Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease

Hofmann, Anna; Häsler, Lisa M.; Lambert, Marius; Kaeser, Stephan A. ; Gräber-Sultan, Susanne; Obermüller, Ulrike; Kuder-Buletta, Elke; La Fougere, Christian ; Laske, Christoph; Vöglein, Jonathan ; Levin, Johannes ; Fox, Nick C. ; Ryan, Natalie S.; Zetterberg, Henrik ; Llibre-Guerra, Jorge J. ; Perrin, Richard J. ; Ibanez, Laura; Schofield, Peter R. ; Brooks, William S. ; Day, Gregory S. ; Farlow, Martin R. ; Allegri, Ricardo F. ; Chrem Mendez, Patricio; Ikeuchi, Takeshi ; Kasuga, Kensaku ; Lee, Jae-Hong; Roh, Jee Hoon ; Mori, Hiroshi; Lopera, Francisco ; Bateman, Randall J. ; McDade, Eric; Gordon, Brian A. ; Chhatwal, Jasmeer P. ; Jucker, Mathias und Schultz, Stephanie A. (2024): Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease. In: Nature Communications, Bd. 15, 9982

Abstract

Disease-modifying therapies for Alzheimer’s disease (AD) are likely to be most beneficial when initiated in the presymptomatic phase. To track the benefit of such interventions, fluid biomarkers are of great importance, with neurofilament light chain protein (NfL) showing promise for monitoring neurodegeneration and predicting cognitive outcomes. Here, we update and complement previous findings from the Dominantly Inherited Alzheimer Network Observational Study by using matched cross-sectional and longitudinal cerebrospinal fluid (CSF) and plasma samples from 567 individuals, allowing timely comparative analyses of CSF and blood trajectories across the entire disease spectrum. CSF and plasma trajectories were similar at presymptomatic stages, discriminating mutation carriers from non-carrier controls 10-20 years before the estimated onset of clinical symptoms, depending on the statistical model used. However, after symptom onset the rate of change in CSF NfL continued to increase steadily, whereas the rate of change in plasma NfL leveled off. Both plasma and CSF NfL changes were associated with grey-matter atrophy, but not with Aβ-PET changes, supporting a temporal decoupling of Aβ deposition and neurodegeneration. These observations support NfL in both CSF and blood as an early marker of neurodegeneration but suggest that NfL measured in the CSF may be better suited for monitoring clinical trial outcomes in symptomatic AD patients.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy) ; Medizin > Institut für Schlaganfall- und Demenzforschung (ISD) ; Medizin > Klinikum der LMU München > Neurologische Klinik und Poliklinik mit Friedrich-Baur-Institut
• Fakultätsübergreifende Einrichtungen: Center for Advanced Studies (CAS)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 2041-1723
• Bemerkung: with the Dominantly Inherited Alzheimer Network; a complete list of all authors are available within the article
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198