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Veröffentlichungsdatum
Anzahl der Publikationen: 21
2024
Sichler, Sonja; Höfner, Georg 
ORCID: https://orcid.org/0000-0002-7957-4503; Nitsche, Valentin; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Paintner, Franz F. und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 394: S. 23-31
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-7957-4503; Nitsche, Valentin; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Paintner, Franz F. und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 394: S. 23-31
[PDF, 2MB]
Bernauer, Tamara; Nitsche, Valentin; Kaiser, Jesko; Gertzen, Christoph G.W.; Höfner, Georg ORCID: https://orcid.org/0000-0002-7957-4503; Niessen, Karin V.; Seeger, Thomas; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425 und Paintner, Franz F.
(2024):
Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents.
In: Toxicology Letters, Bd. 397: S. 151-162
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-7957-4503; Niessen, Karin V.; Seeger, Thomas; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425 und Paintner, Franz F.
(2024):
Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents.
In: Toxicology Letters, Bd. 397: S. 151-162
[PDF, 2MB]
Nitsche, Valentin; Höfner, Georg; Kaiser, Jesko; Gertzen, Christoph G.W.; Seeger, Thomas; Niessen, Karin V.; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Paintner, Franz F. und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 392: S. 94-106
[PDF, 4MB]
ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 392: S. 94-106
[PDF, 4MB]
2022
Kaiser, Jesko; Gertzen, Christoph G. W.; Bernauer, Tamara; Hoefner, Georg; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Wanner, Klaus T.; Worek, Franz; Thiermann, Horst und Gohlke, Holger
(2022):
A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment.
In: Toxicology Letters, Bd. 373: S. 160-171
2021
Stigler, Lisa; Köhler, Anja; Koller, Marianne; Job, Laura; Escher, Benjamin; Potschka, Heidrun; Thiermann, Horst; Skerra, Arne; Worek, Franz und Wille, Timo
(2021):
Post-VX exposure treatment of rats with engineered phosphotriesterases.
In: Archives of Toxicology, Bd. 96, Nr. 2: S. 571-583
2019
Wein, Thomas; Wanner, Klaus T.; Rappenglueck, Sebastian; Sichler, Sonja; Niessen, Karin; Seeger, Thomas; Worek, Franz und Thiermann, Horst
(2019):
New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling.
In: Current Computer-Aided Drug Design, Bd. 15, Nr. 1: S. 104-109
2018
Scheffel, Corinna; Niessen, Karin V.; Rappenglück, Sebastian; Wanner, Klaus T.; Thiermann, Horst; Worek, Franz und Seeger, Thomas
(2018):
Counteracting desensitization of human alpha 7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning.
In: Toxicology Letters, Bd. 293: S. 149-156
Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
In: Chemmedchem, Bd. 13, Nr. 17: S. 1806-1816
Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
In: Chemmedchem, Bd. 13, Nr. 24: S. 2653-2663
Wein, Thomas; Höfner, Georg; Rappenglück, Sebastian; Sichler, Sonja; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 293: S. 184-189
Scheffel, Corinna; Niessen, Karin V.; Rappenglück, Sebastian; Wanner, Klaus. T.; Thiermann, Horst; Worek, Franz und Seeger, Thomas
(2018):
Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human alpha 7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis.
In: Toxicology Letters, Bd. 293: S. 157-166
Rothmiller, Simone; Schröder, Sarah; Strobelt, Romano; Wolf, Markus; Wang, Jin; Jiang, Xiqian; Worek, Franz; Steinritz, Dirk; Thiermann, Horst und Schmidt, Annette
(2018):
Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism.
In: Toxicology Letters, Bd. 293: S. 51-61
Rothmiller, Simone; Wolf, Markus; Worek, Franz; Steinritz, Dirk; Thiermann, Horst und Schmidt, Annette
(2018):
Alteration of miRNA expression in a sulfur mustard resistant cell line.
In: Toxicology Letters, Bd. 293: S. 38-44
Menacher, Georg; Steinritz, Dirk; Schmidt, Annette; Popp, Tanja; Worek, Franz; Gudermann, Thomas; Thiermann, Horst und Balszuweit, Frank
(2018):
Effects of anti-inflammatory compounds on sulfur mustard injured cells: Recommendations and caveats suggested by in vitro cell culture models.
In: Toxicology Letters, Bd. 293: S. 91-97
Schmidt, Annette; Wolf, Markus; Rothmiller, Simone; Worek, Franz; Steinritz, Dirk und Thiermann, Horst
(2018):
Cytostatic resistance profile of the sulfur mustard resistant keratinocyte cell line HaCaT/SM.
In: Toxicology Letters, Bd. 293: S. 16-20
Popp, Tanja; Lueling, Robin; Boekhoff, Ingrid; Seeger, Thomas; Branoner, Francisco; Gudermann, Thomas; Thiermann, Horst; Worek, Franz und Steinritz, Dirk
(2018):
Immediate responses of the cockroach Blaptica dubia after the exposure to sulfur mustard.
In: Archives of Toxicology, Bd. 92, Nr. 1: S. 337-346
2017
Rappenglück, Sebastian; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2017):
Regioselective and Transition-Metal-Free Addition of tert-Butyl Magnesium Reagents to Pyridine Derivatives: A Convenient Method for the Synthesis of 3-Substituted 4-tert-Butylpyridine Derivatives.
In: Synthesis-Stuttgart, Bd. 49, Nr. 17: S. 4055-4064
2016
Wolf, Markus; Siegert, Markus; Rothmiller, Simone; Scheithauer, Nina; Strobelt, Romano; Steinritz, Dirk; Worek, Franz; Thiermann, Horst und Schmidt, Annette
(2016):
Characterization of sulfur mustard resistant keratinocyte cell line HaCaT/SM.
In: Toxicology Letters, Bd. 244: S. 49-55
Balszuweit, Frank; Menacher, Georg; Schmidt, Annette; Kehe, Kai; Popp, Tanja; Worek, Franz; Thiermann, Horst und Steinritz, Dirk
(2016):
Protective effects of the thiol compounds GSH and NAC against sulfur mustard toxicity in a human keratinocyte cell line.
In: Toxicology Letters, Bd. 244: S. 35-43
Steinritz, Dirk; Eyer, Florian; Worek, Franz; Thiermann, Horst und John, Harald
(2016):
Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report.
In: Toxicology Letters, Bd. 244: S. 121-123
2009
Eddleston, Michael; Eyer, Peter; Worek, Franz; Juszczak, Edmund; Alder, Nicola; Mohamed, Fahim; Senarathna, Lalith; Hittarage, Ariyasena; Azher, Shifa; Jeganathan, K.; Jayamanne, Shaluka; Meyer, Ludwig von; Dawson, Andrew H.; Sheriff, Mohamed Hussain Rezvi und Buckley, Nick A.
(Juni 2009):
Pralidoxime in Acute Organophosphorus Insecticide Poisoning-A Randomised Controlled Trial.
In: PLOS Medicine 6(6), e1000104 [PDF, 427kB]
In: PLOS Medicine 6(6), e1000104 [PDF, 427kB]