Taeger, Christian D.; Gudermann, Thomas; Dietrich, Alexander; Thiermann, Horst und John, Harald
(2021):
Alkylated epidermal creatine kinase as a biomarker for sulfur mustard exposure: comparison to adducts of albumin and DNA in an in vivo rat study.
In: Archives of Toxicology, Bd. 95, Nr. 4: S. 1323-1333
Schmeißer, Wolfgang; Lüling, Robin; Steinritz, Dirk; Thiermann, Horst; Rein, Theo und John, Harald
(2021):
Transthyretin as a target of alkylation and a potential biomarker for sulfur mustard poisoning: Electrophoretic and mass spectrometric identification and characterization.
In: Drug Testing and Analysis, Bd. 14, Nr. 1: S. 80-91
Rothmiller, Simone; Jaeger, Niklas; Meier, Nicole; Meyer, Thimo; Neu, Adrian; Steinritz, Dirk; Thiermann, Horst; Scherer, Michael; Rummel, Christoph; Mangerich, Aswin; Buerkle, Alexander und Schmidt, Annette
(2021):
Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard.
In: Archives of Toxicology, Bd. 95, Nr. 2: S. 727-747
Colozza, Noemi; Mazzaracchio, Vincenzo; Kehe, Kai; Tsoutsoulopoulos, Amelie; Schioppa, Sara; Fabiani, Laura; Steinritz, Dirk; Moscone, Danila und Arduini, Fabiana
(2021):
Development of novel carbon black-based heterogeneous oligonucleotide-antibody assay for sulfur mustard detection.
In: Sensors and Actuators B-Chemical, Bd. 328, 129054
Colozza, Noemi; Kehe, Kai; Popp, Tanja; Steinritz, Dirk; Moscone, Danila und Arduini, Fabiana
(2021):
Paper-based electrochemical sensor for on-site detection of the sulphur mustard.
In: Environmental Science and Pollution Research, Bd. 28, Nr. 20: S. 25069-25080
Steinritz, Dirk; Lüling, Robin; Siegert, Markus; Mückter, Harald; Popp, Tanja; Reinemer, Peter; Gudermann, Thomas; Thiermann, Horst und John, Harald
(2021):
Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro.
In: Archives of toxicology, Bd. 95, Nr. 10: S. 3253-3261
[PDF, 1MB]
2020
Rothmiller, Simone; Balszuweit, Frank; Menacher, Georg; Steinritz, Dirk; Kehe, Kai; Thiermann, Horst und Schmidt, Annette
(2020):
Validation of automated pipetting systems for cell culture seeding, exposure and bio-analytical assays in sulfur mustard toxicology.
In: Toxicology Letters, Bd. 320: S. 80-86
Kranawetvogl, Tamara; Steinritz, Dirk; Thiermann, Horst und John, Harald
(2020):
A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma.
In: Drug Testing and Analysis, Bd. 12, Nr. 7: S. 938-947
Lueling, Robin; Schmeisser, Wolfgang; Siegert, Markus; Mueckter, Harald; Dietrich, Alexander; Thiermann, Horst; Gudermann, Thomas; John, Harald und Steinritz, Dirk
(2020):
Identification of creatine kinase and alpha-1 antitrypsin as protein targets of alkylation by sulfur mustard.
In: Drug Testing and Analysis, Bd. 13, Nr. 2: S. 268-282
Popp, Tanja; Balszuweit, Frank; Schmidt, Annette; Eyer, Florian; Thiermann, Horst und Steinritz, Dirk
(2020):
Assessment of alpha-amanitin toxicity and effects of silibinin and penicillin in different in vitro models.
In: Toxicology in Vitro, Bd. 67, 104921
Müller-Dotta, Katharina; Thiermann, Horst; Steinritz, Dirk und Popp, Tanja
(2020):
Effect of sulfur mustard on melanogenesis in vitro.
In: Toxicology Letters, Bd. 319: S. 197-203
Tsoutsoulopoulos, Amelie; Brockmoeller, Sabrina; Thiermann, Horst und Steinritz, Dirk
(2020):
Comparison of the toxicity of sulfur mustard and its oxidation products in vitro.
In: Toxicology Letters, Bd. 321: S. 69-72
Tsoutsoulopoulos, Amelie; Gohlsch, Katrin; Moehle, Niklas; Breit, Andreas; Hoffmann, Sebastian; Krischenowski, O.; Mueckter, Harald; Gudermann, Thomas; Thiermann, Horst; Aufderheide, Michaela und Steinritz, Dirk
(2020):
Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface.
In: Jove-Journal of Visualized Experiments, Nr. 156, e60572
2019
Tsoutsoulopoulos, Amelie; Siegert, Markus; John, Harald; Zubel, Tabea; Mangerich, Aswin; Schmidt, Annette; Mueckter, Harald; Gudermann, Thomas; Thiermann, Horst; Steinritz, Dirk und Popp, Tanja
(2019):
A novel exposure system generating nebulized aerosol of sulfur mustard in comparison to the standard submerse exposure.
In: Chemico-Biological Interactions, Bd. 298: S. 121-128
Menacher, Georg; Balszuweit, Frank; Lang, Simon; Thiermann, Horst; Kehe, Kai; Gudermann, Thomas; Schmidt, Annette; Steinritz, Dirk und Popp, Tanja
(2019):
Necrosulfonamide - Unexpected effect in the course of a sulfur mustard intoxication.
In: Chemico-Biological Interactions, Bd. 298: S. 80-85
Colozza, Noemi; Kehe, Kai; Dionisi, Giulio; Popp, Tanja; Tsoutsoulopoulos, Amelie; Steinritz, Dirk; Moscone, Danila und Arduini, Fabiana
(2019):
A wearable origami-like paper-based electrochemical biosensor for sulfur mustard detection.
In: Biosensors & Bioelectronics, Bd. 129: S. 15-23
Tsoutsoulopoulos, Amelie; Gohlsch, Katrin; Moehle, Niklas; Breit, Andreas; Hoffmann, Sebastian; Krischenowski, Olaf; Mueckter, Harald; Gudermann, Thomas; Thiermann, Horst; Aufderheide, Michaela und Steinritz, Dirk
(2019):
Validation of the CULTEX (R) Radial Flow System for the assessment of the acute inhalation toxicity of airborne particles.
In: Toxicology in Vitro, Bd. 58: S. 245-255
Wagner, Simon; Lang, Simon; Popp, Tanja; Schmidt, Annette; Thiermann, Horst; Steinritz, Dirk und Kehe, Kai
(2019):
Evaluation of selective and non-selective cyclooxygenase inhibitors on sulfur mustard-induced pro-inflammatory cytokine formation in normal human epidermal keratinocytes.
In: Toxicology Letters, Bd. 312: S. 109-117
Steinritz, Dirk; Lang, Simon; Popp, Tanja; Siegert, Markus; Rothmiller, Simone; Kranawetvogl, Andreas; Schmidt, Annette; John, Harald; Gudermann, Thomas; Thiermann, Horst und Kehe, Kai
(2019):
Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines.
In: Toxicology Letters, Bd. 314: S. 172-180
Gohlsch, Katrin; Mueckter, Harald; Steinritz, Dirk; Aufderheide, Michaela; Hoffmann, Sebastian; Gudermann, Thomas und Breit, Andreas
(2019):
Exposure of 19 substances to lung A549 cells at the air liquid interface or under submerged conditions reveals high correlation between cytotoxicity in vitro and CLP classifications for acute lung toxicity.
In: Toxicology Letters, Bd. 316: S. 119-126
Lueling, Robin; Singer, Helena; Popp, Tanja; John, Harald; Boekhoff, Ingrid; Thiermann, Horst; Daumann, Lena J.; Karaghiosoff, Konstantin; Gudermann, Thomas und Steinritz, Dirk
(2019):
Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro.
In: Archives of Toxicology, Bd. 93, Nr. 11: S. 3141-3152
2018
Rothmiller, Simone; Wolf, Markus; Worek, Franz; Steinritz, Dirk; Thiermann, Horst und Schmidt, Annette
(2018):
Alteration of miRNA expression in a sulfur mustard resistant cell line.
In: Toxicology Letters, Bd. 293: S. 38-44
Schreier, Cassandra; Rothmiller, Simone; Scherer, Michael A.; Rummel, Christoph; Steinritz, Dirk; Thiermann, Horst und Schmidt, Annette
(2018):
Mobilization of human mesenchymal stem cells through different cytokines and growth factors after their immobilization by sulfur mustard.
In: Toxicology Letters, Bd. 293: S. 105-111
Rothmiller, Simone; Schröder, Sarah; Strobelt, Romano; Wolf, Markus; Wang, Jin; Jiang, Xiqian; Worek, Franz; Steinritz, Dirk; Thiermann, Horst und Schmidt, Annette
(2018):
Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism.
In: Toxicology Letters, Bd. 293: S. 51-61
Schmidt, Annette; Steinritz, Dirk; Rothmiller, Simone; Thiermann, Horst und Scherer, A. Michael
(2018):
Effects of sulfur mustard on mesenchymal stem cells.
In: Toxicology Letters, Bd. 293: S. 98-104
Buech, Thomas R. H.; Büch, Eva A. M.; Boekhoff, Ingrid; Steinritz, Dirk und Aigner, Achim
(2018):
Role of Chemosensory TRP Channels in Lung Cancer.
In: Pharmaceuticals, Bd. 11, Nr. 4
[PDF, 595kB]
Lueling, Robin; John, Harald; Gudermann, Thomas; Thiermann, Horst; Mueckter, Harald; Popp, Tanja und Steinritz, Dirk
(2018):
Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 (HSPA6) In Vitro.
In: Cells, Bd. 7, Nr. 9, 126
[PDF, 1MB]
Steinritz, Dirk; Stenger, Bernhard; Dietrich, Alexander; Gudermann, Thomas und Popp, Tanja
(2018):
TRPs in Tox: Involvement of Transient Receptor Potential-Channels in Chemical-Induced Organ Toxicity-A Structured Review.
In: Cells, Bd. 7, Nr. 8, 98
[PDF, 2MB]
Kannler, Martina; Lueling, Robin; Yildirim, Ali Oender; Gudermann, Thomas; Steinritz, Dirk und Dietrich, Alexander
(2018):
TRPA1 channels: expression in non-neuronal murine lung tissues and dispensability for hyperoxia-induced alveolar epithelial hyperplasia.
In: Pflugers Archiv-European Journal of Physiology, Bd. 470, Nr. 8: S. 1231-1241
Simons, Thilo; Steinritz, Dirk; Boelck, Birgit; Schmidt, Annette; Popp, Tanja; Thiermann, Horst; Gudermann, Thomas; Bloch, Wilhelm und Kehe, Kai
(2018):
Sulfur mustard-induced epigenetic modifications over time - a pilot study.
In: Toxicology Letters, Bd. 293: S. 45-50
Menacher, Georg; Steinritz, Dirk; Schmidt, Annette; Popp, Tanja; Worek, Franz; Gudermann, Thomas; Thiermann, Horst und Balszuweit, Frank
(2018):
Effects of anti-inflammatory compounds on sulfur mustard injured cells: Recommendations and caveats suggested by in vitro cell culture models.
In: Toxicology Letters, Bd. 293: S. 91-97
Schmidt, Annette; Wolf, Markus; Rothmiller, Simone; Worek, Franz; Steinritz, Dirk und Thiermann, Horst
(2018):
Cytostatic resistance profile of the sulfur mustard resistant keratinocyte cell line HaCaT/SM.
In: Toxicology Letters, Bd. 293: S. 16-20
Lang, Simon; Popp, Tanja; Kriegs, Christian Silvester; Schmidt, Annette; Balszuweit, Frank; Menacher, Georg; Kehe, Kai; Thiermann, Horst; Gudermann, Thomas und Steinritz, Dirk
(2018):
Anti-apoptotic and moderate anti-inflammatory effects of berberine in sulfur mustard exposed keratinocytes.
In: Toxicology Letters, Bd. 293: S. 2-8
Schmidt, Annette; Steinritz, Dirk; Rudolf, Klaus-Dieter; Thiermann, Horst und Striepling, Enno
(2018):
Accidental sulfur mustard exposure: A case report.
In: Toxicology Letters, Bd. 293: S. 62-66
Steinritz, Dirk; Zehfuss, Franziska; Stenger, Bernhard; Schmidt, Annette; Popp, Tanja; Kehe, Kai; Mueckter, Harald; Thiermann, Horst und Gudermann, Thomas
(2018):
Zinc chloride-induced TRPA1 activation does not contribute to toxicity in vitro.
In: Toxicology Letters, Bd. 293: S. 133-139
Popp, Tanja; Lueling, Robin; Boekhoff, Ingrid; Seeger, Thomas; Branoner, Francisco; Gudermann, Thomas; Thiermann, Horst; Worek, Franz und Steinritz, Dirk
(2018):
Immediate responses of the cockroach Blaptica dubia after the exposure to sulfur mustard.
In: Archives of Toxicology, Bd. 92, Nr. 1: S. 337-346
2017
Stenger, Bernhard; Popp, Tanja; John, Harald; Siegert, Markus; Tsoutsoulopoulos, Amelie; Schmidt, Annette; Mückter, Harald; Gudermann, Thomas; Thiermann, Horst und Steinritz, Dirk
(2017):
N-Acetyl-L-cysteine inhibits sulfur mustard-induced and TRPA1-dependent calcium influx.
In: Archives of Toxicology, Bd. 91, Nr. 5: S. 2179-2189
Dietrich, Alexander; Steinritz, Dirk und Gudermann, Thomas
(2017):
Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseases.
In: Cell Calcium, Bd. 67: S. 123-137
Steinritz, Dirk; Gudermann, Thomas; Popp, Tanja; Dietrich, Alexander; Stenger, Bernhard und Thiermann, Horst
(2017):
Transient receptor potential (TRP) channels as therapeutic targets in toxic lung injury.
In: Clinical Toxicology, Bd. 55, Nr. 5: S. 425
Giesche, Robert; John, Harald; Kehe, Kai; Schmidt, Annette; Popp, Tanja; Balzuweit, Frank; Thiermann, Horst; Gudermann, Thomas und Steinritz, Dirk
(2017):
S - and N-alkylating agents diminish the fluorescence of fluorescent dye-stained DNA.
In: Chemico-Biological interactions, Bd. 262: S. 12-18
2016
Steinritz, Dirk; Eyer, Florian; Worek, Franz; Thiermann, Horst und John, Harald
(2016):
Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report.
In: Toxicology Letters, Bd. 244: S. 121-123
Wolf, Markus; Siegert, Markus; Rothmiller, Simone; Scheithauer, Nina; Strobelt, Romano; Steinritz, Dirk; Worek, Franz; Thiermann, Horst und Schmidt, Annette
(2016):
Characterization of sulfur mustard resistant keratinocyte cell line HaCaT/SM.
In: Toxicology Letters, Bd. 244: S. 49-55
Deppe, Janina; Popp, Tanja; Egea, Virginia; Steinritz, Dirk; Schmidt, Annette; Thiermann, Horst; Weber, Christian und Ries, Christian
(2016):
Impairment of hypoxia-induced HIF-1 alpha signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor.
In: Archives of Toxicology, Bd. 90, Nr. 5: S. 1141-1150
Schmidt, Annette; Steinritz, Dirk; Thiermann, Horst; Meineke, Viktor und Abend, Michael
(2016):
Alteration of miRNA expression in early endothelial cells after exposure with sub-lethal sulfur mustard concentrations.
In: Toxicology Letters, Bd. 244: S. 88-94
Schmidt, Annette; Steinritz, Dirk und Thiermann, Horst
(2016):
Development of the sulfur mustard resistant keratinocyte cell line HaCaT/SM.
In: Toxicology Letters, Bd. 244: S. 44-48
Steinritz, Dirk; Schmidt, Annette; Balszuweit, Frank; Thiermann, Horst; Simons, Thilo; Striepling, Enno; Bölck, Birgit und Bloch, Wilhelm
(2016):
Epigenetic modulations in early endothelial cells and DNA hypermethylation in human skin after sulfur mustard exposure.
In: Toxicology Letters, Bd. 244: S. 95-102
Deppe, Janina; Steinritz, Dirk; Santovito, Donato; Egea, Virginia; Schmidt, Annette; Weber, Christian und Ries, Christian
(2016):
Upregulation of miR-203 and miR-210 affect growth and differentiation of keratinocytes after exposure to sulfur mustard in normoxia and hypoxia.
In: Toxicology Letters, Bd. 244: S. 81-87
Mangerich, Aswin; Debiak, Malgorzata; Birtel, Matthias; Ponath, Viviane; Balszuweit, Frank; Lex, Kirsten; Martello, Rita; Burckhardt-Boer, Waltraud; Strobelt, Romano; Siegert, Markus; Thiermann, Horst; Steinritz, Dirk; Schmidt, Annette und Bürkle, Alexander
(2016):
Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences.
In: Toxicology Letters, Bd. 244: S. 56-71
Debiak, Malgorzata; Lex, Kirsten; Ponath, Viviane; Burckhardt-Boer, Waltraud; Thiermann, Horst; Steinritz, Dirk; Schmidt, Annette; Mangerich, Aswin und Bürkle, Alexander
(2016):
Immunochemical analysis of poly(ADP-ribosyl)ation in HaCaT keratinocytes induced by the mono-alkylating agent 2-chloroethyl ethyl sulfide (CEES): Impact of experimental conditions.
In: Toxicology Letters, Bd. 244: S. 72-80
Tsoutsoulopoulos, Amelie; Möhle, Niklas; Aufderheide, Michaela; Schmidt, Annette; Thiermann, Horst und Steinritz, Dirk
(2016):
Optimization of the CULTEX (R) radial flow system for in vitro investigation of lung damaging agents.
In: Toxicology Letters, Bd. 244: S. 28-34
Balszuweit, Frank; Menacher, Georg; Schmidt, Annette; Kehe, Kai; Popp, Tanja; Worek, Franz; Thiermann, Horst und Steinritz, Dirk
(2016):
Protective effects of the thiol compounds GSH and NAC against sulfur mustard toxicity in a human keratinocyte cell line.
In: Toxicology Letters, Bd. 244: S. 35-43
Steinritz, Dirk; Striepling, Enno; Rudolf, Klaus-Dieter; Schröder-Kraft, Claudia; Püschel, Klaus; Hullard-Pulstinger, Andreas; Koller, Marianne; Thiermann, Horst; Gandor, Felix; Gawlik, Michael und John, Harald
(2016):
Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations.
In: Toxicology Letters, Bd. 244: S. 112-120