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Gruppiert nach: Dokumententyp | Veröffentlichungsdatum
Anzahl der Publikationen: 21

Zeitschriftenartikel

Sichler, Sonja; Höfner, Georg ORCID logoORCID: https://orcid.org/0000-0002-7957-4503; Nitsche, Valentin; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Paintner, Franz F. und Wanner, Klaus T. ORCID logoORCID: https://orcid.org/0000-0003-4399-1425 (2024): Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor. In: Toxicology Letters, Bd. 394: S. 23-31 [PDF, 2MB]

Bernauer, Tamara; Nitsche, Valentin; Kaiser, Jesko; Gertzen, Christoph G.W.; Höfner, Georg ORCID logoORCID: https://orcid.org/0000-0002-7957-4503; Niessen, Karin V.; Seeger, Thomas; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Wanner, Klaus T. ORCID logoORCID: https://orcid.org/0000-0003-4399-1425 und Paintner, Franz F. (2024): Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents. In: Toxicology Letters, Bd. 397: S. 151-162 [PDF, 2MB]

Nitsche, Valentin; Höfner, Georg; Kaiser, Jesko; Gertzen, Christoph G.W.; Seeger, Thomas; Niessen, Karin V.; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Paintner, Franz F. und Wanner, Klaus T. ORCID logoORCID: https://orcid.org/0000-0003-4399-1425 (2024): MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor. In: Toxicology Letters, Bd. 392: S. 94-106 [PDF, 4MB]

Kaiser, Jesko; Gertzen, Christoph G. W.; Bernauer, Tamara; Hoefner, Georg; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Wanner, Klaus T.; Worek, Franz; Thiermann, Horst und Gohlke, Holger (2022): A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment. In: Toxicology Letters, Bd. 373: S. 160-171

Stigler, Lisa; Köhler, Anja; Koller, Marianne; Job, Laura; Escher, Benjamin; Potschka, Heidrun; Thiermann, Horst; Skerra, Arne; Worek, Franz und Wille, Timo (2021): Post-VX exposure treatment of rats with engineered phosphotriesterases. In: Archives of Toxicology, Bd. 96, Nr. 2: S. 571-583

Wein, Thomas; Wanner, Klaus T.; Rappenglueck, Sebastian; Sichler, Sonja; Niessen, Karin; Seeger, Thomas; Worek, Franz und Thiermann, Horst (2019): New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling. In: Current Computer-Aided Drug Design, Bd. 15, Nr. 1: S. 104-109

Scheffel, Corinna; Niessen, Karin V.; Rappenglück, Sebastian; Wanner, Klaus T.; Thiermann, Horst; Worek, Franz und Seeger, Thomas (2018): Counteracting desensitization of human alpha 7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning. In: Toxicology Letters, Bd. 293: S. 149-156

Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T. (2018): Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor. In: Chemmedchem, Bd. 13, Nr. 17: S. 1806-1816

Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T. (2018): Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor. In: Chemmedchem, Bd. 13, Nr. 24: S. 2653-2663

Wein, Thomas; Höfner, Georg; Rappenglück, Sebastian; Sichler, Sonja; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst und Wanner, Klaus T. (2018): Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor. In: Toxicology Letters, Bd. 293: S. 184-189

Scheffel, Corinna; Niessen, Karin V.; Rappenglück, Sebastian; Wanner, Klaus. T.; Thiermann, Horst; Worek, Franz und Seeger, Thomas (2018): Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human alpha 7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis. In: Toxicology Letters, Bd. 293: S. 157-166

Rothmiller, Simone; Schröder, Sarah; Strobelt, Romano; Wolf, Markus; Wang, Jin; Jiang, Xiqian; Worek, Franz; Steinritz, Dirk; Thiermann, Horst und Schmidt, Annette (2018): Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism. In: Toxicology Letters, Bd. 293: S. 51-61

Rothmiller, Simone; Wolf, Markus; Worek, Franz; Steinritz, Dirk; Thiermann, Horst und Schmidt, Annette (2018): Alteration of miRNA expression in a sulfur mustard resistant cell line. In: Toxicology Letters, Bd. 293: S. 38-44

Menacher, Georg; Steinritz, Dirk; Schmidt, Annette; Popp, Tanja; Worek, Franz; Gudermann, Thomas; Thiermann, Horst und Balszuweit, Frank (2018): Effects of anti-inflammatory compounds on sulfur mustard injured cells: Recommendations and caveats suggested by in vitro cell culture models. In: Toxicology Letters, Bd. 293: S. 91-97

Schmidt, Annette; Wolf, Markus; Rothmiller, Simone; Worek, Franz; Steinritz, Dirk und Thiermann, Horst (2018): Cytostatic resistance profile of the sulfur mustard resistant keratinocyte cell line HaCaT/SM. In: Toxicology Letters, Bd. 293: S. 16-20

Popp, Tanja; Lueling, Robin; Boekhoff, Ingrid; Seeger, Thomas; Branoner, Francisco; Gudermann, Thomas; Thiermann, Horst; Worek, Franz und Steinritz, Dirk (2018): Immediate responses of the cockroach Blaptica dubia after the exposure to sulfur mustard. In: Archives of Toxicology, Bd. 92, Nr. 1: S. 337-346

Rappenglück, Sebastian; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst und Wanner, Klaus T. (2017): Regioselective and Transition-Metal-Free Addition of tert-Butyl Magnesium Reagents to Pyridine Derivatives: A Convenient Method for the Synthesis of 3-Substituted 4-tert-Butylpyridine Derivatives. In: Synthesis-Stuttgart, Bd. 49, Nr. 17: S. 4055-4064

Wolf, Markus; Siegert, Markus; Rothmiller, Simone; Scheithauer, Nina; Strobelt, Romano; Steinritz, Dirk; Worek, Franz; Thiermann, Horst und Schmidt, Annette (2016): Characterization of sulfur mustard resistant keratinocyte cell line HaCaT/SM. In: Toxicology Letters, Bd. 244: S. 49-55

Balszuweit, Frank; Menacher, Georg; Schmidt, Annette; Kehe, Kai; Popp, Tanja; Worek, Franz; Thiermann, Horst und Steinritz, Dirk (2016): Protective effects of the thiol compounds GSH and NAC against sulfur mustard toxicity in a human keratinocyte cell line. In: Toxicology Letters, Bd. 244: S. 35-43

Steinritz, Dirk; Eyer, Florian; Worek, Franz; Thiermann, Horst und John, Harald (2016): Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report. In: Toxicology Letters, Bd. 244: S. 121-123

Eddleston, Michael; Eyer, Peter; Worek, Franz; Juszczak, Edmund; Alder, Nicola; Mohamed, Fahim; Senarathna, Lalith; Hittarage, Ariyasena; Azher, Shifa; Jeganathan, K.; Jayamanne, Shaluka; Meyer, Ludwig von; Dawson, Andrew H.; Sheriff, Mohamed Hussain Rezvi und Buckley, Nick A. (Juni 2009): Pralidoxime in Acute Organophosphorus Insecticide Poisoning-A Randomised Controlled Trial.
In: PLOS Medicine 6(6), e1000104 [PDF, 427kB]

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