Anzahl der Publikationen: 55
Zeitschriftenartikel
Kaiser, Jesko; Gertzen, Christoph G. W.; Bernauer, Tamara; Hoefner, Georg; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Wanner, Klaus T.; Worek, Franz; Thiermann, Horst und Gohlke, Holger
(2022):
A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment.
In: Toxicology Letters, Bd. 373: S. 160-171
Stigler, Lisa; Köhler, Anja; Koller, Marianne; Job, Laura; Escher, Benjamin; Potschka, Heidrun; Thiermann, Horst; Skerra, Arne; Worek, Franz und Wille, Timo
(2021):
Post-VX exposure treatment of rats with engineered phosphotriesterases.
In: Archives of Toxicology, Bd. 96, Nr. 2: S. 571-583
Steinritz, Dirk; Luling, Robin; Siegert, Markus; Mueckter, Harald; Popp, Tanja; Reinemer, Peter; Gudermann, Thomas; Thiermann, Horst und John, Harald
(2021):
Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro.
In: Archives of Toxicology, Bd. 95, Nr. 10: S. 3253-3261
Steinritz, Dirk; Lueling, Robin; Siegert, Markus; Herbert, Julia; Mueckter, Harald; Taeger, Christian D.; Gudermann, Thomas; Dietrich, Alexander; Thiermann, Horst und John, Harald
(2021):
Alkylated epidermal creatine kinase as a biomarker for sulfur mustard exposure: comparison to adducts of albumin and DNA in an in vivo rat study.
In: Archives of Toxicology, Bd. 95, Nr. 4: S. 1323-1333
Rothmiller, Simone; Jaeger, Niklas; Meier, Nicole; Meyer, Thimo; Neu, Adrian; Steinritz, Dirk; Thiermann, Horst; Scherer, Michael; Rummel, Christoph; Mangerich, Aswin; Buerkle, Alexander und Schmidt, Annette
(2021):
Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard.
In: Archives of Toxicology, Bd. 95, Nr. 2: S. 727-747
Steinritz, Dirk; Lüling, Robin; Siegert, Markus; Mückter, Harald; Popp, Tanja; Reinemer, Peter; Gudermann, Thomas; Thiermann, Horst und John, Harald
(2021):
Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro.
In: Archives of toxicology, Bd. 95, Nr. 10: S. 3253-3261
[PDF, 1MB]
Lueling, Robin; Schmeisser, Wolfgang; Siegert, Markus; Mueckter, Harald; Dietrich, Alexander; Thiermann, Horst; Gudermann, Thomas; John, Harald und Steinritz, Dirk
(2020):
Identification of creatine kinase and alpha-1 antitrypsin as protein targets of alkylation by sulfur mustard.
In: Drug Testing and Analysis, Bd. 13, Nr. 2: S. 268-282
Tsoutsoulopoulos, Amelie; Gohlsch, Katrin; Moehle, Niklas; Breit, Andreas; Hoffmann, Sebastian; Krischenowski, O.; Mueckter, Harald; Gudermann, Thomas; Thiermann, Horst; Aufderheide, Michaela und Steinritz, Dirk
(2020):
Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface.
In: Jove-Journal of Visualized Experiments, Nr. 156, e60572
Wein, Thomas; Wanner, Klaus T.; Rappenglueck, Sebastian; Sichler, Sonja; Niessen, Karin; Seeger, Thomas; Worek, Franz und Thiermann, Horst
(2019):
New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling.
In: Current Computer-Aided Drug Design, Bd. 15, Nr. 1: S. 104-109
Tsoutsoulopoulos, Amelie; Siegert, Markus; John, Harald; Zubel, Tabea; Mangerich, Aswin; Schmidt, Annette; Mueckter, Harald; Gudermann, Thomas; Thiermann, Horst; Steinritz, Dirk und Popp, Tanja
(2019):
A novel exposure system generating nebulized aerosol of sulfur mustard in comparison to the standard submerse exposure.
In: Chemico-Biological Interactions, Bd. 298: S. 121-128
Menacher, Georg; Balszuweit, Frank; Lang, Simon; Thiermann, Horst; Kehe, Kai; Gudermann, Thomas; Schmidt, Annette; Steinritz, Dirk und Popp, Tanja
(2019):
Necrosulfonamide - Unexpected effect in the course of a sulfur mustard intoxication.
In: Chemico-Biological Interactions, Bd. 298: S. 80-85
Tsoutsoulopoulos, Amelie; Gohlsch, Katrin; Moehle, Niklas; Breit, Andreas; Hoffmann, Sebastian; Krischenowski, Olaf; Mueckter, Harald; Gudermann, Thomas; Thiermann, Horst; Aufderheide, Michaela und Steinritz, Dirk
(2019):
Validation of the CULTEX (R) Radial Flow System for the assessment of the acute inhalation toxicity of airborne particles.
In: Toxicology in Vitro, Bd. 58: S. 245-255
Steinritz, Dirk; Lang, Simon; Popp, Tanja; Siegert, Markus; Rothmiller, Simone; Kranawetvogl, Andreas; Schmidt, Annette; John, Harald; Gudermann, Thomas; Thiermann, Horst und Kehe, Kai
(2019):
Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines.
In: Toxicology Letters, Bd. 314: S. 172-180
Lueling, Robin; Singer, Helena; Popp, Tanja; John, Harald; Boekhoff, Ingrid; Thiermann, Horst; Daumann, Lena J.; Karaghiosoff, Konstantin; Gudermann, Thomas und Steinritz, Dirk
(2019):
Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro.
In: Archives of Toxicology, Bd. 93, Nr. 11: S. 3141-3152
Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
In: Chemmedchem, Bd. 13, Nr. 17: S. 1806-1816
Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
In: Chemmedchem, Bd. 13, Nr. 24: S. 2653-2663
Wein, Thomas; Höfner, Georg; Rappenglück, Sebastian; Sichler, Sonja; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 293: S. 184-189
Rothmiller, Simone; Schröder, Sarah; Strobelt, Romano; Wolf, Markus; Wang, Jin; Jiang, Xiqian; Worek, Franz; Steinritz, Dirk; Thiermann, Horst und Schmidt, Annette
(2018):
Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism.
In: Toxicology Letters, Bd. 293: S. 51-61
Lueling, Robin; John, Harald; Gudermann, Thomas; Thiermann, Horst; Mueckter, Harald; Popp, Tanja und Steinritz, Dirk
(2018):
Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 (HSPA6) In Vitro.
In: Cells, Bd. 7, Nr. 9, 126
[PDF, 1MB]
Simons, Thilo; Steinritz, Dirk; Boelck, Birgit; Schmidt, Annette; Popp, Tanja; Thiermann, Horst; Gudermann, Thomas; Bloch, Wilhelm und Kehe, Kai
(2018):
Sulfur mustard-induced epigenetic modifications over time - a pilot study.
In: Toxicology Letters, Bd. 293: S. 45-50
Lang, Simon; Popp, Tanja; Kriegs, Christian Silvester; Schmidt, Annette; Balszuweit, Frank; Menacher, Georg; Kehe, Kai; Thiermann, Horst; Gudermann, Thomas und Steinritz, Dirk
(2018):
Anti-apoptotic and moderate anti-inflammatory effects of berberine in sulfur mustard exposed keratinocytes.
In: Toxicology Letters, Bd. 293: S. 2-8
Steinritz, Dirk; Zehfuss, Franziska; Stenger, Bernhard; Schmidt, Annette; Popp, Tanja; Kehe, Kai; Mueckter, Harald; Thiermann, Horst und Gudermann, Thomas
(2018):
Zinc chloride-induced TRPA1 activation does not contribute to toxicity in vitro.
In: Toxicology Letters, Bd. 293: S. 133-139
Popp, Tanja; Lueling, Robin; Boekhoff, Ingrid; Seeger, Thomas; Branoner, Francisco; Gudermann, Thomas; Thiermann, Horst; Worek, Franz und Steinritz, Dirk
(2018):
Immediate responses of the cockroach Blaptica dubia after the exposure to sulfur mustard.
In: Archives of Toxicology, Bd. 92, Nr. 1: S. 337-346
Stenger, Bernhard; Popp, Tanja; John, Harald; Siegert, Markus; Tsoutsoulopoulos, Amelie; Schmidt, Annette; Mückter, Harald; Gudermann, Thomas; Thiermann, Horst und Steinritz, Dirk
(2017):
N-Acetyl-L-cysteine inhibits sulfur mustard-induced and TRPA1-dependent calcium influx.
In: Archives of Toxicology, Bd. 91, Nr. 5: S. 2179-2189
Giesche, Robert; John, Harald; Kehe, Kai; Schmidt, Annette; Popp, Tanja; Balzuweit, Frank; Thiermann, Horst; Gudermann, Thomas und Steinritz, Dirk
(2017):
S - and N-alkylating agents diminish the fluorescence of fluorescent dye-stained DNA.
In: Chemico-Biological interactions, Bd. 262: S. 12-18
Wolf, Markus; Siegert, Markus; Rothmiller, Simone; Scheithauer, Nina; Strobelt, Romano; Steinritz, Dirk; Worek, Franz; Thiermann, Horst und Schmidt, Annette
(2016):
Characterization of sulfur mustard resistant keratinocyte cell line HaCaT/SM.
In: Toxicology Letters, Bd. 244: S. 49-55
Deppe, Janina; Popp, Tanja; Egea, Virginia; Steinritz, Dirk; Schmidt, Annette; Thiermann, Horst; Weber, Christian und Ries, Christian
(2016):
Impairment of hypoxia-induced HIF-1 alpha signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor.
In: Archives of Toxicology, Bd. 90, Nr. 5: S. 1141-1150
Mangerich, Aswin; Debiak, Malgorzata; Birtel, Matthias; Ponath, Viviane; Balszuweit, Frank; Lex, Kirsten; Martello, Rita; Burckhardt-Boer, Waltraud; Strobelt, Romano; Siegert, Markus; Thiermann, Horst; Steinritz, Dirk; Schmidt, Annette und Bürkle, Alexander
(2016):
Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences.
In: Toxicology Letters, Bd. 244: S. 56-71
Debiak, Malgorzata; Lex, Kirsten; Ponath, Viviane; Burckhardt-Boer, Waltraud; Thiermann, Horst; Steinritz, Dirk; Schmidt, Annette; Mangerich, Aswin und Bürkle, Alexander
(2016):
Immunochemical analysis of poly(ADP-ribosyl)ation in HaCaT keratinocytes induced by the mono-alkylating agent 2-chloroethyl ethyl sulfide (CEES): Impact of experimental conditions.
In: Toxicology Letters, Bd. 244: S. 72-80
Steinritz, Dirk; Striepling, Enno; Rudolf, Klaus-Dieter; Schröder-Kraft, Claudia; Püschel, Klaus; Hullard-Pulstinger, Andreas; Koller, Marianne; Thiermann, Horst; Gandor, Felix; Gawlik, Michael und John, Harald
(2016):
Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations.
In: Toxicology Letters, Bd. 244: S. 112-120
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