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Veröffentlichungsdatum
Anzahl der Publikationen: 84
2022
Murenu, Elisa; Gerhardt, Maximilian-Joachim; Biel, Martin und Michalakis, Stylianos
(29. November 2022):
More than meets the eye: The role of microglia in healthy and diseased retina.
In: Frontiers in Immunology, Bd. 13
[PDF, 1MB]
Gehrke, Miranda; Diedrichs-Möhring, Maria; Bogedein, Jacqueline; Büning, Hildegard; Michalakis, Stylianos und Wildner, Gerhild
(9. Juni 2022):
Immunogenicity of Novel AAV Capsids for Retinal Gene Therapy.
In: Cells, Bd. 11: S. 1-17
[PDF, 3MB]
Yan, Jie; Guenter, Alexander; Das, Soumyaparna; Muehlfriedel, Regine; Michalakis, Stylianos; Jiao, Kangwei; Seeliger, Mathias W. und Paquet-Durand, Francois
(2022):
Inherited Retinal Degeneration: PARP-Dependent Activation of Calpain Requires CNG Channel Activity.
In: Biomolecules, Bd. 12, Nr. 3, 455
Traube, Franziska R.; Stern, Marcel; Tölke, Annika J.; Rudelius, Martina; Mejias-Perez, Ernesto; Raddaoui, Nada; Kümmerer, Beate M.; Douat, Celine; Streshnev, Filipp; Albanese, Manuel; Wratil, Paul R.; Gärtner, Yasmin; Nainyte, Milda; Giorgio, Grazia; Michalakis, Stylianos; Schneider, Sabine; Streeck, Hendrik; Müller, Markus; Keppler, Oliver T. und Carell, Thomas
(2022):
Suppression of SARS-CoV-2 Replication with Stabilized and Click-Chemistry Modified siRNAs.
In: Angewandte Chemie International Edition, Bd. 61, Nr. 38
[PDF, 6MB]
Michalakis, Stylianos; Gerhardt, Maximilian; Rudolph, Günther; Priglinger, Siegfried und Priglinger, Claudia
(2022):
Achromatopsia: Genetics and Gene Therapy.
In: Molecular diagnosis & therapy, Bd. 26: S. 51-59
[PDF, 1MB]
Rieser, Ruth; Menzen, Tim; Biel, Martin; Michalakis, Stylianos und Winter, Gerhard
(2022):
Systematic Studies on Stabilization of AAV Vector Formulations by Lyophilization.
In: Journal of Pharmaceutical Sciences, Bd. 111, Nr. 8: S. 2288-2298
Riedmayr, Lisa M.; Hinrichsmeyer, Klara S.; Karguth, Nina; Böhm, Sybille; Splith, Victoria; Michalakis, Stylianos und Becirovic, Elvir
(2022):
dCas9-VPR-mediated transcriptional activation of functionally equivalent genes for gene therapy.
In: Nature Protocols, Bd. 17, Nr. 3: S. 781-818
Kunz, Patrick; Stuckenberger, Eva; Hausmann, Kerstin; Gentiluomo, Lorenzo; Neustrup, Malene; Michalakis, Stylianos; Rieser, Ruth; Romeijn, Stefan; Wichmann, Christian; Windisch, Roland; Hawe, Andrea; Jiskoot, Wim und Menzen, Tim
(2022):
Understanding opalescence measurements of biologics-A comparison study of methods, standards, and molecules.
In: International Journal of Pharmaceutics, Bd. 628, 122321
Kandaswamy, Surabhi; Zobel, Lena; John, Bina; Santhiya, Sathiyaveedu Thyagarajan; Bogedein, Jacqueline; Przemeck, Gerhard K. H.; Gailus-Durner, Valerie; Fuchs, Helmut; Biel, Martin; Hrabě de Angelis, Martin; Graw, Jochen; Michalakis, Stylianos und Amarie, Oana Veronica
(2022):
Mutations within the cGMP-binding domain of CNGA1 causing autosomal recessive retinitis pigmentosa in human and animal model.
In: Cell Death Discovery, Bd. 8, Nr. 1, 387
Pavlou, Marina; Babutzka, Sabrina und Michalakis, Stylianos
(2022):
A Bioengineered In Vitro Model to Assess AAV-Based Gene Therapies for Cyclic GMP-Related Disorders.
In: International Journal of Molecular Sciences, Bd. 23, Nr. 9, 4538
Burgers, Luisa D.; Li, Yanfen; Michalakis, Stylianos; Ciurus, Sarah; Zahler, Stefan; Mueller, Rolf und Fuerst, Robert
(2022):
The protein biosynthesis inhibitor vioprolide A evokes anti-angiogenic and pro-survival actions by targeting NOP14 and decreasing VEGF receptor 2and TAZ-signaling.
In: Biomedicine & Pharmacotherapy, Bd. 152, 113174
2021
Li, Yanfen; Schoen, Christian; Chen, Cheng-Chang; Yang, Zhuo; Liegl, Raffael; Murenu, Elisa; Schworm, Benedikt; Klugbauer, Norbert; Grimm, Christian; Wahl-Schott, Christian; Michalakis, Stylianos und Biel, Martin
(2021):
TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration.
In: Life Science Alliance, Bd. 4, Nr. 8, e202101047
Brantl, Victor; Schworm, Benedikt; Weber, Gregor; Schiefelbein, Johannes; Kreutzer, Thomas C.; Michalakis, Stylianos; Siedlecki, Jakob und Priglinger, Siegfried G.
(2021):
Long-term ocular damage after recovery from COVID-19: lack of evidence at three months.
In: BMC Ophthalmology, Bd. 21, Nr. 1, 421
Burgers, Luisa D.; Luong, Betty; Li, Yanfen; Fabritius, Matthias P.; Michalakis, Stylianos; Reichel, Christoph A.; Mueller, Rolf und Fuerst, Robert
(2021):
The natural product vioprolide A exerts anti-inflammatory actions through inhibition of its cellular target NOP14 and downregulation of importin-dependent NF-kappa B p65 nuclear translocation.
In: Biomedicine & Pharmacotherapy, Bd. 144, 112255
Koch, Mirja; Scheel, Constanze; Ma, Hongwei; Yang, Fan; Stadlmeier, Michael; Glück, Andrea F.; Murenu, Elisa; Traube, Franziska R.; Carell, Thomas; Biel, Martin; Ding, Xi-Qin und Michalakis, Stylianos
(2021):
The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia.
In: International Journal of Molecular Sciences, Bd. 22, Nr. 1, 52
Michalakis, Stylianos; Gerhardt, Maximilian; Rudolph, Günter; Priglinger, Siegfried und Priglinger, Claudia
(2021):
Gene Therapy for Inherited Retinal Disorders: Update on Clinical Trials.
In: Klinische Monatsblätter für Augenheilkunde, Bd. 238, Nr. 3: S. 272-281
Michalakis, Stylianos; Gerhardt, Maximilian; Rudolph, Günther; Priglinger, Siegfried und Priglinger, Claudia
(2021):
Achromatopsia: Genetics and Gene Therapy.
In: Molecular Diagnosis & Therapy, Bd. 26, Nr. 1: S. 51-59
Murenu, Elisa; Kostidis, Sarantos; Lahiri, Shibojyoti; Geserich, Anna S.; Imhof, Axel; Giera, Martin und Michalakis, Stylianos
(2021):
Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice.
In: International Journal of Molecular Sciences, Bd. 22, Nr. 5, 2345
Nassisi, Marco; Smirnov, Vasily M.; Solis Hernandez, Cyntia; Mohand-Said, Saddek; Condroyer, Christel; Antonio, Aline; Kuehlewein, Laura; Kempf, Melanie; Kohl, Susanne; Wissinger, Bernd; Nasser, Fadi; Ragi, Sara D.; Wang, Nan-Kai; Sparrow, Janet R.; Greenstein, Vivienne C.; Michalakis, Stylianos; Mahroo, Omar A.; Ba-Abbad, Rola; Michaelides, Michel; Webster, Andrew R.; Degli Esposti, Simona; Saffren, Brooke; Capasso, Jenina; Levin, Alex; Hauswirth, William W.; Dhaenens, Claire-Marie; Defoort-Dhellemmes, Sabine; Tsang, Stephen H.; Zrenner, Eberhart; Sahel, Jose-Alain; Petersen-Jones, Simon M.; Zeitz, Christina und Audo, Isabelle
(2021):
CNGB1-related rod-cone dystrophy: A mutation review and update.
In: Human Mutation, Bd. 42, Nr. 6: S. 641-666
Pavlou, Marina; Schön, Christian; Occelli, Laurence M.; Rossi, Axel; Meumann, Nadja; Boyd, Ryan F.; Bartoe, Joshua T.; Siedlecki, Jakob; Gerhardt, Maximilian J.; Babutzka, Sabrina; Bogedein, Jacqueline; Wagner, Johanna E.; Priglinger, Siegfried G.; Biel, Martin; Petersen-Jones, Simon M.; Büning, Hildegard und Michalakis, Stylianos
(2021):
Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders.
In: EMBO Molecular Medicine, Bd. 13, Nr. 4, e13392
Rieser, Ruth; Koch, Johanna; Faccioli, Greta; Richter, Klaus; Menzen, Tim; Biel, Martin; Winter, Gerhard und Michalakis, Stylianos
(2021):
Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors.
In: Pharmaceutics, Bd. 13, Nr. 5, 748
Traube, Franziska R.; Ozdemir, Dilara; Sahin, Hanife; Scheel, Constanze; Glück, Andrea F.; Geserich, Anna S.; Oganesian, Sabine; Kostidis, Sarantos; Iwan, Katharina; Rahimoff, Rene; Giorgio, Grazia; Mueller, Markus; Spada, Fabio; Biel, Martin; Cox, Juergen; Giera, Martin; Michalakis, Stylianos und Carell, Thomas
(2021):
Redirected nuclear glutamate dehydrogenase supplies Tet3 with alpha-ketoglutarate in neurons.
In: Nature Communications, Bd. 12, Nr. 1, 4100
Voelkner, Manuela; Pavlou, Marina; Buening, Hildegard; Michalakis, Stylianos und Karl, Mike O.
(2021):
Optimized Adeno-Associated Virus Vectors for Efficient Transduction of Human Retinal Organoids.
In: Human Gene Therapy, Bd. 32, Nr. 13-14: S. 694-706
Reichel, Felix Friedrich 
ORCID: https://orcid.org/0000-0001-9325-5616; Michalakis, Stylianos ORCID: https://orcid.org/0000-0001-5092-9238; Wilhelm, Barbara; Zobor, Ditta; Muehlfriedel, Regine; Kohl, Susanne; Weisschuh, Nicole; Sothilingam, Vithiyanjali; Kuehlewein, Laura ORCID: https://orcid.org/0000-0003-1906-8681; Kahle, Nadine; Seitz, Immanuel ORCID: https://orcid.org/0000-0002-3086-6425; Paquet-Durand, Francois ORCID: https://orcid.org/0000-0001-7355-5742; Tsang, Stephen H.; Martus, Peter; Peters, Tobias; Seeliger, Mathias; Bartz-Schmidt, Karl Ulrich; Ueffing, Marius; Zrenner, Eberhard; Biel, Martin; Wissinger, Bernd und Fischer, Dominik
(2021):
Three-year results of phase I retinal gene therapy trial for CNGA3-mutated achromatopsia: results of a non randomised controlled trial.
In: British Journal of Ophthalmology, Bd. 106, Nr. 11: S. 1567-1572
ORCID: https://orcid.org/0000-0001-9325-5616; Michalakis, Stylianos ORCID: https://orcid.org/0000-0001-5092-9238; Wilhelm, Barbara; Zobor, Ditta; Muehlfriedel, Regine; Kohl, Susanne; Weisschuh, Nicole; Sothilingam, Vithiyanjali; Kuehlewein, Laura ORCID: https://orcid.org/0000-0003-1906-8681; Kahle, Nadine; Seitz, Immanuel ORCID: https://orcid.org/0000-0002-3086-6425; Paquet-Durand, Francois ORCID: https://orcid.org/0000-0001-7355-5742; Tsang, Stephen H.; Martus, Peter; Peters, Tobias; Seeliger, Mathias; Bartz-Schmidt, Karl Ulrich; Ueffing, Marius; Zrenner, Eberhard; Biel, Martin; Wissinger, Bernd und Fischer, Dominik
(2021):
Three-year results of phase I retinal gene therapy trial for CNGA3-mutated achromatopsia: results of a non randomised controlled trial.
In: British Journal of Ophthalmology, Bd. 106, Nr. 11: S. 1567-1572
Murenu, Elisa; Pavlou, Marina; Richter, Lisa; Rapti, Kleopatra; Just, Sabrina; Cehajic-Kapetanovic, Jasmina; Tafrishi, Neda; Hayes, Andrew; Scholey, Rachel; Lucas, Robert; Buening, Hildegard; Grimm, Dirk und Michalakis, Stylianos
(2021):
A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting.
In: Molecular Therapy-Methods & Clinical Development, Bd. 20: S. 587-600
2020
Thumbs, Peter; Ensfelder, Timm T.; Hillmeier, Markus; Wagner, Mirko; Heiss, Matthias; Scheel, Constanze; Schön, Alexander; Müller, Markus; Michalakis, Stylianos; Kellner, Stefanie und Carell, Thomas
(11. März 2020):
Synthesis of Galactosyl-Queuosine and Distribution of Hypermodified Q-Nucleosides in Mouse Tissues.
In: Angewandte Chemie International Edition
[PDF, 1MB]
Fischer, M. Dominik; Michalakis, Stylianos; Wilhelm, Barbara; Zobor, Ditta; Muehlfriedel, Regine; Kohl, Susanne; Weisschuh, Nicole; Ochakovski, G. Alex; Klein, Reinhild; Schoen, Christian; Sothilingam, Vithiyanjali; Garcia-Garrido, Marina; Kuehlewein, Laura; Kahle, Nadine; Werner, Annette; Dauletbekov, Daniyar; Paquet-Durand, Francois; Tsang, Stephen; Martus, Peter; Peters, Tobias; Seeliger, Mathias; Bartz-Schmidt, Karl Ulrich; Ueffing, Marius; Zrenner, Eberhart; Biel, Martin und Wissinger, Bernd
(2020):
Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia A Nonrandomized Controlled Trial.
In: Jama Ophthalmology, Bd. 138, Nr. 6: S. 643-651
Rieser, Ruth; Penaud-Budloo, Magalie; Bouzelha, Mohammed; Rossi, Axel; Menzen, Tim; Biel, Martin; Buening, Hildegard; Ayuso, Eduard; Winter, Gerhard und Michalakis, Stylianos
(2020):
Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes.
In: Journal of Pharmaceutical Sciences, Bd. 109, Nr. 1: S. 854-862
Siedlecki, Jakob; Brantl, Victor; Schworm, Benedikt; Mayer, Wolfgang Johann; Gerhardt, Maximilian; Michalakis, Stylianos; Kreutzer, Thomas und Priglinger, Siegfried
(2020):
COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic.
In: Klinische Monatsblatter für Augenheilkunde, Bd. 237, Nr. 5: S. 1-6
Boehm, Sybille; Splith, Victoria; Riedmayr, Lisa Maria; Rotzer, Rene Dominik; Gasparoni, Gilles; Nordstroem, Karl J. V.; Wagner, Johanna Elisabeth; Hinrichsmeyer, Klara Sonnie; Walter, Joern; Wahl-Schott, Christian; Fenske, Stefanie; Biel, Martin; Michalakis, Stylianos und Becirovic, Elvir
(2020):
A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation.
In: Science Advances, Bd. 6, Nr. 34, eaba5614
Kallenborn-Gerhardt, Wiebke; Metzner, Katharina; Lu, Ruirui; Petersen, Jonas; Kuth, Miriam S.; Heine, Sandra; Drees, Oliver; Paul, Mandy; Becirovic, Elvir; Kennel, Lea; Flauaus, Cathrin; Gross, Tilman; Wack, Gesine; Hohmann, Stephan W.; Nemirovski, Dina; Del Turco, Domenico; Biel, Martin; Geisslinger, Gerd; Michalakis, Stylianos und Schmidtko, Achim
(2020):
Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1.
In: Neuropharmacology, Bd. 171, 108087
2019
Petersen-Jones, Simon M.; Occelli, Laurence M.; Biel, Martin und Michalakis, Stylianos
(2019):
Advancing Gene Therapy for PDE6A Retinitis Pigmentosa.
In: Retinal Degenerative Diseases: Mechanisms and Experimental Therapy, Bd. 1185: S. 103-107
Tobias, Peters; Philipp, Seitz Immanuel; Stylianos, Michalakis; Martin, Biel; Barbara, Wilhelm; Felix, Reichel; Alexander, Ochakovski Guy; Eberhart, Zrenner; Marius, Ueffing; Birgit, Korbmacher; Sven, Korte; Ulrich, Bartz-Schmidt Karl; Dominik, Fischer Manuel; Bartz-Schmidt, Karl Ulrich; Bolz, Sylvia; Fischer, Dominik; Kohl, Susanne; Kuehlewein, Laura; Muehlfriedel, Regine; Neubauer, Jonas; Ochakovski, Alex; Paquet-Durand, Francois; Seeliger, Mathias; Sothilingam, Vithiyanjali; Ueffing, Marius; Weisschuh, Nicole; Wissinger, Bernd; Zhour, Ahmad; Zobor, Ditta; Zrenner, Eberhart; Biel, Martin; Michalakis, Stylianos; Schön, Christian; Kahle, Nadine; Peters, Tobias; Wilhelm, Barbara; Tsang, Steven und Gloeckner, Christian Johannes
(2019):
Safety and Toxicology of Ocular Gene Therapy with Recombinant AAV Vector rAAV.hCNGA3 in Nonhuman Primates.
In: Human Gene Therapy Clinical Development, Bd. 30, Nr. 2: S. 50-56
Santos-Ferreira, Tiago; Herbig, Maik; Otto, Oliver; Carido, Madalena; Karl, Mike O.; Michalakis, Stylianos; Guck, Jochen und Ader, Marius
(2019):
Morpho-Rheological Fingerprinting of Rod Photoreceptors Using Real-Time Deformability Cytometry.
In: Cytometry Part A, Bd. 95, Nr. 11: S. 1145-1157
Borland, Kayla; Diesend, Jan; Ito-Kureha, Taku; Heissmeyer, Vigo; Hammann, Christian; Buck, Amy H.; Michalakis, Stylianos und Kellner, Stefanie
(2019):
Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis.
In: Genes, Bd. 10, Nr. 1, 26
Rudan Njavro, Jasenka; Klotz, Jakob; Dislich, Bastian; Wanngren, Johanna; Shmueli, Merav D.; Herber, Julia; Kuhn, Peer-Hendrik; Kumar, Rohit; Koeglsperger, Thomas; Conrad, Marcus; Wurst, Wolfgang; Feederle, Regina; Vlachos, Andreas; Michalakis, Stylianos; Jedlicka, Peter; Müller, Stephan A. und Lichtenthaler, Stefan F.
(2019):
Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.
In: FASEB Journal, Bd. 34, Nr. 2: S. 2465-2482
[PDF, 708kB]
2018
Blank, Thomas; Goldmann, Tobias; Koch, Mirja; Amann, Lukas; Schön, Christian; Bonin, Michael; Pang, Shengru; Prinz, Marco; Burnet, Michael; Wagner, Johanna E.; Biel, Martin und Michalakis, Stylianos
(2018):
Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa.
In: Frontiers in Immunology, Bd. 8, 1930
[PDF, 7MB]
Barben, Maya; Ail, Divya; Storti, Federica; Klee, Katrin; Schori, Christian; Samardzija, Marijana; Michalakis, Stylianos; Biel, Martin; Meneau, Isabelle; Blaser, Frank; Barthelmes, Daniel und Grimm, Christian
(2018):
Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress.
In: Cell Death and Differentiation, Bd. 25, Nr. 12: S. 2071-2085
[PDF, 6MB]
Michalakis, Stylianos; Becirovic, Elvir und Biel, Martin
(2018):
Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy.
In: International Journal of Molecular Sciences, Bd. 19, Nr. 3, 749
[PDF, 2MB]
Petersen-Jones, Simon M.; Occelli, Laurence M.; Winkler, Paige A.; Lee, Winston; Sparrow, Janet R.; Tsukikawa, Mai; Boye, Sanford L.; Chiodo, Vince; Capasso, Jenina E.; Becirovic, Elvir; Schön, Christian; Seeliger, Mathias W.; Levin, Alex V.; Michalakis, Stylianos; Hauswirth, William W. und Tsang, Stephen H.
(2018):
Patients and animal models of CNG beta 1-deficient retinitis pigmentosa support gene augmentation approach.
In: Journal of Clinical Investigation, Bd. 128, Nr. 1: S. 190-206
[PDF, 23MB]
Reichel, Felix F.; Peters, Tobias; Wilhelm, Barbara; Biel, Martin; Ueffing, Marius; Wissinger, Bernd; Bartz-Schmidt, Karl U.; Klein, Reinhild; Michalakis, Stylianos und Fischer, M. Dominik
(2018):
Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients.
In: Investigative Ophthalmology & Visual Science, Bd. 59, Nr. 5: S. 1910-1915
[PDF, 559kB]
Kahle, Nadine A.; Peters, Tobias; Zobor, Ditta; Kuehlewein, Laura; Kohl, Susanne; Zhour, Ahmad; Werner, Annette; Seitz, Immanuel P.; Sothilingam, Vithiyanjali; Michalakis, Stylianos; Biel, Martin; Ueffing, Marius; Zrenner, Eberhart; Bartz-Schmidt, Karl U.; Fischer, M. Dominik und Wilhelm, Barbara J. C.
(2018):
Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial.
In: Human Gene Therapy Clinical Development, Bd. 29, Nr. 3: S. 121-131
Riedmayr, Lisa Maria; Böhm, Sybille; Michalakis, Stylianos und Becirovic, Elvir
(2018):
Construction and Cloning of Minigenes for in vivo Analysis of Potential Splice Mutations.
In: Bio-Protocol, Bd. 8, Nr. 5, e2760
Falk, Nathalie; Kessler, Kristin; Schramm, Sinja-Fee; Boldt, Karsten; Becirovic, Elvir; Michalakis, Stylianos; Regus-Leidig, Hanna; Noegel, Angelika A.; Ueffing, Marius; Thiel, Christian T.; Roepman, Ronald; Brandstaetter, Johann Helmut und Giessl, Andreas
(2018):
Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis.
In: Journal of Cell Science, Bd. 131, Nr. 16
Stieglitz, Marc S.; Fenske, Stefanie; Hammelmann, Verena; Becirovic, Elvir; Schöttle, Verena; Delorme, James E.; Schöll-Weidinger, Martha; Mader, Robert; Deussing, Jan; Wolfer, David P.; Seeliger, Mathias W.; Albrecht, Urs; Wotjak, Carsten T.; Biel, Martin; Michalakis, Stylianos und Wahl-Schott, Christian
(2018):
Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.
In: Frontiers in Molecular Neuroscience, Bd. 10, 436
[PDF, 4MB]
Keplinger, Stefan; Beiderbeck, Barbara; Michalakis, Stylianos; Biel, Martin; Grothe, Benedikt ORCID: https://orcid.org/0000-0001-7317-0615 und Kunz, Lars ORCID: https://orcid.org/0000-0003-3141-0005
(2018):
Optogenetic Control of Neural Circuits in the Mongolian Gerbil.
In: Frontiers in Cellular Neuroscience, Bd. 12, 111
[PDF, 2MB]
ORCID: https://orcid.org/0000-0001-7317-0615 und Kunz, Lars ORCID: https://orcid.org/0000-0003-3141-0005
(2018):
Optogenetic Control of Neural Circuits in the Mongolian Gerbil.
In: Frontiers in Cellular Neuroscience, Bd. 12, 111
[PDF, 2MB]
Burkard, Markus; Kohl, Susanne; Kratzig, Timm; Tanimoto, Naoyuki; Brennenstuhl, Christina; Bausch, Anne E.; Junger, Katrin; Reuter, Peggy; Sothilingam, Vithiyanjali; Beck, Susanne C.; Huber, Gesine; Ding, Xi-Qin; Mayer, Anja K.; Baumann, Britta; Weisschuh, Nicole; Zobor, Ditta; Hahn, Gesa-Astrid; Kellner, Ulrich; Venturelli, Sascha; Becirovic, Elvir; Charbel Issa, Peter; Koenekoop, Robert K.; Rudolph, Gunther; Heckenlively, John; Sieving, Paul; Weleber, Richard G.; Hamel, Christian; Zong, Xiangang; Biel, Martin; Lukowski, Robert; Seeliger, Matthias W.; Michalakis, Stylianos; Wissinger, Bernd und Ruth, Peter
(2018):
Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy.
In: The Journal of Clinical Investigation, Bd. 128, Nr. 12: S. 5663-5675
2017
Butler, Michael R.; Ma, Hongwei; Yang, Fan; Belcher, Joshua; Le, Yun-Zheng; Mikoshiba, Katsuhiko; Biel, Martin; Michalakis, Stylianos; Iuso, Anthony; Krizaj, David und Ding, Xi-Qin
(2017):
Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency.
In: Journal of Biological Chemistry, Bd. 292, Nr. 27: S. 11189-11205
Laprell, Laura; Tochitsky, Ivan; Kaur, Kuldeep; Manookin, Michael B.; Stein, Marco; Barber, David M.; Schön, Christian; Michalakis, Stylianos; Biel, Martin; Kramer, Richard H.; Sumser, Martin P.; Trauner, Dirk und Gelder, Russell N. van
(2017):
Photopharmacological control of bipolar cells restores visual function in blind mice.
In: Journal of Clinical investigation, Bd. 127, Nr. 7: S. 2598-2611
Reichel, Felix F.; Dauletbekov, Daniyar L.; Klein, Reinhild; Peters, Tobias; Ochakoyski, G. Alex; Seitz, Immanuel P.; Wilhelm, Barbara; Üffing, Marius; Biel, Martin; Wissinger, Bernd; Michalakis, Stylianos; Bartz-Schmidt, Karl Ulrich und Fischer, M. Dominik
(2017):
AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.
In: Molecular therapy, Bd. 25, Nr. 12: S. 2648-2660
Schön, Christian; Sothilingam, Vithiyanjali; Mühlfriedel, Regine; Garrido, Marina Garcia; Beck, Susanne C.; Tanimoto, Naoyuki; Wissinger, Bernd; Paquet-Durand, Francois; Biel, Martin; Michalakis, Stylianos und Seeliger, Mathias W.
(2017):
Gene Therapy Successfully Delays Degeneration in a Mouse Model of PDE6A-Linked Retinitis Pigmentosa (RP43).
In: Human Gene therapy, Bd. 28, Nr. 12: S. 1180-1188
Occelli, Laurence M.; Schön, Christian; Seeliger, Mathias W.; Biel, Martin; Michalakis, Stylianos und Petersen-Jones, Simon M.
(2017):
Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Toward Treating Human PDE6A-Retinitis Pigmentosa.
In: Human Gene therapy, Bd. 28, Nr. 12: S. 1189-1201
Böhm, Sybille; Riedmayr, Lisa M.; Nguyen, O. N. Phuong; Giessl, Andreas; Liebscher, Toni; Butz, Elisabeth S.; Schön, Christian; Michalakis, Stylianos; Wahl-Schott, Christian; Biel, Martin und Becirovic, Elvir
(2017):
Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.
In: Scientific Reports, Bd. 7, 2321
[PDF, 3MB]
Michalakis, Stylianos; Fischer, M. Dominik; Schön, Christian; Wilhelm, Barbara; Zobor, Ditta; Muhlfriedel, Regine; Sothilingam, Vithiyanjali; Kohl, Susanne; Peters, Tobias; Zrenner, Eberhart; Bartz-Schmidt, Karl Ulrich; Üffing, Marius; Wissinger, Bernd; Seeliger, Mathias und Biel, Martin
(2017):
Gene Supplementation Therapy for CNGA3-Linked Achromatopsia.
In: Molecular therapy, Bd. 25, Nr. 5: S. 354
Ochakovski, G. Alex; Peters, Tobias; Michalakis, Stylianos; Wilhelm, Barbara; Wissinger, Bernd; Bie, Martin; Bartz-Schmidt, K. Ulrich und Fischer, M. Dominik
(2017):
Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae.
In: Investigative Ophthalmology & Visual Science, Bd. 58, Nr. 10: S. 4155-4160
Mühlfriedel, Regine; Tanimoto, Naoyuki; Schön, Christian; Sothilingam, Vithiyanjali; Garrido, Marina Garcia; Beck, Susanne C.; Huber, Gesine; Biel, Martin; Seeliger, Mathias W. und Michalakis, Stylianos
(2017):
AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects.
In: Frontiers in Neuroscience, Bd. 11, 292
[PDF, 5MB]
Schiffers, Sarah; Ebert, Charlotte; Rahimoff, Rene; Kosmatchev, Olesea; Steinbacher, Jessica; Bohne, Alexandra-Viola; Spada, Fabio; Michalakis, Stylianos; Nickelsen, Jörg; Müller, Markus und Carell, Thomas
(2017):
Quantitative LC-MS Provides No Evidence for m(6)dA or m(4)dC in the Genome of Mouse Embryonic Stem Cells and Tissues.
In: Angewandte Chemie-international Edition, Bd. 56, Nr. 37: S. 11268-11271
Michalakis, Stylianos; Shaltiel, Lior; Sothilingam, Vithiyanjali; Koch, Susanne; Schludi, Verena; Krause, Stefanie; Zeitz, Christina; Audo, Isabelle; Lancelot, Marie-Elise; Hamel, Christian; Meunier, Isabelle; Preising, Markus N.; Friedburg, Christoph; Lorenz, Birgit; Zabouri, Nawal; Haverkamp, Silke; Garcia Garrido, Marina; Tanimoto, Naoyuki; Seeliger, Mathias W.; Biel, Martin und Wahl-Schott, Christian A.
(2017):
Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2 (vol 23, pg 1538, 2014).
In: Human Molecular Genetics, Bd. 26, Nr. 2: S. 466
Michalakis, Stylianos; Schön, Christian; Becirovic, Elvir und Biel, Martin
(2017):
Gene therapy for achromatopsia.
In: Journal of Gene Medicine, Bd. 19, Nr. 3, e2944
2016
Fischer, M. Dominik; Wilhelm, Barbara; Michalakis, Stylianos; Zobor, Ditta; Kohl, Susanne; Seeliger, Matthias; Zrenner, Eberhart; Ueffing, Marius; Wissinger, Bernd; Biel, Martin und Bartz-Schmidt, Karl Ulrich
(2016):
Successful delivery of rAAV8.CNGA3 in a patient with CNGA3 achromatopsia.
In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12
Becirovic, Elvir; Böhm, Sybille; Nguyen, Ong N. P.; Riedmayr, Lisa M.; Hammelmann, Verena; Schön, Christian; Butz, Elisabeth S.; Wahl-Schott, Christian; Biel, Martin und Michalakis, Stylianos
(2016):
AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments.
In: Frontiers in Neuroscience, Bd. 10, 356
[PDF, 3MB]
Schön, Christian; Paquet-Durand, Francois und Michalakis, Stylianos
(2016):
Ca(v)1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice.
In: PLOS ONE 11(6), e0156974 [PDF, 1MB]
In: PLOS ONE 11(6), e0156974 [PDF, 1MB]
Sothilingam, Vithiyanjali; Michalakis, Stylianos; Garrido, Marina Garcia; Biel, Martin; Tanimoto, Naoyuki und Seeliger, Mathias W.
(2016):
HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.
In: PLOS ONE 11(1), e0147728 [PDF, 1MB]
In: PLOS ONE 11(1), e0147728 [PDF, 1MB]
Auffenberg, Eva; Jurik, Angela; Mattusch, Corinna; Stoffel, Rainer; Genewsky, Andreas; Namendorf, Christian; Schmid, Roland M.; Rammes, Gerhard; Biel, Martin; Uhr, Manfred; Moosmang, Sven; Michalakis, Stylianos; Wotjak, Carsten T. und Thoeringer, Christoph K.
(2016):
Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization.
In: Scientific Reports, Bd. 6, 19293
[PDF, 977kB]
Santos-Ferreira, Tiago; Völkner, Manuela; Borsch, Oliver; Haas, Jochen; Cimalla, Peter; Vasudevan, Praveen; Carmeliet, Peter; Corbeil, Denis; Michalakis, Stylianos; Koch, Edmund; Karl, Mike O. und Ader, Marius
(2016):
Stem Cell-Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy.
In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 7: S. 3509-3520
Becirovic, Elvir; Boehm, Sybille; Nguyen, Ong Nam Phuong; Riedmayr, Lisa Maria; Schroeder, Nadja; Giessl, Andreas; Michalakis, Stylianos und Biel, Martin
(2016):
Differential rescue of protein expression and localization of two adRP-linked PRPH2 mutants in rods is mediated by their specific binding characteristics.
In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12
Belcher, Josh; Butler, Michael R.; Ma, Hongwei; Xu, Catherine; Biel, Martin; Michalakis, Stylianos; Iuso, Anthony; Krizaj, David und Ding, Xi-Qin
(2016):
Inhibition of Endoplasmic Reticulum Calcium Channels Reduces Endoplasmic Reticulum Stress and Cone Death in CNG Channel-Deficient Mice.
In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12
Tanimoto, Naoyuki; Michalakis, Stylianos; Weber, Bernhard H. F.; Wahl-Schott, Christian A.; Hammes, Hans-Peter und Seeliger, Mathias W.
(2016):
In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.
In: Retinal Degenerative Diseases: Mechanisms and Experimental therapy, Bd. 854: S. 619-625
Becirovic, Elvir; Böhm, Sybille; Nguyen, Ong Nam Phuong; Riedmayr, Lisa Maria; Koch, Mirja Annika; Schulze, Elisabeth; Kohl, Susanne; Borsch, Oliver; Santos-Ferreira, Tiago; Ader, Marius; Michalakis, Stylianos und Biel, Martin
(2016):
In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors.
In: PLOS Genetics 12(1), e1005811 [PDF, 8MB]
In: PLOS Genetics 12(1), e1005811 [PDF, 8MB]
Schön, Christian; Asteriti, Sabrina; Koch, Susanne; Sothilingam, Vithiyanjali; Garrido, Marina Garcia; Tanimoto, Naoyuki; Herms, Jochen; Seeliger, Mathias W.; Cangiano, Lorenzo; Biel, Martin und Michalakis, Stylianos
(2016):
Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia.
In: Human Molecular Genetics, Bd. 25, Nr. 6: S. 1165-1175
Michalakis, Stylianos; Koch, Mirwa; Ma, Hongwei; Ding, Xi-Qin und Biel, Martin
(2016):
cGMP-cGKII signalling contributes to cone photoreceptor degeneration in achromatopsia.
In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12
Reichel, Felix Friedrich; Peters, Tobias; Muehlfriedel, Regine; Biel, Martin; Paquet-Durand, Francois; Ueffing, Marius; Wissinger, Bernd; Bartz-Schmidt, Karl Ulrich; Fischer, M. Dominik und Michalakis, Stylianos
(2016):
Humoral immune response to subretinal AAV8 in non-human primates.
In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12
Santos-Ferreira, Tiago; Völkner, Manuela; Borsch, Oliver; Haas, Jochen; Cimalla, Peter; Vasudevan, Praveen; Carmeliet, Peter; Corbeil, Denis; Michalakis, Stylianos; Koch, Edmund; Karl, Mike O. und Ader, Marius
(2016):
Author Response: Possibility of Cytoplasmic Transportation Between Donor-Host Cell Following Photoreceptor Transplantation.
In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 13: S. 5336-5337
Grimm, Christian; Barben, Maya; Ail, Divya; Kast, Brigitt; Schori, Christian; Giger-Lange, Christina; Michalakis, Stylianos und Samardzija, Marijana
(2016):
Inactivation of Hif1a rescues rods and cones from degeneration induced by a chronic hypoxia-like response: HIF1A as therapeutic target in AMD?
In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12
Seitz, Immanuel Philipp; Fischer, M. Dominik; Michalakis, Stylianos; Wilhelm, Barbara; Kahle, Nadine; Zrenner, Eberhart; Ueffing, Marius; Bartz-Schmidt, Karl Ulrich; Biel, Martin; Wissinger, Bernd und Peters, Tobias
(2016):
rAAV8 biodistribution and shedding after subretinal injection in non-human primates.
In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12
2015
Feodorova, Yana; Koch, Mirja; Bultman, Sebastian; Michalakis, Stylianos und Solovei, Irina
(2015):
Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice.
In: Methodsx, Bd. 2: S. 39-46
Perera, Arshan; Eisen, David; Wagner, Mirko; Laube, Silvia K.; Künzel, Andrea F.; Koch, Susanne; Steinbacher, Jessica; Schulze, Elisabeth; Splith, Victoria; Mittermeier, Nana; Mueller, Markus; Biel, Martin; Carell, Thomas und Michalakis, Stylianos
(2015):
TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression.
In: Cell Reports, Bd. 11, Nr. 2: S. 283-294
[PDF, 3MB]
Bender, Julia; Engeholm, Maik; Ederer, Marion S.; Breu, Johannes; Moller, Thor C.; Michalakis, Stylianos; Rasko, Tamas; Wanker, Erich E.; Biel, Martin; Martinez, Karen L.; Wurst, Wolfgang und Deussing, Jan M.
(2015):
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.
In: PLOS ONE 10(9), e0136768 [PDF, 20MB]
In: PLOS ONE 10(9), e0136768 [PDF, 20MB]
2014
Neuner, Johanna; Filser, Severin; Michalakis, Stylianos; Biel, Martin und Herms, Jochen
(2014):
A30P alpha-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network.
In: Scientific Reports, Bd. 4, 3931
[PDF, 11MB]
Neuner, Johanna; Ovsepian, Saak V.; Dorostkar, Mario; Filser, Severin; Gupta, Aayush; Michalakis, Stylianos; Biel, Martin und Herms, Jochen
(2014):
Pathological alpha-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb.
In: Nature Communications, Bd. 5, 3915
[PDF, 2MB]
Arango-Gonzalez, Blanca; Trifunović, Dragana; Sahaboglu, Ayse; Kranz, Katharina; Michalakis, Stylianos; Farinelli, Pietro; Koch, Susanne; Koch, Fred; Cottet, Sandra; Janssen-Bienhold, Ulrike; Dedek, Karin; Biel, Martin; Zrenner, Eberhart; Euler, Thomas; Ekstrom, Per; Ueffing, Marius und Paquet-Durand, François
(2014):
Identification of a Common Non-Apoptotic Cell Death Mechanism in Hereditary Retinal Degeneration.
In: PLOS ONE 9(11), e112142 [PDF, 1MB]
In: PLOS ONE 9(11), e112142 [PDF, 1MB]
2011
Hammelmann, Verena; Zong, Xiangang; Hofmann, Franz; Michalakis, Stylianos und Biel, Martin
(2011):
The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel.
In: PLOS ONE 6(2), e17078 [PDF, 3MB]
In: PLOS ONE 6(2), e17078 [PDF, 3MB]
2010
Becirovic, Elvir; Nakova, Kostadinka; Hammelmann, Verena; Hennel, Roman; Biel, Martin und Michalakis, Stylianos
(29. Januar 2010):
The retinitis pigmentosa mutation c.3444+1G>A in CNGB1 results in skipping of exon 32.
In: PLOS ONE 5(1), e8969 [PDF, 173kB]
In: PLOS ONE 5(1), e8969 [PDF, 173kB]
Globisch, Daniel; Münzel, Martin; Müller, Markus; Michalakis, Stylianos; Wagner, Mirko; Koch, Susanne; Brückl, Tobias; Biel, Martin und Carell, Thomas
(2010):
Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates.
In: PLOS ONE 5(12), e15367 [PDF, 3MB]
In: PLOS ONE 5(12), e15367 [PDF, 3MB]