Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia

Ruiz-Rizzo, Adriana L. ; Finke, Kathrin ; Damoiseaux, Jessica S.; Bartels, Claudia; Buerger, Katharina; Cosma, Nicoleta Carmen; Dechent, Peter; Dobisch, Laura; Ewers, Michael; Fliessbach, Klaus; Frommann, Ingo; Glanz, Wenzel; Goerss, Doreen; Hetzer, Stefan; Incesoy, Enise I.; Janowitz, Daniel; Kilimann, Ingo; Laske, Christoph; Melo van Lent, Debora; Munk, Matthias H.; Peters, Oliver; Priller, Josef; Ramirez, Alfredo; Rostamzadeh, Ayda; Roy, Nina; Scheffler, Klaus; Schneider, Anja; Spottke, Annika; Spruth, Eike Jakob; Teipel, Stefan; Wagner, Michael; Wiltfang, Jens; Yakupov, Renat; Jessen, Frank; Duezel, Emrah; Perneczky, Robert und Rauchmann, Boris-Stephan (9. Februar 2024): Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia. In: Neurobiology of Aging, Bd. 136: S. 99-110

Abstract

Here, we investigated whether fractional anisotropy (FA) of hippocampus-relevant white-matter tracts mediates the association between baseline Mediterranean diet adherence (MeDiAd) and verbal episodic memory over four years. Participants were healthy older adults with and without subjective cognitive decline and patients with amnestic mild cognitive impairment from the DELCODE cohort study (n = 376; age: 71.47 ± 6.09 years; 48.7 % female). MeDiAd and diffusion data were obtained at baseline. Verbal episodic memory was assessed at baseline and four yearly follow-ups. The associations between baseline MeDiAd and white matter, and verbal episodic memory’s mean and rate of change over four years were tested with latent growth curve modeling. Baseline MeDiAd was associated with verbal episodic memory four years later (95 % confidence interval, CI [0.01, 0.32]) but not with its rate of change over this period. Baseline Fornix FA mediated – and, thus, explained – that association (95 % CI [0.002, 0.09]). Fornix FA may be an appropriate response biomarker of Mediterranean diet interventions on verbal memory in older adults.

• Dokumententyp: Zeitschriftenartikel
• EU Funded Grant Agreement Number: 754388
• EU-Projekte: Horizon 2020 > Marie Skłodowska Curie Actions > Marie Skłodowska-Curie: Sonstige Programme > 754388: The LMU Research Fellowship Program: Promoting excellent early-stage postdoctoral researchers at LMU Munich
• Keywords: Diet; latent growth curve modeling; Longitudinal analysis; mild cognitive impairment; white matter
• Fakultät: Psychologie und Pädagogik > Department Psychologie > Allgemeine und Experimentelle Psychologie ; Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 100 Philosophie und Psychologie > 150 Psychologie ; 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
• ISSN: 0197-4580
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198