T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis

Kedia, Shreeya; Ji, Hao; Feng, Ruoqing; Androvic, Peter; Spieth, Lena; Liu, Lu ; Franz, Jonas ; Zdiarstek, Hanna ; Anderson, Katrin Perez; Kaboglu, Cem ; Liu, Qian; Mattugini, Nicola; Cherif, Fatma; Prtvar, Danilo ; Cantuti-Castelvetri, Ludovico ; Liesz, Arthur ; Schifferer, Martina ; Stadelmann, Christine ; Tahirovic, Sabina ; Gokce, Ozgun und Simons, Mikael (2024): T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis. In: Nature Neuroscience, Bd. 27, Nr. 8: S. 1468-1474

Abstract

Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer’s disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Adolf-Butenandt-Institut ; Medizin > Munich Cluster for Systems Neurology (SyNergy) ; Medizin > Institut für Schlaganfall- und Demenzforschung (ISD)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1097-6256
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198