Anzahl der Publikationen: 87
Zeitschriftenartikel
Boukovala, Myrto; Modest, Dominik Paul; Ricard, Ingrid; Fischer von Weikersthal, Ludwig; Decker, Thomas; Vehling-Kaiser, Ursula; Uhlig, Jens; Schenk, Michael; Freiberg-Richter, Jens; Peuser, Bettina; Denzlinger, Claudio; Peveling Genannt Reddemann, C.; Graeven, Ullrich ORCID: https://orcid.org/0000-0001-6082-7710; Schuch, Gunter ORCID: https://orcid.org/0000-0001-7503-457X; Schwaner, Ingo ORCID: https://orcid.org/0000-0001-8865-7282; Heinrich, Kathrin ORCID: https://orcid.org/0000-0003-3580-2313; Neumann, Jens; Jung, Andreas; Held, Swantje ORCID: https://orcid.org/0000-0002-1344-9056; Stintzing, Sebastian ORCID: https://orcid.org/0000-0002-3297-5801; Heinemann, Volker ORCID: https://orcid.org/0000-0002-1349-3321 und Michl, Marlies ORCID: https://orcid.org/0000-0002-4198-3627
(2024):
Evaluation of the inflammation-based modified Glasgow Prognostic Score (mGPS) as a prognostic and predictive biomarker in patients with metastatic colorectal cancer receiving first-line chemotherapy: a post hoc analysis of the randomized phase III XELAVIRI trial (AIO KRK0110).
In: ESMO Open, Bd. 9, Nr. 5, 103374
[PDF, 725kB]
Pretzsch, Elise; Heinemann, Volker; Stintzing, Sebastian; Bender, Andreas; Chen, Shuo; Holch, Julian Walter; Hofmann, Felix Oliver; Ren, Haoyu; Bösch, Florian; Küchenhoff, Helmut; Werner, Jens und Angele, Martin Konrad
(14. November 2022):
EMT-Related Genes Have No Prognostic Relevance in Metastatic Colorectal Cancer as Opposed to Stage II/III: Analysis of the Randomised, Phase III Trial FIRE-3 (AIO KRK 0306; FIRE-3).
In: Cancers, Bd. 14, Nr. 22
[PDF, 650kB]
Arai, Hiroyuki; Millstein, Joshua; Yang, Yan; Stintzing, Sebastian; Wang, Jingyuan; Battaglin, Francesca; Kawanishi, Natsuko; Jayachandran, Priya; Soni, Shivani; Zhang, Wu; Heinemann, Volker und Lenz, Heinz-Josef
(2022):
Germline Polymorphisms in Genes Involved in the Antioxidant System Predict the Efficacy of Cetuximab in Metastatic Colorectal Cancer Patients Enrolled in FIRE-3 Trial.
In: Clinical Colorectal Cancer, Bd. 21, Nr. 3: S. 259-266
Hofmann, Felix O. ORCID: https://orcid.org/0000-0002-6913-2429; Heinemann, Volker; D'Anastasi, Melvin; Gesenhues, Alena B.; Hesse, Nina; Weikersthal, Ludwig Fischer von; Decker, Thomas; Kiani, Alexander; Moehler, Markus; Kaiser, Florian; Heintges, Tobias; Kahl, Christoph; Kullmann, Frank; Scheithauer, Werner; Link, Hartmut; Modest, Dominik P.; Stintzing, Sebastian und Holch, Julian W.
(2022):
Standard diametric versus volumetric early tumor shrinkage as a predictor of survival in metastatic colorectal cancer: subgroup findings of the randomized, open-label phase III trial FIRE-3/AIO KRK-0306.
In: European Radiology, Bd. 33, Nr. 2: S. 1174-1184
[PDF, 2MB]
Fischer, Laura E. ORCID: https://orcid.org/0000-0001-8752-5827; Stintzing, Sebastian; Weikersthal, Ludwig Fischer von; Modest, Dominik P.; Decker, Thomas; Kiani, Alexander ORCID: https://orcid.org/0000-0002-2494-4087; Kaiser, Florian; Al-Batran, Salah-Eddin; Heintges, Tobias; Lerchenmüller, Christian; Kahl, Christoph; Seipelt, Gernot; Kullmann, Frank; Stauch, Martina; Scheithauer, Werner; Giessen-Jung, Clemens; Uhlig, Jens; Peuser, Bettina; Denzlinger, Claudio; Stahler, Arndt; Weiss, Lena; Heinrich, Kathrin; Held, Swantje; Jung, Andreas; Kirchner, Thomas und Heinemann, Volker
(2022):
Efficacy of FOLFIRI plus cetuximab vs FOLFIRI plus bevacizumab in 1st-line treatment of older patients with RAS wild-type metastatic colorectal cancer: an analysis of the randomised trial FIRE-3.
In: British Journal of Cancer, Bd. 127, Nr. 5: S. 836-843
[PDF, 788kB]
Kumbrink, Jorg; Bohlmann, Lisa; Mamlouk, Soulafa; Redmer, Torben; Peilstocker, Daniela; Li, Pan; Lorenzen, Sylvie; Alguel, Hana; Kasper, Stefan; Hempel, Dirk; Kaiser, Florian; Michl, Marlies; Bartsch, Harald; Neumann, Jens; Klauschen, Frederick; Bergwelt-Baildon, Michael von; Modest, Dominik Paul; Stahler, Arndt; Stintzing, Sebastian; Jung, Andreas; Kirchner, Thomas; Schäfer, Reinhold; Heinemann, Volker und Holch, Julian W.
(2022):
Serial Analysis of Gene Mutations and Gene Expression during First-Line Chemotherapy against Metastatic Colorectal Cancer: Identification of Potentially Actionable Targets within the Multicenter Prospective Biomarker Study REVEAL.
In: Cancers, Bd. 14, Nr. 15
[PDF, 4MB]
Hofheinz, Ralf; Arnold, Dirk; Fichtner-Feigl, Stefan; Fokas, Emmanouil; Folprecht, Gunnar; Geissler, Michael; Ghadimi, Michael; Hegewisch-Becker, Susanne; Heinemann, Volker; Kasper-Virchow, Stefan; Kubicka, Stefan; Modest, Dominik Paul; Piso, Pompilio; Reinacher-Schick, Anke; Rodel, Claus-Michael; Seufferlein, Thomas; Stein, Alexander und Stintzing, Sebastian
(2022):
Arbeitsgruppen zu kolorektalen Tumoren der AIO, der ACO und der ARO – „past, present, and future“.
In: Onkologe, Bd. 28, Nr. SUPPL 1: S. 44-49
Wang, Jingyuan; Xiao, Yi; Loupakis, Fotios; Stintzing, Sebastian; Yang, Yan; Arai, Hiroyuki; Battaglin, Francesca; Kawanishi, Natsuko; Jayachandran, Priya; Soni, Shivani; Zhang, Wu; Mancao, Christoph; Cremolini, Chiara; Liu, Tianshu; Heinemann, Volker; Falcone, Alfredo; Shen, Lin; Millstein, Joshua und Lenz, Heinz-Josef
(2022):
Genetic variants involved in the cGAS-STING pathway predict outcome in patients with metastatic colorectal cancer: Data from FIRE-3 and TRIBE trials.
In: European Journal of Cancer, Bd. 172: S. 22-30
Stahler, Arndt; Modest, Dominik P.; Fischer von Weikersthal, Ludwig; Kaiser, Florian; Decker, Thomas; Held, Swantje; Graeven, Ullrich; Schwaner, Ingo; Denzlinger, Claudio; Schenk, Michael; Kurreck, Annika; Heinrich, Kathrin; Giessen-Jung, Clemens; Neumann, Jens; Kirchner, Thomas; Jung, Andreas; Stintzing, Sebastian und Heinemann, Volker
(2022):
First-line fluoropyrimidine plus bevacizumab followed by irinotecan-escalation versus initial fluoropyrimidine, irinotecan and bevacizumab in patients with metastatic colorectal cancer - Final survival and per-protocol analysis of the randomised XELAVIRI trial (AIO KRK 0110).
In: European Journal of Cancer, Bd. 173: S. 194-203
Sommerhauser, Greta; Kurreck, Annika; Beck, Alexander; Fehrenbach, Uli; Karthaus, Meinolf; Fruehauf, Stefan; Graeven, Ullrich; Mueller, Lothar; Koenig, Alexander O.; Weikersthal, Ludwig F. v.; Goekkurt, Eray; Haas, Siegfried; Stahler, Arndt; Heinemann, Volker; Held, Swantje; Alig, Annabel H. S.; Kasper, Stefan; Stintzing, Sebastian; Trarbach, Tanja und Modest, Dominik P.
(2022):
Depth of response of induction therapy and consecutive maintenance treatment in patients with RAS wild-type metastatic colorectal cancer: An analysis of the PanaMa trial (AIO KRK 0212).
In: European Journal of Cancer, Bd. 178: S. 37-48
Arends, Christopher Maximilian; Dimitriou, Savvina; Stahler, Arndt; Hablesreiter, Raphael; Strzelecka, Paulina M.; Stein, Catarina M.; Tilgner, Marlon; Saiki, Ryunosuke; Ogawa, Seishi; Bullinger, Lars; Modest, Dominik P.; Stintzing, Sebastian; Heinemann, Volker und Damm, Frederik
(2022):
Clonal hematopoiesis is associated with improved survival in patients with metastatic colorectal cancer from the FIRE-3 trial.
In: Blood, Bd. 139, Nr. 10: S. 1593-1597
Modest, Dominik Paul; Karthaus, Meinolf; Fruehauf, Stefan; Graeven, Ullrich; Müller, Lothar; König, Alexander Otto; Fischer von Weikersthal, Ludwig; Caca, Karel; Kretzschmar, Albrecht; Goekkurt, Eray; Haas, Siegfried; Kurreck, Annika; Stahler, Arndt; Held, Swantje; Jarosch, Armin; Horst, David; Reinacher-Schick, Anke; Kasper, Stefan; Heinemann, Volker; Stintzing, Sebastian und Trarbach, Tanja
(2022):
Panitumumab Plus Fluorouracil and Folinic Acid Versus Fluorouracil and Folinic Acid Alone as Maintenance Therapy in RAS Wild-Type Metastatic Colorectal Cancer: The Randomized PANAMA Trial (AIO KRK 0212).
In: Journal of Clinical Oncology, Bd. 40, Nr. 1: S. 72-82
Kurreck, Annika; Heinemann, Volker; Fischer von Weikersthal, Ludwig; Decker, Thomas; Kaiser, Florian; Uhlig, Jens; Schenk, Michael; Freiberg-Richter, Jens; Peuser, Bettina; Denzlinger, Claudio; Graeven, Ullrich; Heinrich, Kathrin; Held, Swantje; Stahler, Arndt; Alig, Annabel Helga Sophie; Jelas, Ivan; Einem, Jobst C. von; Stintzing, Sebastian; Giessen-Jung, Clemens und Modest, Dominik P.
(2022):
Response and Disease Dynamics in Untreated Metastatic Colorectal Cancer With Bevacizumab-Based Sequential vs. Combination Chemotherapy-Analysis of the Phase 3 XELAVIRI Trial.
In: Frontiers in Oncology, Bd. 12, 751453
Fischer, Laura E.; Stintzing, Sebastian; Heinemann, Volker; Keilholz, Ulrich; Keune, Dietmar; Vollbrecht, Claudia; Burmeister, Thomas; Kind, Andreas; Weiss, Lena; Horst, David; Kirchner, Thomas; Klauschen, Frederick; Jung, Andreas; Westphalen, Christoph Benedikt und Jelas, Ivan
(2022):
Liquid Biopsy in Colorectal Cancer: Quo Vadis? Implementation of Liquid Biopsies in Routine Clinical Patient Care in Two German Comprehensive Cancer Centers.
In: Frontiers in Oncology, Bd. 12, 870411
Claass, Luise Victoria; Schultheiss, Christoph; Scholz, Rebekka; Paschold, Lisa; Simnica, Donjete; Heinemann, Volker; Stintzing, Sebastian und Binder, Mascha
(2022):
PD-L1 Amino Acid Position 88 Represents a Hotspot for PD-L1 Stability With Relevance for PD-L1 Inhibition.
In: Frontiers in Oncology, Bd. 12, 941666
Alig, Annabel H. S.; Heinemann, Volker; Geissler, Michael; Fischer von Weikersthal, Ludwig; Decker, Thomas; Heinrich, Kathrin; Held, Swantje; Weiss, Lena; Moosmann, Nicolas; Stahler, Arndt; Jelas, Ivan; Kurreck, Annika; Einem, Jobst C. von; Reinacher-Schick, Anke C.; Tannapfel, Andrea; Giessen-Jung, Clemens; Stintzing, Sebastian und Modest, Dominik P. von
(2022):
Exact Primary Tumor Location in mCRC: Prognostic Value and Predictive Impact on Anti-EGFR mAb Efficacy.
In: Cancers, Bd. 14, Nr. 3, 526
Raschzok, Nathanael; Stintzing, Sebastian; Heinemann, Volker; Rauch, Geraldine; Ricke, Jens; Guckenberger, Matthias; Kurreck, Annika; Alig, Annabel H. S.; Stahler, Arndt; Bullinger, Lars; Schmelzle, Moritz; Schoening, Wenzel; Lurje, Georg; Krenzien, Felix; Haase, Oliver; Rau, Beate; Gebauer, Bernhard; Sauer, Igor M.; Pratschke, Johann und Modest, Dominik P.
(2022):
FIRE-9-PORT/AIO-KRK-0418: a prospective, randomized, open, multicenter Phase III trial to investigate the efficacy of adjuvant/additive chemotherapy in patients with definitely-treated metastatic colorectal cancer.
In: BMC Cancer, Bd. 22, Nr. 1, 359
Vangala, Deepak; Ladigan, Swetlana; Liffers, Sven-Thorsten; Noseir, Soha; Maghnouj, Abdelouahid; Götze, Tina-Maria; Verdoodt, Berlinda; Klein-Scory, Susanne; Godfrey, Laura; Zowada, Martina K.; Huerta, Mario; Edelstein, Daniel L.; Villarreal, Jaime Martinez de; Marqués, Miriam; Kumbrink, Jörg; Jung, Andreas; Schiergens, Tobias S.; Werner, Jens; Heinemann, Volker; Stintzing, Sebastian; Lindoerfer, Doris ORCID: https://orcid.org/0000-0003-3078-0856; Mansmann, Ulrich; Pohl, Michael; Teschendorf, Christian; Bernhardt, Christiane; Wolters, Heiner; Stern, Josef; Usta, Selami; Viebahn, Richard; Admard, Jacob; Casadei, Nicolas; Fröhling, Stefan; Ball, Claudia R.; Siveke, Jens T.; Glimm, Hanno; Tannapfel, Andrea; Schmiegel, Wolff und Hahn, Stephan A.
(2021):
Secondary resistance to anti-EGFR therapy by transcriptional reprogramming in patient-derived colorectal cancer models.
In: Genome Medicine, Bd. 13, Nr. 116
[PDF, 4MB]
Vangala, Deepak; Ladigan, Swetlana; Liffers, Sven T.; Noseir, Soha; Maghnouj, Abdelouahid; Gotze, Tina-Maria; Verdoodt, Berlinda; Klein-Scory, Susanne; Godfrey, Laura; Zowada, Martina K.; Huerta, Mario; Edelstein, Daniel L.; de Villarreal, Jaime Martinez; Marques, Miriam; Kumbrink, Jorg; Jung, Andreas; Schiergens, Tobias; Werner, Jens; Heinemann, Volker; Stintzing, Sebastian; Lindoerfer, Doris; Mansmann, Ulrich; Pohl, Michael; Teschendorf, Christian; Bernhardt, Christiane; Wolters, Heiner; Stern, Josef; Usta, Selami; Viebahn, Richard; Admard, Jacob; Casadei, Nicolas; Frohling, Stefan; Ball, Claudia R.; Siveke, Jens T.; Glimm, Hanno; Tannapfel, Andrea; Schmiegel, Wolff und Hahn, Stephan A.
(2021):
Secondary resistance to anti-EGFR therapy by transcriptional reprogramming in patient-derived colorectal cancer models.
In: Genome Medicine, Bd. 13, Nr. 1, 116
Stahler, Arndt; Heinemann, Volker; Schuster, Veronika; Heinrich, Kathrin; Kurreck, Annika; Giessen-Jung, Clemens; Weikersthal, Ludwig Fischer von; Kaiser, Florian; Decker, Thomas; Held, Swantje; Graeven, Ullrich; Schwaner, Ingo; Denzlinger, Claudio; Schenk, Michael; Neumann, Jens; Kirchner, Thomas; Jung, Andreas; Kumbrink, Jorg; Stintzing, Sebastian und Modest, Dominik P.
(2021):
Consensus molecular subtypes in metastatic colorectal cancer treated with sequential versus combined fluoropyrimidine, bevacizumab and irinotecan (XELAVIRI trial).
In: European Journal of Cancer, Bd. 157: S. 71-80
Naseem, Madiha; Cao, Shu; Yang, Dongyun; Millstein, Joshua; Puccini, Alberto; Loupakis, Fotios; Stintzing, Sebastian; Cremolini, Chiara; Tokunaga, Ryuma; Battaglin, Francesca; Soni, Shivani; Berger, Martin D.; Barzi, Afsaneh; Zhang, Wu; Falcone, Alfredo; Heinemann, Volker und Lenz, Heinz-Josef
(2021):
Random survival forests identify pathways with polymorphisms predictive of survival in KRAS mutant and KRAS wild-type metastatic colorectal cancer patients.
In: Scientific Reports, Bd. 11, Nr. 1, 12191
Liu, Lian; Erickson, Nicole Tonya; Ricard, Ingrid; Weikersthal, Ludwig Fischer von; Lerch, Markus M.; Decker, Thomas; Kiani, Alexander; Kaiser, Florian; Heintges, Tobias; Kahl, Christoph; Kullmann, Frank; Scheithauer, Werner; Link, Hartmut; Hoeffkes, Heinz-Gert; Moehler, Markus; Gesenhues, Alena Britta; Theurich, Sebastian; Michl, Marlies; Modest, Dominik P.; Alguel, Hana; Stintzing, Sebastian; Heinemann, Volker und Holch, Julian W.
(2021):
Early weight loss is an independent risk factor for shorter survival and increased side effects in patients with metastatic colorectal cancer undergoing first-line treatment within the randomized Phase III trial FIRE-3 (AIO KRK-0306).
In: International Journal of Cancer, Bd. 150, Nr. 1: S. 112-123
Heinrich, Kathrin; Modest, Dominik P.; Ricard, Ingrid; Fischer von Weikersthal, Ludwig; Decker, Thomas; Kaiser, Florian; Graeven, Ullrich; Uhlig, Jens; Schenk, Michael; Freiberg-Richter, Jens; Peuser, Bettina; Denzlinger, Claudio; Giessen-Jung, Clemens; Stahler, Arndt; Michl, Marlies; Held, Swantje; Jung, Andreas; Kirchner, Thomas; Stintzing, Sebastian und Heinemann, Volker
(2021):
Gender-dependent survival benefit from first-line irinotecan in metastatic colorectal cancer. Subgroup analysis of a phase III trial (XELAVIRI-study, AIO-KRK-0110).
In: European Journal of Cancer, Bd. 147: S. 128-139
Arai, Hiroyuki; Millstein, Joshua; Loupakis, Fotios; Stintzing, Sebastian; Wang, Jingyuan; Battaglin, Francesca; Kawanishi, Natsuko; Jayachandran, Priya; Soni, Shivani; Zhang, Wu; Mumenthaler, Shannon M.; Cremolini, Chiara; Heinemann, Volker; Falcone, Alfredo und Lenz, Heinz-Josef
(2021):
Germ line polymorphisms of genes involved in pluripotency transcription factors predict efficacy of cetuximab in metastatic colorectal cancer.
In: European Journal of Cancer, Bd. 150: S. 133-142
Arai, Hiroyuki; Cao, Shu; Battaglin, Francesca; Wang, Jingyuan; Kawanishi, Natsuko; Tokunaga, Ryuma; Loupakis, Fotios; Stintzing, Sebastian; Soni, Shivani; Zhang, Wu; Mancao, Christoph; Salhia, Bodour; Mumenthaler, Shannon M.; Cremolini, Chiara; Heinemann, Volker; Falcone, Alfredo; Millstein, Joshua und Lenz, Heinz-Josef
(2021):
RNA-Binding Protein Polymorphisms as Novel Biomarkers to Predict Outcomes of Metastatic Colorectal Cancer: A Meta-analysis from TRIBE, FIRE-3, and MAVERICC.
In: Molecular Cancer Therapeutics, Bd. 20, Nr. 6: S. 1153-1160
Volz, Nico B.; Hanna, Diana L.; Stintzing, Sebastian; Zhang, Wu; Yang, Dongyun; Cao, Shu; Ning, Yan; Matsusaka, Satoshi; Sunakawa, Yu; Berger, Martin D.; Cremolini, Chiara; Loupakis, Fotios; Falcone, Alfredo und Lenz, Heinz-Josef
(2020):
Polymorphisms within Immune Regulatory Pathways Predict Cetuximab Efficacy and Survival in Metastatic Colorectal Cancer Patients.
In: Cancers, Bd. 12, Nr. 10, 2947
Modest, Dominik Paul; Heinemann, Volker; Folprecht, Gunnar; Denecke, Timm; Pratschke, Johann; Lang, Hauke; Bemelmans, Marc; Becker, Thomas; Rentsch, Markus; Seehofer, Daniel; Bruns, Christiane J.; Gebauer, Bernhard; Held, Swantje; Stahler, Arndt; Heinrich, Kathrin; Einem, Jobst C. von; Stintzing, Sebastian; Neumann, Ulf P. und Ricard, Ingrid
(2020):
Factors That Influence Conversion to Resectability and Survival After Resection of Metastases in RAS WT Metastatic Colorectal Cancer (mCRC): Analysis of FIRE-3-AIOKRK0306.
In: Annals of Surgical Oncology, Bd. 27, Nr. 7: S. 2389-2401
Stahler, Arndt; Stintzing, Sebastian; Modest, Dominik P.; Ricard, Ingrid; Giessen-Jung, Clemens; Kapaun, Christine; Ivanova, Boryana; Kaiser, Florian; Fischer von Weikersthal, Ludwig; Moosmann, Nicolas; Schalhorn, Andreas; Stauch, Martina; Kiani, Alexander; Held, Swantje; Decker, Thomas; Moehler, Markus; Neumann, Jens; Kirchner, Thomas; Jung, Andreas und Heinemann, Volker
(2020):
Amphiregulin Expression Is a Predictive Biomarker for EGFR Inhibition in Metastatic Colorectal Cancer: Combined Analysis of Three Randomized Trials.
In: Clinical Cancer Research, Bd. 26, Nr. 24: S. 6559-6567
Schulz, Christoph; Heinemann, Volker; Heinrich, Kathrin; Haas, Michael; Holch, Julian W.; Fraccaroli, Alessia; Held, Swantje; Einem, Jobst C.von; Modest, Dominik P.; Fischer von Weikersthal, Ludwig; Kullmann, Frank; Moehler, Markus; Scheithauer, Werner; Jung, Andreas und Stintzing, Sebastian
(2020):
Predictive and prognostic value of magnesium serum level in FOLFIRI plus cetuximab or bevacizumab treated patients with stage IV colorectal cancer: results from the FIRE-3 (AIO KRK-0306) study.
In: Anti-Cancer Drugs, Bd. 31, Nr. 8: S. 856-865
Millstein, Joshua; Battaglin, Francesca; Barrett, Malcolm; Cao, Shu; Zhang, Wu; Stintzing, Sebastian; Heinemann, Volker und Lenz, Heinz-Josef
(2020):
Partition: a surjective mapping approach for dimensionality reduction.
In: Bioinformatics, Bd. 36, Nr. 3: S. 676-681
Heinemann, Volker; Fischer von Weikersthal, Ludwig; Decker, Thomas; Kiani, Alexander; Kaiser, Florian; Al-Batran, Salah-Edin; Heintges, Tobias; Lerchenmüller, Christoph; Kahl, Christoph; Seipelt, Gernot; Kullmann, Frank; Moehler, Markus; Scheithauer, Werner; Held, Swantje; Miller-Phillips, Lisa; Modest, Dominik Paul; Jung, Andreas; Kirchner, Thomas und Stintzing, Sebastian
(2020):
FOLFIRI plus cetuximab or bevacizumab for advanced colorectal cancer: final survival and per-protocol analysis of FIRE-3, a randomised clinical trial.
In: British Journal of Cancer, Bd. 124, Nr. 3: S. 587-594
Stahler, Arndt; Stintzing, Sebastian; Einem, Jobst C. von; Westphalen, Christoph B.; Heinrich, Kathrin; Kraemer, Nicole; Michl, Marlies; Modest, Dominik P.; Fischer von Weikersthal, Ludwig; Decker, Thomas; Kiani, Alexander; Heintges, Tobias; Kahl, Christoph; Kullmann, Frank; Scheithauer, Werner; Moehler, Markus; Kaiser, Florian; Kirchner, Thomas; Jung, Andreas und Heinemann, Volker
(2020):
Single-nucleotide variants, tumour mutational burden and microsatellite instability in patients with metastatic colorectal cancer: Next-generation sequencing results of the FIRE-3 trial.
In: European Journal of Cancer, Bd. 137: S. 250-259
Kurreck, Annika; Heinemann, Volker; Fischer von Weikersthal, Ludwig; Decker, Thomas; Kaiser, Florian; Uhlig, Jens; Schenk, Michael; Freiberg-Richter, Jens; Peuser, Bettina; Denzlinger, Claudio; Graeven, Ullrich; Schwaner, Ingo; Stahler, Arndt; Heinrich, Kathrin; Jung, Andreas; Held, Swantje; von Einem, Jobst C.; Stintzing, Sebastian; Giessen-Jung, Clemens und Modest, Dominik P.
(2020):
Impact of age on efficacy and early mortality of initial sequential treatment versus upfront combination chemotherapy in patients with metastatic colorectal cancer: a subgroup analysis of a phase III trial (AIO KRK0110, XELAVIRI study).
In: European Journal of Cancer, Bd. 137: S. 81-92
Berger, Martin D.; Ning, Yan; Stintzing, Sebastian; Heinemann, Volker; Cao, Shu; Zhang, Wu; Yang, Dongyun; Miyamoto, Yuji; Suenaga, Mitsukuni; Schirripa, Marta; Hanna, Diana L.; Soni, Shivani; Puccini, Alberto; Tokunaga, Ryuma; Naseem, Madiha; Battaglin, Francesca; Cremolini, Chiara; Falcone, Alfredo; Loupakis, Fotios und Lenz, Heinz-Josef
(2020):
A polymorphism within the R-spondin 2 gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab: data from FIRE-3 and TRIBE trials.
In: European Journal of Cancer, Bd. 131: S. 89-97
Froelich, Matthias F.; Petersen, Elina L.; Heinemann, Volker; Noerenberg, Dominik; Hesse, Nina; Gesenhues, Alena B.; Modest, Dominik P.; Sommer, Wieland H.; Hofmann, Felix O.; Stintzing, Sebastian und Holch, Julian W.
(2020):
Impact of Size and Location of Metastases on Early Tumor Shrinkage and Depth of Response in Patients With Metastatic Colorectal Cancer: Subgroup Findings of the Randomized, Open-Label Phase 3 Trial FIRE-3/AIO KRK-0306.
In: Clinical Colorectal Cancer, Bd. 19, Nr. 4: S. 291-300
Stahler, Arndt ORCID: https://orcid.org/0000-0003-1041-0137; Heinemann, Volker; Ricard, Ingrid; Einem, Jobst C. von; Giessen-Jung, Clemens; Westphalen, Christoph Benedikt; Michl, Marlies; Heinrich, Kathrin; Miller-Phillips, Lisa; Jelas, Ivan; Stintzing, Sebastian und Modest, Dominik Paul
(2020):
Current treatment options in RAS mutant metastatic colorectal cancer patients: a meta-analysis of 14 randomized phase III trials.
In: Journal of cancer research and clinical oncology, Bd. 146, Nr. 8: S. 2077-2087
[PDF, 1MB]
Tokunaga, Ryuma; Cao, Shu; Naseem, Madiha; Lo, Jae Ho; Battaglin, Francesca; Puccini, Alberto; Berger, Martin D.; Soni, Shivani; Millstein, Joshua; Zhang, Wu; Stintzing, Sebastian; Loupakis, Fotios; Cremolini, Chiara; Heinemann, Volker; Falcone, Alfredo und Lenz, Heinz-Josef
(2019):
Prognostic Effect of Adenosine-related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab-based Chemotherapy.
In: Clinical Colorectal Cancer, Bd. 18, Nr. 1, E8-E19
Modest, Dominik Paul; Fischer von Weikersthal, Ludwig; Decker, Thomas; Vehling-Kaiser, Ursula; Uhlig, Jens; Schenk, Michael; Freiberg-Richter, Jens; Peuser, Bettina; Denzlinger, Claudio; Reddemann, Christina Peveling Genannt; Graeven, Ullrich; Schuch, Gunter; Schwaner, Ingo; Stahler, Arndt; Jung, Andreas; Kirchner, Thomas; Held, Swantje; Stintzing, Sebastian; Giessen-Jung, Clemens und Heinemann, Volker
(2019):
Sequential Versus Combination Therapy of Metastatic Colorectal Cancer Using Fluoropyrimidines, Irinotecan, and Bevacizumab: A Randomized, Controlled StudyXELAVIRI (AIO KRK0110).
In: Journal of Clinical Oncology, Bd. 37, Nr. 1
Laurent-Puig, Pierre; Grisoni, Marie-Lise; Heinemann, Volker; Liebaert, Francois; Neureiter, Daniel; Jung, Andreas; Montestruc, Francois; Gaston-Mathe, Yann; Thiebaut, Raphaeele und Stintzing, Sebastian
(2019):
Validation of miR-31-3p Expression to Predict Cetuximab Efficacy When Used as First-Line Treatment in RAS Wild-Type Metastatic Colorectal Cancer.
In: Clinical Cancer Research, Bd. 25, Nr. 1: S. 134-141
Suenaga, Mitsukuni; Stintzing, Sebastian; Cao, Shu; Zhang, Wu; Yang, Dongyun; Ning, Yan; Okazaki, Satoshi; Berger, Martin D.; Miyamoto, Yuji; Schirripa, Marta; Soni, Shivani; Barzi, Afsaneh; Heinemann, Volker und Lenz, Heinz-Josef
(2019):
Role of CCL5 and CCR5 gene polymorphisms in epidermal growth factor receptor signalling blockade in metastatic colorectal cancer: analysis of the FIRE-3 trial.
In: European Journal of Cancer, Bd. 107: S. 100-114
Schmit, Stephanie L.; Edlund, Christopher K.; Schumacher, Fredrick R.; Gong, Jian; Harrison, Tabitha A.; Huyghe, Jeroen R.; Qu, Chenxu; Melas, Marilena; Van den Berg, David J.; Wang, Hansong; Tring, Stephanie; Plummer, Sarah J.; Albanes, Demetrius; Alonso, M. Henar; Amos, Christopher I.; Anton, Kristen; Aragaki, Aaron K.; Arndt, Volker; Barry, Elizabeth L.; Berndt, Sonja I.; Bezieau, Stephane; Bien, Stephanie; Bloomer, Amanda; Boehm, Jürgen; Boutron-Ruault, Marie-Christine; Brenner, Hermann; Brezina, Stefanie; Buchanan, Daniel D.; Butterbach, Katja; Caan, Bette J.; Campbell, Peter T.; Carlson, Christopher S.; Castelao, Jose E.; Chan, Andrew T.; Chang-Claude, Jenny; Chanock, Stephen J.; Cheng, Iona; Cheng, Ya-Wen; Chin, Lee Soo; Church, James M.; Church, Timothy; Coetzee, Gerhard A.; Cotterchio, Michelle; Correa, Marcia Cruz; Curtis, Keith R.; Duggan, David; Easton, Douglas F.; English, Dallas; Feskens, Edith J. M.; Fischer, Rocky; FitzGerald, Liesel M.; Fortini, Barbara K.; Fritsche, Lars G.; Fuchs, Charles S.; Gago-Dominguez, Manuela; Gala, Manish; Gallinger, Steven J.; Gauderman, W. James; Giles, Graham G.; Giovannucci, Edward L.; Gogarten, Stephanie M.; Gonzalez-Villalpando, Clicerio; Gonzalez-Villalpando, Elena M.; Grady, William M.; Greenson, Joel K.; Gsur, Andrea; Gunter, Marc; Haiman, Christopher A.; Hampe, Jochen; Harlid, Sophia; Harju, John F.; Hayes, Richard B.; Hofer, Philipp; Hoffmeister, Michael; Hopper, John L.; Huang, Shu-Chen; Huerta, Jose Maria; Hudson, Thomas J.; Hunter, David J.; Idos, Gregory E.; Iwasaki, Motoki; Jackson, Rebecca D.; Jacobs, Eric J.; Jee, Sun Ha; Jenkins, Mark A.; Jia, Wei-Hua; Jiao, Shuo; Joshi, Amit D.; Kolonel, Laurence N.; Kono, Suminori; Kooperberg, Charles; Krogh, Vittorio; Kühn, Tilman; Kury, Sebastien; LaCroix, Andrea; Laurie, Cecelia A.; Lejbkowicz, Flavio; Lemire, Mathieu; Lenz, Heinz-Josef; Levine, David; Li, Christopher I.; Li, Li; Lieb, Wolfgang; Lin, Yi; Lindor, Noralane M.; Liu, Yun-Ru; Loupakis, Fotios; Lu, Yingchang; Luh, Frank; Ma, Jing; Mancao, Christoph; Manion, Frank J.; Markowitz, Sanford D.; Martin, Vicente; Matsuda, Koichi; Matsuo, Keitaro; McDonnell, Kevin J.; McNeil, Caroline E.; Milne, Roger; Molina, Antonio J.; Mukherjee, Bhramar; Murphy, Neil; Newcomb, Polly A.; Offit, Kenneth; Omichessan, Hanane; Palli, Domenico; Cotore, Jesus P. Paredes; Perez-Mayoral, Julyann; Pharoah, Paul D.; Potter, John D.; Qu, Conghui; Raskin, Leon; Rennert, Gad; Rennert, Hedy S.; Riggs, Bridget M.; Schafmayer, Clemens; Schön, Robert E.; Sellers, Thomas A.; Seminara, Daniela; Severi, Gianluca; Shi, Wei; Shibata, David; Shu, Xiao-Ou; Siegel, Erin M.; Slattery, Martha L.; Southey, Melissa; Stadler, Zsofia K.; Stern, Mariana C.; Stintzing, Sebastian; Taverna, Darin; Thibodeau, Stephen N.; Thomas, Duncan C.; Trichopoulou, Antonia; Tsugane, Shoichiro; Ulrich, Cornelia M.; van Duijnhoven, Franzel J. B.; van Guelpan, Bethany; Vijai, Joseph; Virtamo, Jarmo; Weinstein, Stephanie J.; White, Emily; Win, Aung Ko; Wolk, Alicja; Woods, Michael; Wu, Anna H.; Wu, Kana; Xiang, Yong-Bing; Yen, Yun; Zanke, Brent W.; Zeng, Yi-Xin; Zhang, Ben; Zubair, Niha; Kweon, Sun-Seog; Figueiredo, Jane C.; Zheng, Wei; Le Marchand, Loic; Lindblom, Annika; Moreno, Victor; Peters, Ulrike; Casey, Graham; Hsu, Li; Conti, David V. und Gruber, Stephen B.
(2019):
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
In: Jnci-Journal of the National Cancer Institute, Bd. 111, Nr. 2: S. 146-157
Puccini, Alberto; Loupakis, Fotios; Stintzing, Sebastian; Cao, Shu; Battaglin, Francesca; Togunaka, Ryuma; Naseem, Madiha; Berger, Martin D.; Soni, Shivani; Zhang, Wu; Mancao, Christoph; Salhia, Bodour; Mumenthaler, Shannon M.; Weisenberger, Daniel J.; Liang, Gangning; Cremolini, Chiara; Heinemann, Volker; Falcone, Alfredo; Millstein, Joshua und Lenz, Heinz-Josef
(2019):
Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3.
In: European Journal of Cancer, Bd. 111: S. 138-147
Goldberg, Richard M.; Montagut, Clara; Wainberg, Zev A.; Ronga, Philippe; Audhuy, Francois; Taieb, Julien; Stintzing, Sebastian; Siena, Salvatore und Santini, Daniele
(2018):
Optimising the use of cetuximab in the continuum of care for patients with metastatic colorectal cancer.
In: Esmo Open, Bd. 3, Nr. 4
[PDF, 1MB]
Froelich, Matthias F.; Stintzing, Sebastian; Kumbrink, Jörg; Grünewald, Thomas G. P.; Mansmann, Ulrich; Heinemann, Volker; Kirchner, Thomas und Jung, Andreas
(2018):
The DNA-polymorphism rs849142 is associated with skin toxicity induced by targeted anti-EGFR therapy using cetuximab.
In: OncoTarget, Bd. 9, Nr. 54: S. 30279-30288
[PDF, 3MB]
Stintzing, Sebastian; Ivanova, Boryana; Ricard, Ingrid; Jung, Andreas; Kirchner, Thomas; Tannapfel, Andrea; Juette, Hendrik; Hegewisch-Becker, Susanna; Arnold, Dirk und Reinacher-Schick, Anke
(2018):
Amphiregulin (AREG) and Epiregulin (EREG) Gene Expression as Predictor for Overall Survival (OS) in Oxaliplatin/Fluoropyrimidine Plus Bevacizumab Treated mCRC Patients-Analysis of the Phase III AIO KRK-0207 Trial.
In: Frontiers in Oncology, Bd. 8, Nr. 474
[PDF, 1MB]
Holch, J. W.; Ricard, I.; Stintzing, Sebastian; Fischer von Weikersthal, Ludwig; Decker, T.; Kiani, A.; Vehling-Kaiser, U.; Heintges, T.; Kahl, C.; Kullmann, F.; Scheithauer, W.; Moehler, M.; Jelas, I.; Modest, D. P.; Westphalen, C. B.; Einem, J. C. von; Michl, M. und Heinemann, V.
(2018):
Relevance of baseline carcinoembryonic antigen for first-line treatment against metastatic colorectal cancer with FOLFIRI plus cetuximab or bevacizumab (FIRE-3 trial).
In: European Journal of Cancer, Bd. 106: S. 115-125
Holch, Julian W.; Ricard, Ingrid; Stintzing, Sebastian; Fischer von Weikersthal, Ludwig; Decker, Thomas; Kiani, Alexander; Vehling-Kaiser, Ursula; Al-Batran, Salah; Heintges, Tobias; Lerchenmüller, Christian; Kahl, Christoph; Kullmann, Frank; Scheithauer, Werner; Scholz, Michael; Müller, Sebastian; Link, Hartmut; Rost, Andreas; Höffkes, Heinz-Gert; Moehler, Markus; Lindig, Reinhard Udo; Miller-Phillips, Lisa; Kirchner, Thomas; Jung, Andreas; Einem, Jobst C. von; Modest, Dominik Paul und Heinemann, Volker
(2018):
Relevance of liver-limited disease in metastatic colorectal cancer: Subgroup findings of the FIRE-3/AIO KRK0306 trial.
In: International Journal of Cancer, Bd. 142, Nr. 5: S. 1047-1055
Hofmann, Felix O.; Holch, Julian W.; Heinemann, Volker; Ricard, Ingrid; Reiser, Maximilian F.; Baumann, Alena B.; Hesse, Nina; D'Anastasi, Melvin; Modest, Dominik P.; Stintzing, Sebastian und Sommer, Wieland H.
(2018):
Prognostic value of radiologically enlarged lymph nodes in patients with metastatic colorectal cancer: Subgroup findings of the randomized, open-label FIRE-3/AIO KRK0306 trial.
In: European Journal of Radiology, Bd. 100: S. 124-129
Suenaga, Mitsukuni; Schirripa, Marta; Cao, Shu; Zhang, Wu; Yang, Dongyun; Cremolini, Chiara; Lonardi, Sara; Bergamo, Francesca; Ning, Yang; Yamamoto, Noriko; Okazaki, Satoshi; Berger, Martin D.; Miyamoto, Yuji; Gopez, Roel; Barzi, Afsaneh; Yamaguchi, Toshiharu; Stintzing, Sebastian; Heinemann, Volker; Loupakis, Fotios; Falcone, Alfredo und Lenz, Heinz-Josef
(2018):
Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer.
In: Pharmacogenomics Journal, Bd. 18, Nr. 5: S. 623-632
Schulz, Christoph; Zhang, Wu; Lenz, Heinz-Josef; Neumann, Jens; Kullmann, Frank; Kunzmann, Volker; Fuchs, Martin; Heinemann, Volker; Holch, Julian Walter und Stintzing, Sebastian
(2018):
Germline polymorphisms (SNPs) to predict toxicity and efficacy in FLOT-treated patients with locally advanced gastroesophageal junction or gastric adenocarcinoma-data from the NeoFLOT study.
In: Translational Cancer Research, Bd. 7, Nr. 6: S. 1393-1405
Winter, Katharina S.; Hofmann, Felix O.; Thierfelder, Kolja M.; Holch, Julian W.; Hesse, Nina; Baumann, Alena B.; Modest, Dominik P.; Stintzing, Sebastian; Heinemann, Volker; Ricke, Jens; Sommer, Wieland H. und D'Anastasi, Melvin
(2018):
Towards volumetric thresholds in RECIST 1.1: Therapeutic response assessment in hepatic metastases.
In: European Radiology, Bd. 28, Nr. 11: S. 4839-4848
Berger, Martin D.; Stintzing, Sebastian; Heinemann, Volker; Cao, Shu; Yang, Dongyun; Sunakawa, Yu; Matsusaka, Satoshi; Ning, Yan; Okazaki, Satoshi; Miyamoto, Yuji; Suenaga, Mitsukuni; Schirripa, Marta; Hanna, Diana L.; Soni, Shivani; Puccini, Alberto; Zhang, Wu; Cremolini, Chiara; Falcone, Alfredo; Loupakis, Fotios und Lenz, Heinz-Josef
(2018):
A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab.
In: Clinical Cancer Research, Bd. 24, Nr. 4: S. 784-793
Schirripa, Marta; Zhang, Wu; Yang, Dongyun; Cao, Shu; Okazaki, Satoshi; Loupakis, Fotios; Berger, Martin D.; Ning, Yan; Miyamoto, Yuji; Suenaga, Mitsukuni; Alberti, Giulia; West, Jordan D.; Lonardi, Sara; Khoukaz, Taline; Bergamo, Francesca; Battaglin, Francesca; Antoniotti, Carlotta; Falcone, Alfredo; Stintzing, Sebastian; Heinemann, Volker und Lenz, Heinz-Josef
(2018):
NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients.
In: PLOS One
13(3), e0193640
[PDF, 2MB]
McSkane, Michelle; Stintzing, Sebastian; Heinemann, Volker; Puccini, Alberto; Naseem, Madiha; Cao, Shu; Lenz, Heinz-Josef und Jelas, Ivan
(2018):
Association Between Height and Clinical Outcome in Metastatic Colorectal Cancer Patients Enrolled Onto a Randomized Phase 3 Clinical Trial: Data From the FIRE-3 Study.
In: Clinical Colorectal Cancer, Bd. 17, Nr. 3: S. 215-222
Froelich, Matthias F.; Heinemann, Volker; Sommer, Wieland H.; Holch, Julian W.; Schöppe, Franziska; Hesse, Nina; Baumann, Alena B.; Kunz, Wolfgang G.; Reiser, Maximilian F.; Ricke, Jens; D'Anastasi, Melvin; Stintzing, Sebastian; Modest, Dominik P.; Kazmierczak, Philipp M. und Hofmann, Felix O.
(2018):
CT attenuation of liver metastases before targeted therapy is a prognostic factor of overall survival in colorectal cancer patients. Results from the randomised, open-label FIRE-3/AIO KRK0306 trial.
In: European Radiology, Bd. 28, Nr. 12: S. 5284-5292
Schirripa, Marta; Zhang, Wu; Heinemann, Volker; Cao, Shu; Okazaki, Satoshi; Yang, Dongyun; Loupakis, Fotios; Berger, Martin D.; Ning, Yan; Miyamoto, Yuji; Suenaga, Mitsukuni; Gopez, Roel F.; West, Jordan D.; Hanna, Diana; Barzi, Afsaneh; Falcone, Alfredo; Stintzing, Sebastian und Lenz, Heinz-Josef
(2017):
Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial.
In: International Journal of Cancer, Bd. 141, Nr. 2: S. 383-392
Albertsmeier, Markus; Engel, Andrea; Guba, Markus; Stintzing, Sebastian; Schiergens, Tobias S.; Schubert-Fritschle, Gabriele; Hölzel, Dieter; Werner, Jens; Angele, Martin K. und Engel, Jutta
(2017):
Synchronous colorectal liver metastases: focus on the elderly. An effectiveness Study from Routine Care.
In: Langenbeck's Archives of Surgery, Bd. 402, Nr. 8: S. 1223-1232
Modest, Dominik P.; Ricard, Ingrid; Stintzing, Sebastian; Fischer von Weikersthal, L.; Decker, T.; Kiani, A.; Vehling-Kaiser, U.; Al-Batran, S.-E.; Heintges, T.; Kahl, C.; Seipelt, G.; Kullmann, F.; Scheithauer, W.; Moehler, M.; Westphalen, C. B.; Holch, Julian W.; Einem, J. C. von; Held, S. und Heinemann, Volker
(2017):
Evaluation of survival across several treatment lines in
metastatic colorectal cancer: analysis of the FIRE-3 trial (AIO KRK0306).
In: European Journal of Cancer, Bd. 84: S. 262-269
Stahler, Arndt; Heinemann, Volker; Neumann, Jens; Crispin, Alexander; Schalhorn, Andreas; Stintzing, Sebastian; Giessen-Jung, Clemens; Fischer von Weikersthal, Ludwig; Vehling-Kaiser, Ursula; Stauch, Martina; Quietzsch, Detlef; Holch, Julian W.; Kruger, Stephan; Haas, Michael; Michl, Marlies; Einem, Jobst von; Kirchner, Thomas; Jung, Andreas und Modest, Dominik P.
(2017):
Prevalence and influence on outcome of HER2/neu, HER3 and NRG1 expression in patients with metastatic colorectal cancer.
In: Anti-cancer drugs, Bd. 28, Nr. 7: S. 717-722
[PDF, 422kB]
Okazaki, Satoshi; Stintzing, Sebastian; Sunakawa, Yu; Cao, Shu; Zhang, Wu; Yang, Dongyun; Ning, Yan; Matsusaka, Satoshi; Berger, Martin D.; Miyamoto, Yuji; Suenaga, Mitsukuni; Schirripa, Marta; West, Jordan D.; Gopez, Roel; Akihito, Tsuji; Ichikawa, Wataru; Heinemann, Volker; DePaolo, R. William und Lenz, Heinz-Josef
(2017):
Predictive value of TLR7 polymorphism for cetuximab-based chemotherapy in patients with metastatic colorectal cancer.
In: International Journal of Cancer, Bd. 141, Nr. 6: S. 1222-1230
Tejpar, Sabine; Stintzing, Sebastian; Ciardiello, Fortunato; Tabernero, Josep; Cutsem, Eric van; Beier, Frank; Esser, Regina; Lenz, Heinz-Josef und Heinemann, Volker
(2017):
Prognostic and Predictive Relevance of Primary Tumor Location in Patients With RAS Wild-Type Metastatic Colorectal Cancer Retrospective Analyses of the CRYSTAL and FIRE-3 Trials.
In: Jama Oncology, Bd. 3, Nr. 2: S. 194-201
Modest, Dominik P.; Stintzing, Sebastian; Fischer von Weikersthal, Ludwig; Decker, Thomas; Kiani, Alexander; Vehling-Kaiser, Ursula; Al-Batran, Salah-Eddin; Heintges, Tobias; Lerchenmüller, Christian; Kahl, Christoph; Seipelt, Gernot; Kullmann, Frank; Scheithauer, Werner; Kirchner, Thomas; Jung, Andreas; Stauch, Martina; Einem, Jobst Christian von; Möhler, Markus; Held, Swantje und Heinemann, Volker
(2017):
Relation of early tumor shrinkage (ETS) observed in first-line treatment to efficacy parameters of subsequent treatment in FIRE-3 (AIOKRK0306).
In: International Journal of Cancer, Bd. 140, Nr. 8: S. 1918-1925
Berger, Martin D.; Yamauchi, Shinichi; Cao, Shu; Hanna, Diana L.; Sunakawa, Yu; Schirripa, Marta; Matsusaka, Satoshi; Yang, Dongyun; Groshen, Susan; Zhang, Wu; Ning, Yan; Okazaki, Satoshi; Miyamoto, Yuji; Suenaga, Mitsukuni; Lonardi, Sara; Cremolini, Chiara; Falcone, Alfredo; Heinemann, Volker; Loupakis, Fotios; Stintzing, Sebastian und Lenz, Heinz-Josef
(2017):
Autophagy-related polymorphisms predict hypertension in patients with metastatic colorectal cancer treated with FOLFIRI and bevacizumab: Results from TRIBE and FIRE-3 trials.
In: European Journal of Cancer, Bd. 77: S. 13-20
Modest, Dominik P.; Ricard, Ingrid; Heinemann, Volker; Hegewisch-Becker, S.; Schmiegel, W.; Porschen, R.; Stintzing, Sebastian; Graeven, U.; Arnold, D.; Fischer von Weikersthal, L.; Giessen-Jung, Clemens; Stahler, A.; Schmoll, H. J.; Jung, A.; Kirchner, T.; Tannapfel, A. und Reinacher-Schick, A.
(September 2016):
Outcome according to KRAS-, NRAS- and BRAF-mutation as well as KRAS mutation variants: pooled analysis of five randomized trials in metastatic colorectal cancer by the AIO colorectal cancer study group.
In: Annals of Oncology, Bd. 27, Nr. 9: S. 1746-1753
[PDF, 410kB]
Matsusaka, Satoshi; Hanna, Diana L.; Cao, Shu; Zhang, Wu; Yang, Dongyun; Ning, Yan; Sunakawa, Yu; Okazaki, Satoshi; Berger, Martin D.; Miyamato, Yuji; Parekh, Anish; Stintzing, Sebastian; Loupakis, Fotios und Lenz, Heinz-Josef
(2016):
Prognostic Impact of IL6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy.
In: Clinical Cancer Research, Bd. 22, Nr. 13: S. 3218-3226
Okazaki, Satoshi; Loupakis, Fotios; Stintzing, Sebastian; Cao, Shu; Zhang, Wu; Yang, Dongyun; Ning, Yan; Sunakawa, Yu; Stremitzer, Stefan; Matsusaka, Satoshi; Berger, Martin D.; Parekh, Anish; West, Jordan D.; Miyamoto, Yuji; Suenaga, Mitsukuni; Schirripa, Marta; Cremolini, Chiara; Falcone, Alfredo; Heinemann, Volker; DePaolo, R. William und Lenz, Heinz-Josef
(2016):
Clinical Significance of TLR1 I602S Polymorphism for Patients with Metastatic Colorectal Cancer Treated with FOLFIRI plus Bevacizumab.
In: Molecular Cancer therapeutics, Bd. 15, Nr. 7: S. 1740-1745
Okazaki, Satoshi; Stintzing, Sebastian; Heinemann, Volker; Cao, Shu; Zhang, Wu; Yang, Dongyun; Ning, Yan; Matsusaka, Satoshi; Berger, Martin D.; West, Jordan D.; Miyamoto, Yuji; Suenaga, Mitsukuni und Lenz, Heinz-Josef
(2016):
Association of TLR9 polymorphism with overall survival in metastatic colorectal cancer patients treated with FOLFIRI plus bevacizumab enrolled in FIRE3.
In: Journal of Clinical Oncology, Bd. 34, Nr. 4
Stintzing, Sebastian; Modest, Dominik Paul; Jung, Andreas; Kirchner, Thomas; Schäfer, Reinhold; Sers, Christine; Hildebrandt, Bert; Daum, Severin; Folprecht, Gunnar; Schuler, Martin H.; Kasper, Stefan; Trojan, Jorg; Jaeger, Dirk; Schulze-Bergkamen, Henning; Fischer von Weikersthal, Ludwig; Schalhorn, Alexander und Heinemann, Volker
(2016):
Differences in gene-expression in mCRC tissue samples with regard to tumor location and used chemotherapeutic substances: Data of the FIRE-1 study.
In: Journal of Clinical Oncology, Bd. 34, Nr. 4
Berger, Martin D.; Stintzing, Sebastian; Heinemann, Volker; Yang, Dongyun; Sunakawa, Yu; Ning, Yan; Matsusaka, Satoshi; Okazaki, Satoshi; Miyamoto, Yuji; Suenaga, Mitsukuni; West, Jordan David; Zhang, Wu; Petasis, Nicos und Lenz, Heinz-Josef
(2016):
Serum amyloid a (SAA-1) SNP rs12218 to predict outcome for mCRC patients treated with FOLFIRI and bevacizumab: Data from FIRE-3 trial.
In: Journal of Clinical Oncology, Bd. 34, Nr. 4
Modest, Dominik Paul; Stintzing, Sebastian; Fischer von Weikersthal, Ludwig; Sobrero, Alberto F.; Decker, Thomas; Kiani, Alexander; Vehling-Kaiser, Ursula; Al-Batran, Salah-Eddin; Heintges, Tobias; Seipelt, Gernot; Lerchenmüller, Christian A.; Kahl, Christoph; Kullmann, Frank; Stauch, Martina; Scheithauer, Werner; Held, Swantje; Moehler, Markus H.; Jung, Andreas; Kirchner, Thomas und Heinemann, Volker
(2016):
Time-course evaluation of survival and treatment in FIRE-3 (AIO KRK0306, first-line therapy of KRAS wild-type metastatic colorectal cancer with FOLFIRI plus cetuximab or bevacizumab).
In: Journal of Clinical Oncology, Bd. 34, Nr. 4
Stintzing, Sebastian; Modest, Dominik P.; Rossius, Lisa; Lerch, Markus M.; Fischer von Weikersthal, Ludwig; Decker, Thomas; Kiani, Alexander; Vehling-Kaiser, Ursula; Al-Batran, Salah-Eddin; Heintges, Tobias; Lerchenmüller, Christian; Kahl, Christoph; Seipelt, Gernot; Kullmann, Frank; Stauch, Martina; Scheithauer, Werner; Held, Swantje; Giessen-Jung, Clemens; Moehler, Markus; Jagenburg, Andreas; Kirchner, Thomas; Jung, Andreas und Heinemann, Volker
(2016):
FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab for metastatic colorectal cancer (FIRE-3): a post-hoc analysis of tumour dynamics in the final RAS wild-type subgroup of this randomised open-label phase 3 trial.
In: Lancet Oncology, Bd. 17, Nr. 10: S. 1426-1434
Gamba, Sebastian; Camaj, Peter; Heinemann, Volker; Laubender, Rüdiger P.; Wang, Yan; Zhao, Yue; Stintzing, Sebastian; Giessen, Clemens; Boeck, Stefan; Haertl, Christoph; Bruns, Christiane J. und Modest, Dominik P.
(2015):
Effect of KRAS exon 2 mutations on antitumor activity of afatinib and gefitinib.
In: Anti-Cancer Drugs, Bd. 26, Nr. 4: S. 371-378
[PDF, 251kB]
Modest, Dominik P.; Schulz, Christoph; Fischer von Weikersthal, Ludwig; Quietzsch, Detlef; Einem, J. C. von; Schalhorn, Andreas; Vehling-Kaiser, Ursula; Laubender, Rüdiger P.; Giessen, Clemens; Stintzing, Sebastian und Heinemann, Volker
(2014):
Outcome of patients with metastatic colorectal cancer depends on the primary tumor site (midgut vs. hindgut): analysis of the FIRE1-trial (FuFIRI or mIROX as first-line treatment).
In: Anticancer Drugs, Bd. 25, Nr. 2: S. 212-218
[PDF, 442kB]
Stintzing, Sebastian; Fischhaber, Doris; Mook, Charlotte; Modest, Dominik P.; Giessen, Clemens; Schulz, Christoph; Haas, Michael; Böck, Stefan; Michl, Marlies; Stemmler, Joachim; Laubender, Ruediger P. und Heinemann, Volker
(Oktober 2013):
Clinical relevance and utility of cetuximab-related changes in magnesium and calcium serum levels.
In: Anti-Cancer Drugs, Bd. 24, Nr. 9: S. 969-974
[PDF, 372kB]
Modest, Dominik P.; Brodowicz, Thomas; Stintzing, Sebastian; Jung, Andreas; Neumann, Jens; Laubender, Ruediger P.; Ocvirk, Janja; Kurteva, Galina; Papai, Zsuzsanna; Knittelfelder, Regina; Kirchner, Thomas; Heinemann, Volker und Zielinski, Christoph C.
(2012):
Impact of the Specific Mutation in KRAS Codon 12 Mutated Tumors on Treatment Efficacy in Patients with Metastatic Colorectal Cancer Receiving Cetuximab-Based First-Line Therapy: A Pooled Analysis of Three Trials.
In: Oncology, Nr. 5: S. 241-247
[PDF, 200kB]
Giessen, Clemens; Fischer von Weikersthal, Ludwig; Hinke, Axel; Stintzing, Sebastian; Kullmann, Frank; Vehling-Kaiser, Ursula; Mayerle, Julia; Bangerter, Markus; Denzlinger, Claudio; Sieber, Markus; Teschendorf, Christian; Freiberg-Richter, Jens; Schulz, Christoph; Modest, Dominik Paul; Moosmann, Nicolas; Aubele, Philipp und Heinemann, Volker
(2011):
A randomized, phase III trial of capecitabine plus bevacizumab (Cape-Bev) versus capecitabine plus irinotecan plus bevacizumab (CAPIRI-Bev) in first-line treatment of metastatic colorectal cancer: The AIO KRK 0110 Trial/ML22011 Trial.
In: BMC Cancer
11:367
[PDF, 533kB]
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