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Veröffentlichungsdatum
Anzahl der Publikationen: 33
2022
Scotto Rosato, Anna; Krogsaeter, Einar K; Jaślan, Dawid; Abrahamian, Carla; Montefusco, Sandro; Soldati, Chiara; Spix, Barbara; Pizzo, Maria Teresa; Grieco, Giuseppina; Böck, Julia; Wyatt, Amanda; Wünkhaus, Daniela; Passon, Marcel; Stieglitz, Marc; Keller, Marco; Hermey, Guido; Markmann, Sandra; Gruber‐Schoffnegger, Doris; Cotman, Susan; Johannes, Ludger; Crusius, Dennis; Boehm, Ulrich; Wahl-Schott, Christian; Biel, Martin; Bracher, Franz; De Leonibus, Elvira; Polishchuk, Elena; Medina, Diego L; Paquet, Dominik und Grimm, Christian
(5. August 2022):
TPC2 rescues lysosomal storage in mucolipidosis type IV , Niemann–Pick type C1, and Batten disease.
In: EMBO Molecular Medicine, Bd. 14, Nr. 9
[PDF, 27MB]
Hennis, Konstantin; Roetzer, Rene D.; Rilling, Julia; Wu, Yakun; Thalhammer, Stefan B.; Biel, Martin; Wahl-Schott, Christian und Fenske, Stefanie
(2022):
In vivo and ex vivo electrophysiological study of the mouse heart to characterize the cardiac conduction system, including atrial and ventricular vulnerability.
In: Nature Protocols, Bd. 17, Nr. 5: S. 1189-1222
Hennis, Konstantin; Biel, Martin; Fenske, Stefanie und Wahl-Schott, Christian
(2022):
Paradigm shift: new concepts for HCN4 function in cardiac pacemaking.
In: Pflugers Archiv-European Journal of Physiology, Bd. 474, Nr. 7: S. 649-663
[PDF, 4MB]
Spix, Barbara; Butz, Elisabeth S.; Chen, Cheng-Chang; Rosato, Anna Scotto; Tang, Rachel; Jeridi, Aicha; Kudrina, Veronika; Plesch, Eva; Wartenberg, Philipp; Arlt, Elisabeth; Briukhovetska, Daria; Ansari, Meshal; Günsel, Gizem Günes; Conlon, Thomas M.; Wyatt, Amanda; Wetzel, Sandra; Teupser, Daniel; Holdt, Lesca M.; Ectors, Fabien; Boekhoff, Ingrid; Boehm, Ulrich; García-Añoveros, Jaime; Saftig, Paul; Giera, Martin; Kobold, Sebastian; Schiller, Herbert B.; Zierler, Susanna; Gudermann, Thomas; Wahl-Schott, Christian; Bracher, Franz; Yildirim, Ali Önder; Biel, Martin und Grimm, Christian
(2022):
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
In: Nature Communications, Bd. 13, 318
[PDF, 3MB]
2021
Hennis, Konstantin; Roetzer, Rene D.; Piantoni, Chiara; Biel, Martin; Wahl-Schott, Christian und Fenske, Stefanie
(27. Mai 2021):
Speeding Up the Heart? Traditional and New Perspectives on HCN4 Function.
In: Frontiers in Physiology, Bd. 12, 669029
[PDF, 4MB]
Rotzer, Rene D.; Brox, Verena F.; Hennis, Konstantin; Thalhammer, Stefan B.; Biel, Martin; Wahl-Schott, Christian und Fenske, Stefanie
(2021):
Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice.
In: Jove-Journal of Visualized Experiments, Nr. 168, e62101
Li, Yanfen; Schoen, Christian; Chen, Cheng-Chang; Yang, Zhuo; Liegl, Raffael; Murenu, Elisa; Schworm, Benedikt; Klugbauer, Norbert; Grimm, Christian; Wahl-Schott, Christian; Michalakis, Stylianos und Biel, Martin
(2021):
TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration.
In: Life Science Alliance, Bd. 4, Nr. 8, e202101047
Hennis, Konstantin; Biel, Martin; Wahl-Schott, Christian und Fenske, Stefanie
(2021):
Beyond pacemaking: HCN channels in sinoatrial node function.
In: Progress in Biophysics & Molecular Biology, Bd. 166: S. 51-60
2020
Fenske, Stefanie; Hennis, Konstantin; Roetzer, Rene D.; Brox, Verena F.; Becirovic, Elvir; Scharr, Andreas; Gruner, Christian; Ziegler, Tilman; Mehlfeld, Verena; Brennan, Jaclyn; Efimov, Igor R.; Pauza, Audrys G.; Moser, Markus; Wotjak, Carsten T.; Kupatt, Christian; Goenner, Rasmus; Zhang, Rai; Zhang, Henggui; Zong, Xiangang; Biel, Martin und Wahl-Schott, Christian
(2020):
cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells.
In: Nature Communications, Bd. 11, Nr. 1, 5555
[PDF, 10MB]
Boehm, Sybille; Splith, Victoria; Riedmayr, Lisa Maria; Rotzer, Rene Dominik; Gasparoni, Gilles; Nordstroem, Karl J. V.; Wagner, Johanna Elisabeth; Hinrichsmeyer, Klara Sonnie; Walter, Joern; Wahl-Schott, Christian; Fenske, Stefanie; Biel, Martin; Michalakis, Stylianos und Becirovic, Elvir
(2020):
A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation.
In: Science Advances, Bd. 6, Nr. 34, eaba5614
Gerndt, Susanne; Chen, Cheng-Chang; Chao, Yu-Kai; Yuan, Yu; Burgstaller, Sandra; Rosato, Anna Scotto; Krogsaeter, Einar; Urban, Nicole; Jacob, Katharina; Ong, Nam Phuong Nguyen; Miller, Meghan T.; Keller, Marco; Vollmar, Angelika M.; Gudermann, Thomas; Zierler, Susanna; Schredelseker, Johann; Schaefer, Michael; Biel, Martin; Malli, Roland; Wahl-Schott, Christian; Bracher, Franz; Patel, Sandip und Grimm, Christian
(2020):
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
In: eLife, Bd. 9, e54712
[PDF, 4MB]
Chen, Cheng-Chang; Krogsaeter, Einar; Butz, Elisabeth S.; Li, Yanfen; Puertollano, Rosa; Wahl-Schott, Christian; Biel, Martin und Grimm, Christian
(2020):
TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles.
In: Science Advances, Bd. 6, Nr. 46, eabb5064
Arlt, Elisabeth; Fraticelli, Marco; Tsvilovskyy, Volodymyr; Nadolni, Wiebke; Breit, Andreas; O'Neill, Thomas J.; Resenberger, Stefanie; Wennemuth, Gunther; Wahl-Schott, Christian; Biel, Martin; Grimm, Christian; Freichel, Marc; Gudermann, Thomas; Klugbauer, Norbert; Boekhoff, Ingrid und Zierler, Susanna
(2020):
TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 117, Nr. 30: S. 18068-18078
2019
Krogsaeter, Einar K.; Biel, Martin; Wahl-Schott, Christian und Grimm, Christian
(2019):
The protein interaction networks of mucolipins and two-pore channels.
In: Biochimica et Biophysica Acta-Molecular Cell Research, Bd. 1866, Nr. 7: S. 1111-1123
Hammelmann, Verena; Stieglitz, Marc Sebastian; Huelle, Henrik; Le Meur, Karim; Kass, Jennifer; Bruemmer, Manuela; Gruner, Christian; Roetzer, Rene Dominik; Fenske, Stefanie; Hartmann, Jana; Zott, Benedikt; Luthi, Anita; Spahn, Saskia; Moser, Markus; Isbrandt, Dirk; Ludwig, Andreas; Konnerth, Arthur; Wahl-Schott, Christian und Biel, Martin
(2019):
Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures.
In: Jci Insight, Bd. 4, Nr. 9, e126418
2018
Plesch, Eva; Chen, Cheng-Chang; Butz, Elisabeth; Rosato, Anna Scotto; Krogsaeter, Einar K.; Yinan, Hua; Bartel, Karin; Keller, Marco; Robaa, Dina; Teupser, Daniel; Holdt, Lesca M.; Vollmar, Angelika M.; Sippl, Wolfgang; Puertollano, Rosa; Medina, Diego; Biel, Martin; Wahl-Schott, Christian; Bracher, Franz und Grimm, Christian
(2018):
Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells.
In: eLife, Bd. 7, e39720
[PDF, 4MB]
Stieglitz, Marc S.; Fenske, Stefanie; Hammelmann, Verena; Becirovic, Elvir; Schöttle, Verena; Delorme, James E.; Schöll-Weidinger, Martha; Mader, Robert; Deussing, Jan; Wolfer, David P.; Seeliger, Mathias W.; Albrecht, Urs; Wotjak, Carsten T.; Biel, Martin; Michalakis, Stylianos und Wahl-Schott, Christian
(2018):
Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.
In: Frontiers in Molecular Neuroscience, Bd. 10, 436
[PDF, 4MB]
2017
Grimm, Christian; Chen, Cheng-Chang; Wahl-Schott, Christian und Biel, Martin
(Februar 2017):
Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function.
In: Frontiers in Pharmacology, Bd. 8, 45
[PDF, 662kB]
Bobak, Nicole; Feliciangeli, Sylvain; Chen, Cheng-Chang; Ben Soussia, Ismail; Bittner, Stefan; Pagnotta, Sophie; Ruck, Tobias; Biel, Martin; Wahl-Schott, Christian; Grimm, Christian; Meuth, Sven G. und Lesage, Florian
(2017):
Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels.
In: Scientific Reports, Bd. 7, 649
[PDF, 11MB]
Nguyen, Ong Nam Phuong; Grimm, Christian; Schneider, Lina S.; Chao, Yu-Kai; Atzberger, Carina; Bartel, Karin; Watermann, Anna; Ulrich, Melanie; Mayr, Doris; Wahl-Schott, Christian; Biel, Martin und Vollmar, Angelika M.
(2017):
Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.
In: Cancer Research, Bd. 77, Nr. 6: S. 1427-1438
Böhm, Sybille; Riedmayr, Lisa M.; Nguyen, O. N. Phuong; Giessl, Andreas; Liebscher, Toni; Butz, Elisabeth S.; Schön, Christian; Michalakis, Stylianos; Wahl-Schott, Christian; Biel, Martin und Becirovic, Elvir
(2017):
Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.
In: Scientific Reports, Bd. 7, 2321
[PDF, 3MB]
Chen, Cheng-Chang; Butz, Elisabeth S.; Chao, Yu-Kai; Grishchuk, Yulia; Becker, Lars; Heller, Stefan; Slaugenhaupt, Susan A.; Biel, Martin; Wahl-Schott, Christian und Grimm, Christian
(2017):
Small Molecules for Early Endosome-Specific Patch Clamping.
In: Cell Chemical Biology, Bd. 24, Nr. 7: S. 907-916
Chen, Cheng-Chang; Cang, Chunlei; Fenske, Stefanie; Butz, Elisabeth; Chao, Yu-Kai; Biel, Martin; Ren, Dejian; Wahl-Schott, Christian und Grimm, Christian
(2017):
Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.
In: Nature Protocols, Bd. 12, Nr. 8: S. 1639-1658
Castonguay, Jan; Orth, Joachim H. C.; Müller, Thomas; Sleman, Faten; Grimm, Christian; Wahl-Schott, Christian; Biel, Martin; Mallmann, Robert Theodor; Bildl, Wolfgang; Schulte, Uwe und Klugbauer, Norbert
(2017):
The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.
In: Scientific Reports, Bd. 7, 10038
[PDF, 4MB]
Herrmann, Stefan; Rajab, Hamsa; Christ, Irina; Schirdewahn, Christoph; Höfler, Daniel; Fischer, Michael J. M.; Bruno, Ariane; Fenske, Stefanie; Gruner, Christian; Kramer, Felix; Wachsmann, Tassilo; Wahl-Schott, Christian; Stieber, Juliane; Biel, Martin und Ludwig, Andreas
(2017):
Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons.
In: Pain, Bd. 158, Nr. 10: S. 2012-2024
Grimm, Christian; Butz, Elisabeth; Chen, Cheng-Chang; Wahl-Schott, Christian und Biel, Martin
(2017):
From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease.
In: Cell Calcium, Bd. 67: S. 148-155
2016
Nguyen, O. N. Phuong; Böhm, Sybille; Gießl, Andreas; Butz, Elisabeth S.; Wolfrum, Uwe; Brandstätter, Johann H.; Wahl-Schott, Christian; Biel, Martin und Becirovic, Elvir
(2016):
Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.
In: Human Molecular Genetics, Bd. 25, Nr. 12: S. 2367-2377
Fenske, Stefanie; Pröbstle, Rasmus; Auer, Franziska; Hassan, Sami; Marks, Vanessa; Pauza, Danius H.; Biel, Martin und Wahl-Schott, Christian
(2016):
Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology.
In: Nature Protocols, Bd. 11, Nr. 1: S. 61-86
Barthmes, Maria; Liao, Jun; Jiang, Youxing; Brüggemann, Andrea und Wahl-Schott, Christian
(2016):
Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology.
In: Journal of General Physiology, Bd. 147, Nr. 6: S. 485-496
Becirovic, Elvir; Böhm, Sybille; Nguyen, Ong N. P.; Riedmayr, Lisa M.; Hammelmann, Verena; Schön, Christian; Butz, Elisabeth S.; Wahl-Schott, Christian; Biel, Martin und Michalakis, Stylianos
(2016):
AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments.
In: Frontiers in Neuroscience, Bd. 10, 356
[PDF, 3MB]
2014
Grimm, Christian; Holdt, Lesca M.; Chen, Cheng-Chang; Hassan, Sami; Müller, Christoph; Jörs, Simone; Cuny, Hartmut; Kissing, Sandra; Schröder, Bernd; Butz, Elisabeth; Northoff, Bernd; Castonguay, Jan; Luber, Christian A.; Moser, Markus; Spahn, Saskia; Luellmann-Rauch, Renate; Fendel, Christina; Klugbauer, Norbert; Griesbeck, Oliver; Haas, Albert; Mann, Matthias; Bracher, Franz; Teupser, Daniel; Saftig, Paul; Biel, Martin und Wahl-Schott, Christian
(2014):
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.
In: Nature Communications, Bd. 5, 4699
[PDF, 3MB]
Soltysinska, Ewa; Bentzen, Bo Hjorth; Barthmes, Maria; Hattel, Helle; Thrush, A. Brianne; Harper, Mary-Ellen; Qvortrup, Klaus; Larsen, Filip J.; Schiffer, Tomas A.; Losa-Reyna, Jose; Straubinger, Julia; Kniess, Angelina; Thomsen, Morten Bækgaard; Brüggemann, Andrea; Fenske, Stefanie; Biel, Martin; Ruth, Peter; Wahl-Schott, Christian; Boushel, Robert Christopher; Olesen, Søren-Peter und Lukowski, Robert
(2014):
KCNMA1 Encoded Cardiac BK Channels Afford Protection against Ischemia-Reperfusion Injury.
In: PLOS ONE 9(7), e103402 [PDF, 1MB]
In: PLOS ONE 9(7), e103402 [PDF, 1MB]
Chen, Cheng-Chang; Keller, Marco; Hess, Martin; Schiffmann, Raphael; Urban, Nicole; Wolfgardt, Annette; Schaefer, Michael; Bracher, Franz; Biel, Martin; Wahl-Schott, Christian und Grimm, Christian
(2014):
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.
In: Nature Communications, Bd. 5, 4681
[PDF, 1MB]