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Veröffentlichungsdatum
Anzahl der Publikationen: 56
2024
Sichler, Sonja; Höfner, Georg 
ORCID: https://orcid.org/0000-0002-7957-4503; Nitsche, Valentin; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Paintner, Franz F. und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 394: S. 23-31
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-7957-4503; Nitsche, Valentin; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Paintner, Franz F. und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 394: S. 23-31
[PDF, 2MB]
Bernauer, Tamara; Nitsche, Valentin; Kaiser, Jesko; Gertzen, Christoph G.W.; Höfner, Georg ORCID: https://orcid.org/0000-0002-7957-4503; Niessen, Karin V.; Seeger, Thomas; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425 und Paintner, Franz F.
(2024):
Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents.
In: Toxicology Letters, Bd. 397: S. 151-162
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-7957-4503; Niessen, Karin V.; Seeger, Thomas; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425 und Paintner, Franz F.
(2024):
Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents.
In: Toxicology Letters, Bd. 397: S. 151-162
[PDF, 2MB]
Nitsche, Valentin; Höfner, Georg; Kaiser, Jesko; Gertzen, Christoph G.W.; Seeger, Thomas; Niessen, Karin V.; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Paintner, Franz F. und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 392: S. 94-106
[PDF, 4MB]
ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 392: S. 94-106
[PDF, 4MB]
2023
Währa, Mark; Allmendinger, Lars; Höfner, Georg ORCID: https://orcid.org/0000-0002-7957-4503 und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2023):
Benocyclidine (BTCP) as Non‐labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR).
In: ChemMedChem, Bd. 18, Nr. 10
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-7957-4503 und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2023):
Benocyclidine (BTCP) as Non‐labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR).
In: ChemMedChem, Bd. 18, Nr. 10
[PDF, 1MB]
2022
Kaiser, Jesko; Gertzen, Christoph G. W.; Bernauer, Tamara; Hoefner, Georg; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Wanner, Klaus T.; Worek, Franz; Thiermann, Horst und Gohlke, Holger
(2022):
A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment.
In: Toxicology Letters, Bd. 373: S. 160-171
Kipka, Hannah; Tomasi, Roland; Hübner, Max; Liebchen, Uwe; Hagl, Christian; Wanner, Klaus T.; Mannell, Hanna und Höfner, Georg
(2022):
Simultaneous LC-ESI-MS/MS Quantification of Levosimendan and Its Metabolites for Therapeutic Drug Monitoring of Cardiac Surgery Patients.
In: Pharmaceutics, Bd. 14, Nr. 7
[PDF, 1MB]
2021
Ackermann, Thomas M.; Höfner, Georg und Wanner, Klaus T.
(2021):
Screening for New Inhibitors of Glycine Transporter 1 and 2 by Means of MS Binding Assays.
In: Chemmedchem, Bd. 16, Nr. 19: S. 3094-3104
Rudy, Heinrich-Karl A.; Höfner, Georg und Wanner, Klaus T.
(2021):
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with tricyclic cage structures in the lipophilic domain as GABA uptake inhibitors.
In: Medicinal Chemistry Research, Bd. 30, Nr. 3: S. 586-609
[PDF, 1MB]
Gryzlo, Beata; Zareba, Paula; Malawska, Katarzyna; Mazur, Gabriela; Rapacz, Anna; Latka, Kamil; Höfner, Georg C.; Latacz, Gniewomir; Bajda, Marek; Salat, Kinga; Wanner, Klaus T.; Malawska, Barbara und Kulig, Katarzyna
(2021):
Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity.
In: ACS Chemical Neuroscience, Bd. 12, Nr. 16: S. 3073-3100
Zareba, Paula; Salat, Kinga; Höfner, Georg C.; Latka, Kamil; Bajda, Marek; Latacz, Gniewomir; Kotniewicz, Krzysztof; Rapacz, Anna; Podkowa, Adrian; Maj, Maciej; Jozwiak, Krzysztof; Filipek, Barbara; Wanner, Klaus T.; Malawska, Barbara und Kulig, Katarzyna
(2021):
Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity.
In: European Journal of Medicinal Chemistry, Bd. 221, 113512
2020
Andreß, Janina C.; Böck, Michael C.; Höfner, Georg und Wanner, Klaus T.
(2020):
Synthesis and biological evaluation of α- and β-hydroxy substituted amino acid derivatives as potential mGAT1-4 inhibitors.
In: Medicinal Chemistry Research, Bd. 29, Nr. 8: S. 1321-1340
[PDF, 1MB]
Gabriel, Jeurgen; Höfner, Georg und Wanner, Klaus T.
(2020):
Combination of MS Binding Assays and affinity selection mass spectrometry for screening of structurally homogenous libraries as exemplified for a focused oxime library addressing the neuronal GABA transporter 1.
In: European Journal of Medicinal Chemistry, Bd. 206, 112598
Zareba, Paula; Gryzlo, Beata; Malawska, Katarzyna; Salat, Kinga; Höfner, Georg C.; Nowaczyk, Alicja; Fijalkowski, Lukasz; Rapacz, Anna; Podkowa, Adrian; Furgala, Anna; Zmudzki, Pawel; Wanner, Klaus T.; Malawska, Barbara und Kulig, Katarzyna
(2020):
Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.
In: European Journal of Medicinal Chemistry, Bd. 188, 111920
Daerr, Markus; Allmendinger, Lars; Höfner, Georg und Wanner, Klaus T.
(2020):
Synthesis and biological evaluation of fluorescent GAT-ligands based on asymmetric substituted BODIPY dyes.
In: Medicinal Chemistry Research, Bd. 29, Nr. 4: S. 767-782
Daerr, Markus; Pabel, Jörg; Höfner, Georg; Mayer, Peter und Wanner, Klaus T.
(2020):
Synthesis and biological evaluation of fluorescent GAT-ligands based on meso-substituted BODIPY dyes.
In: Medicinal Chemistry Research, Bd. 29, Nr. 2: S. 301-327
Ackermann, Thomas M.; Allmendinger, Lars; Höfner, Georg und Wanner, Klaus T.
(2020):
MS Binding Assays for Glycine Transporter 2 (GlyT2) Employing Org25543 as Reporter Ligand.
In: Chemmedchem, Bd. 16, Nr. 1: S. 199-215
[PDF, 2MB]
Rudy, Heinrich‐Karl A.; Mayer, Peter und Wanner, Klaus T.
(2020):
Synthesis of 1,5‐Ring‐Fused Imidazoles from Cyclic Imines and TosMIC – Identification of in situ Generated N‐Methyleneformamide as a Catalyst in the van Leusen Imidazole Synthesis.
In: European Journal of Organic Chemistry, Bd. 2020, Nr. 24: S. 3599-3612
[PDF, 2MB]
Böck, Michael C.; Höfner, Georg und Wanner, Klaus T.
(2020):
N‐Substituted Nipecotic Acids as (S )‐SNAP‐5114 Analogues with Modified Lipophilic Domains.
In: ChemMedChem, Bd. 15, Nr. 9: S. 756-771
[PDF, 2MB]
2019
Gabriel, Jürgen; Hoefner, Georg und Wanner, Klaus T.
(4. Oktober 2019):
A Library Screening Strategy Combining the Concepts of MS Binding Assays and Affinity Selection Mass Spectrometry.
In: Frontiers in Chemistry, Bd. 7, 665: S. 1-18
[PDF, 2MB]
Hauke, Tobias J.; Hoefner, Georg und Wanner, Klaus T.
(2019):
Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4.
In: Bioorganic & Medicinal Chemistry, Bd. 27, Nr. 1: S. 144-152
Wein, Thomas; Wanner, Klaus T.; Rappenglueck, Sebastian; Sichler, Sonja; Niessen, Karin; Seeger, Thomas; Worek, Franz und Thiermann, Horst
(2019):
New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling.
In: Current Computer-Aided Drug Design, Bd. 15, Nr. 1: S. 104-109
Toth, Krisztian; Hoefner, Georg und Wanner, Klaus T.
(2019):
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a cis-alkene spacer as GABA uptake inhibitors.
In: Bioorganic & Medicinal Chemistry, Bd. 27, Nr. 5: S. 822-831
Hauke, Tobias J.; Hoefner, Georg und Wanner, Klaus T.
(2019):
MS-Based Screening of 5-Substituted Nipecotic Acid Derived Hydrazone Libraries as Ligands of the GABA Transporter 1.
In: Chemmedchem, Bd. 14, Nr. 5: S. 583-593
Kern, Felix und Wanner, Klaus T.
(2019):
Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors gamma-aminobutyric acid transporter 1.
In: Bioorganic & Medicinal Chemistry, Bd. 27, Nr. 7: S. 1232-1245
Schaarschmidt, Maren; Hoefner, Georg und Wanner, Klaus T.
(2019):
Synthesis and Biological Evaluation of Nipecotic Acid and Guvacine Derived 1,3-Disubstituted Allenes as Inhibitors of Murine GABA Transporter mGAT1.
In: Chemmedchem, Bd. 14, Nr. 12: S. 1135-1151
Huber, Simone K.; Hoefner, Georg und Wanner, Klaus T.
(2019):
Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of gamma-aminobutyric acid transporter 1 (GAT1).
In: Bioorganic & Medicinal Chemistry, Bd. 27, Nr. 13: S. 2753-2763
Rudy, Heinrich-Karl A. und Wanner, Klaus T.
(2019):
Accessing Tricyclic Imines Comprising a 2-Azabicyclo[2.2.2]octane Scaffold by Intramolecular Hetero-Diels-Alder Reaction of 4-Alkenyl-Substituted N-Silyl-1,4-dihydropyridines.
In: Synthesis-Stuttgart, Bd. 51, Nr. 22: S. 4296-4310
Ackermann, Thomas M.; Bhokare, Karuna; Hoefner, Georg und Wanner, Klaus T.
(2019):
MS binding assays for GlyT1 based on Org24598 as nonlabelled reporter ligand.
In: Neuropharmacology, Bd. 161, 107561
Petz, Susanne; Allmendinger, Lars; Mayer, Peter und Wanner, Klaus T.
(2019):
Construction of 4-substituted 2-(pyrrolidine-3-yl)acetic acid derivatives as cyclic gamma-aminobutyric acid analogues employing intermolecular [2+2]-photocycloaddition as key steps.
In: Tetrahedron, Bd. 75, Nr. 19: S. 2755-2762
2018
Lutz, Toni; Wein, Thomas; Höfner, Georg; Pabel, Jörg; Eder, Matthias; Dine, Julien und Wanner, Klaus T.
(2018):
Development of New Photoswitchable Azobenzene Based gamma-Aminobutyric Acid (GABA) Uptake Inhibitors with Distinctly Enhanced Potency upon Photoactivation.
In: Journal of Medicinal Chemistry, Bd. 61, Nr. 14: S. 6211-6235
Hauke, Tobias J.; Wein, Thomas; Hofner, Georg und Wanner, Klaus T.
(2018):
Novel Allosteric Ligands of gamma-Aminobutyric Acid Transporter 1 (GAT1) by MS Based Screening of Pseudostatic Hydrazone Libraries.
In: Journal of Medicinal Chemistry, Bd. 61, Nr. 22: S. 10310-10332
Scheffel, Corinna; Niessen, Karin V.; Rappenglück, Sebastian; Wanner, Klaus T.; Thiermann, Horst; Worek, Franz und Seeger, Thomas
(2018):
Counteracting desensitization of human alpha 7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning.
In: Toxicology Letters, Bd. 293: S. 149-156
Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
In: Chemmedchem, Bd. 13, Nr. 17: S. 1806-1816
Toth, Krisztian; Höfner, Georg und Wanner, Klaus T.
(2018):
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors.
In: Bioorganic & Medicinal Chemistry, Bd. 26, Nr. 22: S. 5944-5961
Neiens, Patrick; De Simone, Angela; Höfner, Georg und Wanner, Klaus T.
(2018):
Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters.
In: Chemmedchem, Bd. 13, Nr. 5: S. 453-463
Huber, Simone K.; Höfner, Georg und Wanner, Klaus T.
(2018):
Identification of Pyrrolidine-3-acetic Acid Derived Oximes as Potent Inhibitors of gamma-Aminobutyric Acid Transporter 1 through Library Screening with MS Binding Assays.
In: Chemmedchem, Bd. 13, Nr. 23: S. 2488-2503
Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
In: Chemmedchem, Bd. 13, Nr. 24: S. 2653-2663
Toth, Krisztian; Höfner, Georg und Wanner, Klaus T.
(2018):
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with an alkyne spacer as GABA uptake inhibitors.
In: Bioorganic & Medicinal Chemistry, Bd. 26, Nr. 12: S. 3668-3687
Wein, Thomas; Höfner, Georg; Rappenglück, Sebastian; Sichler, Sonja; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 293: S. 184-189
Neiens, Patrick; De Simone, Angela; Ramershoven, Anna; Höfner, Georg; Allmendinger, Lars und Wanner, Klaus T.
(2018):
Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET.
In: Biomedical Chromatography, Bd. 32, Nr. 7, e4231
2017
Neiens, Patrick; Höfner, Georg und Wanner, Klaus T.
(2017):
Determination of the enantiomeric purity of the selective dopamine transporter inhibitor (+)-R,R-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol.
In: Chirality, Bd. 29, Nr. 6: S. 294-303
Ellwart, Mario; Höfner, Georg; Gerwien, Aaron; Wanner, Klaus T. und Knochel, Paul
(2017):
Synthesis and Bioactivity of Novel N-Benzylic and N-Phenethylic Ephedrine Derivatives.
In: Synthesis-Stuttgart, Bd. 49, Nr. 23: S. 5159-5166
Schuller, Marion; Höfner, Georg und Wanner, Klaus T.
(2017):
Simultaneous Multiple MS Binding Assays Addressing D-1 and D-2 Dopamine Receptors.
In: ChemMedChem, Bd. 12, Nr. 19: S. 1585-1594
Schaarschmidt, Maren und Wanner, Klaus T.
(2017):
Synthesis of Allene Substituted Nipecotic Acids by Allenylation of Terminal Alkynes.
In: Journal of Organic Chemistry, Bd. 82, Nr. 16: S. 8371-8388
Lutz, Toni; Wein, Thomas; Höfner, Georg und Wanner, Klaus T.
(2017):
Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives with N-Arylalkynyl Substituents.
In: ChemMedChem, Bd. 12, Nr. 5: S. 362-371
Rappenglück, Sebastian; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2017):
Regioselective and Transition-Metal-Free Addition of tert-Butyl Magnesium Reagents to Pyridine Derivatives: A Convenient Method for the Synthesis of 3-Substituted 4-tert-Butylpyridine Derivatives.
In: Synthesis-Stuttgart, Bd. 49, Nr. 17: S. 4055-4064
Schmidt, Simone K.; Höfner, Georg und Wanner, Klaus T.
(2017):
Determination of enantiomeric excess of nipecotic acid as 1-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) derivatives.
In: Chirality, Bd. 29, Nr. 1: S. 48-56
Sałat, Kinga; Podkowa, Adrian; Malikowska, Natalia; Kern, Felix; Pabel, Jörg; Wojcieszak, Ewelina; Kulig, Katarzyna; Wanner, Klaus T.; Strach, Beata und Wyska, Elżbieta
(2017):
Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties.
In: Neuropharmacology, Bd. 113: S. 331-342
2016
Sohail, Azmat; Jayaraman, Kumaresan; Venkatesan, Santhoshkannan; Gotfryd, Kamil; Daerr, Markus; Gether, Ulrik; Loland, Claus J.; Wanner, Klaus T.; Freissmuth, Michael; Sitte, Harald H.; Sandtner, Walter und Stockner, Thomas
(2016):
The Environment Shapes the Inner Vestibule of LeuT.
In: PLOS Computational Biology 12(11), e1005197 [PDF, 5MB]
In: PLOS Computational Biology 12(11), e1005197 [PDF, 5MB]
Lutz, Toni A.; Spanner, Patrick und Wanner, Klaus T.
(2016):
A general approach to substituted diphenyldiazenes.
In: Tetrahedron, Bd. 72, Nr. 12: S. 1579-1589
Hellenbrand, Tim; Höfner, Georg; Wein, Thomas und Wanner, Klaus T.
(2016):
Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors.
In: Bioorganic & Medicinal Chemistry, Bd. 24, Nr. 9: S. 2072-2096
Wein, Thomas; Petrera, Marilena; Allmendinger, Lars; Höfner, Georg; Pabel, Jörg und Wanner, Klaus T.
(2016):
Different Binding Modes of Small and Large Binders of GAT1.
In: ChemMedChem, Bd. 11, Nr. 5: S. 509-518
Petrera, Marilena; Wein, Thomas; Allmendinger, Lars; Sindelar, Miriam; Pabel, Jörg; Höfner, Georg und Wanner, Klaus T.
(2016):
Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives by Suzuki-Miyaura Cross-Coupling Reactions.
In: ChemMedChem, Bd. 11, Nr. 5: S. 519-538
Cattaneo, Giulia; Ubiali, Daniela; Calleri, Enrica; Rabuffetti, Marco; Höfner, Georg C.; Wanner, Klaus T.; Moraes, Marcela C. de; Martinelli, Leonardo K. B.; Santiago Santos, Diógenes; Speranza, Giovanna und Massolini, Gabriella
(2016):
Development, validation and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase.
In: Analytica Chimica Acta, Bd. 943: S. 89-97
Kerscher-Hack, Silke; Renukappa-Gutke, Thejavathi; Höfner, Georg und Wanner, Klaus T.
(2016):
Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.
In: European Journal of Medicinal Chemistry, Bd. 124: S. 852-880
Kirmeier, Thomas; Gopalakrishnan, Ranganath; Gormanns, Vanessa; Werner, Anna M.; Cuboni, Serena; Rudolf, Georg C.; Höfner, Georg; Wanner, Klaus T.; Sieber, Stephan A.; Schmidt, Ulrike; Holsboer, Florian; Rein, Theo und Hausch, Felix
(2016):
Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores.
In: PLOS ONE 11(2), e0148608 [PDF, 768kB]
In: PLOS ONE 11(2), e0148608 [PDF, 768kB]