Biological Motion induced mu suppression is reduced in Early Psychosis (EP) patients with active negative symptoms and Autism Spectrum Disorders (ASD)

Minichino, Amedeo; Singh, Fiza; Pineda, Jaime; Friedrich, Elisabeth V. C. und Cadenhead, Kristin S. (30. April 2016): Biological Motion induced mu suppression is reduced in Early Psychosis (EP) patients with active negative symptoms and Autism Spectrum Disorders (ASD). In: Psychiatry Research, Bd. 238: S. 374-377

Abstract

There is evidence of genetic and neural system overlap in Autism Spectrum Disorder (ASD) and Early Psychosis (EP). Five datasets were pooled to compare mu suppression index (MSI), a proxy of mirror neuron activity, in EP, high functioning ASD, and healthy subjects (HS). ASDs and EPs with “active” negative symptoms showed significant differences in mu suppression, in response to Biological Motion/point-light display animation, compared to HS. Preliminary findings suggest that similar neural network deficits in ASD and EP could be driven by the expression of negative symptoms in the latter group of patients. These findings may aid future studies on EP and ASD and facilitate the formulation of new hypotheses regarding their pathophysiology.

• Dokumententyp: Zeitschriftenartikel
• Keywords: Mirror neurons; Posterior superior temporal sulcus; Biological Motion; Early Psychosis; Negative symptoms
• Fakultät: Psychologie und Pädagogik > Department Psychologie > Neuropsychologie und Biologische Psychologie
• Themengebiete: 100 Philosophie und Psychologie > 150 Psychologie
• ISSN: 0165-1781
• Sprache: Englisch