Horizon 2020 > Marie Skłodowska Curie Actions > Marie Skłodowska-Curie Innovative Training Networks > 675074: PIPPI - Protein-excipient Interactions and Protein-Protein Interactions in formulation

2020

Svilenov, Hristo ORCID: 0000-0001-5863-9569 (January 2020): Orthogonal techniques to study the effect of pH, sucrose and arginine salts on monoclonal antibody physical stability and aggregation during long-term storage. In: Journal of Pharmaceutical Sciences [Forthcoming] [PDF, 2MB]

Tosstorff, Andreas ORCID: 0000-0002-4969-3667; Menzen, Tim; Winter, Gerhard ORCID: 0000-0002-7413-6627 (January 2020): Exploring Chemical Space for new Substances to stabilize a therapeutic Monoclonal Antibody. In: Journal of Pharmaceutical Sciences [PDF, 1MB]

2019

Gentiluomo, Lorenzo; Roessner, Dierk; Augustijn, Dillen; Svilenov, Hristo ORCID: 0000-0001-5863-9569; Kulakova, Alina; Mahapatra, Sujata; Winter, Gerhard; Streicher, Werner; Rinnan, Asmund; Peters, Günther; Harris, Pernille; Friess, Wolfgang (August 2019): Application of interpretable artificial neural networks to early monoclonal antibodies development. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 141: pp. 81-89 [PDF, 1MB]

Svilenov, Hristo ORCID: 0000-0001-5863-9569; Winter, Gerhard (1. May 2019): Rapid sample-saving biophysical characterisation and long-term storage stability of liquid interferon alpha2a formulations Is there a correlation? In: International Journal of Pharmaceutics, Vol. 562: pp. 42-50 [PDF, 1MB]

Svilenov, Hristo ORCID: 0000-0001-5863-9569; Winter, Gerhard (April 2019): The ReFOLD assay for protein formulation studies and prediction of protein aggregation during long-term storage. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 137: pp. 131-139 [PDF, 2MB]

Tosstorff, Andreas ORCID: 0000-0002-4969-3667; Svilenov, Hristo ORCID: 0000-0001-5863-9569; Peters, Günther H. J.; Harris, Pernille; Winter, Gerhard ORCID: 0000-0002-7413-6627 (12. September 2019): Structure-based Discovery of a new Protein-Aggregation Breaking Excipient. In: European Journal of Pharmaceutics and Biopharmaceutics [HTML, 1MB]

2018

Svilenov, Hristo ORCID: 0000-0001-5863-9569; Gentiluomo, Lorenzo; Friess, Wolfgang; Roessner, Dierk; Winter, Gerhard (December 2018): A New Approach to Study the Physical Stability of Monoclonal Antibody Formulations Dilution From a Denaturant. In: Journal of Pharmaceutical Sciences, Vol. 107, No. 12: pp. 3007-3013 [PDF, 1MB]

Svilenov, Hristo ORCID: 0000-0001-5863-9569; Markoja, Uros; Winter, Gerhard (April 2018): Isothermal chemical denaturation as a complementary tool to overcome limitations of thermal differential scanning fluorimetry in predicting physical stability of protein formulations. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 125: pp. 106-113 [PDF, 1MB]