Publikationen von Michalakis, Stylianos

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Anzahl der Publikationen: 84

Zeitschriftenartikel

Murenu, Elisa; Gerhardt, Maximilian-Joachim; Biel, Martin und Michalakis, Stylianos (29. November 2022): More than meets the eye: The role of microglia in healthy and diseased retina. In: Frontiers in Immunology, Bd. 13 [PDF, 1MB]

Gehrke, Miranda; Diedrichs-Möhring, Maria; Bogedein, Jacqueline; Büning, Hildegard; Michalakis, Stylianos und Wildner, Gerhild (9. Juni 2022): Immunogenicity of Novel AAV Capsids for Retinal Gene Therapy. In: Cells, Bd. 11: S. 1-17 [PDF, 3MB]

Yan, Jie; Guenter, Alexander; Das, Soumyaparna; Muehlfriedel, Regine; Michalakis, Stylianos; Jiao, Kangwei; Seeliger, Mathias W. und Paquet-Durand, Francois (2022): Inherited Retinal Degeneration: PARP-Dependent Activation of Calpain Requires CNG Channel Activity. In: Biomolecules, Bd. 12, Nr. 3, 455

Traube, Franziska R.; Stern, Marcel; Tölke, Annika J.; Rudelius, Martina; Mejias-Perez, Ernesto; Raddaoui, Nada; Kümmerer, Beate M.; Douat, Celine; Streshnev, Filipp; Albanese, Manuel; Wratil, Paul R.; Gärtner, Yasmin; Nainyte, Milda; Giorgio, Grazia; Michalakis, Stylianos; Schneider, Sabine; Streeck, Hendrik; Müller, Markus; Keppler, Oliver T. und Carell, Thomas (2022): Suppression of SARS-CoV-2 Replication with Stabilized and Click-Chemistry Modified siRNAs. In: Angewandte Chemie International Edition, Bd. 61, Nr. 38 [PDF, 6MB]

Michalakis, Stylianos; Gerhardt, Maximilian; Rudolph, Günther; Priglinger, Siegfried und Priglinger, Claudia (2022): Achromatopsia: Genetics and Gene Therapy. In: Molecular diagnosis & therapy, Bd. 26: S. 51-59 [PDF, 1MB]

Rieser, Ruth; Menzen, Tim; Biel, Martin; Michalakis, Stylianos und Winter, Gerhard (2022): Systematic Studies on Stabilization of AAV Vector Formulations by Lyophilization. In: Journal of Pharmaceutical Sciences, Bd. 111, Nr. 8: S. 2288-2298

Riedmayr, Lisa M.; Hinrichsmeyer, Klara S.; Karguth, Nina; Böhm, Sybille; Splith, Victoria; Michalakis, Stylianos und Becirovic, Elvir (2022): dCas9-VPR-mediated transcriptional activation of functionally equivalent genes for gene therapy. In: Nature Protocols, Bd. 17, Nr. 3: S. 781-818

Kunz, Patrick; Stuckenberger, Eva; Hausmann, Kerstin; Gentiluomo, Lorenzo; Neustrup, Malene; Michalakis, Stylianos; Rieser, Ruth; Romeijn, Stefan; Wichmann, Christian; Windisch, Roland; Hawe, Andrea; Jiskoot, Wim und Menzen, Tim (2022): Understanding opalescence measurements of biologics-A comparison study of methods, standards, and molecules. In: International Journal of Pharmaceutics, Bd. 628, 122321

Kandaswamy, Surabhi; Zobel, Lena; John, Bina; Santhiya, Sathiyaveedu Thyagarajan; Bogedein, Jacqueline; Przemeck, Gerhard K. H.; Gailus-Durner, Valerie; Fuchs, Helmut; Biel, Martin; Hrabě de Angelis, Martin; Graw, Jochen; Michalakis, Stylianos und Amarie, Oana Veronica (2022): Mutations within the cGMP-binding domain of CNGA1 causing autosomal recessive retinitis pigmentosa in human and animal model. In: Cell Death Discovery, Bd. 8, Nr. 1, 387

Pavlou, Marina; Babutzka, Sabrina und Michalakis, Stylianos (2022): A Bioengineered In Vitro Model to Assess AAV-Based Gene Therapies for Cyclic GMP-Related Disorders. In: International Journal of Molecular Sciences, Bd. 23, Nr. 9, 4538

Burgers, Luisa D.; Li, Yanfen; Michalakis, Stylianos; Ciurus, Sarah; Zahler, Stefan; Mueller, Rolf und Fuerst, Robert (2022): The protein biosynthesis inhibitor vioprolide A evokes anti-angiogenic and pro-survival actions by targeting NOP14 and decreasing VEGF receptor 2and TAZ-signaling. In: Biomedicine & Pharmacotherapy, Bd. 152, 113174

Li, Yanfen; Schoen, Christian; Chen, Cheng-Chang; Yang, Zhuo; Liegl, Raffael; Murenu, Elisa; Schworm, Benedikt; Klugbauer, Norbert; Grimm, Christian; Wahl-Schott, Christian; Michalakis, Stylianos und Biel, Martin (2021): TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration. In: Life Science Alliance, Bd. 4, Nr. 8, e202101047

Brantl, Victor; Schworm, Benedikt; Weber, Gregor; Schiefelbein, Johannes; Kreutzer, Thomas C.; Michalakis, Stylianos; Siedlecki, Jakob und Priglinger, Siegfried G. (2021): Long-term ocular damage after recovery from COVID-19: lack of evidence at three months. In: BMC Ophthalmology, Bd. 21, Nr. 1, 421

Burgers, Luisa D.; Luong, Betty; Li, Yanfen; Fabritius, Matthias P.; Michalakis, Stylianos; Reichel, Christoph A.; Mueller, Rolf und Fuerst, Robert (2021): The natural product vioprolide A exerts anti-inflammatory actions through inhibition of its cellular target NOP14 and downregulation of importin-dependent NF-kappa B p65 nuclear translocation. In: Biomedicine & Pharmacotherapy, Bd. 144, 112255

Koch, Mirja; Scheel, Constanze; Ma, Hongwei; Yang, Fan; Stadlmeier, Michael; Glück, Andrea F.; Murenu, Elisa; Traube, Franziska R.; Carell, Thomas; Biel, Martin; Ding, Xi-Qin und Michalakis, Stylianos (2021): The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia. In: International Journal of Molecular Sciences, Bd. 22, Nr. 1, 52

Michalakis, Stylianos; Gerhardt, Maximilian; Rudolph, Günter; Priglinger, Siegfried und Priglinger, Claudia (2021): Gene Therapy for Inherited Retinal Disorders: Update on Clinical Trials. In: Klinische Monatsblätter für Augenheilkunde, Bd. 238, Nr. 3: S. 272-281

Michalakis, Stylianos; Gerhardt, Maximilian; Rudolph, Günther; Priglinger, Siegfried und Priglinger, Claudia (2021): Achromatopsia: Genetics and Gene Therapy. In: Molecular Diagnosis & Therapy, Bd. 26, Nr. 1: S. 51-59

Murenu, Elisa; Kostidis, Sarantos; Lahiri, Shibojyoti; Geserich, Anna S.; Imhof, Axel; Giera, Martin und Michalakis, Stylianos (2021): Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice. In: International Journal of Molecular Sciences, Bd. 22, Nr. 5, 2345

Nassisi, Marco; Smirnov, Vasily M.; Solis Hernandez, Cyntia; Mohand-Said, Saddek; Condroyer, Christel; Antonio, Aline; Kuehlewein, Laura; Kempf, Melanie; Kohl, Susanne; Wissinger, Bernd; Nasser, Fadi; Ragi, Sara D.; Wang, Nan-Kai; Sparrow, Janet R.; Greenstein, Vivienne C.; Michalakis, Stylianos; Mahroo, Omar A.; Ba-Abbad, Rola; Michaelides, Michel; Webster, Andrew R.; Degli Esposti, Simona; Saffren, Brooke; Capasso, Jenina; Levin, Alex; Hauswirth, William W.; Dhaenens, Claire-Marie; Defoort-Dhellemmes, Sabine; Tsang, Stephen H.; Zrenner, Eberhart; Sahel, Jose-Alain; Petersen-Jones, Simon M.; Zeitz, Christina und Audo, Isabelle (2021): CNGB1-related rod-cone dystrophy: A mutation review and update. In: Human Mutation, Bd. 42, Nr. 6: S. 641-666

Pavlou, Marina; Schön, Christian; Occelli, Laurence M.; Rossi, Axel; Meumann, Nadja; Boyd, Ryan F.; Bartoe, Joshua T.; Siedlecki, Jakob; Gerhardt, Maximilian J.; Babutzka, Sabrina; Bogedein, Jacqueline; Wagner, Johanna E.; Priglinger, Siegfried G.; Biel, Martin; Petersen-Jones, Simon M.; Büning, Hildegard und Michalakis, Stylianos (2021): Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders. In: EMBO Molecular Medicine, Bd. 13, Nr. 4, e13392 [PDF, 4MB]

Rieser, Ruth; Koch, Johanna; Faccioli, Greta; Richter, Klaus; Menzen, Tim; Biel, Martin; Winter, Gerhard und Michalakis, Stylianos (2021): Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors. In: Pharmaceutics, Bd. 13, Nr. 5, 748

Traube, Franziska R.; Ozdemir, Dilara; Sahin, Hanife; Scheel, Constanze; Glück, Andrea F.; Geserich, Anna S.; Oganesian, Sabine; Kostidis, Sarantos; Iwan, Katharina; Rahimoff, Rene; Giorgio, Grazia; Mueller, Markus; Spada, Fabio; Biel, Martin; Cox, Juergen; Giera, Martin; Michalakis, Stylianos und Carell, Thomas (2021): Redirected nuclear glutamate dehydrogenase supplies Tet3 with alpha-ketoglutarate in neurons. In: Nature Communications, Bd. 12, Nr. 1, 4100

Voelkner, Manuela; Pavlou, Marina; Buening, Hildegard; Michalakis, Stylianos und Karl, Mike O. (2021): Optimized Adeno-Associated Virus Vectors for Efficient Transduction of Human Retinal Organoids. In: Human Gene Therapy, Bd. 32, Nr. 13-14: S. 694-706

Reichel, Felix Friedrich

; Michalakis, Stylianos

; Wilhelm, Barbara; Zobor, Ditta; Muehlfriedel, Regine; Kohl, Susanne; Weisschuh, Nicole; Sothilingam, Vithiyanjali; Kuehlewein, Laura

; Kahle, Nadine; Seitz, Immanuel

; Paquet-Durand, Francois

; Tsang, Stephen H.; Martus, Peter; Peters, Tobias; Seeliger, Mathias; Bartz-Schmidt, Karl Ulrich; Ueffing, Marius; Zrenner, Eberhard; Biel, Martin; Wissinger, Bernd und Fischer, Dominik (2021): Three-year results of phase I retinal gene therapy trial for CNGA3-mutated achromatopsia: results of a non randomised controlled trial. In: British Journal of Ophthalmology, Bd. 106, Nr. 11: S. 1567-1572

Murenu, Elisa; Pavlou, Marina; Richter, Lisa; Rapti, Kleopatra; Just, Sabrina; Cehajic-Kapetanovic, Jasmina; Tafrishi, Neda; Hayes, Andrew; Scholey, Rachel; Lucas, Robert; Buening, Hildegard; Grimm, Dirk und Michalakis, Stylianos (2021): A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting. In: Molecular Therapy-Methods & Clinical Development, Bd. 20: S. 587-600

Thumbs, Peter; Ensfelder, Timm T.; Hillmeier, Markus; Wagner, Mirko; Heiss, Matthias; Scheel, Constanze; Schön, Alexander; Müller, Markus; Michalakis, Stylianos; Kellner, Stefanie und Carell, Thomas (11. März 2020): Synthesis of Galactosyl-Queuosine and Distribution of Hypermodified Q-Nucleosides in Mouse Tissues. In: Angewandte Chemie International Edition [PDF, 1MB]

Fischer, M. Dominik; Michalakis, Stylianos; Wilhelm, Barbara; Zobor, Ditta; Muehlfriedel, Regine; Kohl, Susanne; Weisschuh, Nicole; Ochakovski, G. Alex; Klein, Reinhild; Schoen, Christian; Sothilingam, Vithiyanjali; Garcia-Garrido, Marina; Kuehlewein, Laura; Kahle, Nadine; Werner, Annette; Dauletbekov, Daniyar; Paquet-Durand, Francois; Tsang, Stephen; Martus, Peter; Peters, Tobias; Seeliger, Mathias; Bartz-Schmidt, Karl Ulrich; Ueffing, Marius; Zrenner, Eberhart; Biel, Martin und Wissinger, Bernd (2020): Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia A Nonrandomized Controlled Trial. In: Jama Ophthalmology, Bd. 138, Nr. 6: S. 643-651

Rieser, Ruth; Penaud-Budloo, Magalie; Bouzelha, Mohammed; Rossi, Axel; Menzen, Tim; Biel, Martin; Buening, Hildegard; Ayuso, Eduard; Winter, Gerhard und Michalakis, Stylianos (2020): Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes. In: Journal of Pharmaceutical Sciences, Bd. 109, Nr. 1: S. 854-862

Siedlecki, Jakob; Brantl, Victor; Schworm, Benedikt; Mayer, Wolfgang Johann; Gerhardt, Maximilian; Michalakis, Stylianos; Kreutzer, Thomas und Priglinger, Siegfried (2020): COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic. In: Klinische Monatsblatter für Augenheilkunde, Bd. 237, Nr. 5: S. 1-6

Boehm, Sybille; Splith, Victoria; Riedmayr, Lisa Maria; Rotzer, Rene Dominik; Gasparoni, Gilles; Nordstroem, Karl J. V.; Wagner, Johanna Elisabeth; Hinrichsmeyer, Klara Sonnie; Walter, Joern; Wahl-Schott, Christian; Fenske, Stefanie; Biel, Martin; Michalakis, Stylianos und Becirovic, Elvir (2020): A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation. In: Science Advances, Bd. 6, Nr. 34, eaba5614

Kallenborn-Gerhardt, Wiebke; Metzner, Katharina; Lu, Ruirui; Petersen, Jonas; Kuth, Miriam S.; Heine, Sandra; Drees, Oliver; Paul, Mandy; Becirovic, Elvir; Kennel, Lea; Flauaus, Cathrin; Gross, Tilman; Wack, Gesine; Hohmann, Stephan W.; Nemirovski, Dina; Del Turco, Domenico; Biel, Martin; Geisslinger, Gerd; Michalakis, Stylianos und Schmidtko, Achim (2020): Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1. In: Neuropharmacology, Bd. 171, 108087

Petersen-Jones, Simon M.; Occelli, Laurence M.; Biel, Martin und Michalakis, Stylianos (2019): Advancing Gene Therapy for PDE6A Retinitis Pigmentosa. In: Retinal Degenerative Diseases: Mechanisms and Experimental Therapy, Bd. 1185: S. 103-107

Tobias, Peters; Philipp, Seitz Immanuel; Stylianos, Michalakis; Martin, Biel; Barbara, Wilhelm; Felix, Reichel; Alexander, Ochakovski Guy; Eberhart, Zrenner; Marius, Ueffing; Birgit, Korbmacher; Sven, Korte; Ulrich, Bartz-Schmidt Karl; Dominik, Fischer Manuel; Bartz-Schmidt, Karl Ulrich; Bolz, Sylvia; Fischer, Dominik; Kohl, Susanne; Kuehlewein, Laura; Muehlfriedel, Regine; Neubauer, Jonas; Ochakovski, Alex; Paquet-Durand, Francois; Seeliger, Mathias; Sothilingam, Vithiyanjali; Ueffing, Marius; Weisschuh, Nicole; Wissinger, Bernd; Zhour, Ahmad; Zobor, Ditta; Zrenner, Eberhart; Biel, Martin; Michalakis, Stylianos; Schön, Christian; Kahle, Nadine; Peters, Tobias; Wilhelm, Barbara; Tsang, Steven und Gloeckner, Christian Johannes (2019): Safety and Toxicology of Ocular Gene Therapy with Recombinant AAV Vector rAAV.hCNGA3 in Nonhuman Primates. In: Human Gene Therapy Clinical Development, Bd. 30, Nr. 2: S. 50-56

Santos-Ferreira, Tiago; Herbig, Maik; Otto, Oliver; Carido, Madalena; Karl, Mike O.; Michalakis, Stylianos; Guck, Jochen und Ader, Marius (2019): Morpho-Rheological Fingerprinting of Rod Photoreceptors Using Real-Time Deformability Cytometry. In: Cytometry Part A, Bd. 95, Nr. 11: S. 1145-1157

Borland, Kayla; Diesend, Jan; Ito-Kureha, Taku; Heissmeyer, Vigo; Hammann, Christian; Buck, Amy H.; Michalakis, Stylianos und Kellner, Stefanie (2019): Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis. In: Genes, Bd. 10, Nr. 1, 26

Rudan Njavro, Jasenka; Klotz, Jakob; Dislich, Bastian; Wanngren, Johanna; Shmueli, Merav D.; Herber, Julia; Kuhn, Peer-Hendrik; Kumar, Rohit; Koeglsperger, Thomas; Conrad, Marcus; Wurst, Wolfgang; Feederle, Regina; Vlachos, Andreas; Michalakis, Stylianos; Jedlicka, Peter; Müller, Stephan A. und Lichtenthaler, Stefan F. (2019): Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1. In: FASEB Journal, Bd. 34, Nr. 2: S. 2465-2482 [PDF, 708kB]

Blank, Thomas; Goldmann, Tobias; Koch, Mirja; Amann, Lukas; Schön, Christian; Bonin, Michael; Pang, Shengru; Prinz, Marco; Burnet, Michael; Wagner, Johanna E.; Biel, Martin und Michalakis, Stylianos (2018): Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa. In: Frontiers in Immunology, Bd. 8, 1930 [PDF, 7MB]

Barben, Maya; Ail, Divya; Storti, Federica; Klee, Katrin; Schori, Christian; Samardzija, Marijana; Michalakis, Stylianos; Biel, Martin; Meneau, Isabelle; Blaser, Frank; Barthelmes, Daniel und Grimm, Christian (2018): Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress. In: Cell Death and Differentiation, Bd. 25, Nr. 12: S. 2071-2085 [PDF, 6MB]

Michalakis, Stylianos; Becirovic, Elvir und Biel, Martin (2018): Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy. In: International Journal of Molecular Sciences, Bd. 19, Nr. 3, 749 [PDF, 2MB]

Petersen-Jones, Simon M.; Occelli, Laurence M.; Winkler, Paige A.; Lee, Winston; Sparrow, Janet R.; Tsukikawa, Mai; Boye, Sanford L.; Chiodo, Vince; Capasso, Jenina E.; Becirovic, Elvir; Schön, Christian; Seeliger, Mathias W.; Levin, Alex V.; Michalakis, Stylianos; Hauswirth, William W. und Tsang, Stephen H. (2018): Patients and animal models of CNG beta 1-deficient retinitis pigmentosa support gene augmentation approach. In: Journal of Clinical Investigation, Bd. 128, Nr. 1: S. 190-206 [PDF, 23MB]

Reichel, Felix F.; Peters, Tobias; Wilhelm, Barbara; Biel, Martin; Ueffing, Marius; Wissinger, Bernd; Bartz-Schmidt, Karl U.; Klein, Reinhild; Michalakis, Stylianos und Fischer, M. Dominik (2018): Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients. In: Investigative Ophthalmology & Visual Science, Bd. 59, Nr. 5: S. 1910-1915 [PDF, 559kB]

Kahle, Nadine A.; Peters, Tobias; Zobor, Ditta; Kuehlewein, Laura; Kohl, Susanne; Zhour, Ahmad; Werner, Annette; Seitz, Immanuel P.; Sothilingam, Vithiyanjali; Michalakis, Stylianos; Biel, Martin; Ueffing, Marius; Zrenner, Eberhart; Bartz-Schmidt, Karl U.; Fischer, M. Dominik und Wilhelm, Barbara J. C. (2018): Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial. In: Human Gene Therapy Clinical Development, Bd. 29, Nr. 3: S. 121-131

Riedmayr, Lisa Maria; Böhm, Sybille; Michalakis, Stylianos und Becirovic, Elvir (2018): Construction and Cloning of Minigenes for in vivo Analysis of Potential Splice Mutations. In: Bio-Protocol, Bd. 8, Nr. 5, e2760

Falk, Nathalie; Kessler, Kristin; Schramm, Sinja-Fee; Boldt, Karsten; Becirovic, Elvir; Michalakis, Stylianos; Regus-Leidig, Hanna; Noegel, Angelika A.; Ueffing, Marius; Thiel, Christian T.; Roepman, Ronald; Brandstaetter, Johann Helmut und Giessl, Andreas (2018): Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis. In: Journal of Cell Science, Bd. 131, Nr. 16

Stieglitz, Marc S.; Fenske, Stefanie; Hammelmann, Verena; Becirovic, Elvir; Schöttle, Verena; Delorme, James E.; Schöll-Weidinger, Martha; Mader, Robert; Deussing, Jan; Wolfer, David P.; Seeliger, Mathias W.; Albrecht, Urs; Wotjak, Carsten T.; Biel, Martin; Michalakis, Stylianos und Wahl-Schott, Christian (2018): Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice. In: Frontiers in Molecular Neuroscience, Bd. 10, 436 [PDF, 4MB]

Keplinger, Stefan; Beiderbeck, Barbara; Michalakis, Stylianos; Biel, Martin; Grothe, Benedikt

und Kunz, Lars

(2018): Optogenetic Control of Neural Circuits in the Mongolian Gerbil. In: Frontiers in Cellular Neuroscience, Bd. 12, 111 [PDF, 2MB]

Burkard, Markus; Kohl, Susanne; Kratzig, Timm; Tanimoto, Naoyuki; Brennenstuhl, Christina; Bausch, Anne E.; Junger, Katrin; Reuter, Peggy; Sothilingam, Vithiyanjali; Beck, Susanne C.; Huber, Gesine; Ding, Xi-Qin; Mayer, Anja K.; Baumann, Britta; Weisschuh, Nicole; Zobor, Ditta; Hahn, Gesa-Astrid; Kellner, Ulrich; Venturelli, Sascha; Becirovic, Elvir; Charbel Issa, Peter; Koenekoop, Robert K.; Rudolph, Gunther; Heckenlively, John; Sieving, Paul; Weleber, Richard G.; Hamel, Christian; Zong, Xiangang; Biel, Martin; Lukowski, Robert; Seeliger, Matthias W.; Michalakis, Stylianos; Wissinger, Bernd und Ruth, Peter (2018): Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy. In: The Journal of Clinical Investigation, Bd. 128, Nr. 12: S. 5663-5675

Butler, Michael R.; Ma, Hongwei; Yang, Fan; Belcher, Joshua; Le, Yun-Zheng; Mikoshiba, Katsuhiko; Biel, Martin; Michalakis, Stylianos; Iuso, Anthony; Krizaj, David und Ding, Xi-Qin (2017): Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency. In: Journal of Biological Chemistry, Bd. 292, Nr. 27: S. 11189-11205

Laprell, Laura; Tochitsky, Ivan; Kaur, Kuldeep; Manookin, Michael B.; Stein, Marco; Barber, David M.; Schön, Christian; Michalakis, Stylianos; Biel, Martin; Kramer, Richard H.; Sumser, Martin P.; Trauner, Dirk und Gelder, Russell N. van (2017): Photopharmacological control of bipolar cells restores visual function in blind mice. In: Journal of Clinical investigation, Bd. 127, Nr. 7: S. 2598-2611

Reichel, Felix F.; Dauletbekov, Daniyar L.; Klein, Reinhild; Peters, Tobias; Ochakoyski, G. Alex; Seitz, Immanuel P.; Wilhelm, Barbara; Üffing, Marius; Biel, Martin; Wissinger, Bernd; Michalakis, Stylianos; Bartz-Schmidt, Karl Ulrich und Fischer, M. Dominik (2017): AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye. In: Molecular therapy, Bd. 25, Nr. 12: S. 2648-2660

Schön, Christian; Sothilingam, Vithiyanjali; Mühlfriedel, Regine; Garrido, Marina Garcia; Beck, Susanne C.; Tanimoto, Naoyuki; Wissinger, Bernd; Paquet-Durand, Francois; Biel, Martin; Michalakis, Stylianos und Seeliger, Mathias W. (2017): Gene Therapy Successfully Delays Degeneration in a Mouse Model of PDE6A-Linked Retinitis Pigmentosa (RP43). In: Human Gene therapy, Bd. 28, Nr. 12: S. 1180-1188

Occelli, Laurence M.; Schön, Christian; Seeliger, Mathias W.; Biel, Martin; Michalakis, Stylianos und Petersen-Jones, Simon M. (2017): Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Toward Treating Human PDE6A-Retinitis Pigmentosa. In: Human Gene therapy, Bd. 28, Nr. 12: S. 1189-1201

Böhm, Sybille; Riedmayr, Lisa M.; Nguyen, O. N. Phuong; Giessl, Andreas; Liebscher, Toni; Butz, Elisabeth S.; Schön, Christian; Michalakis, Stylianos; Wahl-Schott, Christian; Biel, Martin und Becirovic, Elvir (2017): Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants. In: Scientific Reports, Bd. 7, 2321 [PDF, 3MB]

Michalakis, Stylianos; Fischer, M. Dominik; Schön, Christian; Wilhelm, Barbara; Zobor, Ditta; Muhlfriedel, Regine; Sothilingam, Vithiyanjali; Kohl, Susanne; Peters, Tobias; Zrenner, Eberhart; Bartz-Schmidt, Karl Ulrich; Üffing, Marius; Wissinger, Bernd; Seeliger, Mathias und Biel, Martin (2017): Gene Supplementation Therapy for CNGA3-Linked Achromatopsia. In: Molecular therapy, Bd. 25, Nr. 5: S. 354

Ochakovski, G. Alex; Peters, Tobias; Michalakis, Stylianos; Wilhelm, Barbara; Wissinger, Bernd; Bie, Martin; Bartz-Schmidt, K. Ulrich und Fischer, M. Dominik (2017): Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae. In: Investigative Ophthalmology & Visual Science, Bd. 58, Nr. 10: S. 4155-4160

Mühlfriedel, Regine; Tanimoto, Naoyuki; Schön, Christian; Sothilingam, Vithiyanjali; Garrido, Marina Garcia; Beck, Susanne C.; Huber, Gesine; Biel, Martin; Seeliger, Mathias W. und Michalakis, Stylianos (2017): AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects. In: Frontiers in Neuroscience, Bd. 11, 292 [PDF, 5MB]

Schiffers, Sarah; Ebert, Charlotte; Rahimoff, Rene; Kosmatchev, Olesea; Steinbacher, Jessica; Bohne, Alexandra-Viola; Spada, Fabio; Michalakis, Stylianos; Nickelsen, Jörg; Müller, Markus und Carell, Thomas (2017): Quantitative LC-MS Provides No Evidence for m(6)dA or m(4)dC in the Genome of Mouse Embryonic Stem Cells and Tissues. In: Angewandte Chemie-international Edition, Bd. 56, Nr. 37: S. 11268-11271

Michalakis, Stylianos; Shaltiel, Lior; Sothilingam, Vithiyanjali; Koch, Susanne; Schludi, Verena; Krause, Stefanie; Zeitz, Christina; Audo, Isabelle; Lancelot, Marie-Elise; Hamel, Christian; Meunier, Isabelle; Preising, Markus N.; Friedburg, Christoph; Lorenz, Birgit; Zabouri, Nawal; Haverkamp, Silke; Garcia Garrido, Marina; Tanimoto, Naoyuki; Seeliger, Mathias W.; Biel, Martin und Wahl-Schott, Christian A. (2017): Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2 (vol 23, pg 1538, 2014). In: Human Molecular Genetics, Bd. 26, Nr. 2: S. 466

Michalakis, Stylianos; Schön, Christian; Becirovic, Elvir und Biel, Martin (2017): Gene therapy for achromatopsia. In: Journal of Gene Medicine, Bd. 19, Nr. 3, e2944

Fischer, M. Dominik; Wilhelm, Barbara; Michalakis, Stylianos; Zobor, Ditta; Kohl, Susanne; Seeliger, Matthias; Zrenner, Eberhart; Ueffing, Marius; Wissinger, Bernd; Biel, Martin und Bartz-Schmidt, Karl Ulrich (2016): Successful delivery of rAAV8.CNGA3 in a patient with CNGA3 achromatopsia. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Becirovic, Elvir; Böhm, Sybille; Nguyen, Ong N. P.; Riedmayr, Lisa M.; Hammelmann, Verena; Schön, Christian; Butz, Elisabeth S.; Wahl-Schott, Christian; Biel, Martin und Michalakis, Stylianos (2016): AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments. In: Frontiers in Neuroscience, Bd. 10, 356 [PDF, 3MB]

Schön, Christian; Paquet-Durand, Francois und Michalakis, Stylianos (2016): Ca(v)1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice.
In: PLOS ONE 11(6), e0156974 [PDF, 1MB]

Sothilingam, Vithiyanjali; Michalakis, Stylianos; Garrido, Marina Garcia; Biel, Martin; Tanimoto, Naoyuki und Seeliger, Mathias W. (2016): HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.
In: PLOS ONE 11(1), e0147728 [PDF, 1MB]

Auffenberg, Eva; Jurik, Angela; Mattusch, Corinna; Stoffel, Rainer; Genewsky, Andreas; Namendorf, Christian; Schmid, Roland M.; Rammes, Gerhard; Biel, Martin; Uhr, Manfred; Moosmang, Sven; Michalakis, Stylianos; Wotjak, Carsten T. und Thoeringer, Christoph K. (2016): Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization. In: Scientific Reports, Bd. 6, 19293 [PDF, 977kB]

Santos-Ferreira, Tiago; Völkner, Manuela; Borsch, Oliver; Haas, Jochen; Cimalla, Peter; Vasudevan, Praveen; Carmeliet, Peter; Corbeil, Denis; Michalakis, Stylianos; Koch, Edmund; Karl, Mike O. und Ader, Marius (2016): Stem Cell-Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 7: S. 3509-3520

Becirovic, Elvir; Boehm, Sybille; Nguyen, Ong Nam Phuong; Riedmayr, Lisa Maria; Schroeder, Nadja; Giessl, Andreas; Michalakis, Stylianos und Biel, Martin (2016): Differential rescue of protein expression and localization of two adRP-linked PRPH2 mutants in rods is mediated by their specific binding characteristics. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Belcher, Josh; Butler, Michael R.; Ma, Hongwei; Xu, Catherine; Biel, Martin; Michalakis, Stylianos; Iuso, Anthony; Krizaj, David und Ding, Xi-Qin (2016): Inhibition of Endoplasmic Reticulum Calcium Channels Reduces Endoplasmic Reticulum Stress and Cone Death in CNG Channel-Deficient Mice. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Tanimoto, Naoyuki; Michalakis, Stylianos; Weber, Bernhard H. F.; Wahl-Schott, Christian A.; Hammes, Hans-Peter und Seeliger, Mathias W. (2016): In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination. In: Retinal Degenerative Diseases: Mechanisms and Experimental therapy, Bd. 854: S. 619-625

Becirovic, Elvir; Böhm, Sybille; Nguyen, Ong Nam Phuong; Riedmayr, Lisa Maria; Koch, Mirja Annika; Schulze, Elisabeth; Kohl, Susanne; Borsch, Oliver; Santos-Ferreira, Tiago; Ader, Marius; Michalakis, Stylianos und Biel, Martin (2016): In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors.
In: PLOS Genetics 12(1), e1005811 [PDF, 8MB]

Schön, Christian; Asteriti, Sabrina; Koch, Susanne; Sothilingam, Vithiyanjali; Garrido, Marina Garcia; Tanimoto, Naoyuki; Herms, Jochen; Seeliger, Mathias W.; Cangiano, Lorenzo; Biel, Martin und Michalakis, Stylianos (2016): Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia. In: Human Molecular Genetics, Bd. 25, Nr. 6: S. 1165-1175

Michalakis, Stylianos; Koch, Mirwa; Ma, Hongwei; Ding, Xi-Qin und Biel, Martin (2016): cGMP-cGKII signalling contributes to cone photoreceptor degeneration in achromatopsia. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Reichel, Felix Friedrich; Peters, Tobias; Muehlfriedel, Regine; Biel, Martin; Paquet-Durand, Francois; Ueffing, Marius; Wissinger, Bernd; Bartz-Schmidt, Karl Ulrich; Fischer, M. Dominik und Michalakis, Stylianos (2016): Humoral immune response to subretinal AAV8 in non-human primates. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Santos-Ferreira, Tiago; Völkner, Manuela; Borsch, Oliver; Haas, Jochen; Cimalla, Peter; Vasudevan, Praveen; Carmeliet, Peter; Corbeil, Denis; Michalakis, Stylianos; Koch, Edmund; Karl, Mike O. und Ader, Marius (2016): Author Response: Possibility of Cytoplasmic Transportation Between Donor-Host Cell Following Photoreceptor Transplantation. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 13: S. 5336-5337

Grimm, Christian; Barben, Maya; Ail, Divya; Kast, Brigitt; Schori, Christian; Giger-Lange, Christina; Michalakis, Stylianos und Samardzija, Marijana (2016): Inactivation of Hif1a rescues rods and cones from degeneration induced by a chronic hypoxia-like response: HIF1A as therapeutic target in AMD? In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Seitz, Immanuel Philipp; Fischer, M. Dominik; Michalakis, Stylianos; Wilhelm, Barbara; Kahle, Nadine; Zrenner, Eberhart; Ueffing, Marius; Bartz-Schmidt, Karl Ulrich; Biel, Martin; Wissinger, Bernd und Peters, Tobias (2016): rAAV8 biodistribution and shedding after subretinal injection in non-human primates. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Feodorova, Yana; Koch, Mirja; Bultman, Sebastian; Michalakis, Stylianos und Solovei, Irina (2015): Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice. In: Methodsx, Bd. 2: S. 39-46

Perera, Arshan; Eisen, David; Wagner, Mirko; Laube, Silvia K.; Künzel, Andrea F.; Koch, Susanne; Steinbacher, Jessica; Schulze, Elisabeth; Splith, Victoria; Mittermeier, Nana; Mueller, Markus; Biel, Martin; Carell, Thomas und Michalakis, Stylianos (2015): TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression. In: Cell Reports, Bd. 11, Nr. 2: S. 283-294 [PDF, 3MB]

Bender, Julia; Engeholm, Maik; Ederer, Marion S.; Breu, Johannes; Moller, Thor C.; Michalakis, Stylianos; Rasko, Tamas; Wanker, Erich E.; Biel, Martin; Martinez, Karen L.; Wurst, Wolfgang und Deussing, Jan M. (2015): Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.
In: PLOS ONE 10(9), e0136768 [PDF, 20MB]

Neuner, Johanna; Filser, Severin; Michalakis, Stylianos; Biel, Martin und Herms, Jochen (2014): A30P alpha-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network. In: Scientific Reports, Bd. 4, 3931 [PDF, 11MB]

Neuner, Johanna; Ovsepian, Saak V.; Dorostkar, Mario; Filser, Severin; Gupta, Aayush; Michalakis, Stylianos; Biel, Martin und Herms, Jochen (2014): Pathological alpha-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb. In: Nature Communications, Bd. 5, 3915 [PDF, 2MB]

Arango-Gonzalez, Blanca; Trifunović, Dragana; Sahaboglu, Ayse; Kranz, Katharina; Michalakis, Stylianos; Farinelli, Pietro; Koch, Susanne; Koch, Fred; Cottet, Sandra; Janssen-Bienhold, Ulrike; Dedek, Karin; Biel, Martin; Zrenner, Eberhart; Euler, Thomas; Ekstrom, Per; Ueffing, Marius und Paquet-Durand, François (2014): Identification of a Common Non-Apoptotic Cell Death Mechanism in Hereditary Retinal Degeneration.
In: PLOS ONE 9(11), e112142 [PDF, 1MB]

Hammelmann, Verena; Zong, Xiangang; Hofmann, Franz; Michalakis, Stylianos und Biel, Martin (2011): The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel.
In: PLOS ONE 6(2), e17078 [PDF, 3MB]

Becirovic, Elvir; Nakova, Kostadinka; Hammelmann, Verena; Hennel, Roman; Biel, Martin und Michalakis, Stylianos (29. Januar 2010): The retinitis pigmentosa mutation c.3444+1G>A in CNGB1 results in skipping of exon 32.
In: PLOS ONE 5(1), e8969 [PDF, 173kB]

Globisch, Daniel; Münzel, Martin; Müller, Markus; Michalakis, Stylianos; Wagner, Mirko; Koch, Susanne; Brückl, Tobias; Biel, Martin und Carell, Thomas (2010): Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates.
In: PLOS ONE 5(12), e15367 [PDF, 3MB]

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