![[höher]](/style/images/multi_up.png)
Eine Ebene höherGruppiert nach:
Dokumententyp
| Veröffentlichungsdatum
Springe zu: Zeitschriftenartikel
Anzahl der Publikationen: 101
Zeitschriftenartikel
Batcha, Aarif M. N. 
ORCID: https://orcid.org/0000-0002-7972-7506; Buckup, Nele; Bamopoulos, Stefanos A ORCID: https://orcid.org/0000-0002-5997-7735; Jurinovic, Vindi; Rothenberg-Thurley, Maja; Gittinger, Hanna; Ksienzyk, Bianka; Dufour, Annika; Schneider, Stephanie; Kontro, Mika; Saad, Joseph ORCID: https://orcid.org/0000-0001-7701-0328; Heckman, Caroline A. ORCID: https://orcid.org/0000-0002-4324-8706; Sauerland, Cristina M.; Görlich, Dennis ORCID: https://orcid.org/0000-0002-2574-9419; Berdel, Wolfgang E. ORCID: https://orcid.org/0000-0002-3030-6567; Wörmann, Bernhard; Krug, Utz; Braess, Jan; Mansmann, Ulrich Robert ORCID: https://orcid.org/0000-0002-9955-8906; Hiddemann, Wolfgang; Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957; Metzeler, Klaus H. ORCID: https://orcid.org/0000-0003-3920-7490 und Herold, Tobias ORCID: https://orcid.org/0000-0002-9615-9432
(2023):
Germline SNPs previously implicated as prognostic biomarkers do not associate with outcomes in intensively treated AML.
In: Blood Advances, Bd. 7, Nr. 6: S. 1040-1044
ORCID: https://orcid.org/0000-0002-7972-7506; Buckup, Nele; Bamopoulos, Stefanos A ORCID: https://orcid.org/0000-0002-5997-7735; Jurinovic, Vindi; Rothenberg-Thurley, Maja; Gittinger, Hanna; Ksienzyk, Bianka; Dufour, Annika; Schneider, Stephanie; Kontro, Mika; Saad, Joseph ORCID: https://orcid.org/0000-0001-7701-0328; Heckman, Caroline A. ORCID: https://orcid.org/0000-0002-4324-8706; Sauerland, Cristina M.; Görlich, Dennis ORCID: https://orcid.org/0000-0002-2574-9419; Berdel, Wolfgang E. ORCID: https://orcid.org/0000-0002-3030-6567; Wörmann, Bernhard; Krug, Utz; Braess, Jan; Mansmann, Ulrich Robert ORCID: https://orcid.org/0000-0002-9955-8906; Hiddemann, Wolfgang; Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957; Metzeler, Klaus H. ORCID: https://orcid.org/0000-0003-3920-7490 und Herold, Tobias ORCID: https://orcid.org/0000-0002-9615-9432
(2023):
Germline SNPs previously implicated as prognostic biomarkers do not associate with outcomes in intensively treated AML.
In: Blood Advances, Bd. 7, Nr. 6: S. 1040-1044
Bornhäuser, Martin; Schliemann, Christoph; Schetelig, Johannes; Röllig, Christoph; Kramer, Michael; Glass, Bertram; Platzbecker, Uwe; Burchert, Andreas; Hänel, Mathias; Müller, Lutz P.; Klein, Stefan; Bug, Gesine; Beelen, Dietrich; Rösler, Wolf; Schäfer-Eckart, Kerstin; Schmid, Christoph; Jost, Edgar; Lenz, Georg; Tischer, Johanna; Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957; Pfirrmann, Markus ORCID: https://orcid.org/0000-0002-8948-0690; Serve, Hubert; Stölzel, Friedrich; Alakel, Nael; Middeke, Jan Moritz; Thiede, Christian; Ehninger, Gerhard; Berdel, Wolfgang E. und Stelljes, Matthias
(2023):
Allogeneic Hematopoietic Cell Transplantation vs Standard Consolidation Chemotherapy in Patients With Intermediate-Risk Acute Myeloid Leukemia.
In: JAMA Oncology, Bd. 9, Nr. 4: S. 519-526
ORCID: https://orcid.org/0000-0002-5139-4957; Pfirrmann, Markus ORCID: https://orcid.org/0000-0002-8948-0690; Serve, Hubert; Stölzel, Friedrich; Alakel, Nael; Middeke, Jan Moritz; Thiede, Christian; Ehninger, Gerhard; Berdel, Wolfgang E. und Stelljes, Matthias
(2023):
Allogeneic Hematopoietic Cell Transplantation vs Standard Consolidation Chemotherapy in Patients With Intermediate-Risk Acute Myeloid Leukemia.
In: JAMA Oncology, Bd. 9, Nr. 4: S. 519-526
Pastore, Friederike ORCID: https://orcid.org/0000-0002-2220-2346; Gittinger, Hanna; Raab, Susanne; Tschuri, Sebastian; Ksienzyk, Bianka; Konstandin, Nikola P.; Schneider, Stephanie; Rothenberg‐Thurley, Maja; Horny, Hans‐Peter; Werner, Martin; Sauerland, Maria C. ORCID: https://orcid.org/0000-0002-8748-8218; Amler, Susanne ORCID: https://orcid.org/0000-0001-6903-2906; Görlich, Dennis ORCID: https://orcid.org/0000-0002-2574-9419; Berdel, Wolfgang E. ORCID: https://orcid.org/0000-0002-3030-6567; Wörmann, Bernhard ORCID: https://orcid.org/0000-0003-2273-5502; Braess, Jan; Hiddemann, Wolfgang; Tischer, Johanna ORCID: https://orcid.org/0000-0003-1821-1976; Herold, Tobias ORCID: https://orcid.org/0000-0002-9615-9432; Metzeler, Klaus H. ORCID: https://orcid.org/0000-0003-3920-7490 und Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957
(2023):
Acute megakaryoblastic leukaemia shows high frequency of chromosome 1q aberrations and dismal outcome.
In: British Journal of Haematology, Bd. 202, Nr. 6: S. 1165-1177
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-2220-2346; Gittinger, Hanna; Raab, Susanne; Tschuri, Sebastian; Ksienzyk, Bianka; Konstandin, Nikola P.; Schneider, Stephanie; Rothenberg‐Thurley, Maja; Horny, Hans‐Peter; Werner, Martin; Sauerland, Maria C. ORCID: https://orcid.org/0000-0002-8748-8218; Amler, Susanne ORCID: https://orcid.org/0000-0001-6903-2906; Görlich, Dennis ORCID: https://orcid.org/0000-0002-2574-9419; Berdel, Wolfgang E. ORCID: https://orcid.org/0000-0002-3030-6567; Wörmann, Bernhard ORCID: https://orcid.org/0000-0003-2273-5502; Braess, Jan; Hiddemann, Wolfgang; Tischer, Johanna ORCID: https://orcid.org/0000-0003-1821-1976; Herold, Tobias ORCID: https://orcid.org/0000-0002-9615-9432; Metzeler, Klaus H. ORCID: https://orcid.org/0000-0003-3920-7490 und Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957
(2023):
Acute megakaryoblastic leukaemia shows high frequency of chromosome 1q aberrations and dismal outcome.
In: British Journal of Haematology, Bd. 202, Nr. 6: S. 1165-1177
[PDF, 1MB]
Marcinek, Anetta; Brauchle, Bettina; Rohrbacher, Lisa; Hänel, Gerulf; Philipp, Nora; Märkl, Florian; Strzalkowski, Thaddäus; Lacher, Sonja M.; Udiljak, Dragica; Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957; Theurich, Sebastian; Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673; Kischel, Roman; James, John R.; Bücklein, Veit L. und Subklewe, Marion ORCID: https://orcid.org/0000-0001-9154-9469
(2023):
CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells.
In: Cancer Immunology, Immunotherapy, Bd. 72, Nr. 7: S. 2499-2512
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-5139-4957; Theurich, Sebastian; Kobold, Sebastian ORCID: https://orcid.org/0000-0002-5612-4673; Kischel, Roman; James, John R.; Bücklein, Veit L. und Subklewe, Marion ORCID: https://orcid.org/0000-0001-9154-9469
(2023):
CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells.
In: Cancer Immunology, Immunotherapy, Bd. 72, Nr. 7: S. 2499-2512
[PDF, 1MB]
Fraccaroli, Alessia; Vogt, Daniela; Rothmayer, Margarete; Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957; Pastore, Friederike ORCID: https://orcid.org/0000-0002-2220-2346 und Tischer, Johanna ORCID: https://orcid.org/0000-0003-1821-1976
(2023):
Impact of extramedullary disease in AML patients undergoing sequential RIC for HLA-matched transplantation: occurrence, risk factors, relapse patterns, and outcome.
In: Annals of Hematology, Bd. 102, Nr. 8: S. 2213-2223
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-5139-4957; Pastore, Friederike ORCID: https://orcid.org/0000-0002-2220-2346 und Tischer, Johanna ORCID: https://orcid.org/0000-0003-1821-1976
(2023):
Impact of extramedullary disease in AML patients undergoing sequential RIC for HLA-matched transplantation: occurrence, risk factors, relapse patterns, and outcome.
In: Annals of Hematology, Bd. 102, Nr. 8: S. 2213-2223
[PDF, 1MB]
Kaiser, Rainer ORCID: https://orcid.org/0000-0003-1750-3395; Anjum, Afra ORCID: https://orcid.org/0000-0002-1976-4102; Kammerer, Lisa Maria; Loew, Quentin; Akhalkatsi, Anastassia; Rossaro, Dario; Escaig, Raphael; Droste zu Senden, Augustin; Raude, Ben; Lorenz, Michael; Gold, Christoph; Pekayvaz, Kami ORCID: https://orcid.org/0000-0003-4040-650X; Brocker, Thomas; Kranich, Jan ORCID: https://orcid.org/0000-0002-9928-4132; Holch, Julian Walter; Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957; Massberg, Steffen ORCID: https://orcid.org/0000-0001-7387-3986; Gaertner, Florian ORCID: https://orcid.org/0000-0001-6120-3723 und Nicolai, Leo ORCID: https://orcid.org/0000-0003-0776-5885
(2023):
Mechanosensing via a GpIIb/Src/14-3-3ζ axis critically regulates platelet migration in vascular inflammation.
In: Blood, Bd. 141, Nr. 24: S. 2973-2992
ORCID: https://orcid.org/0000-0003-1750-3395; Anjum, Afra ORCID: https://orcid.org/0000-0002-1976-4102; Kammerer, Lisa Maria; Loew, Quentin; Akhalkatsi, Anastassia; Rossaro, Dario; Escaig, Raphael; Droste zu Senden, Augustin; Raude, Ben; Lorenz, Michael; Gold, Christoph; Pekayvaz, Kami ORCID: https://orcid.org/0000-0003-4040-650X; Brocker, Thomas; Kranich, Jan ORCID: https://orcid.org/0000-0002-9928-4132; Holch, Julian Walter; Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957; Massberg, Steffen ORCID: https://orcid.org/0000-0001-7387-3986; Gaertner, Florian ORCID: https://orcid.org/0000-0001-6120-3723 und Nicolai, Leo ORCID: https://orcid.org/0000-0003-0776-5885
(2023):
Mechanosensing via a GpIIb/Src/14-3-3ζ axis critically regulates platelet migration in vascular inflammation.
In: Blood, Bd. 141, Nr. 24: S. 2973-2992
Nicolai, Leo ORCID: https://orcid.org/0000-0003-0776-5885; Leunig, Alexander ORCID: https://orcid.org/0000-0002-9179-9203; Pekayvaz, Kami ORCID: https://orcid.org/0000-0003-4040-650X; Esefeld, Max ORCID: https://orcid.org/0000-0002-8425-618X; Anjum, Afra ORCID: https://orcid.org/0000-0002-1976-4102; Rath, Justina; Riedlinger, Eva; Ehreiser, Vincent ORCID: https://orcid.org/0000-0002-8820-8839; Mader, Magdalena; Eivers, Luke ORCID: https://orcid.org/0000-0002-6049-0377; Hoffknecht, Marie-Louise ORCID: https://orcid.org/0000-0002-5894-0308; Zhang, Zhe; Kugelmann, Daniela ORCID: https://orcid.org/0000-0002-2512-4240; Rossaro, Dario ORCID: https://orcid.org/0000-0003-1301-8739; Escaig, Raphael; Kaiser, Rainer ORCID: https://orcid.org/0000-0003-1750-3395; Polewka, Vivien; Titova, Anna; Petzold, Tobias ORCID: https://orcid.org/0000-0001-7805-5632; Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957; Iannacone, Matteo ORCID: https://orcid.org/0000-0002-9370-2671; Thiele, Thomas; Greinacher, Andreas ORCID: https://orcid.org/0000-0001-8343-7336; Stark, Konstantin ORCID: https://orcid.org/0000-0002-5369-8399 und Massberg, Steffen ORCID: https://orcid.org/0000-0001-7387-3986
(2022):
Thrombocytopenia and splenic platelet-directed immune responses after IV ChAdOx1 nCov-19 administration.
In: Blood, Bd. 140, Nr. 5: S. 478-490
[PDF, 2MB]
ORCID: https://orcid.org/0000-0003-0776-5885; Leunig, Alexander ORCID: https://orcid.org/0000-0002-9179-9203; Pekayvaz, Kami ORCID: https://orcid.org/0000-0003-4040-650X; Esefeld, Max ORCID: https://orcid.org/0000-0002-8425-618X; Anjum, Afra ORCID: https://orcid.org/0000-0002-1976-4102; Rath, Justina; Riedlinger, Eva; Ehreiser, Vincent ORCID: https://orcid.org/0000-0002-8820-8839; Mader, Magdalena; Eivers, Luke ORCID: https://orcid.org/0000-0002-6049-0377; Hoffknecht, Marie-Louise ORCID: https://orcid.org/0000-0002-5894-0308; Zhang, Zhe; Kugelmann, Daniela ORCID: https://orcid.org/0000-0002-2512-4240; Rossaro, Dario ORCID: https://orcid.org/0000-0003-1301-8739; Escaig, Raphael; Kaiser, Rainer ORCID: https://orcid.org/0000-0003-1750-3395; Polewka, Vivien; Titova, Anna; Petzold, Tobias ORCID: https://orcid.org/0000-0001-7805-5632; Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957; Iannacone, Matteo ORCID: https://orcid.org/0000-0002-9370-2671; Thiele, Thomas; Greinacher, Andreas ORCID: https://orcid.org/0000-0001-8343-7336; Stark, Konstantin ORCID: https://orcid.org/0000-0002-5369-8399 und Massberg, Steffen ORCID: https://orcid.org/0000-0001-7387-3986
(2022):
Thrombocytopenia and splenic platelet-directed immune responses after IV ChAdOx1 nCov-19 administration.
In: Blood, Bd. 140, Nr. 5: S. 478-490
[PDF, 2MB]
Pastore, Friederike ORCID: https://orcid.org/0000-0002-2220-2346; Pastore, Alessandro; Rothenberg-Thurley, Maja; Metzeler, Klaus H.; Ksienzyk, Bianka; Schneider, Stephanie; Bohlander, Stefan K.; Braess, Jan; Sauerland, Maria C.; Görlich, Dennis; Berdel, Wolfgang E.; Wörmann, Bernhard; Bergwelt-Baildon, Michael von; Hiddemann, Wolfgang und Spiekermann, Karsten
(2022):
Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis.
In: Cancer, Bd. 128, Nr. 24: S. 4213-4222
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-2220-2346; Pastore, Alessandro; Rothenberg-Thurley, Maja; Metzeler, Klaus H.; Ksienzyk, Bianka; Schneider, Stephanie; Bohlander, Stefan K.; Braess, Jan; Sauerland, Maria C.; Görlich, Dennis; Berdel, Wolfgang E.; Wörmann, Bernhard; Bergwelt-Baildon, Michael von; Hiddemann, Wolfgang und Spiekermann, Karsten
(2022):
Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis.
In: Cancer, Bd. 128, Nr. 24: S. 4213-4222
[PDF, 1MB]
Ruzicka, Michael ORCID: https://orcid.org/0000-0002-2451-1070; Wurm, Sonja ORCID: https://orcid.org/0000-0002-7540-737X; Lindner, Lars H. ORCID: https://orcid.org/0000-0003-3708-8264; Dreyling, Martin ORCID: https://orcid.org/0000-0002-0358-5249; Bergwelt-Baildon, Michael von ORCID: https://orcid.org/0000-0002-1952-052X; Boeck, Stefan ORCID: https://orcid.org/0000-0002-1922-2127; Giessen-Jung, Clemens; Milani, Valeria; Stemmler, Joachim H. ORCID: https://orcid.org/0000-0001-8751-8555; Subklewe, Marion ORCID: https://orcid.org/0000-0001-9154-9469; Weigert, Oliver ORCID: https://orcid.org/0000-0002-0987-7373 und Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957
(2022):
Treatment, outcome and re-vaccination of patients with SARS-CoV-2 vaccine-associated immune thrombocytopenia.
In: Infection, Bd. 51, Nr. 1: S. 231-238
[PDF, 723kB]
ORCID: https://orcid.org/0000-0002-2451-1070; Wurm, Sonja ORCID: https://orcid.org/0000-0002-7540-737X; Lindner, Lars H. ORCID: https://orcid.org/0000-0003-3708-8264; Dreyling, Martin ORCID: https://orcid.org/0000-0002-0358-5249; Bergwelt-Baildon, Michael von ORCID: https://orcid.org/0000-0002-1952-052X; Boeck, Stefan ORCID: https://orcid.org/0000-0002-1922-2127; Giessen-Jung, Clemens; Milani, Valeria; Stemmler, Joachim H. ORCID: https://orcid.org/0000-0001-8751-8555; Subklewe, Marion ORCID: https://orcid.org/0000-0001-9154-9469; Weigert, Oliver ORCID: https://orcid.org/0000-0002-0987-7373 und Spiekermann, Karsten ORCID: https://orcid.org/0000-0002-5139-4957
(2022):
Treatment, outcome and re-vaccination of patients with SARS-CoV-2 vaccine-associated immune thrombocytopenia.
In: Infection, Bd. 51, Nr. 1: S. 231-238
[PDF, 723kB]
Berdel, Andrew F.; Koch, Raphael; Gerss, Joachim; Hentrich, Marcus; Peceny, Rudolf; Bartscht, Tobias; Steffen, Bjoern; Bischoff, Marina; Spiekermann, Karsten; Angenendt, Linus; Mikesch, Jan-Henrik; Kewitz, Tobias; Butterfass-Bahloul, Trude; Serve, Hubert; Lenz, Georg; Berdel, Wolfgang E.; Krug, Utz und Schliemann, Christoph
(2022):
A randomized phase 2 trial of nintedanib and low-dose cytarabine in elderly patients with acute myeloid leukemia ineligible for intensive chemotherapy.
In: Annals of Hematology, Bd. 102, Nr. 1: S. 63-72
Hartmann, Luise; Hecker, Judith S.; Rothenberg-Thurley, Maja; Riviere, Jennifer; Jentzsch, Madlen; Ksienzyk, Bianka; Buck, Michele C.; Garde, Mark van der; Fischer, Luise; Winter, Susann; Rauner, Martina; Tsourdi, Elena; Weidner, Heike; Sockel, Katja; Schneider, Marie; Kubasch, Anne S.; Nolde, Martin; Hausmann, Dominikus; Luetzner, Joerg; Goralski, Szymon; Bassermann, Florian; Spiekermann, Karsten; Hofbauer, Lorenz C.; Schwind, Sebastian; Platzbecker, Uwe; Goetze, Katharina S. und Metzeler, Klaus H.
(2022):
Compartment-specific mutational landscape of clonal hematopoiesis.
In: Leukemia, Bd. 36, Nr. 11: S. 2647-2655
Rausch, Christian; Hiddemann, Wolfgang; Bergwelt-Baildon, Michael von; Spiekermann, Karsten und Herold, Tobias
(2022):
Akute Myeloische Leukämien – Update 2022.
In: Deutsche Medizinische Wochenschrift, Bd. 147, Nr. 17: S. 1108-1113
Hoffmeister-Wittmann, Paula; Mock, Andreas; Nichetti, Federico; Korell, Felix; Heilig, Christop E.; Scherr, Anna-Lena; Gunther, Michael; Albrecht, Thomas; Kelmendi, Eblina; Xu, Kaiyu; Nader, Luisa; Kessler, Annika; Schmitt, Nathalie; Fritzsche, Sarah; Weiler, Sofia; Sobol, Benjamin; Stenzinger, Albrecht; Boeck, Stefan; Westphalen, Christoph B.; Schulze-Osthoff, Klaus; Trojan, Jörg; Kindler, Thomas; Weichert, Wilko; Spiekermann, Karsten; Bitzer, Michael; Folprecht, Gunnar; Illert, Anna-Lena; Boerries, Melanie; Klauschen, Frederick; Ochsenreiter, Sebastian; Siveke, Jens; Bauer, Sebastian; Glimm, Hanno; Brors, Benedikt; Huellein, Jennifer; Huebschmann, Daniel; Uhrig, Sebastian; Horak, Peter; Kreutzfeld, Simon; Banales, Jesus M.; Springfeld, Christoph; Jaeger, Dirk; Schirmacher, Peter; Roessler, Stephanie; Ormanns, Steffen; Goeppert, Benjamin; Froehling, Stefan und Koehler, Bruno C.
(2022):
Bcl-x(L) as prognostic marker and potential therapeutic target in cholangiocarcinoma.
In: Liver International, Bd. 42, Nr. 12: S. 2855-2870
Middeke, Jan M.; Metzeler, Klaus H.; Roellig, Christoph; Kraemer, Michael; Eckardt, Jan-Niklas; Stasik, Sebastian; Greif, Philipp A.; Spiekermann, Karsten; Rothenberg-Thurley, Maja; Krug, Utz; Braess, Jan; Kraemer, Alwin; Hochhaus, Andreas; Bruemmendorf, Tim H.; Naumann, Ralph; Steffen, Bjoern; Einsele, Hermann; Schaich, Markus; Burchert, Andreas; Neubauer, Andreas; Goerlich, Dennis; Sauerland, Cristina; Schaefer-Eckart, Kerstin; Schliemann, Christoph; Krause, Stefan W.; Haenel, Mathias; Frickhofen, Norbert; Noppeney, Richard; Kaiser, Ulrich; Kaufmann, Martin; Kunadt, Desiree; Woermann, Bernhard; Sockel, Katja; Bonin, Malte von; Herold, Tobias; Mueller-Tidow, Carsten; Platzbecker, Uwe; Berdel, Wolfgang E.; Serve, Hubert; Baldus, Claudia D.; Ehninger, Gerhard; Schetelig, Johannes; Hiddemann, Wolfgang; Bornhaeuser, Martin; Stoelzel, Friedrich und Thiede, Christian
(2022):
Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study.
In: Blood Advances, Bd. 6, Nr. 5: S. 1394-1405
Kunadt, Desiree; Stasik, Sebastian; Metzeler, Klaus H.; Roellig, Christoph; Schliemann, Christoph; Greif, Philipp A.; Spiekermann, Karsten; Rothenberg-Thurley, Maja; Krug, Utz; Braess, Jan; Kraemer, Alwin; Hochhaus, Andreas; Scholl, Sebastian; Hilgendorf, Inken; Bruemmendorf, Tim H.; Jost, Edgar; Steffen, Bjoern; Bug, Gesine; Einsele, Hermann; Goerlich, Dennis; Sauerland, Cristina; Schaefer-Eckart, Kerstin; Krause, Stefan W.; Haenel, Mathias; Hanoun, Maher; Kaufmann, Martin; Woermann, Bernhard; Kramer, Michael; Sockel, Katja; Egger-Heidrich, Katharina; Herold, Tobias; Ehninger, Gerhard; Burchert, Andreas; Platzbecker, Uwe; Berdel, Wolfgang E.; Mueller-Tidow, Carsten; Hiddemann, Wolfgang; Serve, Hubert; Stelljes, Matthias; Baldus, Claudia D.; Neubauer, Andreas; Schetelig, Johannes; Thiede, Christian; Bornhaeuser, Martin; Middeke, Jan M. und Stoelzel, Friedrich
(2022):
Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation.
In: Journal of Hematology & Oncology, Bd. 15, Nr. 1, 126
Augsberger, Christian; Hanel, Gerulf; Xu, Wei; Pulko, Vesna; Hanisch, Lydia Jasmin; Augustin, Angelique; Challier, John; Hunt, Katharina; Vick, Binje; Rovatti, Pier Eduardo; Krupka, Christina; Rothe, Maurine; Schonle, Anne; Sam, Johannes; Lezan, Emmanuelle; Ducret, Axel; Ortiz-Franyuti, Daniela; Walz, Antje-Christine; Benz, Jorg; Bujotzek, Alexander; Lichtenegger, Felix S.; Gassner, Christian; Carpy, Alejandro; Lyamichev, Victor; Patel, Jigar; Konstandin, Nikola; Tunger, Antje; Schmitz, Marc; Bergwelt-Baildon, Michael von; Spiekermann, Karsten; Vago, Luca; Jeremias, Irmela; Marrer-Berger, Estelle; Umana, Pablo; Klein, Christian und Subklewe, Marion
(2021):
Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody.
In: Blood, Bd. 138, Nr. 25: S. 2655-2669
Hecker, Judith S.; Hartmann, Luise; Riviere, Jennifer; Buck, Michele C.; Garde, Mark van de; Rothenberg-Thurley, Maja; Fischer, Luise; Winter, Susann; Ksienzyk, Bianka; Ziemann, Frank; Solovey, Maria; Rauner, Martina; Tsourdi, Elena; Sockel, Katja; Schneider, Marie; Kubasch, Anne S.; Nolde, Martin; Hausmann, Dominikus; Paulus, Alexander C.; Luetzner, Joerg; Roth, Andreas; Bassermann, Florian; Spiekermann, Karsten; Marr, Carsten; Hofbauer, Lorenz C.; Platzbecker, Uwe; Metzeler, Klaus H. und Goetze, Katharina S.
(2021):
CHIP and hips: clonal hematopoiesis is common in patients undergoing hip arthroplasty and is associated with autoimmune disease.
In: Blood, Bd. 138, Nr. 18: S. 1727-1732
Horak, Peter; Heining, Christoph; Kreutzfeldt, Simon; Hutter, Barbara; Mock, Andreas; Huellein, Jennifer; Froehlich, Martina; Uhrig, Sebastian; Jahn, Arne; Rump, Andreas; Gieldon, Laura; Moehrmann, Lino; Hanf, Dorothea; Teleanu, Veronica; Heilig, Christoph E.; Lipka, Daniel B.; Allgaeuer, Michael; Ruhnke, Leo; Lassmann, Andreas; Endris, Volker; Neumann, Olaf; Penzel, Roland; Beck, Katja; Richter, Daniela; Winter, Ulrike; Wolf, Stephan; Pfuetze, Katrin; Geoerg, Christina; Meissburger, Bettina; Buchhalter, Ivo; Augustin, Marinela; Aulitzky, Walter E.; Hohenberger, Peter; Kroiss, Matthias; Schirmacher, Peter; Schlenk, Richard F.; Keilholz, Ulrich; Klauschen, Frederick; Folprecht, Gunnar; Bauer, Sebastian; Siveke, Jens Thomas; Brandts, Christian H.; Kindler, Thomas; Boerries, Melanie; Illert, Anna L.; Bubnoff, Nikolas von; Jost, Philipp J.; Spiekermann, Karsten; Bitzer, Michael; Schulze-Osthoff, Klaus; Kalle, Christof von; Klink, Barbara; Brors, Benedikt; Stenzinger, Albrecht; Schroeck, Evelin; Huebschmann, Daniel; Weichert, Wilko; Glimm, Hanno und Froehling, Stefan
(2021):
Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers.
In: Cancer Discovery, Bd. 11, Nr. 11: S. 2780-2795
Kayser, Sabine; Schlenk, Richard F.; Lebon, Delphine; Carre, Martin; Goetze, Katharina S.; Stoelzel, Friedrich; Berceanu, Ana; Schaefer-Eckart, Kerstin; Peterlin, Pierre; Hicheri, Yosr; Rahme, Ramy; Raffoux, Emmanuel; Chermat, Fatiha; Krause, Stefan W.; Aulitzky, Walter E.; Rigaudeau, Sophie; Noppeney, Richard; Berthon, Celine; Goerner, Martin; Jost, Edgar; Carassou, Philippe; Keller, Ulrich; Orvain, Corentin; Braun, Thorsten; Saillard, Colombe; Arar, Ali; Kunzmann, Volker; Wemeau, Mathieu; de Wit, Maike; Niemann, Dirk; Bonmati, Caroline; Schwaenen, Carsten; Abraham, Julie; Aljijakli, Ahmad; Haiat, Stephanie; Kraemer, Alwin; Reichle, Albrecht; Gnadler, Martina; Willekens, Christophe; Spiekermann, Karsten; Hiddemann, Wolfgang; Mueller-Tidow, Carsten; Thiede, Christian; Roellig, Christoph; Serve, Hubert; Bornhaeuser, Martin; Baldus, Claudia D.; Lengfelder, Eva; Fenaux, Pierre; Platzbecker, Uwe und Ades, Lionel
(2021):
Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide: an international collaborative.
In: Haematologica, Bd. 106, Nr. 12: S. 3100-3106
Kempf, Julia M.; Weser, Sabrina; Bartoschek, Michael D.; Metzeler, Klaus H.; Vick, Binje; Herold, Tobias; Voelse, Kerstin; Mattes, Raphael; Scholz, Manuela; Wange, Lucas E.; Festini, Moreno; Ugur, Enes; Roas, Maike; Weigert, Oliver; Bultmann, Sebastian; Leonhardt, Heinrich; Schotta, Gunnar; Hiddemann, Wolfgang; Jeremias, Irmela und Spiekermann, Karsten
(2021):
Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML.
In: Scientific Reports, Bd. 11, Nr. 1, 5838
Moser, Christian; Jurinovic, Vindi; Sagebiel-Kohler, Sabine; Ksienzyk, Bianka; Batcha, Aarif M. N.; Dufour, Annika; Schneider, Stephanie; Rothenberg-Thurley, Maja; Sauerland, Cristina M.; Gorlich, Dennis; Berdel, Wolfgang E.; Krug, Utz; Mansmann, Ulrich; Hiddemann, Wolfgang; Braess, Jan; Spiekermann, Karsten; Greif, Philipp A.; Vosberg, Sebastian; Metzeler, Klaus H.; Kumbrink, Joerg und Herold, Tobias
(2021):
A clinically applicable gene expression-based score predicts resistance to induction treatment in acute myeloid leukemia.
In: Blood Advances, Bd. 5, Nr. 22: S. 4752-4761
Rausch, Christian; Rothenberg-Thurley, Maja; Bürger, Simon A.; Tschuri, Sebastian; Dufour, Annika; Neusser, Michaela; Schneider, Stephanie; Spiekermann, Karsten; Metzeler, Klaus H. und Ziemann, Frank
(2021):
Double Drop-Off Droplet Digital PCR A Novel, Versatile Tool for Mutation Screening and Residual Disease Monitoring in Acute Myeloid Leukemia Using Cellular or Cell-Free DNA.
In: Journal of Molecular Diagnostics, Bd. 23, Nr. 8: S. 975-985
Zimmermann, Andreas und Spiekermann, Karsten
(2021):
Abklärung erhöhter Blutungsneigung – Schritt für Schritt.
In: Deutsche Medizinische Wochenschrift, Bd. 146, Nr. 20: S. 1360-1368
Lichtenegger, Felix S.; Schnorfeil, Frauke M.; Rothe, Maurine; Deiser, Katrin; Altmann, Torben; Bücklein, Veit L.; Köhnke, Thomas; Augsberger, Christian; Konstandin, Nikola P.; Spiekermann, Karsten; Moosmann, Andreas; Boehm, Stephan; Boxberg, Melanie; Heemskerk, Mirjam H. M.; Goerlich, Dennis; Wittmann, Georg; Wagner, Beate; Hiddemann, Wolfgang; Schendel, Dolores J.; Kvalheim, Gunnar; Bigalke, Iris und Subklewe, Marion
(2020):
Toll‐like receptor 7/8‐matured RNA‐transduced dendritic cells as post‐remission therapy in acute myeloid leukaemia: results of a phase I trial.
In: Clinical & Translational Immunology, Bd. 9, Nr. 3, e1117
[PDF, 1MB]
Bamopoulos, Stefanos A.; Batcha, Aarif M. N.; Jurinovic, Vindi; Rothenberg-Thurley, Maja; Janke, Hanna; Ksienzyk, Bianka; Philippou-Massier, Julia; Graf, Alexander; Krebs, Stefan; Blum, Helmut; Schneider, Stephanie; Konstandin, Nikola; Sauerland, Maria Cristina; Görlich, Dennis; Berdel, Wolfgang E.; Woermann, Bernhard J.; Bohlander, Stefan K.; Canzar, Stefan; Mansmann, Ulrich; Hiddemann, Wolfgang; Braess, Jan; Spiekermann, Karsten; Metzeler, Klaus H. und Herold, Tobias
(2020):
Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia.
In: Leukemia, Bd. 34, Nr. 10: S. 2621-2634
Herold, Tobias ORCID: https://orcid.org/0000-0002-9615-9432; Rothenberg-Thurley, Maja; Grunwald, Victoria V.; Janke, Hanna; Goerlich, Dennis; Sauerland, Maria C.; Konstandin, Nikola P.; Dufour, Annika; Schneider, Stephanie; Neusser, Michaela; Ksienzyk, Bianka; Greif, Philipp A.; Subklewe, Marion; Faldum, Andreas; Bohlander, Stefan K.; Braess, Jan; Wörmann, Bernhard; Krug, Utz; Berdel, Wolfgang E.; Hiddemann, Wolfgang; Spiekermann, Karsten und Metzeler, Klaus H.
(2020):
Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia.
In: Leukemia, Bd. 34: S. 3161-3172
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-9615-9432; Rothenberg-Thurley, Maja; Grunwald, Victoria V.; Janke, Hanna; Goerlich, Dennis; Sauerland, Maria C.; Konstandin, Nikola P.; Dufour, Annika; Schneider, Stephanie; Neusser, Michaela; Ksienzyk, Bianka; Greif, Philipp A.; Subklewe, Marion; Faldum, Andreas; Bohlander, Stefan K.; Braess, Jan; Wörmann, Bernhard; Krug, Utz; Berdel, Wolfgang E.; Hiddemann, Wolfgang; Spiekermann, Karsten und Metzeler, Klaus H.
(2020):
Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia.
In: Leukemia, Bd. 34: S. 3161-3172
[PDF, 2MB]
Salik, Basit; Yi, Hangyu; Hassan, Nunki; Santiappillai, Nancy; Vick, Binje; Connerty, Patrick; Duly, Alastair; Trahair, Toby; Woo, Andrew J.; Beck, Dominik; Liu, Tao; Spiekermann, Karsten; Jeremias, Irmela; Wang, Jianlong; Kavallaris, Maria; Haber, Michelle; Norris, Murray D.; Liebermann, Dan A.; D'Andrea, Richard J.; Murriel, Christopher und Wang, Jenny Y.
(2020):
Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia.
In: Cancer Cell, Bd. 38, Nr. 2: S. 263-278
Sellmer, Andreas; Pilsl, Bernadette; Beyer, Mandy; Pongratz, Herwig; Wirth, Lukas; Elz, Sigurd; Dove, Stefan; Henninger, Sven Julian; Spiekermann, Karsten; Polzer, Harald; Klaeger, Susan; Kuster, Bernhard; Boehmer, Frank D.; Fiebig, Heinz-Herbert; Kraemer, Oliver H. und Mahboobi, Siavosh
(2020):
A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia.
In: European Journal of Medicinal Chemistry, Bd. 193, 112232
Opatz, Sabrina; Bamopoulos, Stefanos A.; Metzeler, Klaus H.; Herold, Tobias; Ksienzyk, Bianka; Braeundl, Kathrin; Tschuri, Sebastian; Vosberg, Sebastian; Konstandin, Nikola P.; Wang, Christine; Hartmann, Luise; Graf, Alexander; Krebs, Stefan; Blum, Helmut; Schneider, Stephanie; Thiede, Christian; Middeke, Jan Moritz; Stoelzel, Friedrich; Roellig, Christoph; Schetelig, Johannes; Ehninger, Gerhard; Kraemer, Alwin; Braess, Jan; Goerlich, Dennis; Sauerland, Maria Cristina; Berdel, Wolfgang E.; Woermann, Bernhard J.; Hiddemann, Wolfgang; Spiekermann, Karsten; Bohlander, Stefan K. und Greif, Philipp A.
(2020):
The clinical mutatome of core binding factor leukemia.
In: Leukemia, Bd. 34, Nr. 6: S. 1553-1562
Spiekermann, Karsten; Subklewe, Marion; Hildebrandt, Martin; Humpe, Andreas und Bergwelt-Baildon, Michael von
(2020):
COVID-19 aus Sicht der Hämatologie und Hämostaseologie.
In: Deutsche Medizinische Wochenschrift, Bd. 145, Nr. 15: S. 1044-1050
Brauchle, Bettina; Goldstein, Rebecca L.; Karbowski, Christine M.; Henn, Anja; Li, Chi-Ming; Buecklein, Veit L.; Krupka, Christina; Boyle, Michael C.; Koppikar, Priya; Haubner, Sascha; Wahl, Joachim; Dahlhoff, Christoph; Raum, Tobias; Rardin, Matthew J.; Sastri, Christine; Rock, Dan A.; Bergwelt-Baildon, Michael von; Frank, Brendon; Metzeler, Klaus H.; Case, Ryan; Friedrich, Matthias; Balazs, Mercedesz; Spiekermann, Karsten; Coxon, Angela; Subklewe, Marion und Arvedson, Tara
(2020):
Characterization of a Novel FLT3 BITE Molecule for the Treatment of Acute Myeloid Leukemia.
In: Molecular Cancer Therapeutics, Bd. 19, Nr. 9: S. 1875-1888
Stief, Sophie M.; Hanneforth, Anna-Li; Weser, Sabrina; Mattes, Raphael; Carlet, Michela; Liu, Wen-Hsin; Bartoschek, Michael D.; Moreno, Helena Dominguez; Oettle, Matthias; Kempf, Julia; Vick, Binje; Ksienzyk, Bianka; Tizazu, Belay; Rothenberg-Thurley, Maja; Quentmeier, Hilmar; Hiddemann, Wolfgang; Vosberg, Sebastian; Greif, Philipp A.; Metzeler, Klaus H.; Schotta, Gunnar; Bultmann, Sebastian; Jeremias, Irmela; Leonhardt, Heinrich und Spiekermann, Karsten
(2020):
Loss of KDM6A confers drug resistance in acute myeloid leukemia.
In: Leukemia, Bd. 34, Nr. 1: S. 50-62
Batcha, Aarif M. N.; Bamopoulos, Stefanos A.; Kerbs, Paul; Kumar, Ashwini; Jurinovic, Vindi; Rothenberg-Thurley, Maja; Ksienzyk, Bianka; Philippou-Massier, Julia; Krebs, Stefan; Blum, Helmut; Schneider, Stephanie; Konstandin, Nikola; Bohlander, Stefan K.; Heckman, Caroline; Kontro, Mika; Hiddemann, Wolfgang; Spiekermann, Karsten; Braess, Jan; Metzeler, Klaus H.; Greif, Philipp A.; Mansmann, Ulrich und Herold, Tobias
(2019):
Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia.
In: Scientific Reports, Bd. 9, Nr. 11796
[PDF, 1MB]
Angenendt, Linus; Bormann, Eike; Pabst, Caroline; Alla, Vijay; Goerlich, Dennis; Braun, Leonie; Dohlich, Kim; Schwoeppe, Christian; Bohlander, Stefan K.; Arteaga, Maria Francisca; Wethmar, Klaus; Hartmann, Wolfgang; Angenendt, Adrian; Kessler, Torsten; Mesters, Rolf M.; Stelljes, Matthias; Rothenberg-Thurley, Maja; Spiekermann, Karsten; Hebert, Josee; Sauvageau, Guy; Valk, Peter J. M.; Loewenberg, Bob; Serve, Hubert; Müller-Tidow, Carsten; Lenz, Georg; Woermann, Bernhard J.; Sauerland, M. Christina; Hiddemann, Wolfgang; Berdel, Wolfgang E.; Krug, Utz; Metzeler, Klaus H.; Mikesch, Jan-Henrik; Herold, Tobias und Schliemann, Christoph
(2019):
The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia.
In: Leukemia, Bd. 33, Nr. 12: S. 2830-2841
Grunwald, Victoria V.; Hentrich, Marcus; Schiel, Xaver; Dufour, Annika; Schneider, Stephanie; Neusser, Michaela; Subklewe, Marion; Fiegl, Michael; Hiddemann, Wolfgang; Spiekermann, Karsten; Rothenberg-Thurley, Maja und Metzeler, Klaus H.
(2019):
Patients with spontaneous remission of high-risk MDS and AML show persistent preleukemic clonal hematopoiesis.
In: Blood Advances, Bd. 3, Nr. 18: S. 2696-2699
Lynch, Jennifer R.; Salik, Basit; Connerty, Patrick; Vick, Binje; Leung, Halina; Pijning, Aster; Jeremias, Irmela; Spiekermann, Karsten; Trahair, Toby; Liu, Tao; Haber, Michelle; Norris, Murray D.; Woo, Andrew J.; Hogg, Philip; Wang, Jianlong und Wang, Jenny Y.
(2019):
JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis.
In: Leukemia, Bd. 33, Nr. 6: S. 1400-1410
Jawhar, Mohamad; Doehner, Konstanze; Kreil, Sebastian; Schwaab, Juliana; Shoumariyeh, Khalid; Meggendorfer, Manja; Span, Lambert L. F.; Fuhrmann, Stephan; Naumann, Nicole; Horny, Hans-Peter; Sotlar, Karl; Kubuschok, Boris; Bubnoff, Nikolas von; Spiekermann, Karsten; Heuser, Michael; Metzgeroth, Georgia; Fabarius, Alice; Klein, Stefan; Hofmann, Wolf-Karsten; Kluin-Nelemans, Hanneke C.; Haferlach, Torsten; Doehner, Hartmut; Cross, Nicholas C. P.; Sperr, Wolfgang R.; Valent, Peter und Reiter, Andreas
(2019):
KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosis.
In: Leukemia, Bd. 33, Nr. 5: S. 1124-1134
Sandner, Anne-Sophie; Weggel, Ramona; Mehraein, Yasmin; Schneider, Stephanie; Hiddemann, Wolfgang und Spiekermann, Karsten
(2019):
Frequency of hematologic and solid malignancies in the family history of 50 patients with acute myeloid leukemia - a single center analysis.
In: PLOS One 14(4), e0215453 [PDF, 776kB]
In: PLOS One 14(4), e0215453 [PDF, 776kB]
Chen-Wichmann, Linping; Shvartsman, Marina; Preiss, Caro; Hockings, Colin; Windisch, Roland; Monte, Enric Redondo; Leubolt, Georg; Spiekermann, Karsten; Lausen, Jorn; Brendel, Christian; Grez, Manuel; Greif, Philipp A. und Wichmann, Christian
(2019):
Compatibility of RUNX1/ETO fusion protein modules driving CD34+human progenitor cell expansion.
In: Oncogene, Bd. 38, Nr. 2: S. 261-272
Meidert, Agnes S.; Kinzinger, Johannes; Moehnle, Patrick; Pekrul, Isabell; Spiekermann, Karsten; Thorsteinsdottir, Jun; Briegel, Josef und Huge, Volker
(2019):
Perioperative Management of a Patient with Severe Factor V Deficiency Presenting with Chronic Subdural Hematoma: A Clinical Report.
In: World Neurosurgery, Bd. 127: S. 409-413
Herold, Tobias; Jurinovic, Vindi; Batcha, Aarif Mohamed Nazeer; Bamopoulos, Stefanos A.; Rothenberg-Thurley, Maja; Ksienzyk, Bianka; Hartmann, Luise; Greif, Philipp A.; Phillippou-Massier, Julia; Krebs, Stefan; Blum, Helmut; Amler, Susanne; Schneider, Stephanie; Konstandin, Nikola P.; Sauerland, Maria Cristina; Görlich, Dennis; Berdel, Wolfgang E.; Wörmann, Bernhard J.; Tischer, Johanna; Subklewe, Marion; Bohlander, Stefan K.; Braess, Jan; Hiddemann, Wolfgang; Metzeler, Klaus H.; Mansmann, Ulrich und Spiekermann, Karsten
(März 2018):
A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia.
In: Haematologica, Bd. 103, Nr. 3: S. 456-65
Greif, Philipp A.; Hartmann, Luise; Vosberg, Sebastian; Stief, Sophie M.; Mattes, Raphael; Hellmann, Ines; Metzeler, Klaus H.; Herold, Tobias; Bamopoulos, Stefanos A.; Kerbs, Paul; Jurinovic, Vindi; Schumacher, Daniela; Pastore, Friederike; Bräundl, Kathrin; Zellmeier, Evelyn; Ksienzyk, Bianka; Konstandin, Nikola P.; Schneider, Stephanie; Graf, Alexander; Krebs, Stefan; Blum, Helmut; Neumann, Martin; Baldus, Claudia D.; Bohlander, Stefan K.; Wolf, Stephan; Görlich, Dennis; Berdel, Wolfgang E.; Wörmann, Bernhard J.; Hiddemann, Wolfgang und Spiekermann, Karsten
(2018):
Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients.
In: Clinical Cancer Research, Bd. 24, Nr. 7: S. 1716-1726
Hornung, Roman; Jurinovic, Vindi; Batcha, Aarif M. N.; Bamopoulos, Stefanos A.; Rothenberg-Thurley, Maja; Amler, Susanne; Sauerland, Maria Cristina; Berdel, Wolfgang E.; Wörmann, Bernhard J.; Bohlander, Stefan K.; Braess, Jan; Hiddemann, Wolfgang; Lehmann, Sören; Mareschal, Sylvain; Spiekermann, Karsten; Metzeler, Klaus H.; Herold, Tobias und Boulesteix, Anne-Laure
(2018):
Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia.
In: Scientific Reports, Bd. 8, Nr. 1: S. 1-13
[PDF, 1MB]
Schranz, Katrin; Hubmann, Max; Harin, Egor; Vosberg, Sebastian; Herold, Tobias; Metzeler, Klaus H.; Rothenberg-Thurley, Maja; Janke, Hanna; Bräundl, Kathrin; Ksienzyk, Bianka; Batcha, Aarif M. N.; Schaaf, Sebastian; Schneider, Stephanie; Bohlander, Stefan K.; Görlich, Dennis; Berdel, Wolfgang E.; Wörmann, Bernhard J.; Braess, Jan; Krebs, Stefan; Hiddemann, Wolfgang; Mansmann, Ulrich; Spiekermann, Karsten und Greif, Philipp A.
(2018):
Clonal heterogeneity of FLT3-ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute myeloid leukemia.
In: Oncotarget, Bd. 9, Nr. 53: S. 30128-30145
[PDF, 2MB]
Konstandin, Nikola P.; Pastore, Friederike; Herold, Tobias; Dufour, Annika; Rothenberg-Thurley, Maja; Hinrichsen, Tanja; Ksienzyk, Bianka; Tschuri, Sebastian; Schneider, Stephanie; Hoster, Eva; Berdel, Wolfgang E.; Wörmann, Bernhard J.; Sauerland, Maria C.; Braess, Jan; Bohlander, Stefan K.; Klein, Hanns-Georg; Hiddemann, Wolfgang; Metzeler, Klaus H. und Spiekermann, Karsten
(2018):
Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPA.
In: Blood Advances, Bd. 2, Nr. 20: S. 2724-2731
Herrmann, Monika; Krupka, Christina; Deiser, Katrin; Brauchle, Bettina; Marcinek, Anetta; Wagner, Ana Ogrinc; Rataj, Felicitas; Mocikat, Ralph; Metzeler, Klaus H.; Spiekermann, Karsten; Kobold, Sebastian; Fenn, Nadja C.; Hopfner, Karl-Peter und Subklewe, Marion
(2018):
Bifunctional PD-1 x alpha CD3 x alpha CD33 fusion protein reverses adaptive immune escape in acute myeloid leukemia.
In: Blood, Bd. 132, Nr. 23: S. 2484-2494
Braciak, Todd A.; Roskopf, Claudia C.; Wildenhain, Sarah; Fenn, Nadja C.; Schiller, Christian B.; Schubert, Ingo A.; Jacob, Uwe; Honegger, Annemarie; Krupka, Christina; Subklewe, Marion; Spiekermann, Karsten; Hopfner, Karl-Peter; Fey, Georg H.; Aigner, Michael; Krause, Stefan; Mackensen, Andreas und Oduncu, Fuat S.
(2018):
Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells.
In: Oncoimmunology, Bd. 7, Nr. 9, e1472195
Bräss, Jan; Amler, Susanne; Kreuzer, Karl-Anton; Spiekermann, Karsten; Lindemann, Hans Walter; Lengfelder, Eva; Graeven, Ullrich; Staib, Peter; Ludwig, Wolf-Dieter; Biersack, Harald; Ko, Yon-Dschun; Uppenkamp, Michael J.; Wit, Maike de; Korsten, Stefan; Peceny, Rudolf; Gaska, Tobias; Schiel, Xaver; Behringer, Dirk M.; Kiehl, Michael G.; Zinngrebe, Bettina; Meckenstock, Gerald; Römer, Eva; Medgenberg, Dirk; Spaeth-Schwalbe, Ernst; Massenkeil, Gero; Hindahl, Heidrun; Schwerdtfeger, Rainer; Trenn, Guido; Sauerland, Cristina; Koch, Raphael; Lablans, Martin; Faldum, Andreas; Görlich, Dennis; Bohlander, Stefan K.; Schneider, Stephanie; Dufour, Annika; Buske, Christian; Fiegl, Michael; Subklewe, Marion; Bräss, Birgit; Unterhalt, Michael; Baumgartner, Anja; Wörmann, Bernhard; Beelen, Dietrich und Hiddemann, Wolfgang
(2018):
Sequential high-dose cytarabine and mitoxantrone (S-HAM) versus standard double induction in acute myeloid leukemia-a phase 3 study.
In: Leukemia, Bd. 32, Nr. 12: S. 2558-2571
Norgaard, Caroline Holm; Jakobsen, Lasse Hjort; Gentles, Andrew J.; Dybkaer, Karen; El-Galaly, Tarec Christoffer; Bodker, Julie Stove; Schmitz, Alexander; Johansen, Preben; Herold, Tobias; Spiekermann, Karsten; Brown, Jennifer R.; Klitgaard, Josephine L.; Johnsen, Hans Erik und Bogsted, Martin
(2018):
Subtype assignment of CLL based on B-cell subset associated gene signatures from normal bone marrow - A proof of concept study.
In: PLOS One 13(3), e0193249 [PDF, 2MB]
In: PLOS One 13(3), e0193249 [PDF, 2MB]
Prassek, Victoria V.; Rothenberg-Thurley, Maja; Sauerland, Maria C.; Herold, Tobias; Janke, Hanna; Ksienzyk, Bianka; Konstandin, Nikola P.; Goerlich, Dennis; Krug, Utz; Faldum, Andreas; Berdel, Wolfgang E.; Wörmann, Bernhard; Braess, Jan; Schneider, Stephanie; Subklewe, Marion; Bohlander, Stefan K.; Hiddemann, Wolfgang; Spiekermann, Karsten und Metzeler, Klaus H.
(2018):
Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged 75 years or older.
In: Haematologica, Bd. 103, Nr. 11: S. 1853-1861
[PDF, 1MB]
Rothenberg-Thurley, Maja; Amler, Susanne; Goerlich, Dennis; Köhnke, Thomas; Konstandin, Nikola P.; Schneider, Stephanie; Sauerland, Maria C.; Herold, Tobias; Hubmann, Max; Ksienzyk, Bianka; Zellmeier, Evelyn; Bohlander, Stefan K.; Subklewe, Marion; Faldum, Andreas; Hiddemann, Wolfgang; Braess, Jan; Spiekermann, Karsten und Metzeler, Klaus H.
(2018):
Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia.
In: Leukemia, Bd. 32, Nr. 7: S. 1598-1608
Spiekermann, Karsten und Shen, Anne-Sophie
(2018):
Akute myeloische Leukämie bei Erwachsenen.
In: Deutsche Medizinische Wochenschrift, Bd. 143, Nr. 18: S. 1297-1303
Lengfelder, Eva; Goerlich, Dennis; Nowak, Daniel; Spiekermann, Karsten; Haferlach, Claudia; Krug, Utz; Kreuzer, Karl-Anton; Braess, Jan; Schliemann, Christoph; Lindemann, Hans-Walter; Horst, Heinz A.; Schiel, Xaver; Flasshove, Michael; Hecht, Anna; Schnittger, Susanne; Schneider, Stephanie; Wörmann, Bernhard; Hofmann, Wolf-Karsten; Berdel, Wolfgang E.; Bormann, Eike; Sauerland, Cristina; Büchner, Thomas und Hiddemann, Wolfgang
(2018):
Frontline therapy of acute promyelocytic leukemia: Randomized comparison of ATRA and intensified chemotherapy versus ATRA and anthracyclines.
In: European Journal of Haematology, Bd. 100, Nr. 2: S. 154-162
Herold, Tobias; Schneider, S.; Metzeler, Klaus H.; Neumann, Martin; Hartmann, Luise; Roberts, Kathryn G.; Konstandin, Nikola P.; Greif, Philipp A.; Bräundl, Kathrin; Ksienzyk, Bianka; Huk, Natalia; Schneider, Irene; Zellmeier, Evelyn; Jurinovic, Vindi; Mansmann, Ulrich; Hiddemann, Wolfgang; Mullighan, Charles G.; Bohlander, Stefan K.; Spiekermann, Karsten; Hölzel, Dieter; Brüggemann, Monika; Baldus, Claudia D.; Dreyling, Martin und Gökbuget, Nicola
(2017):
Adults with Philadelphia chromosome–like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis.
In: Haematologica, Bd. 102, Nr. 1: S. 130-138
[PDF, 1MB]
Herold, Tobias; Metzeler, Klaus H.; Vosberg, Sebastian; Hartmann, Luise; Jurinovic, Vindi; Opatz, Sabrina; Konstandin, Nikola P.; Schneider, S.; Zellmeier, Evelyn; Ksienzyk, Bianka; Graf, A.; Krebs, S.; Blum, H.; Sauerland, Maria Cristina; Büchner, T.; Berdel, W. E.; Wörmann, Bernhard; Mansmann, Ulrich; Hiddemann, Wolfgang; Bohlander, Stefan K.; Spiekermann, Karsten und Greif, Philipp A.
(2017):
Acute Myeloid Leukemia with Del(9q) is Characterized by Frequent Mutations of NPM1, DNMT3A, WT1 and Low Expression of TLE4.
In: Genes, Chromosomes and Cancer, Bd. 56, Nr. 1: S. 75-86
Hehlmann, Rüdiger; Lauseker, Michael; Saußele, Susanne; Hochhaus, Andreas; Hasford, Joerg; Pfirrmann, Markus; Kolb, Hans-Jochem; Spiekermann, Karsten; Fabarius, Alice; Müller, M. C.; Proetel, Ulrike; Kohlbrenner, K.; Voskanyan, A.; Rinaldetti, S.; Seifarth, W.; Spieß, B.; Krause, S. W.; Neubauer, A.; Burchert, A.; Hossfeld, Dieter K.; Schafhausen, P.; Nerl, C.; Gratwohl, A.; Heim, D.; Baerlocher, Gabriela M.; Brümmendorf, Tim H.; Fuchs, R.; Haferlach, C.; Jeromin, S.; Schlegelberger, Brigitte; Balleisen, L.; Goebeler, M. C.; Hänel, M.; Ho, A.; Dengler, J.; Falge, C.; Kanz, L.; Kremers, S.; Kneba, M.; Stegelmann, F.; Köhne, C. A.; Lindemann, H. W.; Waller, C. F.; Pfreundschuh, Michael; Berdel, Wolfgang E.; Müller, L.; Edinger, M.; Mayer, J.; Beelen, D. W.; Bentz, M.; Link, H.; Hertenstein, Bernd; Wernli, Martin; Schlegel, F.; Schlag, R.; Wit, M. de; Trumper, L.; Hebart, H.; Hahn, M.; Thomalla, J.; Scheid, C.; Verbeek, W.; Eckart, M. J.; Gassmann, W.; Pezzutto, A.; Schenk, M.; Brossart, P.; Geer, T.; Bildat, S. und Schäfer, E.
(2017):
Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants.
In: Leukemia, Bd. 31, Nr. 11: S. 2398-2406
Kläger, Susan; Heinzlmeir, Stephanie; Wilhelm, Mathias; Polzer, Harald; Vick, Binje; König, Paul-Albert; Reinecke, Maria; Ruprecht, Benjamin; Petzoldt, Svenja; Meng, Chen; Zecha, Jana; Reiter, Katrin; Qiao, Huichao; Helm, Dominic; Koch, Heiner; Schoof, Melanie; Canevari, Giulia; Casale, Elena; Depaolini, Stefania Re; Feuchtinger, Annette; Wu, Zhixiang; Schmidt, Tobias; Rückert, Lars; Becker, Wilhelm; Hünges, Jan; Garz, Anne-Kathrin; Gohlke, Björn-Oliver; Zolg, Daniel Paul; Kayser, Gian; Vooder, Tonu; Preissner, Robert; Hahne, Hannes; Tonisson, Neeme; Kramer, Karl; Götze, Katharina; Bassermann, Florian; Schlegl, Judith; Ehrlich, Hans-Christian; Aiche, Stephan; Walch, Axel; Greif, Philipp A.; Schneider, Sabine; Felder, Eduard Rudolf; Ruland, Jürgen; Medard, Guillaume; Jeremias, Irmela; Spiekermann, Karsten und Kuster, Bernhard
(2017):
The target landscape of clinical kinase drugs.
In: Science, Bd. 358, Nr. 6367, eaan4368
Köhnke, Thomas; Wittmann, Veronika K.; Bücklein, Veit L.; Lichtenegger, Felix; Pasalic, Zlatana; Hiddemann, Wolfgang; Spiekermann, Karsten und Subklewe, Marion
(2017):
Diagnosis of CLL revisited: increased specificity by a modified five-marker scoring system including CD200.
In: British Journal of Haematology, Bd. 179, Nr. 3: S. 480-487
Göllner, Stefanie; öllerich, Thomas; Agrawal-Singh, Shuchi; Schenk, Tino; Klein, Hans-Ulrich; Rohde, Christian; Pabst, Caroline; Sauer, Tim; Lerdrup, Mads; Tavor, Sigal; Stölzel, Friedrich; Herold, Sylvia; Ehninger, Gerhard; Köhler, Gabriele; Pan, Kuan-Ting; Urlaub, Henning; Serve, Hubert; Dugas, Martin; Spiekermann, Karsten; Vick, Binje; Jeremias, Irmela; Berdel, Wolfgang E.; Hansen, Klaus; Zelent, Arthur; Wickenhauser, Claudia; Müller, Lutz P.; Thiede, Christian und Müller-Tidow, Carsten
(2017):
Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.
In: Nature Medicine, Bd. 23, Nr. 1: S. 69-78
Spiekermann, Karsten und Plohmann, Philipp
(2017):
Neue Tests zur Alzheimer-Früherkennung.
In: Deutsche Medizinische Wochenschrift, Bd. 142, Nr. 13:
941-U94
Sandhöfer, Nadine; Metzeler, Klaus H.; Kakadia, Purvi M.; Pasalic, Zlatana; Hiddemann, Wolfgang; Neusser, Michaela; Steinlein, Ortrud; Fiegl, Michael; Subklewe, Marion; Spiekermann, Karsten; Bohlander, Stefan K.; Schneider, Stephanie und Bräss, Jan
(2017):
A fluorescence in situ hybridization-based screen allows rapid detection of adverse cytogenetic alterations in patients with acute myeloid leukemia.
In: Genes Chromosomes & Cancer, Bd. 56, Nr. 8: S. 632-638
Hecht, Anna; Doll, Seraphina; Altmann, Heidi; Nowak, Daniel; Lengfelder, Eva; Rollig, Christoph; Ehninger, Gerhard; Spiekermann, Karsten; Hiddemann, Wolfgang; Weiss, Christel; Hofmann, Wolf-Karsten; Nolte, Florian und Platzbecker, Uwe
(2017):
Validation of a Molecular Risk Score for Prognosis of Patients With Acute Promyelocytic Leukemia Treated With All-trans Retinoic Acid and Chemotherapy-containing Regimens.
In: Clinical Lymphoma Myeloma & Leukemia, Bd. 17, Nr. 12: S. 889-896
Vosberg, Sebastian; Herold, Tobias; Hartmann, Luise; Neumann, Martin; Opatz, Sabrina; Metzeler, Klaus H.; Schneider, S.; Graf, A.; Krebs, S.; Blum, H.; Baldus, Claudia D.; Hiddemann, Wolfgang; Spiekermann, Karsten; Bohlander, Stefan K.; Mansmann, Ulrich und Greif, Philipp A.
(2016):
Close Correlation of Copy Number Aberrations Detected by Close correlation of copy number aberrations detected by next-generation sequencing with results from routine cytogenetics in acute myeloid leukemia.
In: Genes, Chromosomes and Cancer, Bd. 55, Nr. 7: S. 553-567
Gratwohl, A.; Pfirrmann, Markus; Zander, A.; Kröger, N.; Beelen, D.; Novotny, J.; Nerl, C.; Scheid, C.; Spiekermann, Karsten; Mayer, J.; Sayer, H. G.; Falge, C.; Bunjes, D.; Döhner, H.; Ganser, A.; Schmidt-Wolf, I.; Schwerdtfeger, R.; Baurmann, H.; Kuse, R.; Schmitz, N.; Wehmeier, A.; Fischer, J. T.; Ho, A. D.; Wilhelm, M.; Goebeler, M. E.; Lindemann, H. W.; Bormann, M.; Hertenstein, B.; Schlimok, G.; Baerlocher, Gabriela M.; Aul, C.; Pfreundschuh, M.; Fabian, M.; Staib, P.; Edinger, M.; Schatz, M.; Fauser, A.; Arnold, R.; Kindler, T.; Wulf, G.; Rosselet, A.; Hellmann, A.; Schäfer, E.; Prümmer, O.; Schenk, M.; Hasford, Joerg; Heimpel, H.; Hossfeld, D. K.; Kolb, H.-J.; Büsche, G.; Haferlach, C.; Schnittger, S.; Müller, M. C.; Reiter, A.; Berger, Ute; Saußele, Susanne; Hochhaus, A. und Hehlmann, R.
(2016):
Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment.
In: Leukemia, Bd. 30, Nr. 3: S. 562-569
Vegi, Naidu M.; Klappacher, Josef; Oswald, Franz; Mulaw, Medhanie A.; Mandoli, Amit; Thiel, Verena N.; Bamezai, Shiva; Feder, Kristin; Martens, Joost H. A.; Rawat, Vijay P. S.; Mandal, Tamoghna; Quintanilla-Martinez, Leticia; Spiekermann, Karsten; Hiddemann, Wolfgang; Döhner, Konstanze; Döhner, Hartmut; Stunnenberg, Hendrik G.; Feuring-Buske, Michaela und Buske, Christian
(2016):
MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AML.
In: Cell Reports, Bd. 16, Nr. 2: S. 498-507
[PDF, 10MB]
Sandhöfer, Nadine; Bauer, Julia; Reiter, Katrin; Dufour, Annika; Rothenberg, Maja; Konstandin, Nikola P.; Zellmeier, Evelyn; Tizazu, Belay; Greif, Philipp A.; Metzeler, Klaus H.; Hiddemann, Wolfgang; Polzer, Harald und Spiekermann, Karsten
(2016):
The new and recurrent FLT3 juxtamembrane deletion mutation shows a dominant negative effect on the wild-type FLT3 receptor.
In: Scientific Reports, Bd. 6, 28032
[PDF, 846kB]
Hartmann, Luise; Dutta, Sayantanee; Opatz, Sabrina; Vosberg, Sebastian; Reiter, Katrin; Leubolt, Georg; Metzeler, Klaus H.; Herold, Tobias; Bamopoulos, Stefanos A.; Bräundl, Kathrin; Zellmeier, Evelyn; Ksienzyk, Bianka; Konstandin, Nikola P.; Schneider, Stephanie; Hopfner, Karl-Peter; Graf, Alexander; Krebs, Stefan; Blum, Helmut; Middeke, Jan Moritz; Stölzel, Friedrich; Thiede, Christian; Wolf, Stephan; Bohlander, Stefan K.; Preiss, Caroline; Chen-Wichmann, Linping; Wichmann, Christian; Sauerland, Maria Cristina; Büchner, Thomas; Berdel, Wolfgang E.; Wörmann, Bernhard J.; Braess, Jan; Hiddemann, Wolfgang; Spiekermann, Karsten und Greif, Philipp A.
(2016):
ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.
In: Nature Communications, Bd. 7, 11733
[PDF, 1MB]
Metzeler, Klaus H.; Herold, Tobias; Rothenberg-Thurley, Maja; Amler, Susanne; Sauerland, Maria C.; Görlich, Dennis; Schneider, Stephanie; Konstandin, Nikola P.; Dufour, Annika; Bräundl, Kathrin; Ksienzyk, Bianka; Zellmeier, Evelyn; Hartmann, Luise; Greif, Philipp A.; Fiegl, Michael; Subklewe, Marion; Bohlander, Stefan K.; Krug, Utz; Faldum, Andreas; Berdel, Wolfgang E.; Wörmann, Bernhard; Büchner, Thomas; Hiddemann, Wolfgang; Braess, Jan und Spiekermann, Karsten
(2016):
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.
In: Blood, Bd. 128, Nr. 5: S. 686-698
Höckendorf, Ulrike; Yabal, Monica; Herold, Tobias; Munkhbaatar, Enkhtsetseg; Rott, Stephanie; Jilg, Stefanie; Kauschinger, Johanna; Magnani, Giovanni; Reisinger, Florian; Heuser, Michael; Kreipe, Hans; Sotlar, Karl; Engleitner, Thomas; Rad, Roland; Weichert, Wilko; Peschel, Christian; Ruland, Jürgen; Heikenwalder, Mathias; Spiekermann, Karsten; Slotta-Huspenina, Julia; Groß, Olaf und Jost, Philipp J.
(2016):
RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells.
In: Cancer Cell, Bd. 30, Nr. 1: S. 75-91
Krupka, Christina; Kufer, Peter; Kischel, Roman; Zugmaier, Gerhard; Köhnke, Thomas; Lichtenegger, Felix; Altmann, Torben; Spiekermann, Karsten; Vick, Binje; Jeremias, Irmela; Hiddemann, Wolfgang; Riethmüller, Gert und Subklewe, Marion
(2016):
Characterization of covariables modulating CD33/CD3 BITE antibody construct mediated cytotoxicity against primary AML cells.
In: Cancer Immunology Research, Bd. 4, Nr. 1
Laverdière, Isabelle; Boileau, Meaghan; Herold, Tobias; Rak, Janusz; Berdel, Wolfgang E.; Wörmann, Bernhard; Hiddemann, Wolfgang; Spiekermann, Karsten; Bohlander, Stefan K. und Eppert, Kolja
(2016):
Complement cascade gene expression defines novel prognostic subgroups of acute myeloid leukemia.
In: Experimental Hematology, Bd. 44, Nr. 11: S. 1039-1043
Zoellner, Anna-Katharina; Fritsch, Susanne; Prevalsek, Dusan; Köhnke, Thomas; Hubmann, Max; Lippl, Stephanie; Kruger, Stephan; Hellmuth, Johannes; Mumm, Friederike; Ledderose, Georg; Barlow, Sophie; Subklewe, Marion; Spiekermann, Karsten; Hiddemann, Wolfgang; Albert, Michael H.; Schmid, Christoph; Hausmann, Andreas und Tischer, Johanna
(2016):
T-Cell-Replete HLA-Haploidentical Transplantation Using Post-Transplantation High-Dose Cyclophosphamide in High Risk and Advanced ALL: Feasibility and Early Outcome.
In: Biology of Blood and Marrow Transplantation, Bd. 22, Nr. 3:
S364-S364
Ebinger, Sarah; Özdemir, Erbey Ziya; Ziegenhain, Christoph; Tiedt, Sebastian; Castro Alves, Catarina; Grunert, Michaela; Dworzak, Michael; Lutz, Christoph; Turati, Virginia A.; Enver, Tariq; Horny, Hans-Peter; Sotlar, Karl; Parekh, Swati; Spiekermann, Karsten; Hiddemann, Wolfgang; Schepers, Aloys; Polzer, Bernhard; Kirsch, Stefan; Hoffmann, Martin; Knapp, Bettina; Hasenauer, Jan; Pfeifer, Heike; Panzer-Grümayer, Renate; Enard, Wolfgang; Gires, Olivier und Jeremias, Irmela
(2016):
Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia.
In: Cancer Cell, Bd. 30, Nr. 6: S. 849-862
Fabarius, A.; Kalmanti, L.; Dietz, C. T.; Lauseker, Michael; Rinaldetti, S.; Haferlach, C.; Göhring, G.; Schlegelberger, B.; Jotterand, M.; Hanfstein, B.; Seifarth, W.; Hänel, M.; Köhne, C. H.; Lindemann, H. W.; Berdel, W. E.; Staib, P.; Müller, M. C.; Proetel, U.; Balleisen, L.; Goebeler, M. E.; Dengler, J.; Falge, C.; Kanz, L.; Burchert, A.; Kneba, M.; Stegelmann, F.; Pfreundschuh, M.; Waller, C. F.; Spiekermann, Karsten; Brümmendorf, Tim H.; Edinger, M.; Hofmann, W. K.; Pfirrmann, Markus; Hasford, Joerg; Krause, S.; Hochhaus, A.; Saußele, Susanne und Hehlmann, R.
(2015):
Impact of unbalanced minor route versus major route karyotypes at diagnosis on prognosis of CML.
In: Annals of Hematology, Bd. 94, Nr. 12: S. 2015-2024
Kalmanti, L.; Saußele, Susanne; Lauseker, Michael; Muller, M. C.; Dietz, C. T.; Heinrich, L.; Hanfstein, B.; Proetel, U.; Fabarius, A.; Krause, S. W.; Rinaldetti, S.; Dengler, J.; Falge, C.; Oppliger-Leibundgut, E.; Burchert, A.; Neubauer, A.; Kanz, L.; Stegelmann, F.; Pfreundschuh, M.; Spiekermann, Karsten; Scheid, C.; Pfirrmann, Markus; Hochhaus, A.; Hasford, Joerg und Hehlmann, R.
(2015):
Safety and efficacy of imatinib in CML over a period of 10 years: data from the randomized CML-study IV.
In: Leukemia, Bd. 29, Nr. 5: S. 1123-1132
Sironi, Silvia; Wagner, Michaela; Kuett, Alexander; Drolle, Heidrun; Polzer, Harald; Spiekermann, Karsten; Rieger, Christina und Fiegl, Michael
(2015):
Microenvironmental Hypoxia regulates FLT3 expression and biology in AML.
In: Scientific Reports, Bd. 5, 17550
[PDF, 1MB]
Vick, Binje; Rothenberg, Maja; Sandhöfer, Nadine; Carlet, Michela; Finkenzeller, Cornelia; Krupka, Christina; Grunert, Michaela; Trumpp, Andreas; Corbacioglu, Selim; Ebinger, Martin; André, Maya C.; Hiddemann, Wolfgang; Schneider, Stephanie; Subklewe, Marion; Metzeler, Klaus H.; Spiekermann, Karsten und Jeremias, Irmela
(2015):
An Advanced Preclinical Mouse Model for Acute Myeloid Leukemia Using Patients' Cells of Various Genetic Subgroups and In Vivo Bioluminescence Imaging.
In: PLOS ONE 10(3), e0120925 [PDF, 3MB]
In: PLOS ONE 10(3), e0120925 [PDF, 3MB]
Pastore, Friederike; Kling, Daniela; Hoster, Eva; Dufour, Annika; Konstandin, Nikola P.; Schneider, Stephanie; Sauerland, Maria C.; Berdel, Wolfgang E.; Buechner, Thomas; Woermann, Bernhard; Braess, Jan; Hiddemann, Wolfgang und Spiekermann, Karsten
(2014):
Long-term follow-up of cytogenetically normal CEBPA-mutated AML.
In: Journal of Hematology & Oncology
7:55
[PDF, 851kB]
Kalmanti, L.; Saußele, Susanne; Lauseker, Michael; Proetel, U.; Muller, M. C.; Hanfstein, B.; Schreiber, A.; Fabarius, A.; Pfirrmann, Markus; Schnittger, S.; Dengler, J.; Falge, C.; Kanz, L.; Neubauer, A.; Stegelmann, F.; Pfreundschuh, M.; Waller, C. F.; Spiekermann, Karsten; Krause, S. W.; Heim, D.; Nerl, C.; Hossfeld, D. K.; Kolb, H. J.; Hochhaus, A.; Hasford, Joerg und Hehlmann, R.
(2014):
Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV.
In: Annals of Hematology, Bd. 93, Nr. 1: S. 71-80
Hehlmann, R.; Müller, M. C.; Lauseker, Michael; Hanfstein, B.; Fabarius, A.; Schreiber, A.; Proetel, U.; Pletsch, N.; Pfirrmann, Markus; Haferlach, C.; Schnittger, S.; Einsele, H.; Dengler, J.; Falge, C.; Kanz, L.; Neubauer, A.; Kneba, M.; Stegelmann, F.; Pfreundschuh, M.; Waller, C. F.; Spiekermann, Karsten; Baerlocher, Gabriela M.; Ehninger, G.; Heim, D.; Heimpel, H.; Nerl, C.; Krause, S. W.; Hossfeld, D. K.; Kolb, H. J.; Hasford, Joerg; Saußele, Susanne und Hochhaus, A.
(2014):
Deep Molecular Response Is Reached by the Majority of Patients Treated With Imatinib, Predicts Survival, and Is Achieved More Quickly by Optimized High-Dose Imatinib: Results From the Randomized CML-Study IV.
In: Journal of Clinical Oncology, Bd. 32, Nr. 5: S. 415-423
Pastore, Friederike; Greif, Philipp A.; Schneider, Stephanie; Ksienzyk, Bianka; Mellert, Gudrun; Zellmeier, Evelyn; Braess, Jan; Sauerland, Cristina M.; Heinecke, Achim; Krug, Utz; Berdel, Wolfgang E.; Buechner, Thomas; Woermann, Bernhard; Hiddemann, Wolfgang und Spiekermann, Karsten
(2014):
The NPM1 Mutation Type Has No Impact on Survival in Cytogenetically Normal AML.
In: PLOS ONE 9(10), e109759 [PDF, 605kB]
In: PLOS ONE 9(10), e109759 [PDF, 605kB]
Hanfstein, Benjamin; Lauseker, Michael; Hehlmann, Rüdiger; Saussele, Susanne; Erben, Philipp; Dietz, Christian; Fabarius, Alice; Proetel, Ulrike; Schnittger, Susanne; Haferlach, Claudia; Krause, Stefan W.; Schubert, Joerg; Einsele, Hermann; Hänel, Mathias; Dengler, Jolanta; Falge, Christiane; Kanz, Lothar; Neubauer, Andreas; Kneba, Michael; Stegelmann, Frank; Pfreundschuh, Michael; Waller, Cornelius F.; Spiekermann, Karsten; Baerlocher, Gabriela M.; Pfirrmann, Markus; Hasford, Jörg; Hofmann, Wolf-Karsten; Hochhaus, Andreas und Müller, Martin C.
(2014):
Distinct characteristics of e13a2 versus e14a2 BCR-ABL1 driven chronic myeloid leukemia under first-line therapy with imatinib.
In: Haematologica, Bd. 99, Nr. 9: S. 1441-1447
[PDF, 784kB]
Hubmann, Max; Köhnke, Thomas; Hoster, Eva; Schneider, Stephanie; Dufour, Annika; Zellmeier, Evelyn; Fiegl, Michael; Braess, Jan; Bohlander, Stefan K.; Subklewe, Marion; Sauerland, Maria-Cristina; Berdel, Wolfgang E.; Büchner, Thomas; Woermann, Bernhard; Hiddemann, Wolfgang und Spiekermann, Karsten
(2014):
Molecular response assessment by quantitative real-time polymerase chain reaction after induction therapy in NPM1-mutated patients identifies those at high risk of relapse.
In: Haematologica, Bd. 99, Nr. 8: S. 1317-1325
[PDF, 838kB]
Pastore, Friederike; Pastore, Alessandro; Wittmann, Georg; Hiddemann, Wolfgang und Spiekermann, Karsten
(2014):
The Role of Therapeutic Leukapheresis in Hyperleukocytotic AML.
In: PLOS ONE 9(4), e95062 [PDF, 492kB]
In: PLOS ONE 9(4), e95062 [PDF, 492kB]
Janke, Hanna; Pastore, Friederike; Schumacher, Daniela; Herold, Tobias; Hopfner, Karl-Peter; Schneider, Stephanie; Berdel, Wolfgang E.; Büchner, Thomas; Woermann, Bernhard J.; Subklewe, Marion; Bohlander, Stefan K.; Hiddemann, Wolfgang; Spiekermann, Karsten und Polzer, Harald
(2014):
Activating FLT3 Mutants Show Distinct Gain-of-Function Phenotypes In Vitro and a Characteristic Signaling Pathway Profile Associated with Prognosis in Acute Myeloid Leukemia.
In: PLOS ONE 9(3), e89560 [PDF, 2MB]
In: PLOS ONE 9(3), e89560 [PDF, 2MB]
Pastore, Friederike; Schneider, Stephanie; Christ, Oliver; Hiddemann, Wolfgang und Spiekermann, Karsten
(2013):
Impressive thrombocytosis evolving in a patient with a BCR-ABL positive CML in major molecular response during dasatinib treatment unmasks an additional JAK2V617F.
In: Experimental Hematology & Oncology
2:24
[PDF, 192kB]
Schneider, F.; Hoster, Eva; Schneider, S.; Dufour, A.; Benthaus, T.; Kakadia, P. M.; Bohlander, Stefan K.; Braess, J.; Heinecke, A.; Sauerland, M. C.; Berdel, W. E.; Büchner, T.; Wörmann, Bernhard; Feuring-Buske, M.; Buske, C.; Creutzig, U.; Thiede, C.; Zwaan, M. C.; Heuvel-Eibrink, M. M. van den; Reinhardt, D.; Hiddemann, Wolfgang und Spiekermann, Karsten
(2012):
Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML).
In: Annals of Hematology, Bd. 91, Nr. 1: S. 9-18
Schneider, F.; Hoster, Eva; Unterhalt, Michael; Schneider, S.; Dufour, A.; Benthaus, T.; Mellert, G.; Zellmeier, Evelyn; Kakadia, P. M.; Bohlander, Stefan K.; Feuring-Buske, M.; Buske, C.; Braess, J.; Heinecke, A.; Sauerland, M. C.; Berdel, W. E.; Büchner, T.; Wörmann, Bernhard; Hiddemann, Wolfgang und Spiekermann, Karsten
(2012):
The FLT3ITD level has a high prognostic impact in NPM1 mutated, but not NPM1 unmutated AML with a normal karyotype.
In: Blood, Bd. 119, Nr. 19: S. 4383-4386
Dufour, A.; Schneider, F.; Hoster, Eva; Benthaus, T.; Ksienzyk, Bianka; Schneider, S.; Kakadia, P. M.; Sauerland, M. C.; Berdel, W. E.; Büchner, T.; Wörmann, Bernhard; Braess, J.; Subklewe, M.; Hiddemann, Wolfgang; Bohlander, Stefan K. und Spiekermann, Karsten
(2012):
Monoallelic CEBPA mutations in normal karyotype acute myeloid leukemia: independent favorable prognostic factor within NPM1 mutated patients.
In: Annals of Hematology, Bd. 91, Nr. 7: S. 1051-1063
Greif, Philipp A.; Dufour, A.; Konstandin, Nikola P.; Ksienzyk, Bianka; Zellmeier, Evelyn; Tizazu, B.; Sturm, J.; Benthaus, T.; Herold, Tobias; Yaghmaie, M.; Dorge, P.; Hopfner, K. P.; Hauser, A.; Graf, A.; Krebs, S.; Blum, H.; Kakadia, P. M.; Schneider, S.; Hoster, Eva; Schneider, F.; Stanulla, M.; Braess, J.; Sauerland, M. C.; Berdel, W. E.; Büchner, T.; Wörmann, Bernhard; Hiddemann, Wolfgang; Spiekermann, Karsten und Bohlander, Stefan K.
(2012):
GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia.
In: Blood, Bd. 120, Nr. 2: S. 395-403
Herold, Tobias; Mulaw, M. A.; Jurinovic, Vindi; Seiler, T.; Metzeler, Klaus H.; Dufour, A.; Schneider, S.; Kakadia, P. M.; Spiekermann, Karsten; Mansmann, Ulrich; Hiddemann, Wolfgang; Buske, C.; Dreyling, Martin und Bohlander, Stefan K.
(2012):
High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature.
In: Leukemia & Lymphoma, Bd. 54, Nr. 8: S. 1652-1657
Hanfstein, B.; Müller, M. C.; Hehlmann, R.; Erben, P.; Lauseker, Michael; Fabarius, A.; Schnittger, S.; Haferlach, C.; Göhring, G.; Proetel, U.; Kolb, H. J.; Krause, S. W.; Hofmann, W. K.; Schubert, J.; Einsele, H.; Dengler, J.; Hänel, M.; Falge, C.; Kanz, L.; Neubauer, A.; Kneba, M.; Stegelmann, F.; Pfreundschuh, M.; Waller, C. F.; Branford, S.; Hughes, T. P.; Spiekermann, Karsten; Baerlocher, Gabriela M.; Pfirrmann, Markus; Hasford, Joerg; Saußele, Susanne und Hochhaus, A.
(2012):
Early molecular and cytogenetic response is predictive for long-term progression-free and overall survival in chronic myeloid leukemia (CML).
In: Leukemia, Bd. 26, Nr. 9: S. 2096-2102
Fabarius, A.; Leitner, A.; Hochhaus, A.; Müller, M. C.; Hanfstein, B.; Haferlach, C.; Göhring, G.; Schlegelberger, B.; Jotterand, M.; Reiter, A.; Jung-Munkwitz, S.; Proetel, U.; Schwaab, J.; Hofmann, W. K.; Schubert, J.; Einsele, H.; Ho, A. D.; Falge, C.; Kanz, L.; Neubauer, A.; Kneba, M.; Stegelmann, F.; Pfreundschuh, M.; Waller, C. F.; Spiekermann, Karsten; Baerlocher, Gabriela M.; Lauseker, Michael; Pfirrmann, Markus; Hasford, Joerg; Saußele, Susanne und Hehlmann, R.
(2011):
Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: Long-term observation of 1151 patients from the randomized CML Study IV.
In: Blood, Bd. 118, Nr. 26: S. 6760-6768
Herold, Tobias; Jurinovic, Vindi; Metzeler, Klaus H.; Boulesteix, Anne-Laure; Bergmann, M.; Seiler, T.; Mulaw, M.; Thoene, S.; Dufour, A.; Pasalic, Z.; Schmidberger, Markus; Schmidt, M.; Schneider, S.; Kakadia, P. M.; Feuring-Buske, M.; Braess, J.; Spiekermann, Karsten; Mansmann, Ulrich; Hiddemann, Wolfgang; Buske, C. und Bohlander, Stefan K.
(2011):
An eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia.
In: Leukemia, Bd. 25, Nr. 10: S. 1639-1645
Herold, Tobias; Jurinovic, Vindi; Mulaw, M.; Seiler, T.; Dufour, A.; Schneider, S.; Kakadia, P. M.; Feuring-Buske, M.; Braess, J.; Spiekermann, Karsten; Mansmann, Ulrich; Hiddemann, Wolfgang; Buske, C. und Bohlander, Stefan K.
(2011):
Expression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia-unexpected expression pattern of the RHO GTPase activator ARHGAP20.
In: Genes, Chromosomes and Cancer, Bd. 50, Nr. 7: S. 546-558
Dufour, A.; Schneider, F.; Metzeler, Klaus H.; Hoster, Eva; Schneider, S.; Zellmeier, Evelyn; Benthaus, T.; Sauerland, M. C.; Berdel, W. E.; Büchner, T.; Wörmann, Bernhard; Braess, J.; Hiddemann, Wolfgang; Bohlander, Stefan K. und Spiekermann, Karsten
(2010):
Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome.
In: Journal of Clinical Oncology, Bd. 28, Nr. 4: S. 570-577
Metzeler, Klaus H.; Dufour, Annika; Benthaus, Tobias; Hummel, Manuela; Sauerland, Maria-Cristina; Heinecke, Achim; Berdel, Wolfgang E.; Büchner, Thomas; Woermann, Bernhard; Mansmann, Ulrich; Braess, Jan; Spiekermann, Karsten; Hiddemann, Wolfgang; Buske, Christian und Bohlander, Stefan K.
(2009):
ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: A comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays.
In: Journal of Clinical Oncology, Bd. 27, Nr. 30: S. 5031-5038
Metzeler, Klaus H.; Dufour, A.; Benthaus, T.; Hummel, Martina; Sauerland, M. C.; Heinecke, A.; Berdel, W. E.; Büchner, T.; Wörmann, Bernhard; Mansmann, Ulrich; Braess, J.; Spiekermann, Karsten; Hiddemann, Wolfgang; Buske, C. und Bohlander, Stefan K.
(2009):
ERG Expression Is an Independent Prognostic Factor and Allows Refined Risk Stratification in Cytogenetically Normal Acute Myeloid Leukemia: A Comprehensive Analysis of ERG, MN1, and BAALC Transcript Levels Using Oligonucleotide Microarrays.
In: Journal of Clinical Oncology, Bd. 27, Nr. 30: S. 5031-5038
Reiff, T.; Stingele, R.; Eckstein, H. H.; Fraedrich, G.; Jansen, O.; Mudra, H.; Mansmann, Ulrich; Hacke, W.; Ringleb, P. A.; Metzeler, Klaus H.; Dufour, A.; Benthaus, T.; Hummel, Martina; Sauerland, M. C.; Heinecke, A.; Berdel, W. E.; Büchner, T.; Wörmann, Bernhard; Braess, J.; Spiekermann, Karsten; Hiddemann, Wolfgang; Buske, C.; Bohlander, Stefan K.; Nagel, J. M.; Wegscheider, K.; Rohmel, J.; Fleckenstein, M.; Adrion, Christine ORCID: https://orcid.org/0000-0003-2408-2533; Schmitz-Valckenberg, S.; Gobel, A. P.; Bindewald-Wittich, A.; Scholl, H. und Holz, F.
(2009):
Stent-Protected Angioplasty in Asymptomatic Carotid Artery Stenosis vs. Endarterectomy: SPACE2 – a Three-Arm Randomised-Controlled Clinical Trial.
In: International Journal of Stroke, Bd. 4, Nr. 4: S. 294-299
ORCID: https://orcid.org/0000-0003-2408-2533; Schmitz-Valckenberg, S.; Gobel, A. P.; Bindewald-Wittich, A.; Scholl, H. und Holz, F.
(2009):
Stent-Protected Angioplasty in Asymptomatic Carotid Artery Stenosis vs. Endarterectomy: SPACE2 – a Three-Arm Randomised-Controlled Clinical Trial.
In: International Journal of Stroke, Bd. 4, Nr. 4: S. 294-299
Schneider, F.; Hoster, Eva; Unterhalt, Michael; Schneider, S.; Dufour, A.; Benthaus, T.; Mellert, G.; Zellmeier, Evelyn; Bohlander, Stefan K.; Feuring-Buske, M.; Buske, C.; Braess, J.; Fritsch, S.; Heinecke, A.; Sauerland, M. C.; Berdel, W. E.; Büchner, T.; Wörmann, Bernhard; Hiddemann, Wolfgang und Spiekermann, Karsten
(2009):
NPM1, but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high risk myelodysplastic syndrome (MDS).
In: Blood, Bd. 113, Nr. 21: S. 5250-5253
Metzeler, Klaus H.; Hummel, Martina; Bloomfield, C. D.; Spiekermann, Karsten; Braess, J.; Sauerland, M. C.; Heinecke, A.; Radmacher, M. D.; Marcucci, G.; Whitman, SP.; Maharry, K.; Paschka, P.; Larson, RA.; Berdel, W. E.; Büchner, T.; Wörmann, Bernhard; Mansmann, Ulrich; Hiddemann, Wolfgang; Bohlander, Stefan K. und Buske, C.
(2008):
An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia.
In: Blood, Bd. 112, Nr. 10: S. 4193-4201