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Anzahl der Publikationen: 82
Zeitschriftenartikel
Stock, Sophia 
ORCID: https://orcid.org/0000-0002-5072-5013; Klüver, Anna‐Kristina; Fertig, Luisa; Menkhoff, Vivien D.; Subklewe, Marion; Endres, Stefan und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2023):
Mechanisms and strategies for safe chimeric antigen receptor T‐cell activity control.
In: International Journal of Cancer, Bd. 153, Nr. 10: S. 1706-1725
[PDF, 4MB]
ORCID: https://orcid.org/0000-0002-5072-5013; Klüver, Anna‐Kristina; Fertig, Luisa; Menkhoff, Vivien D.; Subklewe, Marion; Endres, Stefan und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2023):
Mechanisms and strategies for safe chimeric antigen receptor T‐cell activity control.
In: International Journal of Cancer, Bd. 153, Nr. 10: S. 1706-1725
[PDF, 4MB]
Marcinek, Anetta; Brauchle, Bettina; Rohrbacher, Lisa; Hänel, Gerulf; Philipp, Nora; Märkl, Florian; Strzalkowski, Thaddäus; Lacher, Sonja M.; Udiljak, Dragica; Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957; Theurich, Sebastian; Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673; Kischel, Roman; James, John R.; Bücklein, Veit L. und Subklewe, Marion ORCID: https://orcid.org/0000-0001-9154-9469
(2023):
CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells.
In: Cancer Immunology, Immunotherapy, Bd. 72, Nr. 7: S. 2499-2512
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-5139-4957; Theurich, Sebastian; Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673; Kischel, Roman; James, John R.; Bücklein, Veit L. und Subklewe, Marion ORCID: https://orcid.org/0000-0001-9154-9469
(2023):
CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells.
In: Cancer Immunology, Immunotherapy, Bd. 72, Nr. 7: S. 2499-2512
[PDF, 1MB]
Michaelides, Stefanos; Obeck, Hannah; Kechur, Daryna; Endres, Stefan und Kobold, Sebastian
(2022):
Migratory Engineering of T Cells for Cancer Therapy.
In: Vaccines, Bd. 10, Nr. 11, 1845
Spix, Barbara; Butz, Elisabeth S.; Chen, Cheng-Chang; Rosato, Anna Scotto; Tang, Rachel; Jeridi, Aicha; Kudrina, Veronika; Plesch, Eva; Wartenberg, Philipp; Arlt, Elisabeth; Briukhovetska, Daria; Ansari, Meshal; Günsel, Gizem Günes; Conlon, Thomas M.; Wyatt, Amanda; Wetzel, Sandra; Teupser, Daniel; Holdt, Lesca M.; Ectors, Fabien; Boekhoff, Ingrid; Boehm, Ulrich; García-Añoveros, Jaime; Saftig, Paul; Giera, Martin; Kobold, Sebastian; Schiller, Herbert B.; Zierler, Susanna; Gudermann, Thomas; Wahl-Schott, Christian; Bracher, Franz; Yildirim, Ali Önder; Biel, Martin und Grimm, Christian
(2022):
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
In: Nature Communications, Bd. 13, 318
[PDF, 3MB]
Huynh, Duc; Winter, Pia; Märkl, Florian; Endres, Stefan und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2022):
Beyond direct killing-novel cellular immunotherapeutic strategies to reshape the tumor microenvironment.
In: Seminars in Immunopathology, Bd. 45, Nr. 2: S. 215-227
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-5612-4673
(2022):
Beyond direct killing-novel cellular immunotherapeutic strategies to reshape the tumor microenvironment.
In: Seminars in Immunopathology, Bd. 45, Nr. 2: S. 215-227
[PDF, 1MB]
Lesch, Stefanie; Nottebrock, Alessia; Rataj, Felicitas; Heise, Constanze; Endres, Stefan und Kobold, Sebastian
(2022):
PD-1-CD28 fusion protein strengthens mesothelin-specific TRuC T cells in preclinical solid tumor models.
In: Cellular Oncology, Bd. 46, Nr. 1: S. 227-235
[PDF, 1MB]
Seifert, Matthias; Benmebarek, Mohamed-Reda; Briukhovetska, Daria; Märkl, Florian; Dörr, Janina; Cadilha, Bruno L.; Jobst, Jakob; Stock, Sophia ORCID: https://orcid.org/0000-0002-5072-5013; Andreu-Sanz, David; Lorenzini, Theo; Grünmeier, Ruth ORCID: https://orcid.org/0000-0002-9044-3600; Oner, Arman; Obeck, Hannah; Majed, Lina; Dhoqina, Dario; Feinendegen, Manouk; Gottschlich, Adrian ORCID: https://orcid.org/0000-0002-2898-4182; Zhang, Jin; Schindler, Ulrike; Endres, Stefan ORCID: https://orcid.org/0000-0002-4703-537X und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2022):
Impact of the selective A2(A)R and A2(B)R dual antagonist AB928/etrumadenant on CAR T cell function.
In: British Journal of Cancer, Bd. 127, Nr. 12: S. 2175-2185
[PDF, 845kB]
ORCID: https://orcid.org/0000-0002-5072-5013; Andreu-Sanz, David; Lorenzini, Theo; Grünmeier, Ruth ORCID: https://orcid.org/0000-0002-9044-3600; Oner, Arman; Obeck, Hannah; Majed, Lina; Dhoqina, Dario; Feinendegen, Manouk; Gottschlich, Adrian ORCID: https://orcid.org/0000-0002-2898-4182; Zhang, Jin; Schindler, Ulrike; Endres, Stefan ORCID: https://orcid.org/0000-0002-4703-537X und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2022):
Impact of the selective A2(A)R and A2(B)R dual antagonist AB928/etrumadenant on CAR T cell function.
In: British Journal of Cancer, Bd. 127, Nr. 12: S. 2175-2185
[PDF, 845kB]
Dalloul, Iman; Strzalkowski, Thaddaeus Jan Clemens; Bergwelt-Baildon, Michael von; Nuessler, Volkmar; Zielinski, Christoph und Kobold, Sebastian
(2022):
9th Immunotherapy of Cancer conference (ITOC): A meeting report.
In: Human Vaccines & Immunotherapeutics, Bd. 18, Nr. 7
[PDF, 631kB]
Blaeschke, Franziska; Ortner, Eva; Stenger, Dana; Mahdawi, Jasmin; Apfelbeck, Antonia; Habjan, Nicola; Weisser, Tanja; Käuferle, Theresa; Willier, Semjon; Kobold, Sebastian und Feuchtinger, Tobias
(2022):
Design and Evaluation of TIM-3-CD28 Checkpoint Fusion Proteins to Improve Anti-CD19 CAR T-Cell Function.
In: Frontiers in Immunology, Bd. 13
[PDF, 2MB]
Stock, Sophia ORCID: https://orcid.org/0000-0002-5072-5013; Benmebarek, Mohamed-Reda ORCID: https://orcid.org/0000-0002-1201-7067; Kluever, Anna-Kristina ORCID: https://orcid.org/0000-0001-6246-6082; Darowski, Diana ORCID: https://orcid.org/0000-0002-8778-7920; Jost, Christian ORCID: https://orcid.org/0000-0002-4169-5879; Stubenrauch, Kay-Gunnar; Benz, Joerg; Freimoser-Grundschober, Anne ORCID: https://orcid.org/0000-0001-5715-3639; Moessner, Ekkehard; Umana, Pablo; Subklewe, Marion ORCID: https://orcid.org/0000-0001-9154-9469; Endres, Stefan ORCID: https://orcid.org/0000-0002-4703-537X; Klein, Christian ORCID: https://orcid.org/0000-0001-7594-7280 und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2022):
Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors.
In: Journal for ImmunoTherapy of Cancer, Bd. 10, Nr. 7, e005054
[PDF, 17MB]
ORCID: https://orcid.org/0000-0002-5072-5013; Benmebarek, Mohamed-Reda ORCID: https://orcid.org/0000-0002-1201-7067; Kluever, Anna-Kristina ORCID: https://orcid.org/0000-0001-6246-6082; Darowski, Diana ORCID: https://orcid.org/0000-0002-8778-7920; Jost, Christian ORCID: https://orcid.org/0000-0002-4169-5879; Stubenrauch, Kay-Gunnar; Benz, Joerg; Freimoser-Grundschober, Anne ORCID: https://orcid.org/0000-0001-5715-3639; Moessner, Ekkehard; Umana, Pablo; Subklewe, Marion ORCID: https://orcid.org/0000-0001-9154-9469; Endres, Stefan ORCID: https://orcid.org/0000-0002-4703-537X; Klein, Christian ORCID: https://orcid.org/0000-0001-7594-7280 und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2022):
Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors.
In: Journal for ImmunoTherapy of Cancer, Bd. 10, Nr. 7, e005054
[PDF, 17MB]
Tokarew, Nicholas J.A.; Gosálvez, Javier Suárez; Nottebrock, Alessia; Briukhovestka, Daria; Endres, Stefan ORCID: https://orcid.org/0000-0002-4703-537X; Cadilha, Bruno L. und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2022):
Flow cytometry detection and quantification of CAR T cells into solid tumors.
In: Methods in Cell Biology, Bd. 167: S. 99-122
ORCID: https://orcid.org/0000-0002-4703-537X; Cadilha, Bruno L. und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2022):
Flow cytometry detection and quantification of CAR T cells into solid tumors.
In: Methods in Cell Biology, Bd. 167: S. 99-122
Dezfouli, Ali Bashiri; Yazdi, Mina; Benmebarek, Mohamed-Reda; Schwab, Melissa; Michaelides, Stefanos; Micciche, Arianna; Geerts, Dirk; Stangl, Stefan; Klapproth, Sarah; Wagner, Ernst; Kobold, Sebastian und Multhoff, Gabriele
(2022):
CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells.
In: Frontiers in Immunology, Bd. 13, 883694
Kandra, Prameela; Nandigama, Rajender; Eul, Bastian; Huber, Magdalena; Kobold, Sebastian; Seeger, Werner; Grimminger, Friedrich und Savai, Rajkumar
(2022):
Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer.
In: Frontiers in Immunology, Bd. 13, 903562
Kolorz, Julian; Demir, Salih; Gottschlich, Adrian; Beirith, Iris; Ilmer, Matthias; Luethy, Daniel; Walz, Christoph; Dorostkar, Mario M.; Magg, Thomas; Hauck, Fabian; Schweinitz, Dietrich von; Kobold, Sebastian; Kappler, Roland und Berger, Michael
(2022):
The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors.
In: Current Oncology, Bd. 29, Nr. 1: S. 94-110
Dorman, Klara; Heinemann, Volker; Kobold, Sebastian; Bergwelt-Baildon, Michael von und Boeck, Stefan
(2022):
Novel systemic treatment approaches for metastatic pancreatic cancer.
In: Expert Opinion on Investigational Drugs, Bd. 31, Nr. 3: S. 249-262
Demel, Uta M.; Boeger, Marlitt; Yousefian, Schayan; Grunert, Corinna; Zhang, Le; Hotz, Paul W.; Gottschlich, Adrian; Koese, Hazal; Isaakidis, Konstandina; Vonficht, Dominik; Gruenschlaeger, Florian; Rohleder, Elena; Wagner, Kristina; Doenig, Judith; Igl, Veronika; Brzezicha, Bernadette; Baumgartner, Francis; Habringer, Stefan; Loeber, Jens; Chapuy, Bjoern; Weidinger, Carl; Kobold, Sebastian; Haas, Simon; Busse, Antonia B.; Mueller, Stefan; Wirth, Matthias; Schick, Markus und Keller, Ulrich
(2022):
Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
In: Journal of Clinical Investigation, Bd. 132, Nr. 9, e152383
Markl, Florian; Huynh, Duc; Endres, Stefan und Kobold, Sebastian
(2022):
Utilizing chemokines in cancer immunotherapy.
In: Trends in Cancer, Bd. 8, Nr. 8: S. 670-682
Dickopf, Steffen; Buldun, Can; Vasic, Vedran; Georges, Guy; Hage, Carina; Mayer, Klaus; Forster, Matthias; Wessels, Uwe; Stubenrauch, Kay-Gunnar; Benz, Jörg; Ehler, Andreas; Lauer, Matthias E.; Ringler, Philippe; Kobold, Sebastian; Endres, Stefan; Klein, Christian und Brinkmann, Ulrich
(2022):
Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies.
In: Biological Chemistry, Bd. 403, Nr. 5-6: S. 495-508
Stock, Sophia; Kluever, Anna-Kristina; Endres, Stefan und Kobold, Sebastian
(2022):
Enhanced Chimeric Antigen Receptor T Cell Therapy through Co-Application of Synergistic Combination Partners.
In: Biomedicines, Bd. 10, Nr. 2, 307
Mabrouk, Nesrine; Tran, Thi; Sam, Ikuan; Pourmir, Ivan; Gruel, Nadege; Granier, Clemence; Pineau, Josephine; Gey, Alain; Kobold, Sebastian; Fabre, Elizabeth und Tartour, Eric
(2022):
CXCR6 expressing T cells: Functions and role in the control of tumors.
In: Frontiers in Immunology, Bd. 13, 1022136
Brand, Isabel; Gilberg, Leonard; Bruger, Jan; Gari, Merce; Wieser, Andreas; Eser, Tabea M.; Frese, Jonathan; Ahmed, Mohamed I. M.; Rubio-Acero, Raquel; Guggenbuehl Noller, Jessica M.; Castelletti, Noemi; Diekmannshemke, Jana; Thiesbrummel, Sophie; Huynh, Duc; Winter, Simon; Kroidl, Inge; Fuchs, Christiane; Hoelscher, Michael; Roider, Julia; Kobold, Sebastian; Pritsch, Michael und Geldmacher, Christof
(20. Mai 2021):
Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release Assay.
In: Frontiers in Immunology, Bd. 12, 688436
[PDF, 980kB]
Linder, Andreas; Bothe, Viktoria; Linder, Nicolas; Schwarzlmueller, Paul; Dahlstrom, Frank; Bartenhagen, Christoph; Dugas, Martin; Pandey, Dharmendra; Thorn-Seshold, Julia; Boehmer, Daniel F. R.; Koenig, Lars M.; Kobold, Sebastian; Schnurr, Max; Raedler, Johannes; Spielmann, Giulia; Karimzadeh, Hadi; Schmidt, Andreas; Endres, Stefan und Rothenfusser, Simon
(30. April 2021):
Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner.
In: Frontiers in Immunology, Bd. 12, 595390
[PDF, 2MB]
Karaki, Soumaya; Blanc, Charlotte; Tran, Thi; Galy-Fauroux, Isabelle; Mougel, Alice; Dransart, Estelle; Anson, Marie; Tanchot, Corinne; Paolini, Lea; Gruel, Nadege; Gibault, Laure; Lepimpec-Barhes, Francoise; Fabre, Elizabeth; Benhamouda, Nadine; Badoual, Cecile; Damotte, Diane; Donnadieu, Emmanuel; Kobold, Sebastian; Mami-Chouaib, Fathia; Golub, Rachel; Johannes, Ludger und Tartour, Eric
(2021):
CXCR6 deficiency impairs cancer vaccine efficacy and CD8(+) resident memory T-cell recruitment in head and neck and lung tumors.
In: Journal for Immunotherapy of Cancer, Bd. 9, Nr. 3, e001948
Gottschlich, Adrian; Endres, Stefan und Kobold, Sebastian
(2021):
Therapeutic Strategies for Targeting IL-1 in Cancer.
In: Cancers, Bd. 13, Nr. 3, 477
Di Pilato, Mauro; Kfuri-Rubens, Raphael; Pruessmann, Jasper N.; Ozga, Aleksandra J.; Messemaker, Marius; Cadilha, Bruno L.; Sivakumar, Ramya; Cianciaruso, Chiara; Warner, Ross D.; Marangoni, Francesco; Carrizosa, Esteban; Lesch, Stefanie; Billingsley, James; Perez-Ramos, Daniel; Zavala, Fidel; Rheinbay, Esther; Luster, Andrew D.; Gerner, Michael Y.; Kobold, Sebastian; Pittet, Mikael J. und Mempel, Thorsten R.
(2021):
CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment.
In: Cell, Bd. 184, Nr. 17, e22: S. 4512-4530
Darwich, Abbass; Silvestri, Alessandra; Benmebarek, Mohamed-Reda; Mouries, Juliette; Cadilha, Bruno; Melacarne, Alessia; Morelli, Lapo; Supino, Domenico; Taleb, Alexandre; Obeck, Hannah; Sustmann, Claudio; Losurdo, Agnese; Masci, Giovanna; Curigliano, Giuseppe; Kobold, Sebastian; Penna, Giuseppe und Rescigno, Maria
(2021):
Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1.
In: Journal for Immunotherapy of Cancer, Bd. 9, Nr. 11, e003224
Cadilha, Bruno L.; Benmebarek, Mohamed-Reda; Dorman, Klara; Oner, Arman; Lorenzini, Theo; Obeck, Hannah; Vaenttinen, Mira; Di Pilato, Mauro; Pruessmann, Jasper N.; Stoiber, Stefan; Duc, Huynh; Maerkl, Florian; Seifert, Matthias; Manske, Katrin; Suarez-Gosalvez, Javier; Zeng, Yi; Lesch, Stefanie; Karches, Clara H.; Heise, Constanze; Gottschlich, Adrian; Thomas, Moritz; Marr, Carsten; Zhang, Jin; Pandey, Dharmendra; Feuchtinger, Tobias; Subklewe, Marion; Mempel, Thorsten R.; Endres, Stefan und Kobold, Sebastian
(2021):
Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors.
In: Science Advances, Bd. 7, Nr. 24, eabi5781
Briukhovetska, Dania; Dorr, Janina; Endres, Stefan; Libby, Peter; Dinarello, Charles A. und Kobold, Sebastian
(2021):
Interleukins in cancer: from biology to therapy.
In: Nature Reviews Cancer, Bd. 21, Nr. 8: S. 481-499
Benmebarek, Mohamed-Reda; Cadilha, Bruno L.; Herrmann, Monika; Lesch, Stefanie; Schmitt, Saskia; Stoiber, Stefan; Darwich, Abbass; Augsberger, Christian; Brauchle, Bettina; Rohrbacher, Lisa; Oner, Arman; Seifert, Matthias; Schwerdtfeger, Melanie; Gottschlich, Adrian; Rataj, Felicitas; Fenn, Nadja C.; Klein, Christian; Subklewe, Marion; Endres, Stefan; Hopfner, Karl-Peter und Kobold, Sebastian
(2021):
A modular and controllable T cell therapy platform for acute myeloid leukemia.
In: Leukemia, Bd. 35, Nr. 8: S. 2243-2257
Bashiri Dezfouli, Ali; Yazdi, Mina; Pockley, Alan Graham; Khosravi, Mohammad; Kobold, Sebastian; Wagner, Ernst und Multhoff, Gabriele
(2021):
NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development.
In: Cells, Bd. 10, Nr. 12, 3390
Benmebarek, Mohamed-Reda; Cadilha, Bruno L.; Herrmann, Monika; Lesch, Stefanie; Schmitt, Saskia; Stoiber, Stefan; Darwich, Abbass; Augsberger, Christian; Brauchle, Bettina; Rohrbacher, Lisa; Oner, Arman; Seifert, Matthias; Schwerdtfeger, Melanie; Gottschlich, Adrian; Rataj, Felicitas; Fenn, Nadja C.; Klein, Christian ORCID: https://orcid.org/0000-0001-7594-7280; Subklewe, Marion; Endres, Stefan; Hopfner, Karl-Peter ORCID: https://orcid.org/0000-0002-4528-8357 und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2021):
A modular and controllable T cell therapy platform for acute myeloid leukemia.
In: Leukemia, Bd. 35: S. 2243-2257
[PDF, 5MB]
ORCID: https://orcid.org/0000-0001-7594-7280; Subklewe, Marion; Endres, Stefan; Hopfner, Karl-Peter ORCID: https://orcid.org/0000-0002-4528-8357 und Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673
(2021):
A modular and controllable T cell therapy platform for acute myeloid leukemia.
In: Leukemia, Bd. 35: S. 2243-2257
[PDF, 5MB]
Lesch, Stefanie; Blumenberg, Viktoria; Stoiber, Stefan; Gottschlich, Adrian; Ogonek, Justyna; Cadilha, Bruno L.; Dantes, Zahra; Rataj, Felicitas; Dorman, Klara; Lutz, Johannes; Karches, Clara H.; Heise, Constanze; Kurzay, Mathias; Larimer, Benjamin M.; Grassmann, Simon; Rapp, Moritz; Nottebrock, Alessia; Kruger, Stephan; Tokarew, Nicholas; Metzger, Philipp; Hoerth, Christine; Benmebarek, Mohamed-Reda; Dhoqina, Dario; Grunmeier, Ruth; Seifert, Matthias; Oener, Arman; Umut, Oyku; Joaquina, Sandy; Vimeux, Lene; Tran, Thi; Hank, Thomas; Baba, Taisuke; Huynh, Duc; Megens, Remco T. A.; Janssen, Klaus-Peter; Jastroch, Martin; Lamp, Daniel; Ruehland, Svenja; Di Pilato, Mauro; Pruessmann, Jasper N.; Thomas, Moritz; Marr, Carsten; Ormanns, Steffen; Reischer, Anna; Hristov, Michael; Tartour, Eric; Donnadieu, Emmanuel; Rothenfusser, Simon; Duewell, Peter; Konig, Lars M.; Schnurr, Max; Subklewe, Marion; Liss, Andrew S.; Halama, Niels; Reichert, Maximilian; Mempel, Thorsten R.; Endres, Stefan und Kobold, Sebastian
(2021):
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
In: Nature Biomedical Engineering, Bd. 5, Nr. 11
Patton, E. Elizabeth; Mueller, Kristen L.; Adams, David J.; Anandasabapathy, Niroshana; Aplin, Andrew E.; Bertolotto, Corine; Bosenberg, Marcus; Ceo, Craig J.; Burd, Christin E.; Chi, Ping; Herlyn, Meenhard; Holmen, Sheri L.; Karreth, Florian A.; Kaufman, Charles K.; Khan, Shaheen; Kobold, Sebastian; Leucci, Eleonora; Levy, Carmit; Lombard, David B.; Lund, Amanda W.; Marie, Kerrie L.; Marine, Jean-Christophe; Marais, Richard; McMahon, Martin; Robles-Espinoza, Carla Daniela; Ronai, Ze'ev A.; Samuels, Yardena; Soengas, Maria S.; Villanueva, Jessie; Weeraratna, Ashani T.; White, Richard M.; Yeh, Iwei; Zhu, Jiyue; Zon, Leonard I.; Hurlbert, Marc S. und Merlino, Glenn
(2021):
Melanoma models for the next generation of therapies.
In: Cancer Cell, Bd. 39, Nr. 5: S. 610-631
Prokopi, Anastasia; Tripp, Christoph H.; Tummers, Bart; Hornsteiner, Florian; Spoeck, Sarah; Crawford, Jeremy Chase; Clements, Derek R.; Efremova, Mirjana; Hutter, Katharina; Bellmann, Lydia; Cappellano, Giuseppe; Cadilha, Bruno L.; Kobold, Sebastian; Boon, Louis; Ortner, Daniela; Trajanoski, Zlatko; Chen, Suzie; de Gruijl, Tanja D.; Idoyaga, Juliana; Green, Douglas R. und Stoitzner, Patrizia
(2021):
Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy.
In: Journal for Immunotherapy of Cancer, Bd. 9, Nr. 1, e000832
Schneider, Marcel Andre; Heeb, Laura; Beffinger, Michal Mateusz; Pantelyushin, Stanislav; Linecker, Michael; Roth, Lilian; Lehmann, Kuno; Ungethum, Udo; Kobold, Sebastian; Graf, Rolf; Broek, Maries van den; Vom Berg, Johannes; Gupta, Anurag und Clavien, Pierre-Alain
(2021):
Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models.
In: Science Translational Medicine, Bd. 13, Nr. 611, eabc8188
Schwerdtfeger, Melanie; Benmebarek, Mohamed-Reda; Endres, Stefan; Subklewe, Marion; Desiderio, Vincenzo und Kobold, Sebastian
(2021):
Chimeric Antigen Receptor-Modified T Cells and T Cell-Engaging Bispecific Antibodies: Different Tools for the Same Job.
In: Current Hematologic Malignancy Reports, Bd. 16, Nr. 2: S. 218-233
Schwerdtfeger, Melanie; Desiderio, Vincenzo; Kobold, Sebastian; Regard, Tarik; Zappavigna, Silvia und Caraglia, Michele
(2021):
Long non-coding RNAs in cancer stem cells.
In: Translational Oncology, Bd. 14, Nr. 8, 101134
Schwerdtfeger, Melanie; Benmebarek, Mohamed-Reda; Endres, Stefan; Subklewe, Marion; Desiderio, Vincenzo und Kobold, Sebastian
(2021):
Chimeric Antigen Receptor-Modified T Cells and T Cell-Engaging Bispecific Antibodies: Different Tools for the Same Job.
In: Current hematologic malignancy reports, Bd. 16, Nr. 2: S. 218-233
[PDF, 1MB]
Umut, Öykü; Gottschlich, Adrian; Endres, Stefan und Kobold, Sebastian
(2021):
CAR T cell therapy in solid tumors: a short review.
In: memo - Magazine of European Medical Oncology, Bd. 14, Nr. 2: S. 143-149
[PDF, 448kB]
Umut, Oyku; Gottschlich, Adrian; Endres, Stefan und Kobold, Sebastian
(2021):
CAR T cell therapy in solid tumors: a short review.
In: Memo-Magazine of European Medical Oncology, Bd. 14, Nr. 2: S. 143-149
Pinto, Catarina; Bergmann, Michael; Briukhovetska, Daria; Nuessler, Volkmar; Sznol, Mario; Bergwelt-Baildon, Michael von und Kobold, Sebastian
(2020):
Sixth Immunotherapy of Cancer conference (ITOC): advances and perspectives-a meeting report.
In: Journal for Immunotherapy of Cancer, Bd. 8, Nr. 1, e000268
Lesch, Stefanie; Benmebarek, Mohamed-Reda; Cadilha, Bruno L.; Stoiber, Stefan; Subklewe, Marion; Endres, Stefan und Kobold, Sebastian
(2020):
Determinants of response and resistance to CAR T cell therapy.
In: Seminars in Cancer Biology, Bd. 65: S. 80-90
Stenger, Dana; Stief, Tanja A.; Kaeuferle, Theresa; Willier, Semjon; Rataj, Felicitas; Schober, Kilian; Vick, Binje; Lotfi, Ramin; Wagner, Beate; Grünewald, Thomas G. P.; Kobold, Sebastian; Busch, Dirk H.; Jeremias, Irmela; Blaeschke, Franziska und Feuchtinger, Tobias
(2020):
Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR.
In: Blood, Bd. 136, Nr. 12: S. 1407-1418
Kobold, Sebastian und Reck, Martin
(2020):
Interleukin-1β und pro-tumorale Inflammation – Zentrale Faktoren bei der Entstehung von Krebserkrankungen.
In: Oncology Research and Treatment, Bd. 43, Nr. SUPPL 3: S. 6-12
Geiger, Martina; Stubenrauch, Kay-Gunnar; Sam, Johannes; Richter, Wolfgang F.; Jordan, Gregor; Eckmann, Jan; Hage, Carina; Nicolini, Valeria; Freimoser-Grundschober, Anne; Ritter, Mirko; Lauer, Matthias E.; Stahlberg, Henning; Ringler, Philippe; Patel, Jigar; Sullivan, Eric; Grau-Richards, Sandra; Endres, Stefan; Kobold, Sebastian; Umana, Pablo; Bruenker, Peter und Klein, Christian
(2020):
Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody.
In: Nature Communications, Bd. 11, Nr. 1, 3196
[PDF, 3MB]
Ruzicka, Michael; König, Lars M.; Formisano, Simone; Boehmer, Daniel F. R.; Vick, Binje; Heuer, Eva-M.; Meinl, Hanna; Kocheise, Lorenz; Zeitlhoefler, Marcus; Ahlfeld, Julia; Kobold, Sebastian; Endres, Stefan; Subklewe, Marion; Duewell, Peter; Schnurr, Max; Jeremias, Irmela; Lichtenegger, Felix S. und Rothenfusser, Simon
(2020):
RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade.
In: Leukemia, Bd. 34, Nr. 4: S. 1017-1026
Kruger, Stephan F.; Cadilha, Bruno L.; Bergwelt‐Baildon, Michael von; Endres, Stefan und Kobold, Sebastian
(2020):
Challenges in Clinical Trial Design for T Cell‐Based Cancer Immunotherapy.
In: Clinical Pharmacology & Therapeutics, Bd. 107, Nr. 1: S. 47-49
[PDF, 236kB]
Kruger, Stephan; Schirle, Karoline; Haas, Michael; Crispin, Alexander; Schirra, Jörg; Mayerle, Julia; D'Haese, Jan G.; Kunz, Wolfgang G.; Ricke, Jens; Ormanns, Steffen; Kirchner, Thomas; Kobold, Sebastian; Ilmer, Matthias; Gebauer, Leonie; Westphalen, Christoph B.; Bergwelt-Baildon, Michael von; Werner, Jens; Heinemann, Volker und Boeck, Stefan
(2020):
Prolonged time to treatment initiation in advanced pancreatic cancer patients has no major effect on treatment outcome: a retrospective cohort study controlled for lead time bias and waiting time paradox.
In: Journal of Cancer Research and Clinical Oncology, Bd. 146, Nr. 2: S. 391-399
Mountford, Steffeni; Ringleb, Andrea; Schwaiger, Rahel; Mayr, Doris; Kobold, Sebastian; Dinarello, Charles A. und Bufler, Philip
(8. November 2019):
Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis.
In: Frontiers in Immunology, Bd. 10, 2632
[PDF, 5MB]
Wiedemann, Gabriela M.; Aithal, Celina; Kraechan, Angelina; Heise, Constanze; Cadilha, Bruno L.; Zhang, Jin; Duewell, Peter; Ballotti, Robert; Endres, Stefan; Bertolotto, Corine und Kobold, Sebastian
(2019):
Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma.
In: Translational Oncology, Bd. 12, Nr. 2: S. 350-360
Tokarew, Nicholas; Ogonek, Justyna; Endres, Stefan; Bergwelt-Baildon, Michael von und Kobold, Sebastian
(2019):
Teaching an old dog new tricks: next-generation CAR T cells.
In: British Journal of Cancer, Bd. 120, Nr. 1: S. 26-37
Metzger, Philipp; Kirchleitner, Sabrina; Kluge, Michael; König, Lars M.; Hoerth, Christine; Rambuscheck, Carlotta A.; Bohmer, Daniel; Ahlfeld, Julia; Kobold, Sebastian; Friedel, Caroline C.; Endres, Stefan; Schnurr, Max und Duewell, Peter
(2019):
Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer.
In: Journal for Immunotherapy of Cancer, Bd. 7, Nr. 1, 288
Rataj, Felicitas; Jacobi, Severin J.; Stoiber, Stefan; Asang, Florian; Ogonek, Justyna; Tokarew, Nicholas; Cadilha, Bruno L.; van Puijenbroek, Erwin; Heise, Constanze; Duewell, Peter; Endres, Stefan; Klein, Christian und Kobold, Sebastian
(2019):
High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy.
In: British Journal of Cancer, Bd. 120, Nr. 1: S. 79-87
Karches, Clara H.; Benmebarek, Mohamed-Reda; Schmidbauer, Moritz L.; Kurzay, Mathias; Klaus, Richard; Geiger, Martina; Rataj, Felicitas; Cadilha, Bruno L.; Lesch, Stefanie; Heise, Constanze; Murr, Ramona; vom Berg, Johannes; Jastroch, Martin; Lamp, Daniel; Ding, Jian; Duewell, Peter; Niederfellner, Gerhard; Sustmann, Claudio; Endres, Stefan; Klein, Christian und Kobold, Sebastian
(2019):
Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy.
In: Clinical Cancer Research, Bd. 25, Nr. 19: S. 5890-5900
Krüger, Stephan; Ilmer, Matthias; Kobold, Sebastian; Cadilha, Bruno L.; Endres, Stefan; Ormanns, Steffen; Schuebbe, Gesa; Renz, Bernhard W.; D'Haese, Jan G.; Schloesser, Hans; Heinemann, Volker; Subklewe, Marion; Böck, Stefan; Werner, Jens und Bergwelt-Baildon, Michael von
(2019):
Advances in cancer immunotherapy 2019-latest trends.
In: Journal of Experimental & Clinical Cancer Research, Bd. 38, 268
Liu, Xiao; Li, Junjian; Cadilha, Bruno Loureiro; Markota, Anamarija; Voigt, Cornelia; Huang, Zhe; Lin, Peter P.; Wang, Daisy D.; Dai, Juncheng; Kranz, Gisela; Krandick, Anna; Libl, Darko; Zitzelsberger, Horst; Zagorski, Isabella; Braselmann, Herbert; Pan, Min; Zhu, Sibo; Huang, Yuanchi; Niedermeyer, Sebastian; Reichel, Christoph A.; Uhl, Bernd; Briukhovetska, Daria; Suarez, Javier; Kobold, Sebastian; Gires, Olivier und Wang, Hongxia
(2019):
Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis.
In: Science Advances, Bd. 5, Nr. 6, eaav4275
Darowski, Diana; Jost, Christian; Stubenrauch, Kay; Wessels, Uwe; Benz, Jörg; Ehler, Andreas; Freimoser-Grundschober, Anne; Bruenker, Peter; Moessner, Ekkehard; Umana, Pablo; Kobold, Sebastian und Klein, Christian
(2019):
P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation.
In: Protein Engineering Design & Selection, Bd. 32, Nr. 5: S. 207-218
Stoiber, Stefan; Cadilha, Bruno L.; Benmebarek, Mohamed-Reda; Lesch, Stefanie; Endres, Stefan und Kobold, Sebastian
(2019):
Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy.
In: Cells, Bd. 8, Nr. 5, 472
Darowski, Diana; Kobold, Sebastian; Jost, Christian und Klein, Christian
(2019):
Combining the best of two worlds: highly flexible chimeric antigen receptor adaptor molecules (CAR-adaptors) for the recruitment of chimeric antigen receptor T cells.
In: Mabs, Bd. 11, Nr. 4: S. 621-631
Libby, Peter und Kobold, Sebastian
(2019):
Inflammation: a common contributor to cancer, aging, and cardiovascular diseasesexpanding the concept of cardio-oncology.
In: Cardiovascular Research, Bd. 115, Nr. 5: S. 824-829
Duewell, Peter; Heidegger, Simon und Kobold, Sebastian
(2019):
Innate Immune Stimulation in Cancer Therapy.
In: Hematology-Oncology Clinics of North America, Bd. 33, Nr. 2
Benmebarek, Mohamed-Reda; Karches, Clara Helke; Cadilha, Bruno Loureiro; Lesch, Stefanie; Endres, Stefan und Kobold, Sebastian
(2019):
Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells.
In: International Journal of Molecular Sciences, Bd. 20, Nr. 6, 1283
Zhang, Jin; Endres, Stefan und Kobold, Sebastian
(2019):
Enhancing tumor T cell infiltration to enable cancer immunotherapy.
In: Immunotherapy, Bd. 11, Nr. 3: S. 201-213
Herrmann, Monika; Krupka, Christina; Deiser, Katrin; Brauchle, Bettina; Marcinek, Anetta; Wagner, Ana Ogrinc; Rataj, Felicitas; Mocikat, Ralph; Metzeler, Klaus H.; Spiekermann, Karsten; Kobold, Sebastian; Fenn, Nadja C.; Hopfner, Karl-Peter und Subklewe, Marion
(2018):
Bifunctional PD-1 x alpha CD3 x alpha CD33 fusion protein reverses adaptive immune escape in acute myeloid leukemia.
In: Blood, Bd. 132, Nr. 23: S. 2484-2494
Weidenbusch, Marc; Song, Shangqing; Iwakura, Takamasa; Shi, Chongxu; Rodler, Severin; Kobold, Sebastian; Mulay, Shrikant R.; Honarpisheh, Mohsen M. und Anders, Hans-Joachim
(2018):
IL-22 sustains epithelial integrity in progressive kidney remodeling and fibrosis.
In: Physiological Reports, Bd. 6, Nr. 16, e13817
[PDF, 4MB]
Mak'Anyengo, Rachel; Duewell, Peter; Reichl, Cornelia; Hoerth, Christine; Lehr, Hans-Anton; Fischer, Sandra; Clavel, Thomas; Denk, Gerald; Hohenester, Simon; Kobold, Sebastian; Endres, Stefan; Schnurr, Max und Bauer, Christian
(2018):
Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut.
In: Jci Insight, Bd. 3, Nr. 5, e96322
Rataj, Felicitas; Kraus, Fabian B. T.; Chaloupka, Michael; Grassmann, Simon; Heise, Constanze; Cadilha, Bruno L.; Duewell, Peter; Endres, Stefan und Kobold, Sebastian
(2018):
PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma.
In: Frontiers in Immunology, Bd. 9, 1955
[PDF, 600kB]
Kobold, Sebastian; Pantelyushin, Stanislav; Rataj, Felicitas und Vom Berg, Johannes
(2018):
Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy.
In: Frontiers in Oncology, Bd. 8, 285
[PDF, 1MB]
Kobold, Sebastian; Krackhardt, Angela; Schloesser, Hans und Wolf, Dominik
(2018):
Immunonkologie – ein Überblick.
In: Deutsche Medizinische Wochenschrift, Bd. 143, Nr. 14: S. 1006-1013
Metzger, Philipp; Kirchleitner, Sabrina V.; König, Lars M.; Hörth, Christine; Kobold, Sebastian; Endres, Stefan; Schnurr, Max und Duewell, Peter
(2018):
Dying cells expose a nuclear antigen cross-reacting with anti-PD-1 monoclonal antibodies.
In: Scientific Reports, Bd. 8, 8810
[PDF, 4MB]
Voigt, Cornelia; May, Peter; Gottschlich, Adrian; Markota, Anamarija; Wenk, Daniel; Gerlach, Inga; Voigt, Sebastian; Stathopoulos, Georgios T.; Arendt, Kristina A. M.; Heise, Constanze; Rataj, Felicitas; Janssen, Klaus-Peter; Königshoff, Melanie; Winter, Hauke; Himsl, Isabelle; Thasler, Wolfgang E.; Schnurr, Max; Rothenfußer, Simon; Endres, Stefan und Kobold, Sebastian
(2017):
Cancer cells induce interleukin-22 production from memory CD4(+) T cells via interleukin-1 to promote tumor growth.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 114, Nr. 49: S. 12994-12999
Wennhold, Kerstin; Thelen, Martin; Schlösser, Hans Anton; Haustein, Natalie; Reuter, Sabrina; Garcia-Marquez, Maria; Lechner, Axel; Kobold, Sebastian; Rataj, Felicitas; Utermöhlen, Olaf; Chakupurakal, Geothy; Theurich, Sebastian; Hallek, Michäl; Abken, Hinrich; Shimabukuro-Vornhagen, Alexander und Bergwelt-Baildon, Michäl von
(2017):
Using Antigen-Specific B Cells to Combine Antibody and T Cell-Based Cancer Immunotherapy.
In: Cancer Immunology Research, Bd. 5, Nr. 9: S. 730-743
Berg, Johannes vom und Kobold, Sebastian
(2017):
The need for speed: how PD1-blockade only works if T cells are properly activated.
In: Translational Cancer Research, Bd. 6:
S1018-S1021
Wiedemann, Gabriela Maria; Jacobi, Severin Johannes; Chaloupka, Michael; Krächan, Angelina; Hamm, Svetlana; Strobl, Stefan; Baumgartner, Roland; Rothenfusser, Simon; Duewell, Peter; Endres, Stefan und Kobold, Sebastian
(2016):
A novel TLR7 agonist reverses NK cell anergy and cures RMA-S lymphoma-bearing mice.
In: Oncoimmunology, Bd. 5, Nr. 7, e1189051
Rapp, Moritz; Grassmann, Simon; Chaloupka, Michael; Layritz, Patrick; Kruger, Stephan; Ormanns, Steffen; Rataj, Felicitas; Janssen, Klaus-Peter; Endres, Stefan; Anz, David und Kobold, Sebastian
(2016):
C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer.
In: Oncoimmunology, Bd. 5, Nr. 3, e1105428
Castoldi, Raffaella; Schanzer, Jürgen; Panke, Christian; Jucknischke, Ute; Neubert, Natalie J.; Croasdale, Rebecca; Scheuer, Werner; Auer, Johannes; Klein, Christian; Niederfellner, Gerhard; Kobold, Sebastian und Sustmann, Claudio
(2016):
TetraMabs: simultaneous targeting of four oncogenic receptor tyrosine kinases for tumor growth inhibition in heterogeneous tumor cell populations.
In: Protein Engineering Design & Selection, Bd. 29, Nr. 10: S. 467-475
Roskopf, Claudia C.; Braciak, Todd A.; Fenn, Nadja C.; Kobold, Sebastian; Fey, Georg H.; Hopfner, Karl-Peter und Oduncu, Fuat S.
(2016):
Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19(+) CD33(+) leukemia cells.
In: Oncotarget, Bd. 7, Nr. 16: S. 22579-22589
Pritsch, Michael; Ben-Khaled, Najib; Chaloupka, Michael; Kobold, Sebastian; Berens-Riha, Nicole; Peter, Annabell; Liegl, Gabriele; Schubert, Sören; Hoelscher, Michael; Löscher, Thomas und Wieser, Andreas
(2016):
Comparison of Intranasal Outer Membrane Vesicles with Cholera Toxin and Injected MF59C.1 as Adjuvants for Malaria Transmission Blocking Antigens AnAPN1 and Pfs48/45.
In: Journal of Immunology Research, 3576028
[PDF, 2MB]
Tufman, Amanda; Huber, Rudolf Maria; Volk, Stefanie; Aigner, Frederic; Edelmann, Martin; Gamarra, Fernando; Kiefl, Rosemarie; Kahnert, Kathrin; Tian, Fei; Boulesteix, Anne-Laure; Endres, Stefan und Kobold, Sebastian
(2016):
Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases.
In: BMC Cancer, Bd. 16: S. 409
Kobold, Sebastian; Völk, Stefanie; Clauditz, Till; Küpper, Natascha Jennifer; Minner, Sarah; Tufman, Amanda; Düwell, Peter; Lindner, Michael; Koch, Ina; Heidegger, Simon; Rothenfußer, Simon; Schnurr, Max; Huber, Rudolf Maria; Wilczak, Waldemar und Endres, Stefan
(August 2013):
Interleukin-22 Is Frequently Expressed in Small- and Large-Cell Lung Cancer and Promotes Growth in Chemotherapy-Resistant Cancer Cells.
In: Journal of Thoracic Oncology, Bd. 8, Nr. 8: S. 1032-1042
[PDF, 1MB]
Kobold, Sebastian; Luetkens, Tim; Bartels, Britta Marlen; Cao, Yanran; Hildebrandt, York; Sezer, Orhan; Reinhard, Henrike; Templin, Julia; Bartels, Katrin; Lajmi, Nesrine; Haag, Friedrich; Bokemeyer, Carsten; Kroeger, Nicolaus und Atanackovic, Djordje
(2012):
Longitudinal Analysis of Tetanus- and Influenza-Specific IgG Antibodies in Myeloma Patients.
In: Clinical & Developmental Immunology, Bd. 2012, 134081
[PDF, 1MB]
Kobold, Sebastian; Tams, Sinje; Luetkens, Tim; Cao, Yanran; Sezer, Orhan; Bartels, Britta Marlen; Reinhard, Henrike; Templin, Julia; Bartels, Katrin; Hildebrandt, York; Lajmi, Nesrine; Marx, Andreas; Haag, Friedrich; Bokemeyer, Carsten; Kroeger, Nicolaus und Atanackovic, Djordje
(2011):
Patients with Multiple Myeloma Develop SOX2-Specific Autoantibodies after Allogeneic Stem Cell Transplantation.
In: Clinical & Developmental Immunology, Bd. 2011, 302145
[PDF, 1MB]