Vestibular dysfunction: a hidden risk factor for Alzheimer’s disease

Koriath, Carolin Anna Maria ; Rauchmann, Boris S ; Schöberl, Florian; Zwergal, Andreas ; Falkai, Peter und Perneczky, Robert (2025): Vestibular dysfunction: a hidden risk factor for Alzheimer’s disease. In: Journal of Neurology, Bd. 272, Nr. 285

Abstract

Background: London taxi drivers’ navigationally challenged hippocampi are known to be enlarged, and reduced Alzheimer’s disease (AD)-related mortality has recently been shown in similarly well-versed drivers, implying a neuroprotective effect through hippocampal engagement. Vestibular function has been linked to hippocampal size, suggesting that vestibular input may influence AD risk.

Methods: Including 16 known modifiable lifestyle factors as covariates, we analyzed UK Biobank (UKB) volunteers aged over 55 years and without dementia at baseline to assess how peripheral vestibular dysfunction (PVD) influences the likelihood of an AD diagnosis.

Results: 4684 AD and 2133 PVD cases were identified based on their ICD diagnoses; even accounting for other risk factors, PVD increased the risk of AD 1.7 times in UKB volunteers.

Discussion: Vestibular loss, linked to hippocampal atrophy and default mode network disruption, appears to increase AD risk. Consequently, active vestibular stimulation by balance training or neuromodulation could offer potential for modifying AD progression.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy) ; Medizin > Klinikum der LMU München > Neurologische Klinik und Poliklinik mit Friedrich-Baur-Institut ; Medizin > Klinikum der LMU München > Klinik und Poliklink für Psychiatrie und Psychotherapie
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0340-5354
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198