ORCID: https://orcid.org/0000-0003-1683-8679; Ruiz-Rizzo, Adriana L.
ORCID: https://orcid.org/0000-0003-1467-0745; Sorg, Christian and Finke, Kathrin
(16. March 2020):
Right-lateralized fronto-parietal network and phasic alertness in healthy aging.
In: Scientific Reports, No. 10, 4823
[PDF, 1MB]
Abstract
Phasic alerting cues temporarily increase the brain’s arousal state. In younger and older participants, visual processing speed in a whole report task, estimated based on the theory of visual attention, is higher in cue than no-cue conditions. The present study assessed whether older participants’ ability to profit from warning cues is related to intrinsic functional connectivity (iFC) in the cingulo-opercular and/or right fronto-parietal network. We acquired resting-state functional magnetic resonance imaging data from 31 older participants. By combining an independent component analysis and dual regression, we investigated iFC in both networks. A voxel-wise multiple regression in older participants yielded that higher phasic alerting effects on visual processing speed were significantly related to lower right fronto-parietal network iFC. This result supports a particular role of the right fronto-parietal network in maintaining phasic alerting capabilities in aging. We then compared healthy older participants to a previously reported sample of healthy younger participants to assess whether behaviour-iFC relationships are age group specific. The comparison revealed that the association between phasic alerting and cingulo-opercular network iFC is significantly lower in older than in younger adults.
Item Type: | Journal article |
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EU Funded Grant Agreement Number: | 606901 |
Form of publication: | Publisher's Version |
Keywords: | Phasic Alertness; Aging; Theory of Visual Attention; Resting-State fMRI; Intrinsic Functional Connectivity; ICA, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED |
Faculties: | Psychology and Education Science > Department Psychology > General and Experimental Psychology |
Research Centers: | Graduate School of Systemic Neurosciences (GSN) |
Subjects: | 100 Philosophy and Psychology > 150 Psychology 500 Science > 500 Science |
URN: | urn:nbn:de:bvb:19-epub-77454-2 |
ISSN: | 2045-2322 |
Language: | English |
Item ID: | 77454 |
Date Deposited: | 30. Sep 2021, 05:39 |
Last Modified: | 30. Sep 2021, 05:39 |