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Veröffentlichungsdatum
Anzahl der Publikationen: 39
2024
Sichler, Sonja; Höfner, Georg 
ORCID: https://orcid.org/0000-0002-7957-4503; Nitsche, Valentin; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Paintner, Franz F. und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 394: S. 23-31
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-7957-4503; Nitsche, Valentin; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Paintner, Franz F. und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 394: S. 23-31
[PDF, 2MB]
Bernauer, Tamara; Nitsche, Valentin; Kaiser, Jesko; Gertzen, Christoph G.W.; Höfner, Georg ORCID: https://orcid.org/0000-0002-7957-4503; Niessen, Karin V.; Seeger, Thomas; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425 und Paintner, Franz F.
(2024):
Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents.
In: Toxicology Letters, Bd. 397: S. 151-162
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-7957-4503; Niessen, Karin V.; Seeger, Thomas; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425 und Paintner, Franz F.
(2024):
Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents.
In: Toxicology Letters, Bd. 397: S. 151-162
[PDF, 2MB]
Nitsche, Valentin; Höfner, Georg; Kaiser, Jesko; Gertzen, Christoph G.W.; Seeger, Thomas; Niessen, Karin V.; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Paintner, Franz F. und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 392: S. 94-106
[PDF, 4MB]
ORCID: https://orcid.org/0000-0003-4399-1425
(2024):
MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 392: S. 94-106
[PDF, 4MB]
2023
Zaienne, Daniel; Isigkeit, Laura; Marschner, Julian A.; Duensing‐Kropp, Silke; Höfner, Georg und Merk, Daniel ORCID: https://orcid.org/0000-0002-5359-8128
(2023):
Structural Modification of the Natural Product Valerenic Acid Tunes RXR Homodimer Agonism.
In: ChemMedChem, Bd. 18, Nr. 21
[PDF, 895kB]
ORCID: https://orcid.org/0000-0002-5359-8128
(2023):
Structural Modification of the Natural Product Valerenic Acid Tunes RXR Homodimer Agonism.
In: ChemMedChem, Bd. 18, Nr. 21
[PDF, 895kB]
Währa, Mark; Allmendinger, Lars; Höfner, Georg ORCID: https://orcid.org/0000-0002-7957-4503 und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2023):
Benocyclidine (BTCP) as Non‐labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR).
In: ChemMedChem, Bd. 18, Nr. 10
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-7957-4503 und Wanner, Klaus T. ORCID: https://orcid.org/0000-0003-4399-1425
(2023):
Benocyclidine (BTCP) as Non‐labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR).
In: ChemMedChem, Bd. 18, Nr. 10
[PDF, 1MB]
2022
Kipka, Hannah; Tomasi, Roland; Hübner, Max; Liebchen, Uwe; Hagl, Christian; Wanner, Klaus T.; Mannell, Hanna und Höfner, Georg
(2022):
Simultaneous LC-ESI-MS/MS Quantification of Levosimendan and Its Metabolites for Therapeutic Drug Monitoring of Cardiac Surgery Patients.
In: Pharmaceutics, Bd. 14, Nr. 7
[PDF, 1MB]
2021
Ackermann, Thomas M.; Höfner, Georg und Wanner, Klaus T.
(2021):
Screening for New Inhibitors of Glycine Transporter 1 and 2 by Means of MS Binding Assays.
In: Chemmedchem, Bd. 16, Nr. 19: S. 3094-3104
Rudy, Heinrich-Karl A.; Höfner, Georg und Wanner, Klaus T.
(2021):
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with tricyclic cage structures in the lipophilic domain as GABA uptake inhibitors.
In: Medicinal Chemistry Research, Bd. 30, Nr. 3: S. 586-609
[PDF, 1MB]
2020
Daerr, Markus; Pabel, Jörg; Höfner, Georg; Mayer, Peter und Wanner, Klaus T.
(2020):
Synthesis and biological evaluation of fluorescent GAT-ligands based on meso-substituted BODIPY dyes.
In: Medicinal Chemistry Research, Bd. 29, Nr. 2: S. 301-327
Böck, Michael C.; Höfner, Georg und Wanner, Klaus T.
(2020):
N‐Substituted Nipecotic Acids as (S )‐SNAP‐5114 Analogues with Modified Lipophilic Domains.
In: ChemMedChem, Bd. 15, Nr. 9: S. 756-771
[PDF, 2MB]
Andreß, Janina C.; Böck, Michael C.; Höfner, Georg und Wanner, Klaus T.
(2020):
Synthesis and biological evaluation of α- and β-hydroxy substituted amino acid derivatives as potential mGAT1-4 inhibitors.
In: Medicinal Chemistry Research, Bd. 29, Nr. 8: S. 1321-1340
[PDF, 1MB]
Ackermann, Thomas M.; Allmendinger, Lars; Höfner, Georg und Wanner, Klaus T.
(2020):
MS Binding Assays for Glycine Transporter 2 (GlyT2) Employing Org25543 as Reporter Ligand.
In: Chemmedchem, Bd. 16, Nr. 1: S. 199-215
[PDF, 2MB]
Daerr, Markus; Allmendinger, Lars; Höfner, Georg und Wanner, Klaus T.
(2020):
Synthesis and biological evaluation of fluorescent GAT-ligands based on asymmetric substituted BODIPY dyes.
In: Medicinal Chemistry Research, Bd. 29, Nr. 4: S. 767-782
Gabriel, Jeurgen; Höfner, Georg und Wanner, Klaus T.
(2020):
Combination of MS Binding Assays and affinity selection mass spectrometry for screening of structurally homogenous libraries as exemplified for a focused oxime library addressing the neuronal GABA transporter 1.
In: European Journal of Medicinal Chemistry, Bd. 206, 112598
2018
Toth, Krisztian; Höfner, Georg und Wanner, Klaus T.
(2018):
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with an alkyne spacer as GABA uptake inhibitors.
In: Bioorganic & Medicinal Chemistry, Bd. 26, Nr. 12: S. 3668-3687
Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
In: Chemmedchem, Bd. 13, Nr. 17: S. 1806-1816
Toth, Krisztian; Höfner, Georg und Wanner, Klaus T.
(2018):
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors.
In: Bioorganic & Medicinal Chemistry, Bd. 26, Nr. 22: S. 5944-5961
Neiens, Patrick; De Simone, Angela; Höfner, Georg und Wanner, Klaus T.
(2018):
Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters.
In: Chemmedchem, Bd. 13, Nr. 5: S. 453-463
Huber, Simone K.; Höfner, Georg und Wanner, Klaus T.
(2018):
Identification of Pyrrolidine-3-acetic Acid Derived Oximes as Potent Inhibitors of gamma-Aminobutyric Acid Transporter 1 through Library Screening with MS Binding Assays.
In: Chemmedchem, Bd. 13, Nr. 23: S. 2488-2503
Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
In: Chemmedchem, Bd. 13, Nr. 24: S. 2653-2663
Wein, Thomas; Höfner, Georg; Rappenglück, Sebastian; Sichler, Sonja; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst und Wanner, Klaus T.
(2018):
Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.
In: Toxicology Letters, Bd. 293: S. 184-189
Lutz, Toni; Wein, Thomas; Höfner, Georg; Pabel, Jörg; Eder, Matthias; Dine, Julien und Wanner, Klaus T.
(2018):
Development of New Photoswitchable Azobenzene Based gamma-Aminobutyric Acid (GABA) Uptake Inhibitors with Distinctly Enhanced Potency upon Photoactivation.
In: Journal of Medicinal Chemistry, Bd. 61, Nr. 14: S. 6211-6235
Neiens, Patrick; De Simone, Angela; Ramershoven, Anna; Höfner, Georg; Allmendinger, Lars und Wanner, Klaus T.
(2018):
Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET.
In: Biomedical Chromatography, Bd. 32, Nr. 7, e4231
2017
Schmidt, Simone K.; Höfner, Georg und Wanner, Klaus T.
(2017):
Determination of enantiomeric excess of nipecotic acid as 1-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) derivatives.
In: Chirality, Bd. 29, Nr. 1: S. 48-56
Neiens, Patrick; Höfner, Georg und Wanner, Klaus T.
(2017):
Determination of the enantiomeric purity of the selective dopamine transporter inhibitor (+)-R,R-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol.
In: Chirality, Bd. 29, Nr. 6: S. 294-303
Lutz, Toni; Wein, Thomas; Höfner, Georg und Wanner, Klaus T.
(2017):
Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives with N-Arylalkynyl Substituents.
In: ChemMedChem, Bd. 12, Nr. 5: S. 362-371
Schuller, Marion; Höfner, Georg und Wanner, Klaus T.
(2017):
Simultaneous Multiple MS Binding Assays Addressing D-1 and D-2 Dopamine Receptors.
In: ChemMedChem, Bd. 12, Nr. 19: S. 1585-1594
Ellwart, Mario; Höfner, Georg; Gerwien, Aaron; Wanner, Klaus T. und Knochel, Paul
(2017):
Synthesis and Bioactivity of Novel N-Benzylic and N-Phenethylic Ephedrine Derivatives.
In: Synthesis-Stuttgart, Bd. 49, Nr. 23: S. 5159-5166
2016
Hellenbrand, Tim; Höfner, Georg; Wein, Thomas und Wanner, Klaus T.
(2016):
Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors.
In: Bioorganic & Medicinal Chemistry, Bd. 24, Nr. 9: S. 2072-2096
Kirmeier, Thomas; Gopalakrishnan, Ranganath; Gormanns, Vanessa; Werner, Anna M.; Cuboni, Serena; Rudolf, Georg C.; Höfner, Georg; Wanner, Klaus T.; Sieber, Stephan A.; Schmidt, Ulrike; Holsboer, Florian; Rein, Theo und Hausch, Felix
(2016):
Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores.
In: PLOS ONE 11(2), e0148608 [PDF, 768kB]
In: PLOS ONE 11(2), e0148608 [PDF, 768kB]
Kerscher-Hack, Silke; Renukappa-Gutke, Thejavathi; Höfner, Georg und Wanner, Klaus T.
(2016):
Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.
In: European Journal of Medicinal Chemistry, Bd. 124: S. 852-880
Petrera, Marilena; Wein, Thomas; Allmendinger, Lars; Sindelar, Miriam; Pabel, Jörg; Höfner, Georg und Wanner, Klaus T.
(2016):
Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives by Suzuki-Miyaura Cross-Coupling Reactions.
In: ChemMedChem, Bd. 11, Nr. 5: S. 519-538
Wein, Thomas; Petrera, Marilena; Allmendinger, Lars; Höfner, Georg; Pabel, Jörg und Wanner, Klaus T.
(2016):
Different Binding Modes of Small and Large Binders of GAT1.
In: ChemMedChem, Bd. 11, Nr. 5: S. 509-518
2011
Iovkova-Berends, Ljuba; Wängler, Carmen; Zöller, Thomas; Höfner, Georg; Wanner, Klaus Theodor; Rensch, Christian; Bartenstein, Peter; Kostikov, Alexey; Schirrmacher, Ralf; Jurkschat, Klaus und Wängler, Björn
(September 2011):
τBu₂SiF-Derivatized D₂-Receptor Ligands: The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging.
In: Molecules, Bd. 16, Nr. 9: S. 7458-7479
[PDF, 637kB]
1991
Wanner, Klaus Th. und Höfner, Georg
(1991):
Chelat- und nicht-chelat-kontrollierte reduktionen von β-amido-ketonen. Synthese nicht-racemischer 1,3-aminoalkohole mit pyrrolidinstruktur.
In: Tetrahedron, Bd. 47, Nr. 10-11: S. 1895-1910
[PDF, 1MB]
Wanner, Klaus Th. und Höfner, Georg
(1991):
Konfigurationsbestimmung von (2S,7aR)- und (2S,7aS)-2-Benzyl-5,6,7,7a-tetrahydro-pyrrolo[2,1-b]oxazol-3(2H)-on.
In: Archiv der Pharmazie, Bd. 324, Nr. 3: S. 191-193
[PDF, 272kB]
1990
Wanner, Klaus Th. und Höfner, Georg
(1990):
Asymmetrische elektrophile alpha-Amidoalkylierung, 8. Mitt.: Gewinnung optisch aktiver alpha-Phenacylpyrrolidinamide und erste asymmetrische Totalsynthese des Norruspolins.
In: Archiv der Pharmazie, Bd. 323, Nr. 12: S. 977-986
[PDF, 1MB]
1989
Wanner, Klaus Th. und Höfner, Georg
(1989):
Asymmetrische elektrophile alpha-Amidoalkylierung, 4. Mitt. Erzeugung und Abfangreaktionen chiraler N-Acylpyrrolidiniumionen.
In: Archiv der Pharmazie, Bd. 322, Nr. 2: S. 99-103
[PDF, 805kB]
Wanner, Klaus Th. und Höfner, Georg
(1989):
Asymmetrische elektrophile alpha-Amidoalkylierung, 3.Mitt.: Synthesen von Vorstufen für die Erzeugung chiraler N-Acylpyrrolidiniumionen.
In: Archiv der Pharmazie, Bd. 322, Nr. 2: S. 93-97
[PDF, 909kB]