ALKBH5-induced demethylation of mono- and dimethylated adenosine

Ensfelder, Timm T.; Kurz, Matthias Q.; Iwan, Katharina; Geiger, Simon; Matheisl, Sarah; Müller, Markus; Beckmann, Roland und Carell, Thomas (2018): ALKBH5-induced demethylation of mono- and dimethylated adenosine. In: Chemical Communications, Vol. 54, No. 62: pp. 8591-8593

Abstract

RNA contains methylated A-base derivatives. A methylation to m(6)A and then demethylation regulate homeostasis in mRNA. It is assumed that m(6)A is mainly demethylated by the -ketoglutarate dependent oxidase ALKBH5. Here we show that ALKBH5 also demethylates the dimethylated adenosine m(2)(6)A, which is a non-canonical base present in ribosomal RNA.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry; Chemistry and Pharmacy > Department of Biochemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1359-7345
• Language: English