ALKBH5-induced demethylation of mono- and dimethylated adenosine

Ensfelder, Timm T.; Kurz, Matthias Q.; Iwan, Katharina; Geiger, Simon; Matheisl, Sarah; Müller, Markus; Beckmann, Roland und Carell, Thomas (2018): ALKBH5-induced demethylation of mono- and dimethylated adenosine. In: Chemical Communications, Bd. 54, Nr. 62: S. 8591-8593

Abstract

RNA contains methylated A-base derivatives. A methylation to m(6)A and then demethylation regulate homeostasis in mRNA. It is assumed that m(6)A is mainly demethylated by the -ketoglutarate dependent oxidase ALKBH5. Here we show that ALKBH5 also demethylates the dimethylated adenosine m(2)(6)A, which is a non-canonical base present in ribosomal RNA.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie ; Chemie und Pharmazie > Department Biochemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1359-7345
• Sprache: Englisch