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Eine Ebene höherGruppiert nach: Dokumententyp |
Veröffentlichungsdatum
Anzahl der Publikationen: 35
2024
Zatcepin, Artem 
ORCID: https://orcid.org/0000-0002-0224-088X; Gnörich, Johannes ORCID: https://orcid.org/0000-0003-1554-7765; Rauchmann, Boris-Stephan ORCID: https://orcid.org/0000-0003-4547-6240; Bartos, Laura M.; Wagner, Stephan; Franzmeier, Nicolai ORCID: https://orcid.org/0000-0001-9736-2283; Malpetti, Maura ORCID: https://orcid.org/0000-0001-8923-9656; Xiang, Xianyuan; Shi, Yuan; Parhizkar, Samira; Grosch, Maximilian; Wind-Mark, Karin; Kunte, Sebastian T.; Beyer, Leonie; Meyer, Carolin; Brösamle, Desirée; Wendeln, Ann-Christin; Osei-Sarpong, Collins; Heindl, Steffanie; Liesz, Arthur ORCID: https://orcid.org/0000-0002-9069-2594; Stoecklein, Sophia; Biechele, Gloria; Finze, Anika; Eckenweber, Florian; Lindner, Simon ORCID: https://orcid.org/0009-0007-4379-4436; Rominger, Axel ORCID: https://orcid.org/0000-0002-1954-736X; Bartenstein, Peter ORCID: https://orcid.org/0009-0005-0734-4994; Willem, Michael; Tahirovic, Sabina ORCID: https://orcid.org/0000-0003-4403-9559; Herms, Jochen; Buerger, Katharina; Simons, Mikael ORCID: https://orcid.org/0000-0001-5329-192X; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Rupprecht, Rainer ORCID: https://orcid.org/0000-0003-2939-9062; Riemenschneider, Markus J.; Albert, Nathalie L. ORCID: https://orcid.org/0000-0003-0953-7624; Beyer, Marc; Neher, Jonas J.; Paeger, Lars; Levin, Johannes ORCID: https://orcid.org/0000-0001-5092-4306; Höglinger, Günter U. ORCID: https://orcid.org/0000-0001-7587-6187; Perneczky, Robert ORCID: https://orcid.org/0000-0003-1981-7435; Ziegler, Sibylle I. ORCID: https://orcid.org/0000-0002-5321-4817 und Brendel, Matthias ORCID: https://orcid.org/0000-0002-9247-2843
(2024):
Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease.
In: Molecular Neurodegeneration, Bd. 19, 64
[PDF, 6MB]
ORCID: https://orcid.org/0000-0002-0224-088X; Gnörich, Johannes ORCID: https://orcid.org/0000-0003-1554-7765; Rauchmann, Boris-Stephan ORCID: https://orcid.org/0000-0003-4547-6240; Bartos, Laura M.; Wagner, Stephan; Franzmeier, Nicolai ORCID: https://orcid.org/0000-0001-9736-2283; Malpetti, Maura ORCID: https://orcid.org/0000-0001-8923-9656; Xiang, Xianyuan; Shi, Yuan; Parhizkar, Samira; Grosch, Maximilian; Wind-Mark, Karin; Kunte, Sebastian T.; Beyer, Leonie; Meyer, Carolin; Brösamle, Desirée; Wendeln, Ann-Christin; Osei-Sarpong, Collins; Heindl, Steffanie; Liesz, Arthur ORCID: https://orcid.org/0000-0002-9069-2594; Stoecklein, Sophia; Biechele, Gloria; Finze, Anika; Eckenweber, Florian; Lindner, Simon ORCID: https://orcid.org/0009-0007-4379-4436; Rominger, Axel ORCID: https://orcid.org/0000-0002-1954-736X; Bartenstein, Peter ORCID: https://orcid.org/0009-0005-0734-4994; Willem, Michael; Tahirovic, Sabina ORCID: https://orcid.org/0000-0003-4403-9559; Herms, Jochen; Buerger, Katharina; Simons, Mikael ORCID: https://orcid.org/0000-0001-5329-192X; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Rupprecht, Rainer ORCID: https://orcid.org/0000-0003-2939-9062; Riemenschneider, Markus J.; Albert, Nathalie L. ORCID: https://orcid.org/0000-0003-0953-7624; Beyer, Marc; Neher, Jonas J.; Paeger, Lars; Levin, Johannes ORCID: https://orcid.org/0000-0001-5092-4306; Höglinger, Günter U. ORCID: https://orcid.org/0000-0001-7587-6187; Perneczky, Robert ORCID: https://orcid.org/0000-0003-1981-7435; Ziegler, Sibylle I. ORCID: https://orcid.org/0000-0002-5321-4817 und Brendel, Matthias ORCID: https://orcid.org/0000-0002-9247-2843
(2024):
Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease.
In: Molecular Neurodegeneration, Bd. 19, 64
[PDF, 6MB]
Dunot, Jade; Moreno, Sebastien; Gandin, Carine; Pousinha, Paula A.; Amici, Mascia; Dupuis, Julien; Anisimova, Margarita; Winschel, Alex; Uriot, Magalie; Petshow, Samuel J.; Mensch, Maria; Bethus, Ingrid; Giudici, Camilla; Hampel, Heike; Wefers, Benedikt; Wurst, Wolfgang ORCID: https://orcid.org/0000-0003-4422-7410; Naumann, Ronald; Ashby, Michael C.; Laube, Bodo; Zito, Karen; Mellor, Jack R.; Groc, Laurent; Willem, Michael und Marie, Hélène
(2024):
APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors.
In: Neuron, Bd. 112, Nr. 16, e9: S. 2708-2720
[PDF, 5MB]
ORCID: https://orcid.org/0000-0003-4422-7410; Naumann, Ronald; Ashby, Michael C.; Laube, Bodo; Zito, Karen; Mellor, Jack R.; Groc, Laurent; Willem, Michael und Marie, Hélène
(2024):
APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors.
In: Neuron, Bd. 112, Nr. 16, e9: S. 2708-2720
[PDF, 5MB]
2023
Krammer, Christine; Yang, Bishan; Reichl, Sabrina; Besson‐Girard, Simon ORCID: https://orcid.org/0000-0003-1194-5256; Ji, Hao; Bolini, Verena; Schulte, Corinna; Noels, Heidi; Schlepckow, Kai; Jocher, Georg; Werner, Georg; Willem, Michael; El Bounkari, Omar ORCID: https://orcid.org/0000-0002-3051-2096; Kapurniotu, Aphrodite ORCID: https://orcid.org/0000-0001-6124-7232; Gokce, Ozgun; Weber, Christian; Mohanta, Sarajo ORCID: https://orcid.org/0000-0001-6144-4092 und Bernhagen, Jürgen ORCID: https://orcid.org/0000-0003-2996-2652
(2023):
Pathways linking aging and atheroprotection in Mif‐deficient atherosclerotic mice.
In: The FASEB Journal, Bd. 37, Nr. 3
[PDF, 12MB]
ORCID: https://orcid.org/0000-0003-1194-5256; Ji, Hao; Bolini, Verena; Schulte, Corinna; Noels, Heidi; Schlepckow, Kai; Jocher, Georg; Werner, Georg; Willem, Michael; El Bounkari, Omar ORCID: https://orcid.org/0000-0002-3051-2096; Kapurniotu, Aphrodite ORCID: https://orcid.org/0000-0001-6124-7232; Gokce, Ozgun; Weber, Christian; Mohanta, Sarajo ORCID: https://orcid.org/0000-0001-6144-4092 und Bernhagen, Jürgen ORCID: https://orcid.org/0000-0003-2996-2652
(2023):
Pathways linking aging and atheroprotection in Mif‐deficient atherosclerotic mice.
In: The FASEB Journal, Bd. 37, Nr. 3
[PDF, 12MB]
Njavro, Jasenka Rudan; Vukicevic, Marija; Fiorini, Emma; Dinkel, Lina; Mueller, Stephan A.; Berghofer, Anna; Bordier, Chiara; Kozlov, Stanislav; Halle, Annett; Buschmann, Katrin; Capell, Anja; Giudici, Camilla; Willem, Michael; Feederle, Regina; Lichtenthaler, Stefan F.; Babolin, Chiara; Montanari, Paolo; Pfeifer, Andrea; Kosco-Vilbois, Marie und Tahirovic, Sabina
(2023):
Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model.
In: Cells, Bd. 12, Nr. 1, 79
[PDF, 17MB]
Depp, Constanze; Sun, Ting; Sasmita, Andrew Octavian; Spieth, Lena; Berghoff, Stefan A.; Nazarenko, Taisiia; Overhoff, Katharina; Steixner-Kumar, Agnes A.; Subramanian, Swati; Arinrad, Sahab; Ruhwedel, Torben; Moebius, Wiebke; Goebbels, Sandra; Saher, Gesine; Werner, Hauke B.; Damkou, Alkmini; Zampar, Silvia; Wirths, Oliver; Thalmann, Maik; Simons, Mikael; Saito, Takashi; Saido, Takaomi; Krueger-Burg, Dilja; Kawaguchi, Riki; Willem, Michael; Haass, Christian; Geschwind, Daniel; Ehrenreich, Hannelore; Stassart, Ruth und Nave, Klaus-Armin
(2023):
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease.
In: Nature, Bd. 618, Nr. 7964: S. 349-357
[PDF, 20MB]
Krammer, Christine; Yang, Bishan; Reichl, Sabrina; Besson‐Girard, Simon ORCID: https://orcid.org/0000-0003-1194-5256; Ji, Hao; Bolini, Verena; Schulte, Corinna; Noels, Heidi; Schlepckow, Kai; Jocher, Georg; Werner, Georg; Willem, Michael; El Bounkari, Omar ORCID: https://orcid.org/0000-0002-3051-2096; Kapurniotu, Aphrodite ORCID: https://orcid.org/0000-0001-6124-7232; Gokce, Ozgun; Weber, Christian; Mohanta, Sarajo ORCID: https://orcid.org/0000-0001-6144-4092 und Bernhagen, Jürgen ORCID: https://orcid.org/0000-0003-2996-2652
(2023):
Pathways linking aging and atheroprotection in Mif‐deficient atherosclerotic mice.
In: The FASEB Journal, Bd. 37, Nr. 3
[PDF, 12MB]
ORCID: https://orcid.org/0000-0003-1194-5256; Ji, Hao; Bolini, Verena; Schulte, Corinna; Noels, Heidi; Schlepckow, Kai; Jocher, Georg; Werner, Georg; Willem, Michael; El Bounkari, Omar ORCID: https://orcid.org/0000-0002-3051-2096; Kapurniotu, Aphrodite ORCID: https://orcid.org/0000-0001-6124-7232; Gokce, Ozgun; Weber, Christian; Mohanta, Sarajo ORCID: https://orcid.org/0000-0001-6144-4092 und Bernhagen, Jürgen ORCID: https://orcid.org/0000-0003-2996-2652
(2023):
Pathways linking aging and atheroprotection in Mif‐deficient atherosclerotic mice.
In: The FASEB Journal, Bd. 37, Nr. 3
[PDF, 12MB]
2022
Blume, Tanja; Deussing, Maximilian; Biechele, Gloria; Peters, Finn; Zott, Benedikt; Schmidt, Claudio; Franzmeier, Nicolai; Wind, Karin; Eckenweber, Florian; Sacher, Christian; Shi, Yuan; Ochs, Katharina; Kleinberger, Gernot; Xiang, Xianyuan; Focke, Carola; Lindner, Simon; Gildehaus, Franz-Josef; Beyer, Leonie; von Ungern-Sternberg, Barbara; Bartenstein, Peter; Baumann, Karlheinz; Adelsberger, Helmuth; Rominger, Axel; Cumming, Paul; Willem, Michael; Dorostkar, Mario M.; Herms, Jochen und Brendel, Matthias
(30. März 2022):
Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition.
In: Frontiers in Aging Neuroscience, Bd. 14
[PDF, 7MB]
Biechele, Gloria; Monasor, Laura Sebastian; Wind, Karin; Blume, Tanja; Parhizkar, Samira; Arzberger, Thomas; Sacher, Christian; Beyer, Leonie; Eckenweber, Florian; Gildehaus, Franz-Josef; Ungern-Sternberg, Barbara von; Willem, Michael; Bartenstein, Peter; Cumming, Paul; Rominger, Axel; Herms, Jochen; Lichtenthaler, Stefan F.; Haass, Christian; Tahirovic, Sabina und Brendel, Matthias ORCID: https://orcid.org/0000-0002-9247-2843
(2022):
Glitter in the Darkness? Nonfibrillar beta-Amyloid Plaque Components Significantly Impact the beta-Amyloid PET Signal in Mouse Models of Alzheimer Disease.
In: Journal of Nuclear Medicine, Bd. 63, Nr. 1: S. 117-124
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-9247-2843
(2022):
Glitter in the Darkness? Nonfibrillar beta-Amyloid Plaque Components Significantly Impact the beta-Amyloid PET Signal in Mouse Models of Alzheimer Disease.
In: Journal of Nuclear Medicine, Bd. 63, Nr. 1: S. 117-124
[PDF, 1MB]
Xia, Dan; Lianoglou, Steve; Sandmann, Thomas; Calvert, Meredith; Suh, Jung H.; Thomsen, Elliot; Dugas, Jason; Pizzo, Michelle E.; DeVos, Sarah L.; Earr, Timothy K.; Lin, Chia-Ching; Davis, Sonnet; Ha, Connie; Leung, Amy Wing-Sze; Hoang, Nguyen; Chau, Roni; Yulyaningsih, Ernie; Lopez, Isabel; Solanoy, Hilda; Masoud, Shababa T.; Liang, Chun-chi; Lin, Karin; Astarita, Giuseppe; Khoury, Nathalie; Zuchero, Joy Yu; Thorne, Robert G.; Shen, Kevin; Miller, Stephanie; Palop, Jorge J.; Garceau, Dylan; Sasner, Michael; Whitesell, Jennifer D.; Harris, Julie A.; Hummel, Selina; Gnorich, Johannes; Wind, Karin; Kunze, Lea; Zatcepin, Artem; Brendel, Matthias; Willem, Michael; Haass, Christian; Barnett, Daniel; Zimmer, Till S.; Orr, Anna G.; Scearce-Levie, Kimberly; Lewcock, Joseph W.; Di Paolo, Gilbert und Sanchez, Pascal E.
(2022):
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
In: Molecular Neurodegeneration, Bd. 17, Nr. 1, 41
[PDF, 12MB]
Li, TXiaohang; Ospitalieri, Simona; Robberechts, Tessa; Hofmann, Linda; Schmid, Christina; Upadhaya, Ajeet Rijal; Koper, Marta J.; Arnim, Christine A. F von.; Kumar, Sathish; Willem, Michael; Gnoth, Kathrin; Ramakers, Meine; Schymkowitz, Joost; Rousseau, Frederic; Walter, Jochen; Ronisz, Alicja; Balakrishnan, Karthikeyan und Thal, Dietmar Rudolf
(2022):
Seeding, maturation and propagation of amyloid beta-peptide aggregates in Alzheimer's disease.
In: Brain, Bd. 145, Nr. 10: S. 3558-3570
2021
Vitale, Paola; Salgueiro-Pereira, Ana Rita; Lupascu, Carmen Alina; Willem, Michael; Migliore, Rosanna; Migliore, Michele und Marie, Helene
(11. Juni 2021):
Analysis of Age-Dependent Alterations in Excitability Properties of CA1 Pyramidal Neurons in an APPPS1 Model of Alzheimer’s Disease.
In: Frontiers in Aging Neuroscience, Bd. 13, 668948
[PDF, 4MB]
Xiang, Xianyuan; Wind, Karin; Wiedemann, Thomas; Blume, Tanja; Shi, Yuan; Briel, Nils; Beyer, Leonie; Biechele, Gloria; Eckenweber, Florian; Zatcepin, Artem; Lammich, Sven; Ribicic, Sara; Tahirovic, Sabina; Willem, Michael; Deussing, Maximilian; Palleis, Carla; Rauchmann, Boris-Stephan; Gildehaus, Franz-Josef; Lindner, Simon; Spitz, Charlotte; Franzmeier, Nicolai; Baumann, Karlheinz; Rominger, Axel; Bartenstein, Peter; Ziegler, Sibylle; Drzezga, Alexander; Respondek, Gesine; Buerger, Katharina; Perneczky, Robert; Levin, Johannes; Hoeglinger, Guenter U.; Herms, Jochen; Haass, Christian und Brendel, Matthias
(2021):
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases.
In: Science Translational Medicine, Bd. 13, Nr. 615, eabe5640
Mensch, Maria; Dunot, Jade; Yishan, Sandy M.; Harris, Samuel S.; Blistein, Aline; Avdiu, Alban; Pousinha, Paula A.; Giudici, Camilla; Busche, Marc Aurel; Jedlicka, Peter; Willem, Michael und Marie, Helene
(2021):
A eta-alpha and A eta-beta peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo.
In: Alzheimer's Research & Therapy, Bd. 13, Nr. 1, 125
[PDF, 1MB]
Hampel, Harald; Vassar, Robert; De Strooper, Bart; Hardy, John; Willem, Michael; Singh, Neeraj; Zhou, John; Yan, Riqiang; Vanmechelen, Eugeen; De Vos, Ann; Nistico, Robert; Corbo, Massimo; Imbimbo, Bruno Pietro; Streffer, Johannes; Voytyuk, Iryna; Timmers, Maarten; Monfared, Amir Abbas Tahami; Irizarry, Michael; Albala, Bruce; Koyama, Akihiko; Watanabe, Naoto; Kimura, Teiji; Yarenis, Lisa; Lista, Simone; Kramer, Lynn und Vergallo, Andrea
(2021):
The beta-Secretase BACE1 in Alzheimer's Disease.
In: Biological Psychiatry, Bd. 89, Nr. 8: S. 745-756
Biechele, Gloria; Wind, Karin; Blume, Tanja; Sacher, Christian; Beyer, Leonie; Eckenweber, Florian; Franzmeier, Nicolai; Ewers, Michael; Zott, Benedikt; Lindner, Simon; Gildehaus, Franz-Josef; Ungern-Sternberg, Barbara von; Tahirovic, Sabina; Willem, Michael; Bartenstein, Peter; Cumming, Paul; Rominger, Axel; Herms, Jochen und Brendel, Matthias
(2021):
Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in mice.
In: Neuroimage, Bd. 230, 117707
[PDF, 2MB]
Biechele, Gloria; Blume, Tanja; Deussing, Maximilian; Zott, Benedikt; Shi, Yuan; Xiang, Xianyuan; Franzmeier, Nicolai; Kleinberger, Gernot; Peters, Finn; Ochs, Katharina; Focke, Carola; Sacher, Christian; Wind, Karin; Schmidt, Claudio; Lindner, Simon; Gildehaus, Franz-Josef; Eckenweber, Florian; Beyer, Leonie; Ungern-Sternberg, Barbara von; Bartenstein, Peter; Baumann, Karlheinz; Dorostkar, Mario M.; Rominger, Axel; Cumming, Paul; Willem, Michael; Adelsberger, Helmuth; Herms, Jochen und Brendel, Matthias
(2021):
Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation.
In: Theranostics, Bd. 11, Nr. 18: S. 8964-8976
[PDF, 1MB]
2020
Schlepckow, Kai; Monroe, Kathryn M.; Kleinberger, Gernot; Cantuti‐Castelvetri, Ludovico; Parhizkar, Samira; Xia, Dan; Willem, Michael; Werner, Georg; Pettkus, Nadine; Brunner, Bettina; Sülzen, Alice; Nuscher, Brigitte; Hampel, Heike; Xiang, Xianyuan; Feederle, Regina; Tahirovic, Sabina; Park, Joshua I.; Prorok, Rachel; Mahon, Cathal; Liang, Chun‐Chi; Shi, Ju; Kim, Do Jin; Sabelström, Hanna; Huang, Fen; Paolo, Gilbert di; Simons, Mikael; Lewcock, Joseph W. und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(7. April 2020):
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
, Bd. 12, Nr. 4, e11227
[PDF, 4MB]
ORCID: https://orcid.org/0000-0002-4869-1627
(7. April 2020):
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
, Bd. 12, Nr. 4, e11227
[PDF, 4MB]
Monasor, Laura Sebastian; Müller, Stephan A.; Colombo, Alessio Vittorio; Tanrioever, Gaye; König, Jasmin; Roth, Stefan; Liesz, Arthur; Berghofer, Anna; Piechotta, Anke; Prestel, Matthias; Saito, Takashi; Saido, Takaomi C.; Herms, Jochen; Willem, Michael; Haass, Christian; Lichtenthaler, Stefan F. und Tahirovic, Sabina
(2020):
Fibrillar Aβ (beta) triggers microglial proteome alterations and dysfunction in Alzheimer mouse models.
In: eLife, Bd. 9, e54083
[PDF, 14MB]
Sacher, Christian; Blume, Tanja; Beyer, Leonie; Biechele, Gloria; Sauerbeck, Julia; Eckenweber, Florian; Deussing, Maximilian; Focke, Carola; Parhizkar, Samira; Lindner, Simon; Gildehaus, Franz-Josef; Ungern-Sternberg, Barbara von; Baumann, Karlheinz; Tahirovic, Sabina; Kleinberger, Gernot; Willem, Michael; Haass, Christian; Bartenstein, Peter; Cumming, Paul; Rominger, Axel; Herms, Jochen und Brendel, Matthias
(2020):
Asymmetry of Fibrillar Plaque Burden in Amyloid Mouse Models.
In: Journal of Nuclear Medicine, Bd. 61, Nr. 12
[PDF, 1MB]
Mohammadi, Behnam; Linsenmeier, Luise; Shafiq, Mohsin; Puig, Berta; Galliciotti, Giovanna; Giudici, Camilla; Willem, Michael; Eden, Thomas; Koch-Nolte, Friedrich; Lin, Yu-Hsuan; Tatzelt, Jörg; Glatzel, Markus und Altmeppen, Hermann C.
(2020):
Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation.
In: Molecular Neurobiology, Bd. 57, Nr. 6: S. 2812-2829
2019
Parhizkar, Samira; Arzberger, Thomas; Brendel, Matthias; Kleinberger, Gernot; Deussing, Maximilian; Focke, Carola; Nuscher, Brigitte; Xiong, Monica; Ghasemigharagoz, Alireza; Katzmarski, Natalie; Krasemann, Susanne; Lichtenthaler, Stefan F.; Müller, Stephan A.; Colombo, Alessio; Monasor, Laura Sebastian; Tahirovic, Sabina; Herms, Jochen; Willem, Michael; Pettkus, Nadine; Butovsky, Oleg; Bartenstein, Peter; Edbauer, Dieter; Rominger, Axel; Ertuerk, Ali; Grathwohl, Stefan A.; Neher, Jonas J.; Holtzman, David M.; Meyer-Luehmann, Melanie und Haass, Christian
(2019):
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
In: Nature Neuroscience, Bd. 22, Nr. 2
[PDF, 6MB]
Vnencak, Matej; Schoelvinck, Marieke L.; Schwarzacher, Stephan W.; Deller, Thomas; Willem, Michael und Jedlicka, Peter
(2019):
Lack of -amyloid cleaving enzyme-1 (BACE1) impairs long-term synaptic plasticity but enhances granule cell excitability and oscillatory activity in the dentate gyrus in vivo.
In: Brain Structure & Function, Bd. 224, Nr. 3: S. 1279-1290
Gomes, Luis Aragao; Hipp, Silvia Andrea; Upadhaya, Ajeet Rijal; Balakrishnan, Karthikeyan; Ospitalieri, Simona; Koper, Marta J.; Largo-Barrientos, Pablo; Uytterhoeven, Valerie; Reichwald, Julia; Rabe, Sabine; Vandenberghe, Rik; Arnim, Christine A. F. von; Tousseyn, Thomas; Feederle, Regina; Giudici, Camilla; Willem, Michael; Staufenbiel, Matthias und Thal, Dietmar Rudolf
(2019):
A beta-induced acceleration of Alzheimer-related tau-pathology spreading and its association with prion protein.
In: Acta Neuropathologica, Bd. 138, Nr. 6: S. 913-941
Voeglein, Jonathan; Willem, Michael; Trambauer, Johannes; Schönecker, Sonja; Dieterich, Marianne und Biskup, Saskia
(2019):
Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-beta processing effects.
In: Neurobiology of Aging, Bd. 84, 241.e5-241.e11
[PDF, 597kB]
Haass, Christian und Willem, Michael
(2019):
Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?
In: Neuron, Bd. 101, Nr. 4: S. 557-559
2018
Brendel, Matthias; Jaworska, Anna; Overhoff, Felix; Blume, Tanja; Probst, Federico; Gildehaus, Franz-Josef; Bartenstein, Peter; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Bohrmann, Bernd; Herms, Jochen; Willem, Michael und Rominger, Axel
(2018):
Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional A beta deposition rate and plaque burden at treatment initiation.
In: Theranostics, Bd. 8, Nr. 18: S. 4957-4968
[PDF, 3MB]
ORCID: https://orcid.org/0000-0002-4869-1627; Bohrmann, Bernd; Herms, Jochen; Willem, Michael und Rominger, Axel
(2018):
Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional A beta deposition rate and plaque burden at treatment initiation.
In: Theranostics, Bd. 8, Nr. 18: S. 4957-4968
[PDF, 3MB]
Krämer, Lara Maria; Brettschneider, Johannes; Lennerz, Jochen K.; Walcher, Daniel; Fang, Lubin; Rosenbohm, Angela; Balakrishnan, Karthikeyan; Benckendorff, Julian; Moller, Peter; Just, Steffen; Willem, Michael; Ludolph, Albert C. und Thal, Dietmar Rudolf
(2018):
Amyloid precursor protein-fragments-containing inclusions in cardiomyocytes with basophilic degeneration and its association with cerebral amyloid angiopathy and myocardial fibrosis.
In: Scientific Reports, Bd. 8, 16594 (2018): S. 1-14
[PDF, 5MB]
Hong, Wei; Wang, Zemin; Liu, Wen; O'Malley, Tiernan T.; Jin, Ming; Willem, Michael; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Frosch, Matthew P. und Walsh, Dominic M.
(2018):
Diffusible, highly bioactive oligomers represent a critical minority of soluble A beta in Alzheimer's disease brain.
In: Acta Neuropathologica, Bd. 136, Nr. 1: S. 19-40
ORCID: https://orcid.org/0000-0002-4869-1627; Frosch, Matthew P. und Walsh, Dominic M.
(2018):
Diffusible, highly bioactive oligomers represent a critical minority of soluble A beta in Alzheimer's disease brain.
In: Acta Neuropathologica, Bd. 136, Nr. 1: S. 19-40
2017
Pousinha, Paula A.; Mouska, Xavier; Raymond, Elisabeth F.; Gwizdek, Carole; Dhib, Gihen; Poupon, Gwenola; Zaragosi, Laure-Emmanuelle; Giudici, Camilla; Bethus, Ingrid; Pacary, Emilie; Willem, Michael und Marie, Helene
(2017):
Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein.
In: Elife, Bd. 6, e25659
[PDF, 4MB]
Seipold, Lisa; Damme, Markus; Prox, Johannes; Rabe, Björn; Kasparek, Petr; Sedlacek, Radislav; Altmeppen, Hermann; Willem, Michael; Boland, Barry; Glatzel, Markus und Saftig, Paul
(2017):
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.
In: Biochimica et Biophysica Acta-Molecular Cell Research, Bd. 1864, Nr. 1: S. 217-230
Daria, Anna; Colombo, Alessio; Llovera, Gemma; Hampel, Heike; Willem, Michael; Liesz, Arthur; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627 und Tahirovic, Sabina
(2017):
Young microglia restore amyloid plaque clearance of aged microglia.
In: Embo Journal, Bd. 36, Nr. 5: S. 583-603
ORCID: https://orcid.org/0000-0002-4869-1627 und Tahirovic, Sabina
(2017):
Young microglia restore amyloid plaque clearance of aged microglia.
In: Embo Journal, Bd. 36, Nr. 5: S. 583-603
2016
Willem, Michael
(2016):
Proteolytic processing of Neuregulin-1.
In: Brain Research Bulletin, Bd. 126: S. 178-182
Fleck, Daniel; Voss, Matthias; Brankatschk, Ben; Giudici, Camilla; Hampel, Heike; Schwenk, Benjamin; Edbauer, Dieter; Fukumori, Akio; Steiner, Harald; Kremmer, Elisabeth; Haug-Kröper, Martina; Rossner, Moritz J.; Fluhrer, Regina; Willem, Michael und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2016):
Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.
In: Journal of Biological Chemistry, Bd. 291, Nr. 1: S. 318-333
ORCID: https://orcid.org/0000-0002-4869-1627
(2016):
Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.
In: Journal of Biological Chemistry, Bd. 291, Nr. 1: S. 318-333
Ben Halima, Saoussen; Mishra, Sabyashachi; Raja, K. Muruga Poopathi; Willem, Michael; Baici, Antonio; Simons, Kai; Bruestle, Oliver; Koch, Philipp; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Caflisch, Amedeo und Rajendran, Lawrence
(2016):
Specific Inhibition of beta-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.
In: Cell Reports, Bd. 14, Nr. 9: S. 2127-2141
[PDF, 13MB]
ORCID: https://orcid.org/0000-0002-4869-1627; Caflisch, Amedeo und Rajendran, Lawrence
(2016):
Specific Inhibition of beta-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.
In: Cell Reports, Bd. 14, Nr. 9: S. 2127-2141
[PDF, 13MB]
2009
Itoh, Naohiro; Okochi, Masayasu; Tagami, Shinji; Nishitomi, Kouhei; Nakayama, Taisuke; Yanagida, Kanta; Fukumori, Akio; Jiang, Jingwei; Mori, Kohji; Hosono, Motoko; Kikuchi, Jyunko; Nakano, Yuko; Takinami, Yoshihiko; Dohi, Keiji; Nishigaki, Atsuko; Takemoto, Hiroshi; Minagawa, Kazuyuki; Katoh, Takaaki; Willem, Michael; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Morihara, Takashi; Tanaka, Toshihisa; Kudo, Takashi; Hasegawa, Hiroshi; Nishimura, Masaki; Sakaguchi, Gaku; Kato, Akira und Takeda, Masatoshi
(2009):
Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor.
In: Neurodegenerative Diseases, Nr. 5-6: S. 230-239
[PDF, 556kB]
ORCID: https://orcid.org/0000-0002-4869-1627; Morihara, Takashi; Tanaka, Toshihisa; Kudo, Takashi; Hasegawa, Hiroshi; Nishimura, Masaki; Sakaguchi, Gaku; Kato, Akira und Takeda, Masatoshi
(2009):
Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor.
In: Neurodegenerative Diseases, Nr. 5-6: S. 230-239
[PDF, 556kB]