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Eine Ebene höherGruppiert nach: Dokumententyp |
Veröffentlichungsdatum
Anzahl der Publikationen: 114
2023
Ziegler, Karin A.; Ahles, Andrea; Dueck, Anne; Esfandyari, Dena; Pichler, Pauline; Weber, Karolin; Kotschi, Stefan; Bartelt, Alexander; Sinicina, Inga; Graw, Matthias; Leonhardt, Heinrich; Weckbach, Ludwig T.; Massberg, Steffen; Schifferer, Martina; Simons, Mikael; Hoeher, Luciano; Luo, Jie; Ertuerk, Ali; Schiattarella, Gabriele G.; Sassi, Yassine; Misgeld, Thomas und Engelhardt, Stefan
(2023):
Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.
In: Science, Bd. 381, Nr. 6655: S. 285-290
2022
Wang, Zeyang; Fan, Rui; Russo, Angela; Cernilogar, Filippo M.; Nuber, Alexander; Schirge, Silvia; Shcherbakova, Irina; Dzhilyanova, Iva; Ugur, Enes; Anton, Tobias; Richter, Lisa; Leonhardt, Heinrich; Lickert, Heiko und Schotta, Gunnar
(19. September 2022):
Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm.
In: Nature Communications, Bd. 13
[PDF, 5MB]
Zhang, Lei; Isselstein, Michael; Köhler, Jens; Eleftheriadis, Nikolaos; Huisjes, Nadia M.; Guirao-Ortiz, Miguel; Narducci, Alessandra; Smit, Jochem H.; Stoffels, Janko; Harz, Hartmann; Leonhardt, Heinrich; Herrmann, Andreas und Cordes, Thorben
(2022):
Linker Molecules Convert Commercial Fluorophores into Tailored Functional Probes during Biolabelling.
In: Angewandte Chemie International Edition, Bd. 61, Nr. 19
[PDF, 7MB]
Stolz, Paul; Mantero, Angelo Salazar; Tvardovskiy, Andrey; Ugur, Enes; Wange, Lucas E.; Mulholland, Christopher B.; Cheng, Yuying; Wierer, Michael; Enard, Wolfgang; Schneider, Robert; Bartke, Till; Leonhardt, Heinrich; Elsasser, Simon J. und Bultmann, Sebastian
(2022):
TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation.
In: Nucleic Acids Research, Bd. 50, Nr. 15: S. 8491-8511
[PDF, 4MB]
Qin, Weihua; Steinek, Clemens; Kolobynina, Ksenia; Forne, Ignasi; Imhof, Axel; Cardoso, M. Cristina und Leonhardt, Heinrich
(2022):
Probing protein ubiquitination in live cells.
In: Nucleic Acids Research, Bd. 50, Nr. 21
[PDF, 8MB]
Schmacke, Niklas A.; O'Duill, Fionan; Gaidt, Moritz M.; Szymanska, Inga; Kamper, Julia M.; Schmid-Burgk, Jonathan L.; Maedler, Sophia C.; Mackens-Kiani, Timur; Kozaki, Tatsuya; Chauhan, Dhruv; Nagl, Dennis; Stafford, Che A.; Harz, Hartmann; Froehlich, Adrian L.; Pinci, Francesca; Ginhoux, Florent; Beckmann, Roland; Mann, Matthias; Leonhardt, Heinrich und Hornung, Veit
(2022):
IKKO primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network.
In: Immunity, Bd. 55, Nr. 12: S. 2271-2284
Brandstetter, Katharina; Zulske, Tilo; Ragoczy, Tobias; Hoerl, David; Guirao-Ortiz, Miguel; Steinek, Clemens; Barnes, Toby; Stumberger, Gabriela; Schwach, Jonathan; Haugen, Eric; Rynes, Eric; Korber, Philipp; Stamatoyannopoulos, John A.; Leonhardt, Heinrich; Wedemann, Gero und Harz, Hartmann
(2022):
Differences in nanoscale organization of regulatory active and inactive human chromatin.
In: Biophysical Journal, Bd. 121, Nr. 6: S. 977-990
Leidescher, Susanne; Ribisel, Johannes; Ullrich, Simon; Feodorova, Yana; Hildebrand, Erica; Galitsyna, Alexandra; Bultmann, Sebastian; Link, Stephanie; Thanisch, Katharina; Mulholland, Christopher; Dekker, Job; Leonhardt, Heinrich; Mirny, Leonid und Solovei, Irina
(2022):
Spatial organization of transcribed eukaryotic genes.
In: Nature Cell Biology, Bd. 24, Nr. 3: S. 327-339
Zhang, Hui; Romero, Hector; Schmidt, Annika; Gagova, Katalina; Qin, Weihua; Bertulat, Bianca; Lehmkuhl, Anne; Milden, Manuela; Eck, Malte; Meckel, Tobias; Leonhardt, Heinrich und Cardoso, M. Cristina
(2022):
MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid-liquid phase separation and restricted by DNA methylation.
In: Nucleus, Bd. 13, Nr. 1: S. 1-34
Landspersky, Theresa; Sacma, Mehmet; Riviere, Jennifer; Hecker, Judith S.; Hettler, Franziska; Hameister, Erik; Brandstetter, Katharina; Istvanffy, Rouzanna; Marquez, Sandra Romero; Ludwig, Romina; Gotz, Marilena; Buck, Michele; Wolf, Martin; Schiemann, Matthias; Ruland, Jürgen; Strunk, Dirk; Shimamura, Akiko; Myers, Kasiani; Yamaguchi, Terry P.; Kieslinger, Matthias; Leonhardt, Heinrich; Bassermann, Florian; Gotze, Katharina S.; Geiger, Hartmut; Schreck, Christina und Oostendorp, Robert A. J.
(2022):
Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress.
In: Blood, Bd. 139, Nr. 5: S. 690-703
Hata, Keiichi; Kobayashi, Naohiro; Sugimura, Keita; Qin, Weihua; Haxholli, Deis; Chiba, Yoshie; Yoshimi, Sae; Hayashi, Gosuke; Onoda, Hiroki; Ikegami, Takahisa; Mulholland, Christopher B.; Nishiyama, Atsuya; Nakanishi, Makoto; Leonhardt, Heinrich; Konuma, Tsuyoshi und Arita, Kyohei
(2022):
Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger.
In: Nucleic Acids Research, Bd. 50, Nr. 21: S. 12527-12542
2021
Duan, Ningjun; Arroyo, Maria; Deng, Wen; Cardoso, M. Cristina und Leonhardt, Heinrich
(2021):
Visualization and characterization of RNA-protein interactions in living cells.
In: Nucleic Acids Research, Bd. 49, Nr. 18, e107
Jakubke, Christopher; Roussou, Rodaria; Maiser, Andreas; Schug, Christina; Thoma, Felix; Bunk, David; Horl, David; Leonhardt, Heinrich; Walter, Peter; Klecker, Till und Osman, Christof
(2021):
Cristae-dependent quality control of the mitochondrial genome.
In: Science Advances, Bd. 7, Nr. 36, eabi8886
Kempf, Julia M.; Weser, Sabrina; Bartoschek, Michael D.; Metzeler, Klaus H.; Vick, Binje; Herold, Tobias; Voelse, Kerstin; Mattes, Raphael; Scholz, Manuela; Wange, Lucas E.; Festini, Moreno; Ugur, Enes; Roas, Maike; Weigert, Oliver; Bultmann, Sebastian; Leonhardt, Heinrich; Schotta, Gunnar; Hiddemann, Wolfgang; Jeremias, Irmela und Spiekermann, Karsten
(2021):
Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML.
In: Scientific Reports, Bd. 11, Nr. 1, 5838
Lei, Jian; Ma-Lauer, Yue; Han, Yinze; Thoms, Matthias; Buschauer, Robert; Jores, Joerg; Thiel, Volker; Beckmann, Roland; Deng, Wen; Leonhardt, Heinrich; Hilgenfeld, Rolf und Brunn, Albrecht von
(2021):
The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation.
In: EMBO Journal, Bd. 40, Nr. 11, e102277
Levone, Brunno R.; Lenzken, Silvia C.; Antonaci, Marco; Maiser, Andreas; Rapp, Alexander; Conte, Francesca; Reber, Stefan; Mechtersheimer, Jonas; Ronchi, Antonella E.; Muehlemann, Oliver; Leonhardt, Heinrich; Cardoso, M. Cristina; Ruepp, Marc-David und Barabino, Silvia M. L.
(2021):
FUS-dependent liquid-liquid phase separation is important for DNA repair initiation.
In: Journal of Cell Biology, Bd. 220, Nr. 5, e202008030
Qin, Weihua; Stengl, Andreas; Ugur, Enes; Leidescher, Susanne; Ryan, Joel; Cardoso, M. Cristina und Leonhardt, Heinrich
(2021):
HP1 beta carries an acidic linker domain and requires H3K9me3 for phase separation.
In: Nucleus, Bd. 12, Nr. 1: S. 44-57
Qin, Weihua; Ugur, Enes; Mulholland, Christopher B.; Bultmann, Sebastian; Solovei, Irina; Modic, Miha; Smets, Martha; Wierer, Michael; Forne, Ignasi; Imhof, Axel; Cardoso, M. Cristina und Leonhardt, Heinrich
(2021):
Phosphorylation of the HP1 beta hinge region sequesters KAP1 in heterochromatin and promotes the exit from naive pluripotency.
In: Nucleic Acids Research, Bd. 49, Nr. 13: S. 7406-7423
2020
Schmitt, Saskia; Tahk, Siret; Lohner, Alina; Haenel, Gerulf; Maiser, Andreas; Hauke, Martina; Patel, Lubna; Rothe, Maurine; Josenhans, Christine; Leonhardt, Heinrich; Griffioen, Marieke; Deiser, Katrin; Fenn, Nadja C.; Hopfner, Karl-Peter und Subklewe, Marion
(12. November 2020):
Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells.
In: Frontiers in Immunology, Bd. 11, 602802: S. 1-16
[PDF, 3MB]
Ugur, Enes; Bartoschek, Michael D. und Leonhardt, Heinrich
(2020):
Locus-Specific Chromatin Proteome Revealed by Mass Spectrometry-Based CasID.
In: Hancock, R. (Hrsg.):
The Nucleus. Methods in molecular biology, Bd. 2175. Humana, NY: Springer. S. 109-121
Mulholland, Christopher B.; Nishiyama, Atsuya; Ryan, Joel; Nakamura, Ryohei; Yigit, Merve; Glueck, Ivo M.; Trummer, Carina; Qin, Weihua; Bartoschek, Michael D.; Traube, Franziska R.; Parsa, Edris; Ugur, Enes; Modic, Miha; Acharya, Aishwarya; Stolz, Paul; Ziegenhain, Christoph; Wierer, Michael; Enard, Wolfgang; Carell, Thomas; Lamb, Don C.; Takeda, Hiroyuki; Nakanashi, Makoto; Bultmann, Sebastian und Leonhardt, Heinrich
(2020):
Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals.
In: Nature Communications, Bd. 11, Nr. 1, 5972
[PDF, 8MB]
Mulholland, Christopher B.; Traube, Franziska R.; Ugur, Enes; Parsa, Edris; Eckl, Eva-Maria; Schoenung, Maximilian; Modic, Miha; Bartoschek, Michael D.; Stolz, Paul; Ryan, Joel; Carell, Thomas; Leonhardt, Heinrich und Bultmann, Sebastian
(2020):
Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency.
In: Scientific Reports, Bd. 10, Nr. 1, 12066
[PDF, 1MB]
Stief, Sophie M.; Hanneforth, Anna-Li; Weser, Sabrina; Mattes, Raphael; Carlet, Michela; Liu, Wen-Hsin; Bartoschek, Michael D.; Moreno, Helena Dominguez; Oettle, Matthias; Kempf, Julia; Vick, Binje; Ksienzyk, Bianka; Tizazu, Belay; Rothenberg-Thurley, Maja; Quentmeier, Hilmar; Hiddemann, Wolfgang; Vosberg, Sebastian; Greif, Philipp A.; Metzeler, Klaus H.; Schotta, Gunnar; Bultmann, Sebastian; Jeremias, Irmela; Leonhardt, Heinrich und Spiekermann, Karsten
(2020):
Loss of KDM6A confers drug resistance in acute myeloid leukemia.
In: Leukemia, Bd. 34, Nr. 1: S. 50-62
Deng, Wen; Bates, Jack A.; Wei, Hai; Bartoschek, Michael D.; Conradt, Barbara und Leonhardt, Heinrich
(2020):
Tunable light and drug induced depletion of target proteins.
In: Nature Communications, Bd. 11, Nr. 1, 304
[PDF, 2MB]
Nishiyama, Atsuya; Mulholland, Christopher B.; Bultmann, Sebastian; Kori, Satomi; Endo, Akinori; Saeki, Yasushi; Qin, Weihua; Trummer, Carina; Chiba, Yoshie; Yokoyama, Haruka; Kumamoto, Soichiro; Kawakami, Toru; Hojo, Hironobu; Nagae, Genta; Aburatani, Hiroyuki; Tanaka, Keiji; Arita, Kyohei; Leonhardt, Heinrich und Nakanishi, Makoto
(2020):
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation.
In: Nature Communications, Bd. 11, Nr. 1, 1222
[PDF, 3MB]
Maiser, Andreas; Dillinger, Stefan; Laengst, Gernot; Schermelleh, Lothar; Leonhardt, Heinrich und Nemeth, Attila
(2020):
Super-resolution in situ analysis of active ribosomal DNA chromatin organization in the nucleolus.
In: Scientific Reports, Bd. 10, Nr. 1, 7462
[PDF, 2MB]
Le Poul, Yann; Xin, Yaqun; Ling, Liucong; Muhling, Bettina; Jaenichen, Rita; Horl, David; Bunk, David; Harz, Hartmann; Leonhardt, Heinrich; Wang, Yingfei; Osipova, Elena; Museridze, Mariam; Dharmadhikari, Deepak; Murphy, Eamonn; Rohs, Remo; Preibisch, Stephan; Prud'homme, Benjamin und Gompel, Nicolas
(2020):
Regulatory encoding of quantitative variation in spatial activity of a Drosophila enhancer.
In: Science Advances, Bd. 6, Nr. 49, eabe2955
Schneider, Markus; Trummer, Carina; Stengl, Andreas; Zhang, Peng; Szwagierczak, Aleksandra; Cardoso, M. Cristina; Leonhardt, Heinrich; Bauer, Christina und Antes, Iris
(2020):
Systematic analysis of the binding behaviour of UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads.
In: PLOS One 15(2), e0229144 [PDF, 3MB]
In: PLOS One 15(2), e0229144 [PDF, 3MB]
Schwach, Jonathan; Kolobynina, Ksenia; Brandstetter, Katharina; Gerlach, Marcus; Ochtrop, Philipp; Helma, Jonas; Hackenberger, Christian P. R.; Harz, Hartmann; Cardoso, M. Cristina; Leonhardt, Heinrich und Stengl, Andreas
(2020):
Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy.
In: Chembiochem, Bd. 22, Nr. 7: S. 1205-1209
Bararia, Deepak; Hildebrand, Johannes A.; Stolz, Sebastian; Haebe, Sarah; Alig, Stefan; Trevisani, Christopher P.; Osorio-Barrios, Francisco; Bartoschek, Michael D.; Mentz, Michael; Pastore, Alessandro; Gaitzsch, Erik; Heide, Michael; Jurinovic, Vindi; Rautter, Katharina; Gunawardana, Jay; Sabdia, Muhammed B.; Szczepanowski, Monika; Richter, Julia; Klapper, Wolfram; Louissaint, Abner; Ludwig, Christina; Bultmann, Sebastian; Leonhardt, Heinrich; Eustermann, Sebastian; Hopfner, Karl-Peter; Hiddemann, Wolfgang; Bergwelt-Baildon, Michael von; Steidl, Christian; Kridel, Robert; Tobin, Joshua W. D.; Gandhi, Maher K.; Weinstock, David M.; Schmidt-Supprian, Marc; Sarosi, Menyhart B.; Rudelius, Martina; Passerini, Verena; Mautner, Josef und Weigert, Oliver
(2020):
Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma.
In: Cell Reports, Bd. 31, Nr. 5, 107522
Cremer, Marion; Brandstetter, Katharina; Maiser, Andreas; Rao, Suhas S. P.; Schmid, Volker J.; Guirao-Ortiz, Miguel; Mitra, Namita; Mamberti, Stefania; Klein, Kyle N.; Gilbert, David M.; Leonhardt, Heinrich; Cardoso, M. Cristina; Aiden, Erez Lieberman; Harz, Hartmann und Cremer, Thomas
(2020):
Cohesin depleted cells rebuild functional nuclear compartments after endomitosis.
In: Nature Communications, Bd. 11, Nr. 1, 6146
[PDF, 18MB]
Pandya-Jones, Amy; Markaki, Yolanda; Serizay, Jacques; Chitiashvili, Tsotne; Leon, Walter R. Mancia; Damianov, Andrey; Chronis, Constantinos; Papp, Bernadett; Chen, Chun-Kan; McKee, Robin; Wang, Xiao-Jun; Chau, Anthony; Sabri, Shan; Leonhardt, Heinrich; Zheng, Sika; Guttman, Mitchell; Black, Douglas L. und Plath, Kathrin
(2020):
A protein assembly mediates Xist localization and gene silencing.
In: Nature, Bd. 587, Nr. 7832: S. 145-151
Rausch, Cathia; Weber, Patrick; Prorok, Paulina; Hoerl, David; Maiser, Andreas; Lehmkuhl, Anne; Chagin, Vadim O.; Casas-Delucchi, Corella S.; Leonhardt, Heinrich und Cardoso, M. Cristina
(2020):
Developmental differences in genome replication program and origin activation.
In: Nucleic Acids Research, Bd. 48, Nr. 22: S. 12751-12777
2019
Cremer, Marion; Brandstetter, Katharina; Maiser, Andreas; Rao, Suhas S P; Schmid, Volker J. 
ORCID: https://orcid.org/0000-0003-2195-8130; Mitra, Namita; Mamberti, Stefania; Klein, Kyle-N; Gilbert, David M; Leonhardt, Heinrich; Cardoso, Maria Cristina; Aiden, Erez Lieberman; Harz, Hartmann und Cremer, Thomas
(2019):
Cohesin depleted cells pass through mitosis and reconstitute a functional nuclear architecture.
In: Nature Communications, Bd. 11, Nr. 6146
[PDF, 18MB]
ORCID: https://orcid.org/0000-0003-2195-8130; Mitra, Namita; Mamberti, Stefania; Klein, Kyle-N; Gilbert, David M; Leonhardt, Heinrich; Cardoso, Maria Cristina; Aiden, Erez Lieberman; Harz, Hartmann und Cremer, Thomas
(2019):
Cohesin depleted cells pass through mitosis and reconstitute a functional nuclear architecture.
In: Nature Communications, Bd. 11, Nr. 6146
[PDF, 18MB]
Wagner, Anita; Hofmeister, Olga; Rolland, Stephane G.; Maiser, Andreas; Aasumets, Koit; Schmitt, Sabine; Schorpp, Kenji; Feuchtinger, Annette; Hadian, Kamyar; Schneider, Sabine; Zischka, Hans; Leonhardt, Heinrich; Conradt, Barbara; Gerhold, Joachim M. und Wolf, Alexander
(2019):
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans.
In: Journal of Cell Science, Bd. 132, Nr. 19, UNSP jcs223891
Hoerl, David; Rusak, Fabio Rojas; Preusser, Friedrich; Tillberg, Paul; Randel, Nadine; Chhetri, Raghav K.; Cardona, Albert; Keller, Philipp J.; Harz, Hartmann; Leonhardt, Heinrich; Treier, Mathias und Preibisch, Stephan
(2019):
BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples.
In: Nature Methods, Bd. 16, Nr. 9
Tepper, Sandra; Mortusewicz, Oliver; Czlonka, Ewelina; Bello, Amanda; Schmidt, Angelika; Jeschke, Julia; Fischbach, Arthur; Pfeil, Ines; Petersen-Mahrt, Svend K.; Mangerich, Aswin; Helleday, Thomas; Leonhardt, Heinrich und Jungnickel, Berit
(2019):
Restriction of AID activity and somatic hypermutation by PARP-1.
In: Nucleic Acids Research, Bd. 47, Nr. 14: S. 7418-7429
Mahamid, Julia; Tegunov, Dimitry; Maiser, Andreas; Arnold, Jan; Leonhardt, Heinrich; Plitzko, Jurgen M. und Baumeister, Wolfgang
(2019):
Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 116, Nr. 34: S. 16866-16871
Kasper, Marc-Andre; Glanz, Maria; Stengl, Andreas; Penkert, Martin; Klenk, Simon; Sauer, Tom; Schumacher, Dominik; Helma, Jonas; Krause, Eberhard; Cardoso, M. Cristina; Leonhardt, Heinrich und Hackenberger, Christian P. R.
(2019):
Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations.
In: Angewandte Chemie-International Edition, Bd. 58, Nr. 34: S. 11625-11630
Kasper, Marc-Andre; Stengl, Andreas; Ochtrop, Philipp; Gerlach, Marcus; Stoschek, Tina; Schumacher, Dominik; Helma, Jonas; Penkert, Martin; Krause, Eberhard; Leonhardt, Heinrich und Hackenberger, Christian P. R.
(2019):
Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates.
In: Angewandte Chemie-International Edition, Bd. 58, Nr. 34: S. 11631-11636
Chiasson, David; Gimenez-Oya, Victor; Bircheneder, Martin; Bachmaier, Sabine; Studtrucker, Tanja; Ryan, Joel; Sollweck, Katharina; Leonhardt, Heinrich; Boshart, Michael; Dietrich, Petra und Parniske, Martin
(2019):
A unified multi-kingdom Golden Gate cloning platform.
In: Scientific Reports, Bd. 9, 10131
[PDF, 2MB]
Stengl, Andreas; Gerlach, Marcus; Kasper, Marc-Andre; Hackenberger, Christian P. R.; Leonhardt, Heinrich; Schumacher, Dominik und Helma, Jonas
(2019):
TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles.
In: Organic & Biomolecular Chemistry, Bd. 17, Nr. 20: S. 4964-4969
Effenberger, Manuel; Stengl, Andreas; Schober, Kilian; Gerget, Maria; Kampick, Maximilian; Müller, Thomas R.; Schumacher, Dominik; Helma, Jonas; Leonhardt, Heinrich und Busch, Dirk H.
(2019):
FLEXamers: A Double Tag for Universal Generation of Versatile Peptide-MHC Multimers.
In: Journal of Immunology, Bd. 202, Nr. 7: S. 2164-2171
Chagin, Vadim O.; Reinhart, Britta; Becker, Annette; Mortusewicz, Oliver; Jost, K. Laurence; Rapp, Alexander; Leonhardt, Heinrich und Cardoso, M. Cristina
(2019):
Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair.
In: Nucleus, Bd. 10, Nr. 1: S. 231-253
Falk, Martin; Feodorova, Yana; Naumova, Natalia; Imakaev, Maxim; Lajoie, Bryan R.; Leonhardt, Heinrich; Joffe, Boris; Dekker, Job; Fudenberg, Geoffrey; Solovei, Irina und Mirny, Leonid A.
(2019):
Heterochromatin drives compartmentalization of inverted and conventional nuclei.
In: Nature, Bd. 570, Nr. 7761
2018
Hinrichs, Arne; Kessler, Barbara; Kurome, Mayuko; Blutke, Andreas; Kemter, Elisabeth; Bernau, Maren; Scholz, Armin M.; Rathkolb, Birgit; Renner, Simone; Bultmann, Sebastian; Leonhardt, Heinrich; Hrabe de Angelis, Martin; Nagashima, Hiroshi; Hoeflich, Andreas; Blum, Werner F.; Bidlingmaier, Martin; Wanke, Rüdiger; Dahlhoff, Maik und Wolf, Eckhard
(2018):
Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.
In: Molecular Metabolism, Bd. 11: S. 113-128
[PDF, 3MB]
Rehage, Nina; Davydova, Elena; Conrad, Christine; Behrens, Gesine; Maiser, Andreas; Stehklein, Jenny E.; Brenner, Sven; Klein, Juliane; Jeridi, Aicha; Hoffmann, Anne; Lee, Eunhae; Dianzani, Umberto; Willemsen, Rob; Feederle, Regina; Reiche, Kristin; Hackermüller, Jörg; Leonhardt, Heinrich; Sharma, Sonia; Niessing, Dierk und Heissmeyer, Vigo
(2018):
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
In: Nature Communications, Bd. 9, 299
[PDF, 3MB]
Feldmann, Daniel P.; Cheng, Yilong; Kandil, Rima; Xie, Yuran; Mohammadi, Mariam; Harz, Hartmann; Sharma, Akhil; Peeler, David J.; Moszczynska, Anna; Leonhardt, Heinrich; Pun, Suzie H. und Merkel, Olivia M.
(2018):
In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells.
In: Journal of Controlled Release, Bd. 276: S. 50-58
Gasparoni, Gilles; Bultmann, Sebastian; Lutsik, Pavlo; Kraus, Theo F. J.; Sordon, Sabrina; Vlcek, Julia; Dietinger, Vanessa; Steinmaurer, Martina; Haider, Melanie; Mulholland, Christopher B.; Arzberger, Thomas; Röber, Sigrun; Riemenschneider, Matthias; Kretzschmar, Hans A.; Giese, Armin; Leonhardt, Heinrich und Walter, Jörn
(2018):
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex.
In: Epigenetics & Chromatin
11:41
[PDF, 6MB]
Schumacher, Dominik; Helma-Smets, Jonas; Hackenberger, Christian und Leonhardt, Heinrich
(2018):
Neue Generation von Antikörper‐Wirkstoff‐Konjugaten. Start‐Ups.
In: Chemie in Unserer Zeit, Bd. 52, Nr. 2: S. 80-82
Wenk, Catharina; Garz, Anne-Kathrin; Grath, Sonja; Huberle, Christina; Witham, Denis; Weickert, Marie; Malinverni, Roberto; Niggemeyer, Julia; Kyncl, Michele; Hecker, Judith; Pagel, Charlotta; Mulholland, Christopher B.; Müller-Thomas, Catharina; Leonhardt, Heinrich; Bassermann, Florian; Oostendorp, Robert A. J.; Metzeler, Klaus H.; Buschbeck, Marcus und Götze, Katharina S.
(2018):
Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesis.
In: Blood Advances, Bd. 2, Nr. 23: S. 3447-3461
Schumacher, Dominik; Helma, Jonas; Schneider, Anselm F. L.; Leonhardt, Heinrich und Hackenberger, Christian P. R.
(2018):
Nanobodies: Chemical Functionalization Strategies and Intracellular Applications.
In: Angewandte Chemie-International Edition, Bd. 57, Nr. 9: S. 2314-2333
Chiu, Hsin-Yi; Bates, Jack A.; Helma, Jonas; Engelke, Hanna; Harz, Hartmann; Bein, Thomas und Leonhardt, Heinrich
(2018):
Nanoparticle mediated delivery and small molecule triggered activation of proteins in the nucleus.
In: Nucleus, Bd. 9, Nr. 1: S. 530-542
[PDF, 2MB]
Grigoryan, Ani; Guidi, Novella; Senger, Katharina; Liehr, Thomas; Soller, Karin; Marka, Gina; Vollmer, Angelika; Markaki, Yolanda; Leonhardt, Heinrich; Buske, Christian; Lipka, Daniel B.; Plass, Christoph; Zheng, Yi; Mulaw, Medhanie A.; Geiger, Hartmut und Florian, Maria Carolina
(2018):
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.
In: Genome Biology
19:189
[PDF, 5MB]
2017
Ungewiss, Hanna; Vielmuth, Franziska; Suzuki, Shintaro T.; Maiser, Andreas; Harz, Hartmann; Leonhardt, Heinrich; Kugelmann, Daniela; Schlegel, Nicolas und Waschke, Jens
(2017):
Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase.
In: Scientific Reports, Bd. 7, 6329
[PDF, 4MB]
Essig, Katharina; Hu, Desheng; Guimaraes, Joao C.; Alterauge, Dominik; Edelmann, Stephanie; Raj, Timsse; Kranich, Jan; Behrens, Gesine; Heiseke, Alexander; Floess, Stefan; Klein, Juliane; Maiser, Andreas; Marschall, Susan; Hrabe de Angelis, Martin; Leonhardt, Heinrich; Calkhoven, Cornelis F.; Noessner, Elfriede; Brocker, Thomas; Huehn, Jochen; Krug, Anne B.; Zavolan, Mihaela; Baumjohann, Dirk und Heissmeyer, Vigo
(2017):
Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.
In: Immunity, Bd. 47, Nr. 6: S. 1067-1082
Ungewiss, Hanna; Vielmuth, Franziska; Suzuki, Shintaro T.; Maiser, Andreas; Harz, Hartmann; Leonhardt, Heinrich; Kugelmann, Daniela; Schlegel, Nicolas und Waschke, Jens
(2017):
Desmoglein 2 Regulates the Intestinal Epithelial Barrier via p38 Mitogen-Activated Protein Kinase.
In: FASEB Journal, Bd. 31
Andreeva, Liudmila; Hiller, Björn; Kostrewa, Dirk; Lässig, Charlotte; Oliveira Mann, Carina C. de; Drexler, David Jan; Maiser, Andreas; Gaidt, Moritz; Leonhardt, Heinrich; Hornung, Veit und Hopfner, Karl-Peter
(2017):
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
In: Nature, Bd. 549, Nr. 7672: S. 394-398
Chiu, Hsin-Yi; Leonhardt, Heinrich und Bein, Thomas
(2017):
Synthesis and Functionalization of Ordered Large-Pore Mesoporous Silica Nanoparticles for Biomedical Applications.
In: Chemie ingenieur Technik, Bd. 89, Nr. 7: S. 876-886
Pünzeler, Sebastian; Link, Stephanie; Wagner, Gabriele; Keilhauer, Eva C.; Kronbeck, Nina; Spitzer, Ramona M. M.; Leidescher, Susanne; Markaki, Yolanda; Mentele, Edith; Regnard, Catherine; Schneider, Katrin; Takahashi, Daisuke; Kusakabe, Masayuki; Vardabasso, Chiara; Zink, Lisa M.; Straub, Tobias; Bernstein, Emily; Harata, Masahiko; Leonhardt, Heinrich; Mann, Matthias; Rupp, Ralph A. W. und Hake, Sandra B.
(2017):
Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.
In: Embo Journal, Bd. 36, Nr. 15: S. 2263-2279
Schlenker, Ramona; Olguin-Contreras, Luis Felipe; Leisegang, Matthias; Schnappinger, Julia; Disovic, Anja; Ruehland, Svenja; Nelson, Peter J.; Leonhardt, Heinrich; Harz, Hartmann; Wilde, Susanne; Schendel, Dolores J.; Uckert, Wolfgang; Willimsky, Gerald und Nössner, Elfriede
(2017):
Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy.
In: Cancer Research, Bd. 77, Nr. 13: S. 3577-3590
Dahlhoff, Maik; Gaborit, Nadege; Bultmann, Sebastian; Leonhardt, Heinrich; Yarden, Yosef und Schneider, Marlon R.
(2017):
CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes.
In: FEBS Journal, Bd. 284, Nr. 19: S. 3339-3349
Schüder, Florian; Strauss, Maximilian T.; Hörl, David; Schnitzbauer, Jörg; Schlichthaerle, Thomas; Strauss, Sebastian; Yin, Peng; Harz, Hartmann; Leonhardt, Heinrich und Jungmann, Ralf
(2017):
Universal Super-Resolution Multiplexing by DNA Exchange.
In: Angewandte Chemie-international Edition, Bd. 56, Nr. 14: S. 4052-4055
Röder, Ruth; Helma, Jonas; Prei, Tobias; Rädler, Joachim O.; Leonhardt, Heinrich und Wagner, Ernst
(2017):
Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells.
In: Pharmaceutical Research, Bd. 34, Nr. 1: S. 161-174
Ferry, Laure; Fournier, Alexandra; Tsusaka, Takeshi; Adelmant, Guillaume; Shimazu, Tadahiro; Matano, Shohei; Kirsh, Olivier; Amouroux, Rachel; Dohmae, Naoshi; Suzuki, Takehiro; Filion, Guillaume J.; Deng, Wen; Dieuleveult, Maud de; Fritsch, Lauriane; Kudithipudi, Srikanth; Jeltsch, Albert; Leonhardt, Heinrich; Hajkova, Petra; Marto, Jarrod A.; Arita, Kyohei; Shinkai, Yoichi und Defossez, Pierre-Antoine
(2017):
Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.
In: Molecular Cell, Bd. 67, Nr. 4: S. 550-565
Smets, Martha; Link, Stephanie; Wolf, Patricia; Schneider, Katrin; Solis, Veronica; Ryan, Joel; Meilinger, Daniela; Qin, Weihua und Leonhardt, Heinrich
(2017):
DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation.
In: Human Molecular Genetics, Bd. 26, Nr. 8: S. 1522-1534
Kraus, Felix; Miron, Ezequiel; Demmerle, Justin; Chitiashvili, Tsotne; Budco, Alexei; Alle, Quentin; Matsuda, Atsushi; Leonhardt, Heinrich; Schermelleh, Lothar und Markaki, Yolanda
(2017):
Quantitative 3D structured illumination microscopy of nuclear structures.
In: Nature Protocols, Bd. 12, Nr. 5: S. 1011-1028
Gressel, Saskia; Schwalb, Björn; Decker, Tim Michael; Qin, Weihua; Leonhardt, Heinrich; Eick, Dirk und Cramer, Patrick
(2017):
CDK9-dependent RNA polymerase II pausing controls transcription initiation.
In: Elife, Bd. 6, e29736
[PDF, 5MB]
Herce, Henry D.; Schumacher, Dominik; Schneider, Anselm F. L.; Ludwig, Anne K.; Mann, Florian A.; Fillies, Marion; Kasper, Marc-Andre; Reinke, Stefan; Krause, Eberhard; Leonhardt, Heinrich; Cardoso, M. Cristina und Hackenberger, Christian P. R.
(2017):
Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells.
In: Nature Chemistry, Bd. 9, Nr. 8: S. 762-771
Werken, Harmen J. G. van de; Haan, Josien C.; Feodorova, Yana; Bijos, Dominika; Weuts, An; Theunis, Koen; Holwerda, Sjoerd J. B.; Meuleman, Wouter; Pagie, Ludo; Thanisch, Katharina; Kumar, Parveen; Leonhardt, Heinrich; Marynen, Peter; Steensel, Bas van; Voet, Thierry; Laat, Wouter de; Solovei, Irina und Joffe, Boris
(2017):
Small chromosomal regions position themselves autonomously according to their chromatin class.
In: Genome Research, Bd. 27, Nr. 6: S. 922-933
Schumacher, Dominik; Lemke, Oliver; Helma, Jonas; Gerszonowicz, Lena; Waller, Verena; Stoschek, Tina; Durkin, Patrick M.; Budisa, Nediljko; Leonhardt, Heinrich; Keller, Bettina G. und Hackenberger, Christian P. R.
(2017):
Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling.
In: Chemical Science, Bd. 8, Nr. 5: S. 3471-3478
Ludwig, Anne K.; Zhang, Peng; Hastert, Florian D.; Meyer, Stephanie; Rausch, Cathia; Herce, Henry D.; Müller, Udo; Lehmkuhl, Anne; Hellmann, Ines; Trummer, Carina; Storm, Christian; Leonhardt, Heinrich und Cardoso, M. Cristina
(2017):
Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise.
In: Nucleic Acids Research, Bd. 45, Nr. 5: S. 2438-2457
Thanisch, Katharina; Song, Congdi; Engelkamp, Dieter; Koch, Jeannette; Wang, Audrey; Hallberg, Einar; Foisner, Roland; Leonhardt, Heinrich; Stewart, Colin L.; Joffe, Boris und Solovei, Irina
(2017):
Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering.
In: Differentiation, Bd. 94: S. 58-70
Cremer, Marion; Schmid, Volker J. ORCID: https://orcid.org/0000-0003-2195-8130; Kraus, Felix; Markaki, Yolanda; Hellmann, Ines; Maiser, Andreas; Leonhardt, Heinrich; John, Sam; Stamatoyannopoulos, John und Cremer, Thomas
(2017):
Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters.
In: Epigenetics & Chromatin
:10:39
[PDF, 5MB]
ORCID: https://orcid.org/0000-0003-2195-8130; Kraus, Felix; Markaki, Yolanda; Hellmann, Ines; Maiser, Andreas; Leonhardt, Heinrich; John, Sam; Stamatoyannopoulos, John und Cremer, Thomas
(2017):
Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters.
In: Epigenetics & Chromatin
:10:39
[PDF, 5MB]
Natale, Francesco; Rapp, Alexander; Yu, Wei; Maiser, Andreas; Harz, Hartmann; Scholl, Annina; Grulich, Stephan; Anton, Tobias; Hörl, David; Chen, Wei; Durante, Marco; Taucher-Scholz, Gisela; Leonhardt, Heinrich und Cardoso, M. Cristina
(2017):
Identification of the elementary structural units of the DNA damage response.
In: Nature Communications, Bd. 8, 15760
[PDF, 19MB]
Stengl, Andreas; Hörl, David; Leonhardt, Heinrich und Helma, Jonas
(2017):
A Simple and Sensitive High-Content Assay for the Characterization of Antiproliferative Therapeutic Antibodies.
In: Slas Discovery, Bd. 22, Nr. 3: S. 309-315
[PDF, 555kB]
Ziegenhain, Christoph; Vieth, Beate; Parekh, Swati; Reinius, Björn; Guillaumet-Adkins, Amy; Smets, Martha; Leonhardt, Heinrich; Heyn, Holger; Hellmann, Ines und Enard, Wolfgang
(2017):
Comparative Analysis of Single-Cell RNA Sequencing Methods.
In: Molecular Cell, Bd. 65, Nr. 4:
631-+
Borgel, Julie; Tyl, Marek; Schiller, Karin; Pusztai, Zsofia; Dooley, Christopher M.; Deng, Wen; Wooding, Carol; White, Richard J.; Warnecke, Tobias; Leonhardt, Heinrich; Busch-Nentwich, Elisabeth M. und Bartke, Till
(2017):
KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1.
In: Nucleic Acids Research, Bd. 45, Nr. 3: S. 1114-1129
[PDF, 10MB]
Zhang, Peng; Ludwig, Anne K.; Hastert, Florian D.; Rausch, Cathia; Lehmkuhl, Anne; Hellmann, Ines; Smets, Martha; Leonhardt, Heinrich und Cardoso, M. Cristina
(2017):
L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins.
In: Nucleus, Bd. 8, Nr. 5: S. 548-562
2016
Chiu, Hsin-Yi; Deng, Wen; Engelke, Hanna; Helma, Jonas; Leonhardt, Heinrich und Bein, Thomas
(2016):
Intracellular chromobody delivery by mesoporous silica nanoparticles for antigen targeting and visualization in real time.
In: Scientific Reports, Bd. 6, 25019
[PDF, 1MB]
Ma-Lauer, Yue; Carbajo-Lozoya, Javier; Hein, Marco Y.; Müller, Marcel A.; Deng, Wen; Lei, Jian; Meyer, Benjamin; Kusov, Yuri; Brunn, Brigitte von; Bairad, Dev Raj; Hünten, Sabine; Drosten, Christian; Hermeking, Heiko; Leonhardt, Heinrich; Mann, Matthias; Hilgenfeld, Rolf und Brunn, Albrecht von
(2016):
p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 113, Nr. 35, E5192-E5201
Becker, Annette; Zhang, Peng; Allmann, Lena; Meilinger, Daniela; Bertulat, Bianca; Eck, Daniel; Hofstaetter, Maria; Bartolomei, Giody; Hottiger, Michael O.; Schreiber, Valérie; Leonhardt, Heinrich und Cardoso, M. Cristina
(2016):
Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure.
In: Journal of Biological Chemistry, Bd. 291, Nr. 10: S. 4873-4881
Crevenna, Alvaro H.; Blank, Birgit; Maiser, Andreas; Emin, Derya; Prescher, Jens; Beck, Gisela; Kienzle, Christine; Bartnik, Kira; Habermann, Bianca; Pakdel, Mehrshad; Leonhardt, Heinrich; Lamb, Don C. und Blume, Julia von
(2016):
Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network.
In: Journal of Cell Biology, Bd. 213, Nr. 3: S. 305-314
Schumacher, Dominik; Hackenberger, Christian P. R.; Leonhardt, Heinrich und Helma, Jonas
(2016):
Current Status: Site-Specific Antibody Drug Conjugates.
In: Journal of Clinical Immunology, Bd. 36:
S100-S107
Schmidtmann, Elisabeth; Anton, Tobias; Rombaut, Pascaline; Herzog, Franz und Leonhardt, Heinrich
(2016):
Determination of local chromatin composition by CasID.
In: Nucleus, Bd. 7, Nr. 5: S. 476-484
Schmidtmann, Elisabeth; Anton, Tobias; Rombaut, Pascaline; Herzog, Franz ORCID: https://orcid.org/0000-0001-8270-1449 und Leonhardt, Heinrich
(2016):
Determination of local chromatin composition by CasID.
In: Nucleus, Bd. 7, Nr. 5: S. 476-484
[PDF, 1MB]
ORCID: https://orcid.org/0000-0001-8270-1449 und Leonhardt, Heinrich
(2016):
Determination of local chromatin composition by CasID.
In: Nucleus, Bd. 7, Nr. 5: S. 476-484
[PDF, 1MB]
2015
Abendroth, Christian; Hofmeister, Antje; Hake, Sandra B.; Kamweru, Paul K.; Miess, Elke; Dornblut, Carsten; Küffner, Isabell; Deng, Wen; Leonhardt, Heinrich; Orthaus, Sandra; Hoischen, Christian und Diekmann, Stephan
(2015):
The CENP-T C-terminus is exclusively proximal to H3.1 and not to H3.2 or H3.3.
In: International journal of molecular sciences, Bd. 16, Nr. 3: S. 5839-5863
[PDF, 2MB]
Mulholland, Christopher B.; Smets, Martha; Schmidtmann, Elisabeth; Leidescher, Susanne; Markaki, Yolanda; Hofweber, Mario; Qin, Weihua; Manzo, Massimiliano; Kremmer, Elisabeth; Thanisch, Katharina; Bauer, Christina; Rombaut, Pascaline; Herzog, Franz; Leonhardt, Heinrich und Bultmann, Sebastian
(2015):
A modular open platform for systematic functional studies under physiological conditions.
In: Nucleic Acids Research, Bd. 43, Nr. 17, e112
[PDF, 15MB]
Rajan, Malini; Mortusewicz, Oliver; Rothbauer, Ulrich; Hastert, Florian D.; Schmidthals, Katrin; Rapp, Alexander; Leonhardt, Heinrich und Cardoso, M. Cristina
(2015):
Generation of an alpaca-derived nanobody recognizing gamma-H2AX.
In: FEBS Open Bio, Bd. 5: S. 779-788
Borg, Sarah; Popp, Felix; Hofmann, Julia; Leonhardt, Heinrich; Rothbauer, Ulrich und Schüler, Dirk
(2015):
An Intracellular Nanotrap Redirects Proteins and Organelles in Live Bacteria.
In: Mbio, Bd. 6, Nr. 1, e02117-14
[PDF, 1MB]
2014
Smeets, Daniel; Markaki, Yolanda; Schmid, Volker J. ORCID: https://orcid.org/0000-0003-2195-8130; Kraus, Felix; Tattermusch, Anna; Cerase, Andrea; Sterr, Michael; Fiedler, Susanne; Demmerle, Justin; Popken, Jens; Leonhardt, Heinrich; Brockdorff, Neil; Cremer, Thomas; Schermelleh, Lothar und Cremer, Marion
(2014):
Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.
In: Epigenetics & Chromatin
7:8
[PDF, 6MB]
ORCID: https://orcid.org/0000-0003-2195-8130; Kraus, Felix; Tattermusch, Anna; Cerase, Andrea; Sterr, Michael; Fiedler, Susanne; Demmerle, Justin; Popken, Jens; Leonhardt, Heinrich; Brockdorff, Neil; Cremer, Thomas; Schermelleh, Lothar und Cremer, Marion
(2014):
Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.
In: Epigenetics & Chromatin
7:8
[PDF, 6MB]
Song, Congdi; Feodorova, Yana; Guy, Jacky; Peichl, Leo; Jost, Katharina Laurence; Kimura, Hiroshi; Cardoso, Maria Cristina; Bird, Adrian; Leonhardt, Heinrich; Joffe, Boris und Solovei, Irina
(2014):
DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution.
In: Epigenetics & Chromatin
7:17
[PDF, 11MB]
Smeets, Daniel; Markaki, Yolanda; Schmid, Volker J. ORCID: https://orcid.org/0000-0003-2195-8130; Kraus, Felix; Tattermusch, Anna; Cerase, Andrea; Sterr, Michael; Fiedler, Susanne; Demmerle, Justin; Popken, Jens; Leonhardt, Heinrich; Brockdorff, Neil; Cremer, Thomas; Schermelleh, Lothar und Cremer, Marion
(2014):
Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.
In: Epigenetics & Chromatin, Bd. 7, Nr. 8
ORCID: https://orcid.org/0000-0003-2195-8130; Kraus, Felix; Tattermusch, Anna; Cerase, Andrea; Sterr, Michael; Fiedler, Susanne; Demmerle, Justin; Popken, Jens; Leonhardt, Heinrich; Brockdorff, Neil; Cremer, Thomas; Schermelleh, Lothar und Cremer, Marion
(2014):
Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.
In: Epigenetics & Chromatin, Bd. 7, Nr. 8
Aschenbrenner, Daniela; Pippig, Diana A.; Klamecka, Kamila; Limmer, Katja; Leonhardt, Heinrich und Gaub, Hermann E.
(2014):
Parallel Force Assay for Protein-Protein Interactions.
In: PLOS ONE 9(12), e115049 [PDF, 725kB]
In: PLOS ONE 9(12), e115049 [PDF, 725kB]
Thanisch, Katharina; Schneider, Katrin; Morbitzer, Robert; Solovei, Irina; Lahaye, Thomas; Bultmann, Sebastian und Leonhardt, Heinrich
(2014):
Targeting and tracing of specific DNA sequences with dTALEs in living cells.
In: Nucleic Acids Research, Bd. 42, Nr. 6, e38
[PDF, 13MB]
Dornblut, Carsten; Quinn, Nadine; Monajambashi, Shamci; Prendergast, Lisa; Vuuren, Chelly van; Muench, Sandra; Deng, Wen; Leonhardt, Heinrich; Cardoso, M. Cristina; Hoischen, Christian; Diekmann, Stephan und Sullivan, Kevin F.
(2014):
A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle.
In: Open Biology, Bd. 4, Nr. 2, 130229
[PDF, 1MB]
Müller, Udo; Bauer, Christina; Siegl, Michael; Rottach, Andrea und Leonhardt, Heinrich
(2014):
TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation.
In: Nucleic Acids Research, Bd. 42, Nr. 13: S. 8592-8604
[PDF, 6MB]
2013
Liu, Nan; Wang, Mengxi; Deng, Wen; Schmidt, Christine S.; Qin, Weihua; Leonhardt, Heinrich und Spada, Fabio
(2013):
Intrinsic and Extrinsic Connections of Tet3 Dioxygenase with CXXC Zinc Finger Modules.
In: PLOS ONE 8(5), e62755 [PDF, 1MB]
In: PLOS ONE 8(5), e62755 [PDF, 1MB]
Schneider, Katrin M.; Fuchs, Christiane; Dobay, Akos; Rottach, Andrea; Qin, Weihua; Wolf, Patricia; Álvarez-Castro, J.M.; Nalaskowski, Marcus M.; Kremmer, Elisabeth; Schmid, Volker J. ORCID: https://orcid.org/0000-0003-2195-8130; Leonhardt, Heinrich und Schermelleh, Lothar
(2013):
Dissection of cell cycle-dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling.
In: Nucleic Acids Research, Bd. 41, Nr. 9: S. 4860-4876
ORCID: https://orcid.org/0000-0003-2195-8130; Leonhardt, Heinrich und Schermelleh, Lothar
(2013):
Dissection of cell cycle-dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling.
In: Nucleic Acids Research, Bd. 41, Nr. 9: S. 4860-4876
2012
Arand, Julia; Spieler, David; Karius, Tommy; Branco, Miguel R.; Meilinger, Daniela; Meissner, Alexander; Jenuwein, Thomas; Xu, Guoliang; Leonhardt, Heinrich; Wolf, Verena und Walter, Joern
(Juni 2012):
In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases.
In: PLOS Genetics 8(6), e1002750 [PDF, 1MB]
In: PLOS Genetics 8(6), e1002750 [PDF, 1MB]
Schmidt, Christine S.; Bultmann, Sebastian; Meilinger, Daniela; Zacher, Benedikt; Tresch, Achim; Maier, Kerstin C.; Peter, Christian; Martin, Dietmar E.; Leonhardt, Heinrich und Spada, Fabio
(2012):
Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state.
In: PLOS ONE 7(12), e52629 [PDF, 1MB]
In: PLOS ONE 7(12), e52629 [PDF, 1MB]
Helma, Jonas; Schmidthals, Katrin; Lux, Vanda; Nüske, Stefan; Scholz, Armin M.; Kräusslich, Hans-Georg; Rothbauer, Ulrich und Leonhardt, Heinrich
(2012):
Direct and dynamic detection of HIV-1 in living cells.
In: PLOS ONE 7(11), e50026 [PDF, 2MB]
In: PLOS ONE 7(11), e50026 [PDF, 2MB]
Eskat, Anja; Deng, Wen; Hofmeister, Antje; Rudolphi, Sven; Emmerth, Stephan; Hellwig, Daniela; Ulbricht, Tobias; Döring, Volker; Bancroft, James M.; McAinsh, Andrew D.; Cardoso, M. Cristina; Meraldi, Patrick; Hoischen, Christian; Leonhardt, Heinrich und Diekmann, Stephan
(2012):
Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex.
In: PLOS ONE 7(9), e44717 [PDF, 1MB]
In: PLOS ONE 7(9), e44717 [PDF, 1MB]
Gross, Henrik; Hennard, Christine; Masouris, Ilias; Cassel, Christian; Barth, Stephanie; Stober-Grässer, Ute; Mamiani, Alfredo; Moritz, Bodo; Ostareck, Dirk; Ostareck-Lederer, Antje; Neuenkirchen, Nils; Fischer, Utz; Deng, Wen; Leonhardt, Heinrich; Noessner, Elfriede; Kremmer, Elisabeth und Grässer, Friedrich A.
(2012):
Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression.
In: PLOS ONE 7(8), e42106 [PDF, 810kB]
In: PLOS ONE 7(8), e42106 [PDF, 810kB]
2011
Szwagierczak, Aleksandra; Brachmann, Andreas ORCID: https://orcid.org/0000-0001-7980-8173; Schmidt, Christine S.; Bultmann, Sebastian; Leonhardt, Heinrich und Spada, Fabio ORCID: https://orcid.org/0000-0002-7148-9013
(1. Juli 2011):
Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5–hydroxymethylcytosine.
In: Nucleic Acids Research, Bd. 39, Nr. 12: S. 5149-5156
[PDF, 3MB]
ORCID: https://orcid.org/0000-0001-7980-8173; Schmidt, Christine S.; Bultmann, Sebastian; Leonhardt, Heinrich und Spada, Fabio ORCID: https://orcid.org/0000-0002-7148-9013
(1. Juli 2011):
Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5–hydroxymethylcytosine.
In: Nucleic Acids Research, Bd. 39, Nr. 12: S. 5149-5156
[PDF, 3MB]
Frauer, Carina; Rottach, Andrea; Meilinger, Daniela; Bultmann, Sebastian; Fellinger, Karin; Hasenöder, Stefan; Wang, Mengxi; Qin, Weihua; Söding, Johannes; Spada, Fabio und Leonhardt, Heinrich
(2011):
Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1.
In: PLOS ONE 6(2), e16627 [PDF, 2MB]
In: PLOS ONE 6(2), e16627 [PDF, 2MB]
Frauer, Carina; Hoffmann, Thomas; Bultmann, Sebastian; Casa, Valentina; Cardoso, M. Cristina; Antes, Iris und Leonhardt, Heinrich
(2011):
Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain.
In: PLOS ONE 6(6), e21306 [PDF, 648kB]
In: PLOS ONE 6(6), e21306 [PDF, 648kB]
Jost, K. Laurence; Rottach, Andrea; Milden, Manuela; Bertulat, Bianca; Becker, Annette; Wolf, Patricia; Sandoval, Juan; Petazzi, Paolo; Huertas, Dori; Esteller, Manel; Kremmer, Elisabeth; Leonhardt, Heinrich und Cardoso, M. Cristina
(2011):
Generation and characterization of rat and mouse monoclonal antibodies specific for MeCP2 and their use in X-inactivation studies.
In: PLOS ONE 6(11), e26499 [PDF, 1MB]
In: PLOS ONE 6(11), e26499 [PDF, 1MB]
2007
Easwaran, Hariharan P.; Leonhardt, Heinrich und Cardoso, M. Cristina
(2007):
Distribution of DNA replication proteins in Drosophila cells.
In: BMC Cell Biology
8:42
[PDF, 910kB]
Mortusewicz, Oliver und Leonhardt, Heinrich
(2007):
XRCCI and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions.
In: BMC Molecular Biology
8:81
[PDF, 436kB]
1993
Leonhardt, Heinrich und Bestor, Timothy H.
(1993):
Structure, function and regulation of mammalian DNA methyltransferase.
In: Jost, Jean-Pierre und Saluz, Hans-Peter (Hrsg.):
DNA methylation: molecular biology and biological significance. EXS, Bd. 64. Basel: Birkhäuser. S. 109-119
[PDF, 1MB]
Cardoso, M. Cristina; Leonhardt, Heinrich und Nadal-Ginard, Bernardo
(1993):
Reversal of terminal differentiation and control of DNA replication. Cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication.
In: Cell, Bd. 74, Nr. 6: S. 979-992
[PDF, 13MB]
1992
Leonhardt, Heinrich; Page, Andrea W.; Weier, Heinz-Ulrich und Bestor, Timothy H.
(1992):
A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei.
In: Cell, Bd. 71, Nr. 5: S. 865-873
[PDF, 940kB]
1991
Czank, Andreas; Häuselmann, Remo; Page, Andrea W.; Leonhardt, Heinrich; Bestor, Timothy H.; Schaffner, Walter und Hergersberg, Martin
(1991):
Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase.
In: Gene, Bd. 109, Nr. 2: S. 259-263
[PDF, 812kB]