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Publications by Michalakis, Stylianos

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Number of items: 49.

Journal article

Thumbs, Peter; Ensfelder, Timm T.; Hillmeier, Markus; Wagner, Mirko; Heiss, Matthias; Scheel, Constanze; Schön, Alexander; Müller, Markus; Michalakis, Stylianos; Kellner, Stefanie; Carell, Thomas (11. March 2020): Synthesis of Galactosyl-Queuosine and Distribution of Hypermodified Q-Nucleosides in Mouse Tissues. In: Angewandte Chemie International Edition [PDF, 1MB]

Burkard, Markus; Kohl, Susanne; Kratzig, Timm; Tanimoto, Naoyuki; Brennenstuhl, Christina; Bausch, Anne E.; Junger, Katrin; Reuter, Peggy; Sothilingam, Vithiyanjali; Beck, Susanne C.; Huber, Gesine; Ding, Xi-Qin; Mayer, Anja K.; Baumann, Britta; Weisschuh, Nicole; Zobor, Ditta; Hahn, Gesa-Astrid; Kellner, Ulrich; Venturelli, Sascha; Becirovic, Elvir; Charbel Issa, Peter; Koenekoop, Robert K.; Rudolph, Gunther; Heckenlively, John; Sieving, Paul; Weleber, Richard G.; Hamel, Christian; Zong, Xiangang; Biel, Martin; Lukowski, Robert; Seeliger, Matthias W.; Michalakis, Stylianos; Wissinger, Bernd; Ruth, Peter (2018): Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy. In: The Journal of Clinical Investigation, Vol. 128, No. 12: pp. 5663-5675

Keplinger, Stefan; Beiderbeck, Barbara; Michalakis, Stylianos; Biel, Martin; Grothe, Benedikt ORCID: 0000-0001-7317-0615; Kunz, Lars ORCID: 0000-0003-3141-0005 (2018): Optogenetic Control of Neural Circuits in the Mongolian Gerbil. In: Frontiers in Cellular Neuroscience, Vol. 12, 111 [PDF, 2MB]

Stieglitz, Marc S.; Fenske, Stefanie; Hammelmann, Verena; Becirovic, Elvir; Schöttle, Verena; Delorme, James E.; Schöll-Weidinger, Martha; Mader, Robert; Deussing, Jan; Wolfer, David P.; Seeliger, Mathias W.; Albrecht, Urs; Wotjak, Carsten T.; Biel, Martin; Michalakis, Stylianos; Wahl-Schott, Christian (2018): Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice. In: Frontiers in Molecular Neuroscience, Vol. 10, 436 [PDF, 4MB]

Falk, Nathalie; Kessler, Kristin; Schramm, Sinja-Fee; Boldt, Karsten; Becirovic, Elvir; Michalakis, Stylianos; Regus-Leidig, Hanna; Noegel, Angelika A.; Ueffing, Marius; Thiel, Christian T.; Roepman, Ronald; Brandstaetter, Johann Helmut; Giessl, Andreas (2018): Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis. In: Journal of Cell Science, Vol. 131, No. 16

Riedmayr, Lisa Maria; Böhm, Sybille; Michalakis, Stylianos; Becirovic, Elvir (2018): Construction and Cloning of Minigenes for in vivo Analysis of Potential Splice Mutations. In: Bio-Protocol, Vol. 8, No. 5, e2760

Blank, Thomas; Goldmann, Tobias; Koch, Mirja; Amann, Lukas; Schön, Christian; Bonin, Michael; Pang, Shengru; Prinz, Marco; Burnet, Michael; Wagner, Johanna E.; Biel, Martin; Michalakis, Stylianos (2018): Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa. In: Frontiers in Immunology, Vol. 8, 1930 [PDF, 7MB]

Kahle, Nadine A.; Peters, Tobias; Zobor, Ditta; Kuehlewein, Laura; Kohl, Susanne; Zhour, Ahmad; Werner, Annette; Seitz, Immanuel P.; Sothilingam, Vithiyanjali; Michalakis, Stylianos; Biel, Martin; Ueffing, Marius; Zrenner, Eberhart; Bartz-Schmidt, Karl U.; Fischer, M. Dominik; Wilhelm, Barbara J. C. (2018): Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial. In: Human Gene Therapy Clinical Development, Vol. 29, No. 3: pp. 121-131

Reichel, Felix F.; Peters, Tobias; Wilhelm, Barbara; Biel, Martin; Ueffing, Marius; Wissinger, Bernd; Bartz-Schmidt, Karl U.; Klein, Reinhild; Michalakis, Stylianos; Fischer, M. Dominik (2018): Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients. In: Investigative Ophthalmology & Visual Science, Vol. 59, No. 5: pp. 1910-1915 [PDF, 559kB]

Petersen-Jones, Simon M.; Occelli, Laurence M.; Winkler, Paige A.; Lee, Winston; Sparrow, Janet R.; Tsukikawa, Mai; Boye, Sanford L.; Chiodo, Vince; Capasso, Jenina E.; Becirovic, Elvir; Schön, Christian; Seeliger, Mathias W.; Levin, Alex V.; Michalakis, Stylianos; Hauswirth, William W.; Tsang, Stephen H. (2018): Patients and animal models of CNG beta 1-deficient retinitis pigmentosa support gene augmentation approach. In: Journal of Clinical Investigation, Vol. 128, No. 1: pp. 190-206 [PDF, 23MB]

Michalakis, Stylianos; Becirovic, Elvir; Biel, Martin (2018): Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy. In: International Journal of Molecular Sciences, Vol. 19, No. 3, 749 [PDF, 2MB]

Barben, Maya; Ail, Divya; Storti, Federica; Klee, Katrin; Schori, Christian; Samardzija, Marijana; Michalakis, Stylianos; Biel, Martin; Meneau, Isabelle; Blaser, Frank; Barthelmes, Daniel; Grimm, Christian (2018): Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress. In: Cell Death and Differentiation, Vol. 25, No. 12: pp. 2071-2085 [PDF, 6MB]

Laprell, Laura; Tochitsky, Ivan; Kaur, Kuldeep; Manookin, Michael B.; Stein, Marco; Barber, David M.; Schön, Christian; Michalakis, Stylianos; Biel, Martin; Kramer, Richard H.; Sumser, Martin P.; Trauner, Dirk; Gelder, Russell N. van (2017): Photopharmacological control of bipolar cells restores visual function in blind mice. In: Journal of Clinical investigation, Vol. 127, No. 7: pp. 2598-2611

Reichel, Felix F.; Dauletbekov, Daniyar L.; Klein, Reinhild; Peters, Tobias; Ochakoyski, G. Alex; Seitz, Immanuel P.; Wilhelm, Barbara; Üffing, Marius; Biel, Martin; Wissinger, Bernd; Michalakis, Stylianos; Bartz-Schmidt, Karl Ulrich; Fischer, M. Dominik (2017): AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye. In: Molecular therapy, Vol. 25, No. 12: pp. 2648-2660

Schön, Christian; Sothilingam, Vithiyanjali; Mühlfriedel, Regine; Garrido, Marina Garcia; Beck, Susanne C.; Tanimoto, Naoyuki; Wissinger, Bernd; Paquet-Durand, Francois; Biel, Martin; Michalakis, Stylianos; Seeliger, Mathias W. (2017): Gene Therapy Successfully Delays Degeneration in a Mouse Model of PDE6A-Linked Retinitis Pigmentosa (RP43). In: Human Gene therapy, Vol. 28, No. 12: pp. 1180-1188

Occelli, Laurence M.; Schön, Christian; Seeliger, Mathias W.; Biel, Martin; Michalakis, Stylianos; Petersen-Jones, Simon M. (2017): Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Toward Treating Human PDE6A-Retinitis Pigmentosa. In: Human Gene therapy, Vol. 28, No. 12: pp. 1189-1201

Butler, Michael R.; Ma, Hongwei; Yang, Fan; Belcher, Joshua; Le, Yun-Zheng; Mikoshiba, Katsuhiko; Biel, Martin; Michalakis, Stylianos; Iuso, Anthony; Krizaj, David; Ding, Xi-Qin (2017): Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency. In: Journal of Biological Chemistry, Vol. 292, No. 27: pp. 11189-11205

Böhm, Sybille; Riedmayr, Lisa M.; Nguyen, O. N. Phuong; Giessl, Andreas; Liebscher, Toni; Butz, Elisabeth S.; Schön, Christian; Michalakis, Stylianos; Wahl-Schott, Christian; Biel, Martin; Becirovic, Elvir (2017): Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants. In: Scientific Reports, Vol. 7, 2321 [PDF, 3MB]

Michalakis, Stylianos; Fischer, M. Dominik; Schön, Christian; Wilhelm, Barbara; Zobor, Ditta; Muhlfriedel, Regine; Sothilingam, Vithiyanjali; Kohl, Susanne; Peters, Tobias; Zrenner, Eberhart; Bartz-Schmidt, Karl Ulrich; Üffing, Marius; Wissinger, Bernd; Seeliger, Mathias; Biel, Martin (2017): Gene Supplementation Therapy for CNGA3-Linked Achromatopsia. In: Molecular therapy, Vol. 25, No. 5: p. 354

Ochakovski, G. Alex; Peters, Tobias; Michalakis, Stylianos; Wilhelm, Barbara; Wissinger, Bernd; Bie, Martin; Bartz-Schmidt, K. Ulrich; Fischer, M. Dominik (2017): Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae. In: Investigative Ophthalmology & Visual Science, Vol. 58, No. 10: pp. 4155-4160

Mühlfriedel, Regine; Tanimoto, Naoyuki; Schön, Christian; Sothilingam, Vithiyanjali; Garrido, Marina Garcia; Beck, Susanne C.; Huber, Gesine; Biel, Martin; Seeliger, Mathias W.; Michalakis, Stylianos (2017): AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects. In: Frontiers in Neuroscience, Vol. 11, 292 [PDF, 5MB]

Schiffers, Sarah; Ebert, Charlotte; Rahimoff, Rene; Kosmatchev, Olesea; Steinbacher, Jessica; Bohne, Alexandra-Viola; Spada, Fabio; Michalakis, Stylianos; Nickelsen, Jörg; Müller, Markus; Carell, Thomas (2017): Quantitative LC-MS Provides No Evidence for m(6)dA or m(4)dC in the Genome of Mouse Embryonic Stem Cells and Tissues. In: Angewandte Chemie-international Edition, Vol. 56, No. 37: pp. 11268-11271

Michalakis, Stylianos; Shaltiel, Lior; Sothilingam, Vithiyanjali; Koch, Susanne; Schludi, Verena; Krause, Stefanie; Zeitz, Christina; Audo, Isabelle; Lancelot, Marie-Elise; Hamel, Christian; Meunier, Isabelle; Preising, Markus N.; Friedburg, Christoph; Lorenz, Birgit; Zabouri, Nawal; Haverkamp, Silke; Garcia Garrido, Marina; Tanimoto, Naoyuki; Seeliger, Mathias W.; Biel, Martin; Wahl-Schott, Christian A. (2017): Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2 (vol 23, pg 1538, 2014). In: Human Molecular Genetics, Vol. 26, No. 2: p. 466

Michalakis, Stylianos; Schön, Christian; Becirovic, Elvir; Biel, Martin (2017): Gene therapy for achromatopsia. In: Journal of Gene Medicine, Vol. 19, No. 3, e2944

Becirovic, Elvir; Böhm, Sybille; Nguyen, Ong N. P.; Riedmayr, Lisa M.; Hammelmann, Verena; Schön, Christian; Butz, Elisabeth S.; Wahl-Schott, Christian; Biel, Martin; Michalakis, Stylianos (2016): AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments. In: Frontiers in Neuroscience, Vol. 10, 356 [PDF, 3MB]

Schön, Christian; Paquet-Durand, Francois; Michalakis, Stylianos (2016): Ca(v)1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice.
In: PLOS ONE 11(6), e0156974 [PDF, 1MB]

Sothilingam, Vithiyanjali; Michalakis, Stylianos; Garrido, Marina Garcia; Biel, Martin; Tanimoto, Naoyuki; Seeliger, Mathias W. (2016): HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.
In: PLOS ONE 11(1), e0147728 [PDF, 1MB]

Auffenberg, Eva; Jurik, Angela; Mattusch, Corinna; Stoffel, Rainer; Genewsky, Andreas; Namendorf, Christian; Schmid, Roland M.; Rammes, Gerhard; Biel, Martin; Uhr, Manfred; Moosmang, Sven; Michalakis, Stylianos; Wotjak, Carsten T.; Thoeringer, Christoph K. (2016): Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization. In: Scientific Reports, Vol. 6, 19293 [PDF, 977kB]

Santos-Ferreira, Tiago; Völkner, Manuela; Borsch, Oliver; Haas, Jochen; Cimalla, Peter; Vasudevan, Praveen; Carmeliet, Peter; Corbeil, Denis; Michalakis, Stylianos; Koch, Edmund; Karl, Mike O.; Ader, Marius (2016): Stem Cell-Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 7: pp. 3509-3520

Becirovic, Elvir; Boehm, Sybille; Nguyen, Ong Nam Phuong; Riedmayr, Lisa Maria; Schroeder, Nadja; Giessl, Andreas; Michalakis, Stylianos; Biel, Martin (2016): Differential rescue of protein expression and localization of two adRP-linked PRPH2 mutants in rods is mediated by their specific binding characteristics. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 12

Belcher, Josh; Butler, Michael R.; Ma, Hongwei; Xu, Catherine; Biel, Martin; Michalakis, Stylianos; Iuso, Anthony; Krizaj, David; Ding, Xi-Qin (2016): Inhibition of Endoplasmic Reticulum Calcium Channels Reduces Endoplasmic Reticulum Stress and Cone Death in CNG Channel-Deficient Mice. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 12

Tanimoto, Naoyuki; Michalakis, Stylianos; Weber, Bernhard H. F.; Wahl-Schott, Christian A.; Hammes, Hans-Peter; Seeliger, Mathias W. (2016): In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination. In: Retinal Degenerative Diseases: Mechanisms and Experimental therapy, Vol. 854: pp. 619-625

Becirovic, Elvir; Böhm, Sybille; Nguyen, Ong Nam Phuong; Riedmayr, Lisa Maria; Koch, Mirja Annika; Schulze, Elisabeth; Kohl, Susanne; Borsch, Oliver; Santos-Ferreira, Tiago; Ader, Marius; Michalakis, Stylianos; Biel, Martin (2016): In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors.
In: PLOS Genetics 12(1), e1005811 [PDF, 8MB]

Schön, Christian; Asteriti, Sabrina; Koch, Susanne; Sothilingam, Vithiyanjali; Garrido, Marina Garcia; Tanimoto, Naoyuki; Herms, Jochen; Seeliger, Mathias W.; Cangiano, Lorenzo; Biel, Martin; Michalakis, Stylianos (2016): Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia. In: Human Molecular Genetics, Vol. 25, No. 6: pp. 1165-1175

Michalakis, Stylianos; Koch, Mirwa; Ma, Hongwei; Ding, Xi-Qin; Biel, Martin (2016): cGMP-cGKII signalling contributes to cone photoreceptor degeneration in achromatopsia. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 12

Reichel, Felix Friedrich; Peters, Tobias; Muehlfriedel, Regine; Biel, Martin; Paquet-Durand, Francois; Ueffing, Marius; Wissinger, Bernd; Bartz-Schmidt, Karl Ulrich; Fischer, M. Dominik; Michalakis, Stylianos (2016): Humoral immune response to subretinal AAV8 in non-human primates. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 12

Fischer, M. Dominik; Wilhelm, Barbara; Michalakis, Stylianos; Zobor, Ditta; Kohl, Susanne; Seeliger, Matthias; Zrenner, Eberhart; Ueffing, Marius; Wissinger, Bernd; Biel, Martin; Bartz-Schmidt, Karl Ulrich (2016): Successful delivery of rAAV8.CNGA3 in a patient with CNGA3 achromatopsia. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 12

Santos-Ferreira, Tiago; Völkner, Manuela; Borsch, Oliver; Haas, Jochen; Cimalla, Peter; Vasudevan, Praveen; Carmeliet, Peter; Corbeil, Denis; Michalakis, Stylianos; Koch, Edmund; Karl, Mike O.; Ader, Marius (2016): Author Response: Possibility of Cytoplasmic Transportation Between Donor-Host Cell Following Photoreceptor Transplantation. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 13: pp. 5336-5337

Grimm, Christian; Barben, Maya; Ail, Divya; Kast, Brigitt; Schori, Christian; Giger-Lange, Christina; Michalakis, Stylianos; Samardzija, Marijana (2016): Inactivation of Hif1a rescues rods and cones from degeneration induced by a chronic hypoxia-like response: HIF1A as therapeutic target in AMD? In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 12

Seitz, Immanuel Philipp; Fischer, M. Dominik; Michalakis, Stylianos; Wilhelm, Barbara; Kahle, Nadine; Zrenner, Eberhart; Ueffing, Marius; Bartz-Schmidt, Karl Ulrich; Biel, Martin; Wissinger, Bernd; Peters, Tobias (2016): rAAV8 biodistribution and shedding after subretinal injection in non-human primates. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 12

Bender, Julia; Engeholm, Maik; Ederer, Marion S.; Breu, Johannes; Moller, Thor C.; Michalakis, Stylianos; Rasko, Tamas; Wanker, Erich E.; Biel, Martin; Martinez, Karen L.; Wurst, Wolfgang; Deussing, Jan M. (2015): Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.
In: PLOS ONE 10(9), e0136768 [PDF, 20MB]

Perera, Arshan; Eisen, David; Wagner, Mirko; Laube, Silvia K.; Künzel, Andrea F.; Koch, Susanne; Steinbacher, Jessica; Schulze, Elisabeth; Splith, Victoria; Mittermeier, Nana; Mueller, Markus; Biel, Martin; Carell, Thomas; Michalakis, Stylianos (2015): TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression. In: Cell Reports, Vol. 11, No. 2: pp. 283-294 [PDF, 3MB]

Feodorova, Yana; Koch, Mirja; Bultman, Sebastian; Michalakis, Stylianos; Solovei, Irina (2015): Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice. In: Methodsx, Vol. 2: pp. 39-46

Arango-Gonzalez, Blanca; Trifunović, Dragana; Sahaboglu, Ayse; Kranz, Katharina; Michalakis, Stylianos; Farinelli, Pietro; Koch, Susanne; Koch, Fred; Cottet, Sandra; Janssen-Bienhold, Ulrike; Dedek, Karin; Biel, Martin; Zrenner, Eberhart; Euler, Thomas; Ekstrom, Per; Ueffing, Marius; Paquet-Durand, François (2014): Identification of a Common Non-Apoptotic Cell Death Mechanism in Hereditary Retinal Degeneration.
In: PLOS ONE 9(11), e112142 [PDF, 1MB]

Neuner, Johanna; Ovsepian, Saak V.; Dorostkar, Mario; Filser, Severin; Gupta, Aayush; Michalakis, Stylianos; Biel, Martin; Herms, Jochen (2014): Pathological alpha-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb. In: Nature Communications, Vol. 5, 3915 [PDF, 2MB]

Neuner, Johanna; Filser, Severin; Michalakis, Stylianos; Biel, Martin; Herms, Jochen (2014): A30P alpha-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network. In: Scientific Reports, Vol. 4, 3931 [PDF, 11MB]

Hammelmann, Verena; Zong, Xiangang; Hofmann, Franz; Michalakis, Stylianos; Biel, Martin (2011): The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel.
In: PLOS ONE 6(2), e17078 [PDF, 3MB]

Becirovic, Elvir; Nakova, Kostadinka; Hammelmann, Verena; Hennel, Roman; Biel, Martin; Michalakis, Stylianos (29. January 2010): The retinitis pigmentosa mutation c.3444+1G>A in CNGB1 results in skipping of exon 32.
In: PLOS ONE 5(1), e8969 [PDF, 173kB]

Globisch, Daniel; Münzel, Martin; Müller, Markus; Michalakis, Stylianos; Wagner, Mirko; Koch, Susanne; Brückl, Tobias; Biel, Martin; Carell, Thomas (2010): Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates.
In: PLOS ONE 5(12), e15367 [PDF, 3MB]

This list was generated on Fri Aug 14 00:22:04 2020 CEST.