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Anzahl der Publikationen: 15
Zeitschriftenartikel
Wirawan, Ricky 
ORCID: https://orcid.org/0009-0003-6877-3704; Frei, Matthias ORCID: https://orcid.org/0009-0006-4364-0931; Heider, Anna ORCID: https://orcid.org/0009-0004-0285-607X; Papenkordt, Niklas ORCID: https://orcid.org/0000-0003-3420-0695; Friedrich, Florian ORCID: https://orcid.org/0000-0001-5420-6184; Wein, Thomas ORCID: https://orcid.org/0009-0007-0256-7341; Jung, Manfred ORCID: https://orcid.org/0000-0002-6361-7716; Groll, Michael ORCID: https://orcid.org/0000-0002-1660-340X; Huber, Eva M. ORCID: https://orcid.org/0000-0001-8018-7204 und Bracher, Franz ORCID: https://orcid.org/0000-0003-0009-8629
(2025):
Tailored SirReal-type inhibitors enhance SIRT2 inhibition through ligand stabilization and disruption of NAD+ co-factor binding.
In: RSC Medicinal Chemistry [Forthcoming]
ORCID: https://orcid.org/0009-0003-6877-3704; Frei, Matthias ORCID: https://orcid.org/0009-0006-4364-0931; Heider, Anna ORCID: https://orcid.org/0009-0004-0285-607X; Papenkordt, Niklas ORCID: https://orcid.org/0000-0003-3420-0695; Friedrich, Florian ORCID: https://orcid.org/0000-0001-5420-6184; Wein, Thomas ORCID: https://orcid.org/0009-0007-0256-7341; Jung, Manfred ORCID: https://orcid.org/0000-0002-6361-7716; Groll, Michael ORCID: https://orcid.org/0000-0002-1660-340X; Huber, Eva M. ORCID: https://orcid.org/0000-0001-8018-7204 und Bracher, Franz ORCID: https://orcid.org/0000-0003-0009-8629
(2025):
Tailored SirReal-type inhibitors enhance SIRT2 inhibition through ligand stabilization and disruption of NAD+ co-factor binding.
In: RSC Medicinal Chemistry [Forthcoming]
Reynders, Martin ORCID: https://orcid.org/0000-0001-7415-3649; Willems, Sabine ORCID: https://orcid.org/0000-0002-9755-3394; Marschner, Julian A.; Wein, Thomas; Merk, Daniel ORCID: https://orcid.org/0000-0002-5359-8128 und Thorn‐Seshold, Oliver ORCID: https://orcid.org/0000-0003-3981-651X
(2024):
A High‐Quality Photoswitchable Probe that Selectively and Potently Regulates the Transcription Factor RORγ.
In: Angewandte Chemie International Edition, Bd. 63, Nr. 49, e202410139
[PDF, 11MB]
ORCID: https://orcid.org/0000-0001-7415-3649; Willems, Sabine ORCID: https://orcid.org/0000-0002-9755-3394; Marschner, Julian A.; Wein, Thomas; Merk, Daniel ORCID: https://orcid.org/0000-0002-5359-8128 und Thorn‐Seshold, Oliver ORCID: https://orcid.org/0000-0003-3981-651X
(2024):
A High‐Quality Photoswitchable Probe that Selectively and Potently Regulates the Transcription Factor RORγ.
In: Angewandte Chemie International Edition, Bd. 63, Nr. 49, e202410139
[PDF, 11MB]
Reynders, Martin ORCID: https://orcid.org/0000-0001-7415-3649; Willems, Sabine ORCID: https://orcid.org/0000-0002-9755-3394; Marschner, Julian A.; Wein, Thomas; Merk, Daniel ORCID: https://orcid.org/0000-0002-5359-8128 und Thorn‐Seshold, Oliver ORCID: https://orcid.org/0000-0003-3981-651X
(2024):
Eine hochwertige photoschaltbare Sonde, die selektiv und wirksam den Transkriptionsfaktor RORγ moduliert.
In: Angewandte Chemie, Bd. 136, Nr. 49, e202410139
[PDF, 10MB]
ORCID: https://orcid.org/0000-0001-7415-3649; Willems, Sabine ORCID: https://orcid.org/0000-0002-9755-3394; Marschner, Julian A.; Wein, Thomas; Merk, Daniel ORCID: https://orcid.org/0000-0002-5359-8128 und Thorn‐Seshold, Oliver ORCID: https://orcid.org/0000-0003-3981-651X
(2024):
Eine hochwertige photoschaltbare Sonde, die selektiv und wirksam den Transkriptionsfaktor RORγ moduliert.
In: Angewandte Chemie, Bd. 136, Nr. 49, e202410139
[PDF, 10MB]
Arifi, Silvia; Zaienne, Daniel; Heering, Jan; Wein, Thomas; Zhubi, Rezart; Chaikuad, Apirat; Knapp, Stefan; Marschner, Julian A. und Merk, Daniel
(2022):
Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands.
In: Bioorganic Chemistry, Bd. 129, 106164
Gao, Li; Kraus, Yvonne; Stegner, Andrea; Wein, Thomas; Heise, Constanze; Brunn, Leonie von; Fajardo-Ruiz, Elena; Thorn-Seshold, Julia und Thorn-Seshold, Oliver
(2022):
Self-reporting styrylthiazolium photopharmaceuticals: mitochondrial localisation as well as SAR drive biological activity.
In: Organic & Biomolecular Chemistry, Bd. 20, Nr. 39: S. 7787-7794
Wein, Thomas; Wanner, Klaus T.; Rappenglueck, Sebastian; Sichler, Sonja; Niessen, Karin; Seeger, Thomas; Worek, Franz und Thiermann, Horst
(2019):
New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling.
In: Current Computer-Aided Drug Design, Bd. 15, Nr. 1: S. 104-109
Hauke, Tobias J.; Wein, Thomas; Hofner, Georg und Wanner, Klaus T.
(2018):
Novel Allosteric Ligands of gamma-Aminobutyric Acid Transporter 1 (GAT1) by MS Based Screening of Pseudostatic Hydrazone Libraries.
In: Journal of Medicinal Chemistry, Bd. 61, Nr. 22: S. 10310-10332
Lutz, Toni; Wein, Thomas; Höfner, Georg; Pabel, Jörg; Eder, Matthias; Dine, Julien und Wanner, Klaus T.
(2018):
Development of New Photoswitchable Azobenzene Based gamma-Aminobutyric Acid (GABA) Uptake Inhibitors with Distinctly Enhanced Potency upon Photoactivation.
In: Journal of Medicinal Chemistry, Bd. 61, Nr. 14: S. 6211-6235
Wein, Thomas; Höfner, Georg; Rappenglück, Sebastian; Sichler, Sonja; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 293: S. 184-189
Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
In: Chemmedchem, Bd. 13, Nr. 24: S. 2653-2663
Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
In: Chemmedchem, Bd. 13, Nr. 17: S. 1806-1816
Lutz, Toni; Wein, Thomas; Höfner, Georg und Wanner, Klaus T.
(2017):
Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives with N-Arylalkynyl Substituents.
In: ChemMedChem, Bd. 12, Nr. 5: S. 362-371
Petrera, Marilena; Wein, Thomas; Allmendinger, Lars; Sindelar, Miriam; Pabel, Jörg; Höfner, Georg und Wanner, Klaus T.
(2016):
Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives by Suzuki-Miyaura Cross-Coupling Reactions.
In: ChemMedChem, Bd. 11, Nr. 5: S. 519-538
Wein, Thomas; Petrera, Marilena; Allmendinger, Lars; Höfner, Georg; Pabel, Jörg und Wanner, Klaus T.
(2016):
Different Binding Modes of Small and Large Binders of GAT1.
In: ChemMedChem, Bd. 11, Nr. 5: S. 509-518
Hellenbrand, Tim; Höfner, Georg; Wein, Thomas und Wanner, Klaus T.
(2016):
Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors.
In: Bioorganic & Medicinal Chemistry, Bd. 24, Nr. 9: S. 2072-2096