Abstract
Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas. For hypothesis-driven phenotypic analyses, there are thirteen additional pipelines with focus on neurological and behavioral disorders, metabolic dysfunction, respiratory system malfunctions, immune-system disorders and imaging techniques. In this article, we give an overview of the pipelines and describe the scientific rationale behind the different test combinations.
Item Type: | Journal article |
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Faculties: | Medicine > Adolf Butenandt Institute Chemistry and Pharmacy > Department of Biochemistry |
Subjects: | 600 Technology > 610 Medicine and health 500 Science > 540 Chemistry |
ISSN: | 0166-4328 |
Language: | English |
Item ID: | 62885 |
Date Deposited: | 19. Jul 2019, 12:11 |
Last Modified: | 04. Nov 2020, 13:40 |