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Anzahl der Publikationen: 55
Zeitschriftenartikel
Müller-Dott, Katharina; Thiermann, Horst; John, Harald und Steinritz, Dirk
(2022):
Isolation of human TRPA1 channel from transfected HEK293 cells and identification of alkylation sites after sulfur mustard exposure.
In: Archives of Toxicology, Bd. 97, Nr. 2: S. 429-439
Kaiser, Jesko; Gertzen, Christoph G. W.; Bernauer, Tamara; Hoefner, Georg; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Wanner, Klaus T.; Worek, Franz; Thiermann, Horst und Gohlke, Holger
(2022):
A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment.
In: Toxicology Letters, Bd. 373: S. 160-171
Stigler, Lisa; Köhler, Anja; Koller, Marianne; Job, Laura; Escher, Benjamin; Potschka, Heidrun; Thiermann, Horst; Skerra, Arne; Worek, Franz und Wille, Timo
(2021):
Post-VX exposure treatment of rats with engineered phosphotriesterases.
In: Archives of Toxicology, Bd. 96, Nr. 2: S. 571-583
Steinritz, Dirk; Luling, Robin; Siegert, Markus; Mueckter, Harald; Popp, Tanja; Reinemer, Peter; Gudermann, Thomas; Thiermann, Horst und John, Harald
(2021):
Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro.
In: Archives of Toxicology, Bd. 95, Nr. 10: S. 3253-3261
Steinritz, Dirk; Lueling, Robin; Siegert, Markus; Herbert, Julia; Mueckter, Harald; Taeger, Christian D.; Gudermann, Thomas; Dietrich, Alexander; Thiermann, Horst und John, Harald
(2021):
Alkylated epidermal creatine kinase as a biomarker for sulfur mustard exposure: comparison to adducts of albumin and DNA in an in vivo rat study.
In: Archives of Toxicology, Bd. 95, Nr. 4: S. 1323-1333
Schmeißer, Wolfgang; Lüling, Robin; Steinritz, Dirk; Thiermann, Horst; Rein, Theo und John, Harald
(2021):
Transthyretin as a target of alkylation and a potential biomarker for sulfur mustard poisoning: Electrophoretic and mass spectrometric identification and characterization.
In: Drug Testing and Analysis, Bd. 14, Nr. 1: S. 80-91
Rothmiller, Simone; Jaeger, Niklas; Meier, Nicole; Meyer, Thimo; Neu, Adrian; Steinritz, Dirk; Thiermann, Horst; Scherer, Michael; Rummel, Christoph; Mangerich, Aswin; Buerkle, Alexander und Schmidt, Annette
(2021):
Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard.
In: Archives of Toxicology, Bd. 95, Nr. 2: S. 727-747
Steinritz, Dirk; Lüling, Robin; Siegert, Markus; Mückter, Harald; Popp, Tanja; Reinemer, Peter; Gudermann, Thomas; Thiermann, Horst und John, Harald
(2021):
Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro.
In: Archives of toxicology, Bd. 95, Nr. 10: S. 3253-3261
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Lueling, Robin; Schmeisser, Wolfgang; Siegert, Markus; Mueckter, Harald; Dietrich, Alexander; Thiermann, Horst; Gudermann, Thomas; John, Harald und Steinritz, Dirk
(2020):
Identification of creatine kinase and alpha-1 antitrypsin as protein targets of alkylation by sulfur mustard.
In: Drug Testing and Analysis, Bd. 13, Nr. 2: S. 268-282
Kranawetvogl, Tamara; Steinritz, Dirk; Thiermann, Horst und John, Harald
(2020):
A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma.
In: Drug Testing and Analysis, Bd. 12, Nr. 7: S. 938-947
Popp, Tanja; Balszuweit, Frank; Schmidt, Annette; Eyer, Florian; Thiermann, Horst und Steinritz, Dirk
(2020):
Assessment of alpha-amanitin toxicity and effects of silibinin and penicillin in different in vitro models.
In: Toxicology in Vitro, Bd. 67, 104921
Müller-Dotta, Katharina; Thiermann, Horst; Steinritz, Dirk und Popp, Tanja
(2020):
Effect of sulfur mustard on melanogenesis in vitro.
In: Toxicology Letters, Bd. 319: S. 197-203
Rothmiller, Simone; Balszuweit, Frank; Menacher, Georg; Steinritz, Dirk; Kehe, Kai; Thiermann, Horst und Schmidt, Annette
(2020):
Validation of automated pipetting systems for cell culture seeding, exposure and bio-analytical assays in sulfur mustard toxicology.
In: Toxicology Letters, Bd. 320: S. 80-86
Tsoutsoulopoulos, Amelie; Brockmoeller, Sabrina; Thiermann, Horst und Steinritz, Dirk
(2020):
Comparison of the toxicity of sulfur mustard and its oxidation products in vitro.
In: Toxicology Letters, Bd. 321: S. 69-72
Tsoutsoulopoulos, Amelie; Gohlsch, Katrin; Moehle, Niklas; Breit, Andreas; Hoffmann, Sebastian; Krischenowski, O.; Mueckter, Harald; Gudermann, Thomas; Thiermann, Horst; Aufderheide, Michaela und Steinritz, Dirk
(2020):
Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface.
In: Jove-Journal of Visualized Experiments, Nr. 156, e60572
Wein, Thomas; Wanner, Klaus T.; Rappenglueck, Sebastian; Sichler, Sonja; Niessen, Karin; Seeger, Thomas; Worek, Franz und Thiermann, Horst
(2019):
New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling.
In: Current Computer-Aided Drug Design, Bd. 15, Nr. 1: S. 104-109
Tsoutsoulopoulos, Amelie; Siegert, Markus; John, Harald; Zubel, Tabea; Mangerich, Aswin; Schmidt, Annette; Mueckter, Harald; Gudermann, Thomas; Thiermann, Horst; Steinritz, Dirk und Popp, Tanja
(2019):
A novel exposure system generating nebulized aerosol of sulfur mustard in comparison to the standard submerse exposure.
In: Chemico-Biological Interactions, Bd. 298: S. 121-128
Menacher, Georg; Balszuweit, Frank; Lang, Simon; Thiermann, Horst; Kehe, Kai; Gudermann, Thomas; Schmidt, Annette; Steinritz, Dirk und Popp, Tanja
(2019):
Necrosulfonamide - Unexpected effect in the course of a sulfur mustard intoxication.
In: Chemico-Biological Interactions, Bd. 298: S. 80-85
Tsoutsoulopoulos, Amelie; Gohlsch, Katrin; Moehle, Niklas; Breit, Andreas; Hoffmann, Sebastian; Krischenowski, Olaf; Mueckter, Harald; Gudermann, Thomas; Thiermann, Horst; Aufderheide, Michaela und Steinritz, Dirk
(2019):
Validation of the CULTEX (R) Radial Flow System for the assessment of the acute inhalation toxicity of airborne particles.
In: Toxicology in Vitro, Bd. 58: S. 245-255
Wagner, Simon; Lang, Simon; Popp, Tanja; Schmidt, Annette; Thiermann, Horst; Steinritz, Dirk und Kehe, Kai
(2019):
Evaluation of selective and non-selective cyclooxygenase inhibitors on sulfur mustard-induced pro-inflammatory cytokine formation in normal human epidermal keratinocytes.
In: Toxicology Letters, Bd. 312: S. 109-117
Steinritz, Dirk; Lang, Simon; Popp, Tanja; Siegert, Markus; Rothmiller, Simone; Kranawetvogl, Andreas; Schmidt, Annette; John, Harald; Gudermann, Thomas; Thiermann, Horst und Kehe, Kai
(2019):
Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines.
In: Toxicology Letters, Bd. 314: S. 172-180
Lueling, Robin; Singer, Helena; Popp, Tanja; John, Harald; Boekhoff, Ingrid; Thiermann, Horst; Daumann, Lena J.; Karaghiosoff, Konstantin; Gudermann, Thomas und Steinritz, Dirk
(2019):
Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro.
In: Archives of Toxicology, Bd. 93, Nr. 11: S. 3141-3152
Schreier, Cassandra; Rothmiller, Simone; Scherer, Michael A.; Rummel, Christoph; Steinritz, Dirk; Thiermann, Horst und Schmidt, Annette
(2018):
Mobilization of human mesenchymal stem cells through different cytokines and growth factors after their immobilization by sulfur mustard.
In: Toxicology Letters, Bd. 293: S. 105-111
Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
In: Chemmedchem, Bd. 13, Nr. 17: S. 1806-1816
Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
In: Chemmedchem, Bd. 13, Nr. 24: S. 2653-2663
Wein, Thomas; Höfner, Georg; Rappenglück, Sebastian; Sichler, Sonja; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 293: S. 184-189
Scheffel, Corinna; Niessen, Karin V.; Rappenglück, Sebastian; Wanner, Klaus. T.; Thiermann, Horst; Worek, Franz und Seeger, Thomas
(2018):
Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human alpha 7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis.
In: Toxicology Letters, Bd. 293: S. 157-166
Scheffel, Corinna; Niessen, Karin V.; Rappenglück, Sebastian; Wanner, Klaus T.; Thiermann, Horst; Worek, Franz und Seeger, Thomas
(2018):
Counteracting desensitization of human alpha 7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning.
In: Toxicology Letters, Bd. 293: S. 149-156
Rothmiller, Simone; Schröder, Sarah; Strobelt, Romano; Wolf, Markus; Wang, Jin; Jiang, Xiqian; Worek, Franz; Steinritz, Dirk; Thiermann, Horst und Schmidt, Annette
(2018):
Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism.
In: Toxicology Letters, Bd. 293: S. 51-61
Rothmiller, Simone; Wolf, Markus; Worek, Franz; Steinritz, Dirk; Thiermann, Horst und Schmidt, Annette
(2018):
Alteration of miRNA expression in a sulfur mustard resistant cell line.
In: Toxicology Letters, Bd. 293: S. 38-44
Schmidt, Annette; Steinritz, Dirk; Rothmiller, Simone; Thiermann, Horst und Scherer, A. Michael
(2018):
Effects of sulfur mustard on mesenchymal stem cells.
In: Toxicology Letters, Bd. 293: S. 98-104
Lueling, Robin; John, Harald; Gudermann, Thomas; Thiermann, Horst; Mueckter, Harald; Popp, Tanja und Steinritz, Dirk
(2018):
Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 (HSPA6) In Vitro.
In: Cells, Bd. 7, Nr. 9, 126
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Simons, Thilo; Steinritz, Dirk; Boelck, Birgit; Schmidt, Annette; Popp, Tanja; Thiermann, Horst; Gudermann, Thomas; Bloch, Wilhelm und Kehe, Kai
(2018):
Sulfur mustard-induced epigenetic modifications over time - a pilot study.
In: Toxicology Letters, Bd. 293: S. 45-50
Menacher, Georg; Steinritz, Dirk; Schmidt, Annette; Popp, Tanja; Worek, Franz; Gudermann, Thomas; Thiermann, Horst und Balszuweit, Frank
(2018):
Effects of anti-inflammatory compounds on sulfur mustard injured cells: Recommendations and caveats suggested by in vitro cell culture models.
In: Toxicology Letters, Bd. 293: S. 91-97
Schmidt, Annette; Wolf, Markus; Rothmiller, Simone; Worek, Franz; Steinritz, Dirk und Thiermann, Horst
(2018):
Cytostatic resistance profile of the sulfur mustard resistant keratinocyte cell line HaCaT/SM.
In: Toxicology Letters, Bd. 293: S. 16-20
Lang, Simon; Popp, Tanja; Kriegs, Christian Silvester; Schmidt, Annette; Balszuweit, Frank; Menacher, Georg; Kehe, Kai; Thiermann, Horst; Gudermann, Thomas und Steinritz, Dirk
(2018):
Anti-apoptotic and moderate anti-inflammatory effects of berberine in sulfur mustard exposed keratinocytes.
In: Toxicology Letters, Bd. 293: S. 2-8
Schmidt, Annette; Steinritz, Dirk; Rudolf, Klaus-Dieter; Thiermann, Horst und Striepling, Enno
(2018):
Accidental sulfur mustard exposure: A case report.
In: Toxicology Letters, Bd. 293: S. 62-66
Steinritz, Dirk; Zehfuss, Franziska; Stenger, Bernhard; Schmidt, Annette; Popp, Tanja; Kehe, Kai; Mueckter, Harald; Thiermann, Horst und Gudermann, Thomas
(2018):
Zinc chloride-induced TRPA1 activation does not contribute to toxicity in vitro.
In: Toxicology Letters, Bd. 293: S. 133-139
Popp, Tanja; Lueling, Robin; Boekhoff, Ingrid; Seeger, Thomas; Branoner, Francisco; Gudermann, Thomas; Thiermann, Horst; Worek, Franz und Steinritz, Dirk
(2018):
Immediate responses of the cockroach Blaptica dubia after the exposure to sulfur mustard.
In: Archives of Toxicology, Bd. 92, Nr. 1: S. 337-346
Rappenglück, Sebastian; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2017):
Regioselective and Transition-Metal-Free Addition of tert-Butyl Magnesium Reagents to Pyridine Derivatives: A Convenient Method for the Synthesis of 3-Substituted 4-tert-Butylpyridine Derivatives.
In: Synthesis-Stuttgart, Bd. 49, Nr. 17: S. 4055-4064
Steinritz, Dirk; Gudermann, Thomas; Popp, Tanja; Dietrich, Alexander; Stenger, Bernhard und Thiermann, Horst
(2017):
Transient receptor potential (TRP) channels as therapeutic targets in toxic lung injury.
In: Clinical Toxicology, Bd. 55, Nr. 5: S. 425
Stenger, Bernhard; Popp, Tanja; John, Harald; Siegert, Markus; Tsoutsoulopoulos, Amelie; Schmidt, Annette; Mückter, Harald; Gudermann, Thomas; Thiermann, Horst und Steinritz, Dirk
(2017):
N-Acetyl-L-cysteine inhibits sulfur mustard-induced and TRPA1-dependent calcium influx.
In: Archives of Toxicology, Bd. 91, Nr. 5: S. 2179-2189
Giesche, Robert; John, Harald; Kehe, Kai; Schmidt, Annette; Popp, Tanja; Balzuweit, Frank; Thiermann, Horst; Gudermann, Thomas und Steinritz, Dirk
(2017):
S - and N-alkylating agents diminish the fluorescence of fluorescent dye-stained DNA.
In: Chemico-Biological interactions, Bd. 262: S. 12-18
Steinritz, Dirk; Eyer, Florian; Worek, Franz; Thiermann, Horst und John, Harald
(2016):
Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report.
In: Toxicology Letters, Bd. 244: S. 121-123
Wolf, Markus; Siegert, Markus; Rothmiller, Simone; Scheithauer, Nina; Strobelt, Romano; Steinritz, Dirk; Worek, Franz; Thiermann, Horst und Schmidt, Annette
(2016):
Characterization of sulfur mustard resistant keratinocyte cell line HaCaT/SM.
In: Toxicology Letters, Bd. 244: S. 49-55
John, Harald; Siegert, Markus; Gandor, Felix; Gawlik, Michael; Kranawetvogl, Andreas; Karaghiosoff, Konstantin und Thiermann, Horst
(2016):
Optimized verification method for detection of an albumin-sulfur mustard adduct at Cys(34) using a hybrid quadrupole time-of-flight tandem mass spectrometer after direct plasma proteolysis.
In: Toxicology Letters, Bd. 244: S. 103-111
Deppe, Janina; Popp, Tanja; Egea, Virginia; Steinritz, Dirk; Schmidt, Annette; Thiermann, Horst; Weber, Christian und Ries, Christian
(2016):
Impairment of hypoxia-induced HIF-1 alpha signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor.
In: Archives of Toxicology, Bd. 90, Nr. 5: S. 1141-1150
Schmidt, Annette; Steinritz, Dirk; Thiermann, Horst; Meineke, Viktor und Abend, Michael
(2016):
Alteration of miRNA expression in early endothelial cells after exposure with sub-lethal sulfur mustard concentrations.
In: Toxicology Letters, Bd. 244: S. 88-94
Schmidt, Annette; Steinritz, Dirk und Thiermann, Horst
(2016):
Development of the sulfur mustard resistant keratinocyte cell line HaCaT/SM.
In: Toxicology Letters, Bd. 244: S. 44-48
Steinritz, Dirk; Schmidt, Annette; Balszuweit, Frank; Thiermann, Horst; Simons, Thilo; Striepling, Enno; Bölck, Birgit und Bloch, Wilhelm
(2016):
Epigenetic modulations in early endothelial cells and DNA hypermethylation in human skin after sulfur mustard exposure.
In: Toxicology Letters, Bd. 244: S. 95-102
Mangerich, Aswin; Debiak, Malgorzata; Birtel, Matthias; Ponath, Viviane; Balszuweit, Frank; Lex, Kirsten; Martello, Rita; Burckhardt-Boer, Waltraud; Strobelt, Romano; Siegert, Markus; Thiermann, Horst; Steinritz, Dirk; Schmidt, Annette und Bürkle, Alexander
(2016):
Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences.
In: Toxicology Letters, Bd. 244: S. 56-71
Debiak, Malgorzata; Lex, Kirsten; Ponath, Viviane; Burckhardt-Boer, Waltraud; Thiermann, Horst; Steinritz, Dirk; Schmidt, Annette; Mangerich, Aswin und Bürkle, Alexander
(2016):
Immunochemical analysis of poly(ADP-ribosyl)ation in HaCaT keratinocytes induced by the mono-alkylating agent 2-chloroethyl ethyl sulfide (CEES): Impact of experimental conditions.
In: Toxicology Letters, Bd. 244: S. 72-80
Tsoutsoulopoulos, Amelie; Möhle, Niklas; Aufderheide, Michaela; Schmidt, Annette; Thiermann, Horst und Steinritz, Dirk
(2016):
Optimization of the CULTEX (R) radial flow system for in vitro investigation of lung damaging agents.
In: Toxicology Letters, Bd. 244: S. 28-34
Balszuweit, Frank; Menacher, Georg; Schmidt, Annette; Kehe, Kai; Popp, Tanja; Worek, Franz; Thiermann, Horst und Steinritz, Dirk
(2016):
Protective effects of the thiol compounds GSH and NAC against sulfur mustard toxicity in a human keratinocyte cell line.
In: Toxicology Letters, Bd. 244: S. 35-43
Steinritz, Dirk; Striepling, Enno; Rudolf, Klaus-Dieter; Schröder-Kraft, Claudia; Püschel, Klaus; Hullard-Pulstinger, Andreas; Koller, Marianne; Thiermann, Horst; Gandor, Felix; Gawlik, Michael und John, Harald
(2016):
Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations.
In: Toxicology Letters, Bd. 244: S. 112-120