A set of rhamnosylation-specific antibodies enables detection of novel protein glycosylations in bacteria

Gast, Daniel; Koller, Franziska; Krafczyk, Ralph; Bauer, Lukas; Wunder, Swetlana; Lassak, Jürgen und Hoffmann-Roeder, Anja (2020): A set of rhamnosylation-specific antibodies enables detection of novel protein glycosylations in bacteria. In: Organic & Biomolecular Chemistry, Bd. 18, Nr. 35: S. 6823-6828

Abstract

Despite its potential importance for bacterial virulence, protein rhamnosylation has not yet been sufficiently studied. Specificanti-Ser(Rha),anti-Thr(Rha)andanti-Asn(Rha)antibodies allowed the identification of previously unknown monorhamnosylated proteins in cytosol and membrane fractions of bacterial cell lysates. Mapping of the complete rhamnoproteome in pathogens should facilitate development of targeted therapies against bacterial infections.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie ; Katholische Theologie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie ; 200 Religion > 200 Religion
• ISSN: 1477-0520
• Sprache: Englisch